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Items: 1 to 50 of 58

1.

Investigating inherent functional differences between human cardiac fibroblasts cultured from nondiabetic and Type 2 diabetic donors.

Sedgwick B, Riches K, Bageghni SA, O'Regan DJ, Porter KE, Turner NA.

Cardiovasc Pathol. 2014 Jul-Aug;23(4):204-10. doi: 10.1016/j.carpath.2014.03.004. Epub 2014 Mar 26.

2.

Prevalence of loss-of-function FTO mutations in lean and obese individuals.

Meyre D, Proulx K, Kawagoe-Takaki H, Vatin V, Gutiérrez-Aguilar R, Lyon D, Ma M, Choquet H, Horber F, Van Hul W, Van Gaal L, Balkau B, Visvikis-Siest S, Pattou F, Farooqi IS, Saudek V, O'Rahilly S, Froguel P, Sedgwick B, Yeo GS.

Diabetes. 2010 Jan;59(1):311-8. doi: 10.2337/db09-0703. Epub 2009 Oct 15.

3.

Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations.

Boissel S, Reish O, Proulx K, Kawagoe-Takaki H, Sedgwick B, Yeo GS, Meyre D, Golzio C, Molinari F, Kadhom N, Etchevers HC, Saudek V, Farooqi IS, Froguel P, Lindahl T, O'Rahilly S, Munnich A, Colleaux L.

Am J Hum Genet. 2009 Jul;85(1):106-11. doi: 10.1016/j.ajhg.2009.06.002. Epub 2009 Jun 25.

4.

Dynamic states of the DNA repair enzyme AlkB regulate product release.

Bleijlevens B, Shivarattan T, Flashman E, Yang Y, Simpson PJ, Koivisto P, Sedgwick B, Schofield CJ, Matthews SJ.

EMBO Rep. 2008 Sep;9(9):872-7. doi: 10.1038/embor.2008.120. Epub 2008 Jul 11.

5.

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ.

Science. 2007 Nov 30;318(5855):1469-72. Epub 2007 Nov 8.

6.

Replacement of non-heme Fe(II) with Cu(II) in the alpha-ketoglutarate dependent DNA repair enzyme AlkB: spectroscopic characterization of the active site.

Bleijlevens B, Shivarattan T, Sedgwick B, Rigby SE, Matthews SJ.

J Inorg Biochem. 2007 Jul;101(7):1043-8. Epub 2007 Apr 21.

PMID:
17553567
7.

Repair of alkylated DNA: recent advances.

Sedgwick B, Bates PA, Paik J, Jacobs SC, Lindahl T.

DNA Repair (Amst). 2007 Apr 1;6(4):429-42. Epub 2006 Nov 16. Review.

PMID:
17112791
8.

Direct removal of alkylation damage from DNA by AlkB and related DNA dioxygenases.

Sedgwick B, Robins P, Lindahl T.

Methods Enzymol. 2006;408:108-20.

PMID:
16793366
9.
10.

Resonance assignments of Escherichia coli AlkB: a key 2-oxoglutarate and Fe(II) dependent dioxygenase of the adaptive DNA-repair response.

Shivarattan T, Chen HA, Simpson P, Sedgwick B, Matthews S.

J Biomol NMR. 2005 Oct;33(2):138. No abstract available.

PMID:
16258838
11.

Demethylation of 3-methylthymine in DNA by bacterial and human DNA dioxygenases.

Koivisto P, Robins P, Lindahl T, Sedgwick B.

J Biol Chem. 2004 Sep 24;279(39):40470-4. Epub 2004 Jul 20.

12.

Repairing DNA-methylation damage.

Sedgwick B.

Nat Rev Mol Cell Biol. 2004 Feb;5(2):148-57. Review.

PMID:
15040447
13.

Minimal methylated substrate and extended substrate range of Escherichia coli AlkB protein, a 1-methyladenine-DNA dioxygenase.

Koivisto P, Duncan T, Lindahl T, Sedgwick B.

J Biol Chem. 2003 Nov 7;278(45):44348-54. Epub 2003 Aug 27.

14.

Reversal of DNA alkylation damage by two human dioxygenases.

Duncan T, Trewick SC, Koivisto P, Bates PA, Lindahl T, Sedgwick B.

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16660-5. Epub 2002 Dec 16.

15.

Recent progress on the Ada response for inducible repair of DNA alkylation damage.

Sedgwick B, Lindahl T.

Oncogene. 2002 Dec 16;21(58):8886-94. Review. No abstract available.

16.

Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage.

Trewick SC, Henshaw TF, Hausinger RP, Lindahl T, Sedgwick B.

Nature. 2002 Sep 12;419(6903):174-8.

