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Items: 1 to 50 of 69

1.

Intradermal vaccination prevents anti-MOG autoimmune encephalomyelitis in macaques.

Fovet CM, Stimmer L, Contreras V, Horellou P, Hubert A, Seddiki N, Chapon C, Tricot S, Leroy C, Flament J, Massonneau J, Tchitchek N, 't Hart BA, Zurawski S, Klucar P, Hantraye P, Deiva K, Zurawski G, Oh S, Le Grand R, Serguera C.

EBioMedicine. 2019 Sep;47:492-505. doi: 10.1016/j.ebiom.2019.08.052. Epub 2019 Sep 3.

2.

Proliferative memory SAMHD1low CD4+ T cells harbour high levels of HIV-1 with compartmentalized viral populations.

Hani L, Chaillon A, Nere ML, Ruffin N, Alameddine J, Salmona M, Lopez Zaragoza JL, Smith DM, Schwartz O, Lelièvre JD, Delaugerre C, Lévy Y, Seddiki N.

PLoS Pathog. 2019 Jun 20;15(6):e1007868. doi: 10.1371/journal.ppat.1007868. eCollection 2019 Jun.

3.

Possible clearance of transfusion-acquired nef/LTR-deleted attenuated HIV-1 infection by an elite controller with CCR5 Δ32 heterozygous and HLA-B57 genotype.

Zaunders J, Dyer WB, Churchill M, Munier CML, Cunningham PH, Suzuki K, McBride K, Hey-Nguyen W, Koelsch K, Wang B, Hiener B, Palmer S, Gorry PR, Bailey M, Xu Y, Danta M, Seddiki N, Cooper DA, Saksena NK, Sullivan JS, Riminton S, Learmont J, Kelleher AD.

J Virus Erad. 2019 Apr 1;5(2):73-83.

4.

Phenotypic and Functional Differences between Human Herpesvirus 6- and Human Cytomegalovirus-Specific T Cells.

Fastenackels S, Bayard C, Larsen M, Magnier P, Bonnafous P, Seddiki N, Appay V, Gautheret-Dejean A, Sauce D.

J Virol. 2019 Jun 14;93(13). pii: e02321-18. doi: 10.1128/JVI.02321-18. Print 2019 Jul 1.

PMID:
30996090
5.

Early Antiretroviral Therapy Preserves Functional Follicular Helper T and HIV-Specific B Cells in the Gut Mucosa of HIV-1-Infected Individuals.

Planchais C, Hocqueloux L, Ibanez C, Gallien S, Copie C, Surenaud M, Kök A, Lorin V, Fusaro M, Delfau-Larue MH, Lefrou L, Prazuck T, Lévy M, Seddiki N, Lelièvre JD, Mouquet H, Lévy Y, Hüe S.

J Immunol. 2018 May 15;200(10):3519-3529. doi: 10.4049/jimmunol.1701615. Epub 2018 Apr 9.

6.

Regulatory T cells (Tregs): A major immune checkpoint to consider in combinatorial therapeutic HIV-1 vaccines.

Hubert A, Seddiki N.

Hum Vaccin Immunother. 2018 Jun 3;14(6):1432-1437. doi: 10.1080/21645515.2018.1434384. Epub 2018 Feb 23. Review.

7.

Therapeutic HIV-1 vaccine: time for immunomodulation and combinatorial strategies.

Seddiki N, Lévy Y.

Curr Opin HIV AIDS. 2018 Mar;13(2):119-127. doi: 10.1097/COH.0000000000000444. Review.

PMID:
29329113
8.

Negative modulation of suppressive HIV-specific regulatory T cells by IL-2 adjuvanted therapeutic vaccine.

Brezar V, Hani L, Surenaud M, Hubert A, Lacabaratz C, Lelièvre JD, Levy Y, Seddiki N.

PLoS Pathog. 2017 Jul 14;13(7):e1006489. doi: 10.1371/journal.ppat.1006489. eCollection 2017 Jul.

9.

Priming of transcriptional memory responses via the chromatin accessibility landscape in T cells.

