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Items: 18


Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer.

Gabrielli B, Bokhari F, Ranall MV, Oo ZY, Stevenson AJ, Wang W, Murrell M, Shaikh M, Fallaha S, Clarke D, Kelly M, Sedelies K, Christensen M, McKee S, Leggatt G, Leo P, Skalamera D, Soyer HP, Gonda TJ, McMillan NA.

Mol Cancer Ther. 2015 Dec;14(12):2753-61. doi: 10.1158/1535-7163.MCT-15-0506. Epub 2015 Oct 29.


The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress.

Bird CH, Christensen ME, Mangan MS, Prakash MD, Sedelies KA, Smyth MJ, Harper I, Waterhouse NJ, Bird PI.

Cell Death Differ. 2014 Jun;21(6):876-87. doi: 10.1038/cdd.2014.7. Epub 2014 Jan 31.


Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis.

Susanto O, Stewart SE, Voskoboinik I, Brasacchio D, Hagn M, Ellis S, Asquith S, Sedelies KA, Bird PI, Waterhouse NJ, Trapani JA.

Cell Death Differ. 2013 Sep;20(9):1183-93. doi: 10.1038/cdd.2013.59. Epub 2013 Jun 7.


Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737.

Sutton VR, Sedelies K, Dewson G, Christensen ME, Bird PI, Johnstone RW, Kluck RM, Trapani JA, Waterhouse NJ.

Cell Death Dis. 2012 Jul 5;3:e344. doi: 10.1038/cddis.2012.73.


A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells.

Hoves S, Sutton VR, Haynes NM, Hawkins ED, Fernández Ruiz D, Baschuk N, Sedelies KA, Schnurr M, Stagg J, Andrews DM, Villadangos JA, Trapani JA.

J Immunol. 2011 Aug 1;187(3):1166-75. doi: 10.4049/jimmunol.1001670. Epub 2011 Jun 27.


Granule-mediated death by cytotoxic lymphocytes does not require mitochondrial polarization toward the immunologic synapse in target cells.

Susanto O, Sedelies K, Trapani J, Waterhouse N.

Blood. 2009 Feb 12;113(7):1609-11; author reply 1611-2. doi: 10.1182/blood-2008-05-159228. No abstract available.


Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity.

Sedelies KA, Ciccone A, Clarke CJ, Oliaro J, Sutton VR, Scott FL, Silke J, Susanto O, Green DR, Johnstone RW, Bird PI, Trapani JA, Waterhouse NJ.

Cell Death Differ. 2008 Apr;15(4):708-17. doi: 10.1038/sj.cdd.4402300. Epub 2008 Jan 18.


Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis.

Sutton VR, Waterhouse NJ, Browne KA, Sedelies K, Ciccone A, Anthony D, Koskinen A, Mullbacher A, Trapani JA.

J Cell Biol. 2007 Feb 12;176(4):425-33. Epub 2007 Feb 5.


Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.

Waterhouse NJ, Sutton VR, Sedelies KA, Ciccone A, Jenkins M, Turner SJ, Bird PI, Trapani JA.

J Cell Biol. 2006 Apr 10;173(1):133-44.


Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis.

Waterhouse NJ, Sedelies KA, Trapani JA.

Immunol Cell Biol. 2006 Feb;84(1):72-8. Review.


Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis.

Waterhouse NJ, Sedelies KA, Sutton VR, Pinkoski MJ, Thia KY, Johnstone R, Bird PI, Green DR, Trapani JA.

Cell Death Differ. 2006 Apr;13(4):607-18.


A central role for Bid in granzyme B-induced apoptosis.

Waterhouse NJ, Sedelies KA, Browne KA, Wowk ME, Newbold A, Sutton VR, Clarke CJ, Oliaro J, Lindemann RK, Bird PI, Johnstone RW, Trapani JA.

J Biol Chem. 2005 Feb 11;280(6):4476-82. Epub 2004 Dec 1.


Granzyme B; the chalk-mark of a cytotoxic lymphocyte.

Waterhouse NJ, Sedelies KA, Clarke CJ.

J Transl Med. 2004 Oct 25;2(1):36.


Cytotoxic lymphocytes; instigators of dramatic target cell death.

Waterhouse NJ, Clarke CJ, Sedelies KA, Teng MW, Trapani JA.

Biochem Pharmacol. 2004 Sep 15;68(6):1033-40. Review.


Discordant regulation of granzyme H and granzyme B expression in human lymphocytes.

Sedelies KA, Sayers TJ, Edwards KM, Chen W, Pellicci DG, Godfrey DI, Trapani JA.

J Biol Chem. 2004 Jun 18;279(25):26581-7. Epub 2004 Apr 6.


hScrib is a functional homologue of the Drosophila tumour suppressor Scribble.

Dow LE, Brumby AM, Muratore R, Coombe ML, Sedelies KA, Trapani JA, Russell SM, Richardson HE, Humbert PO.

Oncogene. 2003 Dec 18;22(58):9225-30.


Novel mechanisms of apoptosis induced by histone deacetylase inhibitors.

Peart MJ, Tainton KM, Ruefli AA, Dear AE, Sedelies KA, O'Reilly LA, Waterhouse NJ, Trapani JA, Johnstone RW.

Cancer Res. 2003 Aug 1;63(15):4460-71.


Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

Sutton VR, Davis JE, Cancilla M, Johnstone RW, Ruefli AA, Sedelies K, Browne KA, Trapani JA.

J Exp Med. 2000 Nov 20;192(10):1403-14.

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