Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 71


Relevance of experimental paradigms of anesthesia induced neurotoxicity in the mouse.

Johnson SC, Pan A, Sun GX, Freed A, Stokes JC, Bornstein R, Witkowski M, Li L, Ford JM, Howard CRA, Sedensky MM, Morgan PG.

PLoS One. 2019 Mar 21;14(3):e0213543. doi: 10.1371/journal.pone.0213543. eCollection 2019.


Mitochondrial Function in Astrocytes Is Essential for Normal Emergence from Anesthesia in Mice.

Ramadasan-Nair R, Hui J, Itsara LS, Morgan PG, Sedensky MM.

Anesthesiology. 2019 Mar;130(3):423-434. doi: 10.1097/ALN.0000000000002528.


mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases.

Johnson SC, Martinez F, Bitto A, Gonzalez B, Tazaerslan C, Cohen C, Delaval L, Timsit J, Knebelmann B, Terzi F, Mahal T, Zhu Y, Morgan PG, Sedensky MM, Kaeberlein M, Legendre C, Suh Y, Canaud G.

Kidney Int. 2019 Feb;95(2):455-466. doi: 10.1016/j.kint.2018.08.038. Epub 2018 Nov 22.


Traumatic Brain Injury in Flies.

Morgan PG, Sedensky MM.

Anesth Analg. 2018 Nov;127(5):e90. doi: 10.1213/ANE.0000000000003753. No abstract available.


Anesthetics Have Different Effects on the Electrocorticographic Spectra of Wild-type and Mitochondrial Mutant Mice.

Carspecken CW, Chanprasert S, Kalume F, Sedensky MM, Morgan PG.

Anesthesiology. 2018 Oct;129(4):744-755. doi: 10.1097/ALN.0000000000002368.


Isoflurane disrupts excitatory neurotransmitter dynamics via inhibition of mitochondrial complex I.

Zimin PI, Woods CB, Kayser EB, Ramirez JM, Morgan PG, Sedensky MM.

Br J Anaesth. 2018 May;120(5):1019-1032. doi: 10.1016/j.bja.2018.01.036. Epub 2018 Mar 13.


Approaches to Anesthetic Mechanisms: The C. elegans Model.

Steele LM, Sedensky MM.

Methods Enzymol. 2018;602:133-151. doi: 10.1016/bs.mie.2018.01.006. Epub 2018 Mar 3.


Regional knockdown of NDUFS4 implicates a thalamocortical circuit mediating anesthetic sensitivity.

Ramadasan-Nair R, Hui J, Zimin PI, Itsara LS, Morgan PG, Sedensky MM.

PLoS One. 2017 Nov 14;12(11):e0188087. doi: 10.1371/journal.pone.0188087. eCollection 2017.


Cell Biology of the Mitochondrion.

van der Bliek AM, Sedensky MM, Morgan PG.

Genetics. 2017 Nov;207(3):843-871. doi: 10.1534/genetics.117.300262. Review. Erratum in: Genetics. 2018 Apr;208(4):1673.


The genetics of isoflurane-induced developmental neurotoxicity.

Na HS, Brockway NL, Gentry KR, Opheim E, Sedensky MM, Morgan PG.

Neurotoxicol Teratol. 2017 Mar - Apr;60:40-49. doi: 10.1016/ Epub 2016 Oct 29.


Glutamatergic Neurotransmission Links Sensitivity to Volatile Anesthetics with Mitochondrial Function.

Zimin PI, Woods CB, Quintana A, Ramirez JM, Morgan PG, Sedensky MM.

Curr Biol. 2016 Aug 22;26(16):2194-201. doi: 10.1016/j.cub.2016.06.020. Epub 2016 Aug 4.


Ketamine and Mitochondrial Function.

Morgan PG, Sedensky MM, Kayser EB.

Anesth Analg. 2016 Mar;122(3):917-8. doi: 10.1213/ANE.0000000000000872. No abstract available.


Region-Specific Defects of Respiratory Capacities in the Ndufs4(KO) Mouse Brain.

Kayser EB, Sedensky MM, Morgan PG.

PLoS One. 2016 Jan 29;11(1):e0148219. doi: 10.1371/journal.pone.0148219. eCollection 2016.


Glutathione S-transferase mediates an ageing response to mitochondrial dysfunction.

Dancy BM, Brockway N, Ramadasan-Nair R, Yang Y, Sedensky MM, Morgan PG.

Mech Ageing Dev. 2016 Jan;153:14-21. doi: 10.1016/j.mad.2015.12.001. Epub 2015 Dec 15.


Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron-sulfur protein.

Jafari G, Wasko BM, Tonge A, Schurman N, Dong C, Li Z, Peters R, Kayser EB, Pitt JN, Morgan PG, Sedensky MM, Crofts AR, Kaeberlein M.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6148-57. doi: 10.1073/pnas.1509416112. Epub 2015 Oct 26.