Tu WJ, Hardy K, Sutton CR, McCuaig R, Li J, Dunn J, Tan A, Brezar V, Morris M, Denyer G, Lee SK, Turner SJ, Seddiki N, Smith C, Khanna R, Rao S.

Sci Rep. 2017 Mar 20;7:44825. doi: 10.1038/srep44825.

10.

Circulating gluten-specific FOXP3+CD39+ regulatory T cells have impaired suppressive function in patients with celiac disease.

Cook L, Munier CML, Seddiki N, van Bockel D, Ontiveros N, Hardy MY, Gillies JK, Levings MK, Reid HH, Petersen J, Rossjohn J, Anderson RP, Zaunders JJ, Tye-Din JA, Kelleher AD.

J Allergy Clin Immunol. 2017 Dec;140(6):1592-1603.e8. doi: 10.1016/j.jaci.2017.02.015. Epub 2017 Mar 8.

11.

From dendritic cells to B cells dysfunctions during HIV-1 infection: T follicular helper cells at the crossroads.

Ruffin N, Hani L, Seddiki N.

Immunology. 2017 Jun;151(2):137-145. doi: 10.1111/imm.12730. Epub 2017 Mar 27. Review.

12.

CD4+ T Follicular Helper and IgA+ B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals.

Zaunders J, Danta M, Bailey M, Mak G, Marks K, Seddiki N, Xu Y, Templeton DJ, Cooper DA, Boyd MA, Kelleher AD, Koelsch KK.

Front Immunol. 2016 Oct 24;7:438. eCollection 2016.

13.

T-Regulatory Cells and Vaccination "Pay Attention and Do Not Neglect Them": Lessons from HIV and Cancer Vaccine Trials.

Brezar V, Godot V, Cheng L, Su L, Lévy Y, Seddiki N.

Vaccines (Basel). 2016 Sep 5;4(3). pii: E30. doi: 10.3390/vaccines4030030. Review.

14.

Hepatitis C-specific effector and regulatory CD4 T-cell responses are associated with the outcomes of primary infection.

Keoshkerian E, Hunter M, Cameron B, Nguyen N, Sugden P, Bull R, Zekry A, Maher L, Seddiki N, Zaunders J, Kelleher A, Lloyd AR; HITS-p and HITS-c investigators.

J Viral Hepat. 2016 Dec;23(12):985-993. doi: 10.1111/jvh.12576. Epub 2016 Aug 25.

PMID:
27558465
15.

Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4+ T cells through p65 and H2B phosphorylation.

Li J, Hardy K, Phetsouphanh C, Tu WJ, Sutcliffe EL, McCuaig R, Sutton CR, Zafar A, Munier CM, Zaunders JJ, Xu Y, Theodoratos A, Tan A, Lim PS, Knaute T, Masch A, Zerweck J, Brezar V, Milburn PJ, Dunn J, Casarotto MG, Turner SJ, Seddiki N, Kelleher AD, Rao S.

J Cell Sci. 2016 Jun 15;129(12):2448-61. doi: 10.1242/jcs.181248. Epub 2016 May 5.

16.

PKC-Theta in Regulatory and Effector T-cell Functions.

Brezar V, Tu WJ, Seddiki N.

Front Immunol. 2015 Oct 13;6:530. doi: 10.3389/fimmu.2015.00530. eCollection 2015. Review.

17.

Decreased HIV-specific T-regulatory responses are associated with effective DC-vaccine induced immunity.

Brezar V, Ruffin N, Richert L, Surenaud M, Lacabaratz C, Palucka K, Thiébaut R, Banchereau J, Levy Y, Seddiki N.

PLoS Pathog. 2015 Mar 27;11(3):e1004752. doi: 10.1371/journal.ppat.1004752. eCollection 2015 Mar.

18.

Additive effect of nuclear and mitochondrial mutations in a patient with mitochondrial encephalomyopathy.

Nesti C, Meschini MC, Meunier B, Sacchini M, Doccini S, Romano A, Petrillo S, Pezzini I, Seddiki N, Rubegni A, Piemonte F, Donati MA, Brasseur G, Santorelli FM.

