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The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling.

van Tok MN, Na S, Lao CR, Alvi M, Pots D, van de Sande MGH, Taurog JD, Sedgwick JD, Baeten DL, van Duivenvoorde LM.

Front Immunol. 2018 Jul 9;9:1550. doi: 10.3389/fimmu.2018.01550. eCollection 2018.


Loss of TNF signaling facilitates the development of a novel Ly-6C(low) macrophage population permissive for Leishmania major infection.

Fromm PD, Kling J, Mack M, Sedgwick JD, Körner H.

J Immunol. 2012 Jun 15;188(12):6258-66. doi: 10.4049/jimmunol.1100977. Epub 2012 May 21.


A critical function for CD200 in lung immune homeostasis and the severity of influenza infection.

Snelgrove RJ, Goulding J, Didierlaurent AM, Lyonga D, Vekaria S, Edwards L, Gwyer E, Sedgwick JD, Barclay AN, Hussell T.

Nat Immunol. 2008 Sep;9(9):1074-83. doi: 10.1038/ni.1637. Epub 2008 Jul 27.


STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.

Ernst M, Najdovska M, Grail D, Lundgren-May T, Buchert M, Tye H, Matthews VB, Armes J, Bhathal PS, Hughes NR, Marcusson EG, Karras JG, Na S, Sedgwick JD, Hertzog PJ, Jenkins BJ.

J Clin Invest. 2008 May;118(5):1727-38. doi: 10.1172/JCI34944.


CD200 and its receptor, CD200R, modulate bone mass via the differentiation of osteoclasts.

Cui W, Cuartas E, Ke J, Zhang Q, Einarsson HB, Sedgwick JD, Li J, Vignery A.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14436-41. Epub 2007 Aug 28.


Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis.

Copland DA, Calder CJ, Raveney BJ, Nicholson LB, Phillips J, Cherwinski H, Jenmalm M, Sedgwick JD, Dick AD.

Am J Pathol. 2007 Aug;171(2):580-8. Epub 2007 Jun 28.


The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation.

Kikly K, Liu L, Na S, Sedgwick JD.

Curr Opin Immunol. 2006 Dec;18(6):670-5. Epub 2006 Sep 28. Review. Erratum in: Curr Opin Immunol. 2007 Feb;19(1):111.


TNF is important for pathogen control and limits brain damage in murine cerebral listeriosis.

Virna S, Deckert M, Lütjen S, Soltek S, Foulds KE, Shen H, Körner H, Sedgwick JD, Schlüter D.

J Immunol. 2006 Sep 15;177(6):3972-82.


Regulation of microglial cell responses in murine Toxoplasma encephalitis by CD200/CD200 receptor interaction.

Deckert M, Sedgwick JD, Fischer E, Schlüter D.

Acta Neuropathol. 2006 Jun;111(6):548-58. Epub 2006 Apr 28.


Mast cell-associated TNF promotes dendritic cell migration.

Suto H, Nakae S, Kakurai M, Sedgwick JD, Tsai M, Galli SJ.

J Immunol. 2006 Apr 1;176(7):4102-12.


Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice.

Tan SL, Zhao J, Bi C, Chen XC, Hepburn DL, Wang J, Sedgwick JD, Chintalacharuvu SR, Na S.

J Immunol. 2006 Mar 1;176(5):2872-9.


Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF.

Nakae S, Suto H, Iikura M, Kakurai M, Sedgwick JD, Tsai M, Galli SJ.

J Immunol. 2006 Feb 15;176(4):2238-48.


Regulation of myeloid cell function through the CD200 receptor.

Jenmalm MC, Cherwinski H, Bowman EP, Phillips JH, Sedgwick JD.

J Immunol. 2006 Jan 1;176(1):191-9.


Membrane tumor necrosis factor confers partial protection to Listeria infection.

Torres D, Janot L, Quesniaux VF, Grivennikov SI, Maillet I, Sedgwick JD, Ryffel B, Erard F.

Am J Pathol. 2005 Dec;167(6):1677-87.


ELISPOT assay: a personal retrospective.

Sedgwick JD.

Methods Mol Biol. 2005;302:3-14.


Mast cells enhance T cell activation: Importance of mast cell-derived TNF.

Nakae S, Suto H, Kakurai M, Sedgwick JD, Tsai M, Galli SJ.

Proc Natl Acad Sci U S A. 2005 May 3;102(18):6467-72. Epub 2005 Apr 19.


An essential role for tumor necrosis factor in the formation of experimental murine Staphylococcus aureus-induced brain abscess and clearance.

Stenzel W, Soltek S, Miletic H, Hermann MM, Körner H, Sedgwick JD, Schlüter D, Deckert M.

J Neuropathol Exp Neurol. 2005 Jan;64(1):27-36.


The CD200 receptor is a novel and potent regulator of murine and human mast cell function.

Cherwinski HM, Murphy CA, Joyce BL, Bigler ME, Song YS, Zurawski SM, Moshrefi MM, Gorman DM, Miller KL, Zhang S, Sedgwick JD, Phillips JH.

J Immunol. 2005 Feb 1;174(3):1348-56.


IL-23 drives a pathogenic T cell population that induces autoimmune inflammation.

Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, McClanahan T, Kastelein RA, Cua DJ.

J Exp Med. 2005 Jan 17;201(2):233-40.


Enhanced tolerance to autoimmune uveitis in CD200-deficient mice correlates with a pronounced Th2 switch in response to antigen challenge.

Taylor N, McConachie K, Calder C, Dawson R, Dick A, Sedgwick JD, Liversidge J.