Mitochondrial bioenergetics and disease in Caenorhabditis elegans.

Dancy BM, Sedensky MM, Morgan PG.

Front Biosci (Landmark Ed). 2015 Jan 1;20:198-228. Review.


Comparison of proteomic and metabolomic profiles of mutants of the mitochondrial respiratory chain in Caenorhabditis elegans.

Morgan PG, Higdon R, Kolker N, Bauman AT, Ilkayeva O, Newgard CB, Kolker E, Steele LM, Sedensky MM.

Mitochondrion. 2015 Jan;20:95-102. doi: 10.1016/j.mito.2014.12.004. Epub 2014 Dec 19.


A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer.

Burman JL, Itsara LS, Kayser EB, Suthammarak W, Wang AM, Kaeberlein M, Sedensky MM, Morgan PG, Pallanck LJ.

Dis Model Mech. 2014 Oct;7(10):1165-74. doi: 10.1242/dmm.015321. Epub 2014 Aug 1.


Effects of the mitochondrial respiratory chain on longevity in C. elegans.

Dancy BM, Sedensky MM, Morgan PG.

Exp Gerontol. 2014 Aug;56:245-55. doi: 10.1016/j.exger.2014.03.028. Epub 2014 Apr 5. Review.


Propofol compared with isoflurane inhibits mitochondrial metabolism in immature swine cerebral cortex.

Kajimoto M, Atkinson DB, Ledee DR, Kayser EB, Morgan PG, Sedensky MM, Isern NG, Des Rosiers C, Portman MA.

J Cereb Blood Flow Metab. 2014 Mar;34(3):514-21. doi: 10.1038/jcbfm.2013.229. Epub 2014 Jan 8.


mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.

Johnson SC, Yanos ME, Kayser EB, Quintana A, Sangesland M, Castanza A, Uhde L, Hui J, Wall VZ, Gagnidze A, Oh K, Wasko BM, Ramos FJ, Palmiter RD, Rabinovitch PS, Morgan PG, Sedensky MM, Kaeberlein M.

Science. 2013 Dec 20;342(6165):1524-8. doi: 10.1126/science.1244360. Epub 2013 Nov 14.


The power of unbiased genetic screens to discover novel anesthetic targets.

Morgan PG, Sedensky MM.

Anesthesiology. 2013 Oct;119(4):995-6. doi: 10.1097/ALN.0b013e3182a4465c. No abstract available.


Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure.

Karamanlidis G, Lee CF, Garcia-Menendez L, Kolwicz SC Jr, Suthammarak W, Gong G, Sedensky MM, Morgan PG, Wang W, Tian R.

Cell Metab. 2013 Aug 6;18(2):239-50. doi: 10.1016/j.cmet.2013.07.002.


Mitochondrial disease in childhood: mtDNA encoded.

Saneto RP, Sedensky MM.

Neurotherapeutics. 2013 Apr;10(2):199-211. doi: 10.1007/s13311-012-0167-0. Review.


Early developmental exposure to volatile anesthetics causes behavioral defects in Caenorhabditis elegans.

Gentry KR, Steele LM, Sedensky MM, Morgan PG.

Anesth Analg. 2013 Jan;116(1):185-9. doi: 10.1213/ANE.0b013e31826d37c5. Epub 2012 Dec 7.


Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I.

Quintana A, Morgan PG, Kruse SE, Palmiter RD, Sedensky MM.

PLoS One. 2012;7(8):e42904. doi: 10.1371/journal.pone.0042904. Epub 2012 Aug 17.


The worm sheds light on anesthetic mechanisms.

Singaram VK, Morgan PG, Sedensky MM.

Worm. 2012;1(3):164-169.


Optical reversal of halothane-induced immobility in C. elegans.

Singaram VK, Somerlot BH, Falk SA, Falk MJ, Sedensky MM, Morgan PG.

Curr Biol. 2011 Dec 20;21(24):2070-6. doi: 10.1016/j.cub.2011.10.042. Epub 2011 Dec 1.


Caenorhabditis elegans UCP4 protein controls complex II-mediated oxidative phosphorylation through succinate transport.

Pfeiffer M, Kayzer EB, Yang X, Abramson E, Kenaston MA, Lago CU, Lo HH, Sedensky MM, Lunceford A, Clarke CF, Wu SJ, McLeod C, Finkel T, Morgan PG, Mills EM.

J Biol Chem. 2011 Oct 28;286(43):37712-20. doi: 10.1074/jbc.M111.271452. Epub 2011 Aug 23.


The role of DMQ(9) in the long-lived mutant clk-1.

Yang YY, Vasta V, Hahn S, Gangoiti JA, Opheim E, Sedensky MM, Morgan PG.

Mech Ageing Dev. 2011 Jun-Jul;132(6-7):331-9. doi: 10.1016/j.mad.2011.06.009. Epub 2011 Jul 1.