PMID:
12226667
17.

Defective processing of methylated single-stranded DNA by E. coli AlkB mutants.

Dinglay S, Trewick SC, Lindahl T, Sedgwick B.

Genes Dev. 2000 Aug 15;14(16):2097-105.

18.

Delta9-tetrahydrocannabivarin (THCV) as a marker of cannabis use: is the methodology forensically acceptable?

Sedgwick B.

J Anal Toxicol. 2000 Jan-Feb;24(1):73-5. No abstract available.

PMID:
10654574
19.

Repair in Escherichia coli alkB mutants of abasic sites and 3-methyladenine residues in DNA.

Dinglay S, Gold B, Sedgwick B.

Mutat Res. 1998 Mar;407(2):109-16.

PMID:
9637239
21.
22.
23.
24.

Release of 5'-terminal deoxyribose-phosphate residues from incised abasic sites in DNA by the Escherichia coli RecJ protein.

Dianov G, Sedgwick B, Daly G, Olsson M, Lovett S, Lindahl T.

Nucleic Acids Res. 1994 Mar 25;22(6):993-8.

25.

DNA repair.

Barnes DE, Lindahl T, Sedgwick B.

Curr Opin Cell Biol. 1993 Jun;5(3):424-33. Review.

PMID:
8352959
26.
28.

Widespread adaptive response against environmental methylating agents in microorganisms.

Sedgwick B, Vaughan P.

Mutat Res. 1991 Sep-Oct;250(1-2):211-21. Review.

PMID:
1944338
29.

A weak adaptive response to alkylation damage in Salmonella typhimurium.

Vaughan P, Sedgwick B.

J Bacteriol. 1991 Jun;173(12):3656-62.

30.

Environmental mutagens that induce the adaptive response to alkylating agents in Escherichia coli.

Vaughan P, Sedgwick B, Hall J, Gannon J, Lindahl T.

Carcinogenesis. 1991 Feb;12(2):263-8.

PMID:
1995192
32.
33.

Functional domains and methyl acceptor sites of the Escherichia coli ada protein.

Sedgwick B, Robins P, Totty N, Lindahl T.

J Biol Chem. 1988 Mar 25;263(9):4430-3.

34.

Regulation and expression of the adaptive response to alkylating agents.

Lindahl T, Sedgwick B, Sekiguchi M, Nakabeppu Y.

Annu Rev Biochem. 1988;57:133-57. Review. No abstract available.

PMID:
3052269
35.
36.

The intracellular signal for induction of resistance to alkylating agents in E. coli.

Teo I, Sedgwick B, Kilpatrick MW, McCarthy TV, Lindahl T.

Cell. 1986 Apr 25;45(2):315-24.

PMID:
3009022
37.

Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

Demple B, Sedgwick B, Robins P, Totty N, Waterfield MD, Lindahl T.

Proc Natl Acad Sci U S A. 1985 May;82(9):2688-92.

39.

Detection of ritalinic acid in urine by thin-layer chromatography and gas chromatography.

Allen HW, Sedgwick B.

J Anal Toxicol. 1984 Mar-Apr;8(2):61-2.

PMID:
6716975
40.
41.

Inducible DNA repair enzymes involved in the adaptive response to alkylating agents.

Lindahl T, Karran P, Demple B, Sedgwick B, Harris A.

Biochimie. 1982 Aug-Sep;64(8-9):581-3.

PMID:
6814505
43.

The adaptive response to alkylating agents: the removal of O6-methylguanine from DNA is not dependent on DNA polymerase-1.

Karran P, Stevens S, Sedgwick B.

Mutat Res. 1982 Apr;104(1-3):67-73. No abstract available.

PMID:
7043256
45.

A common mechanism for repair of O6-methylguanine and O6-ethylguanine in DNA.

Sedgwick B, Lindahl T.

J Mol Biol. 1982 Jan 5;154(1):169-75. No abstract available.

PMID:
7042978
46.

The coenzyme A requirement of mammalian fatty acid synthetase: evidence for involvement in the elongation of acyl-enzyme thioesters.

Sedgwick B, Smith S.

Arch Biochem Biophys. 1981 May;208(2):365-79. No abstract available.

PMID:
6114710
47.

The inducible repair of alkylated DNA.

Cairns J, Robins P, Sedgwick B, Talmud P.

Prog Nucleic Acid Res Mol Biol. 1981;26:237-44. No abstract available.

PMID:
7025094
49.
50.

The biosynthesis of long-chain fatty acids. Stereochemical differentiation in the enzymic incorporation of chiral acetates.

Sedgwick B, Cornforth JW.

Eur J Biochem. 1977 May 16;75(2):465-79. No abstract available.

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