J Immunol. 2005 Jan 1;174(1):143-54. Erratum in: J Immunol. 2005 Mar 15;174(6):3818. McConnachie, Karen [corrected to McConachie, Karen].


Molecular mechanisms of CD200 inhibition of mast cell activation.

Zhang S, Cherwinski H, Sedgwick JD, Phillips JH.

J Immunol. 2004 Dec 1;173(11):6786-93.


A novel model for lymphocytic infiltration of the thyroid gland generated by transgenic expression of the CC chemokine CCL21.

Martin AP, Coronel EC, Sano G, Chen SC, Vassileva G, Canasto-Chibuque C, Sedgwick JD, Frenette PS, Lipp M, Furtado GC, Lira SA.

J Immunol. 2004 Oct 15;173(8):4791-8.


Involvement of TNF in limiting liver pathology and promoting parasite survival during schistosome infection.

Davies SJ, Lim KC, Blank RB, Kim JH, Lucas KD, Hernandez DC, Sedgwick JD, McKerrow JH.

Int J Parasitol. 2004 Jan;34(1):27-36.


Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation.

Murphy CA, Langrish CL, Chen Y, Blumenschein W, McClanahan T, Kastelein RA, Sedgwick JD, Cua DJ.

J Exp Med. 2003 Dec 15;198(12):1951-7. Epub 2003 Dec 8.


Characterization of the CD200 receptor family in mice and humans and their interactions with CD200.

Wright GJ, Cherwinski H, Foster-Cuevas M, Brooke G, Puklavec MJ, Bigler M, Song Y, Jenmalm M, Gorman D, McClanahan T, Liu MR, Brown MH, Sedgwick JD, Phillips JH, Barclay AN.

J Immunol. 2003 Sep 15;171(6):3034-46.


Intrinsic renal cells are the major source of tumor necrosis factor contributing to renal injury in murine crescentic glomerulonephritis.

Timoshanko JR, Sedgwick JD, Holdsworth SR, Tipping PG.

J Am Soc Nephrol. 2003 Jul;14(7):1785-93.


Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain.

Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W, Kwan S, Churakova T, Zurawski S, Wiekowski M, Lira SA, Gorman D, Kastelein RA, Sedgwick JD.

Nature. 2003 Feb 13;421(6924):744-8.


Membrane lymphotoxin contributes to anti-leishmanial immunity by controlling structural integrity of lymphoid organs.

Wilhelm P, Riminton DS, Ritter U, Lemckert FA, Scheidig C, Hoek R, Sedgwick JD, Körner H.

Eur J Immunol. 2002 Jul;32(7):1993-2003.


Novel concepts of tumor necrosis factor action in autoimmune pathology.

Riminton DS, Sedgwick JD.

Curr Dir Autoimmun. 2000;2:50-82. Review. No abstract available.


Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation.

Ruuls SR, Hoek RM, Ngo VN, McNeil T, Lucian LA, Janatpour MJ, Körner H, Scheerens H, Hessel EM, Cyster JG, McEvoy LM, Sedgwick JD.

Immunity. 2001 Oct;15(4):533-43.


Lymphotoxin controls alphaEbeta7-integrin expression by peripheral CD8+ T cells.

Gabor MJ, Sedgwick JD, Lemckert FA, Godfrey DI, Körner H.

Immunol Cell Biol. 2001 Aug;79(4):323-31.


Recirculating and marginal zone B cell populations can be established and maintained independently of primary and secondary follicles.

Körner H, Winkler TH, Sedgwick JD, Röllinghoff M, Basten A, Cook MC.

Immunol Cell Biol. 2001 Feb;79(1):54-61.


Down-regulation of the macrophage lineage through interaction with OX2 (CD200).

Hoek RM, Ruuls SR, Murphy CA, Wright GJ, Goddard R, Zurawski SM, Blom B, Homola ME, Streit WJ, Brown MH, Barclay AN, Sedgwick JD.

Science. 2000 Dec 1;290(5497):1768-71.


Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy.

Jones DE, Palmer JM, Kirby JA, De Cruz DJ, McCaughan GW, Sedgwick JD, Yeaman SJ, Burt AD, Bassendine MF.

Liver. 2000 Oct;20(5):351-6.


DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming.

Bakker AB, Hoek RM, Cerwenka A, Blom B, Lucian L, McNeil T, Murray R, Phillips LH, Sedgwick JD, Lanier LL.

Immunity. 2000 Sep;13(3):345-53.


Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function.

Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN.

Immunity. 2000 Aug;13(2):233-42.


A chemokine-driven positive feedback loop organizes lymphoid follicles.

Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG.

Nature. 2000 Jul 20;406(6793):309-14.


Tumor necrosis factor: a master-regulator of leukocyte movement.

Sedgwick JD, Riminton DS, Cyster JG, Körner H.

Immunol Today. 2000 Mar;21(3):110-3. Review. No abstract available.


Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotype.

Körner H, Cretney E, Wilhelm P, Kelly JM, Röllinghoff M, Sedgwick JD, Smyth MJ.

J Exp Med. 2000 Jan 3;191(1):89-96. Erratum in: J Exp Med 2000 Apr 17;191(8):following 1948.


Unlinking tumor necrosis factor biology from the major histocompatibility complex: lessons from human genetics and animal models.

Ruuls SR, Sedgwick JD.

Am J Hum Genet. 1999 Aug;65(2):294-301. Review. No abstract available.


Adenovirus-induced liver pathology is mediated through TNF receptors I and II but is independent of TNF or lymphotoxin.

Hayder H, Blanden RV, Körner H, Riminton DS, Sedgwick JD, Müllbacher A.

J Immunol. 1999 Aug 1;163(3):1516-20.

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