Isoflurane selectively inhibits distal mitochondrial complex I in Caenorhabditis elegans.

Kayser EB, Suthammarak W, Morgan PG, Sedensky MM.

Anesth Analg. 2011 Jun;112(6):1321-9. doi: 10.1213/ANE.0b013e3182121d37. Epub 2011 Apr 5.


Mutations in mitochondrial complex III uniquely affect complex I in Caenorhabditis elegans.

Suthammarak W, Morgan PG, Sedensky MM.

J Biol Chem. 2010 Dec 24;285(52):40724-31. doi: 10.1074/jbc.M110.159608. Epub 2010 Oct 22.


Alternatives to mammalian pain models 1: use of C. elegans for the study of volatile anesthetics.

Steele LM, Sedensky MM, Morgan PG.

Methods Mol Biol. 2010;617:1-17. doi: 10.1007/978-1-60327-323-7_1.


Subcomplex Ilambda specifically controls integrated mitochondrial functions in Caenorhabditis elegans.

Falk MJ, Rosenjack JR, Polyak E, Suthammarak W, Chen Z, Morgan PG, Sedensky MM.

PLoS One. 2009 Aug 12;4(8):e6607. doi: 10.1371/journal.pone.0006607.


The effect of different ubiquinones on lifespan in Caenorhabditis elegans.

Yang YY, Gangoiti JA, Sedensky MM, Morgan PG.

Mech Ageing Dev. 2009 Jun;130(6):370-6. doi: 10.1016/j.mad.2009.03.003. Epub 2009 Mar 25.


Complex I function is defective in complex IV-deficient Caenorhabditis elegans.

Suthammarak W, Yang YY, Morgan PG, Sedensky MM.

J Biol Chem. 2009 Mar 6;284(10):6425-35. doi: 10.1074/jbc.M805733200. Epub 2008 Dec 12.


Genetics and the evolution of the anesthetic response.

Sedensky MM, Morgan PG.

Anesth Analg. 2008 Sep;107(3):855-8. doi: 10.1213/ane.0b013e31817d864a. No abstract available.


Metabolic pathway profiling of mitochondrial respiratory chain mutants in C. elegans.

Falk MJ, Zhang Z, Rosenjack JR, Nissim I, Daikhin E, Nissim I, Sedensky MM, Yudkoff M, Morgan PG.

Mol Genet Metab. 2008 Apr;93(4):388-97. doi: 10.1016/j.ymgme.2007.11.007. Epub 2008 Feb 21.


C. elegans and volatile anesthetics.

Morgan PG, Kayser EB, Sedensky MM.

WormBook. 2007 May 3:1-11. Review.


A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia.

Humphrey JA, Hamming KS, Thacker CM, Scott RL, Sedensky MM, Snutch TP, Morgan PG, Nash HA.

Curr Biol. 2007 Apr 3;17(7):624-9. Epub 2007 Mar 15.


Sulfated signal from ASJ sensory neurons modulates stomatin-dependent coordination in Caenorhabditis elegans.

Carroll BT, Dubyak GR, Sedensky MM, Morgan PG.

J Biol Chem. 2006 Nov 24;281(47):35989-96. Epub 2006 Sep 13.


Mitochondrial complex I function modulates volatile anesthetic sensitivity in C. elegans.

Falk MJ, Kayser EB, Morgan PG, Sedensky MM.

Curr Biol. 2006 Aug 22;16(16):1641-5.


Mitochondrial respiration and reactive oxygen species in C. elegans.

Sedensky MM, Morgan PG.

Exp Gerontol. 2006 Oct;41(10):957-67. Epub 2006 Aug 21. Review.


Mitochondrial respiration and reactive oxygen species in mitochondrial aging mutants.

Sedensky MM, Morgan PG.

Exp Gerontol. 2006 Mar;41(3):237-45. Epub 2006 Feb 21. Review.


Mitochondrial complex I function affects halothane sensitivity in Caenorhabditis elegans.

Kayser EB, Morgan PG, Sedensky MM.

Anesthesiology. 2004 Aug;101(2):365-72.


Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1.

Kayser EB, Sedensky MM, Morgan PG, Hoppel CL.

J Biol Chem. 2004 Dec 24;279(52):54479-86. Epub 2004 Jul 21.


A stomatin and a degenerin interact in lipid rafts of the nervous system of Caenorhabditis elegans.

Sedensky MM, Siefker JM, Koh JY, Miller DM 3rd, Morgan PG.

Am J Physiol Cell Physiol. 2004 Aug;287(2):C468-74. Epub 2004 Apr 21.


A mutation in mitochondrial complex I increases ethanol sensitivity in Caenorhabditis elegans.

Kayser EB, Hoppel CL, Morgan PG, Sedensky MM.

Alcohol Clin Exp Res. 2003 Apr;27(4):584-92.


Supplemental Content

Loading ...
Support Center