Hum Mol Genet. 2015 Jun 1;24(11):3248-56. doi: 10.1093/hmg/ddv078. Epub 2015 Mar 3.

PMID:
25736212
19.

Low SAMHD1 expression following T-cell activation and proliferation renders CD4+ T cells susceptible to HIV-1.

Ruffin N, Brezar V, Ayinde D, Lefebvre C, Schulze Zur Wiesch J, van Lunzen J, Bockhorn M, Schwartz O, Hocini H, Lelievre JD, Banchereau J, Levy Y, Seddiki N.

AIDS. 2015 Mar 13;29(5):519-30. doi: 10.1097/QAD.0000000000000594.

20.

Cytokines and cytokine receptors as immunotherapeutics: humble beginnings and exciting futures.

Sedger LM, Seddiki N, Ranasinghe C.

Cytokine Growth Factor Rev. 2014 Aug;25(4):351-3. doi: 10.1016/j.cytogfr.2014.07.021. Epub 2014 Aug 4. No abstract available.

PMID:
25189353
21.

Exploiting differential expression of the IL-7 receptor on memory T cells to modulate immune responses.

Zaunders JJ, Lévy Y, Seddiki N.

Cytokine Growth Factor Rev. 2014 Aug;25(4):391-401. doi: 10.1016/j.cytogfr.2014.07.012. Epub 2014 Jul 29. Review.

PMID:
25130296
22.

Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection.

Kim K, Perera R, Tan DB, Fernandez S, Seddiki N, Waring J, French MA.

Tuberculosis (Edinb). 2014 Sep;94(5):494-501. doi: 10.1016/j.tube.2014.07.002. Epub 2014 Jul 17.

23.

Editorial overview: cell dysfunction and exhaustion in HIV infection.

Seddiki N, Kaufmann DE.

Curr Opin HIV AIDS. 2014 Sep;9(5):437-8. doi: 10.1097/COH.0000000000000098. No abstract available.

24.

Cell exhaustion in HIV-1 infection: role of suppressor cells.

Seddiki N, Brezar V, Draenert R.

Curr Opin HIV AIDS. 2014 Sep;9(5):452-8. doi: 10.1097/COH.0000000000000087. Review.

PMID:
25010895
25.

A highly relevant and efficient single step method for simultaneous depletion and isolation of human regulatory T cells in a clinical setting.

Brezar V, Ruffin N, Lévy Y, Seddiki N.

J Immunol Methods. 2014 Sep;411:70-5. doi: 10.1016/j.jim.2014.06.003. Epub 2014 Jun 10.

PMID:
24925808
26.

Human antigen-specific CD4⁺ CD25⁺ CD134⁺ CD39⁺ T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses.

Seddiki N, Cook L, Hsu DC, Phetsouphanh C, Brown K, Xu Y, Kerr SJ, Cooper DA, Munier CM, Pett S, Ananworanich J, Zaunders J, Kelleher AD.

Eur J Immunol. 2014 Jun;44(6):1644-61. doi: 10.1002/eji.201344102. Epub 2014 Apr 29.

27.

Ratios of effector to central memory antigen-specific CD4(+) T cells vary with antigen exposure in HIV+ patients.

Phetsouphanh C, Xu Y, Bailey M, Pett S, Zaunders J, Seddiki N, Kelleher AD.

Immunol Cell Biol. 2014 Apr;92(4):384-8. doi: 10.1038/icb.2013.101. Epub 2014 Feb 4.

PMID:
24492798
28.

Role of miR-155 in the regulation of lymphocyte immune function and disease.

Seddiki N, Brezar V, Ruffin N, Lévy Y, Swaminathan S.

Immunology. 2014 May;142(1):32-8. doi: 10.1111/imm.12227. Review.

29.

A novel cytomegalovirus-induced regulatory-type T-cell subset increases in size during older life and links virus-specific immunity to vascular pathology.

Terrazzini N, Bajwa M, Vita S, Cheek E, Thomas D, Seddiki N, Smith H, Kern F.

J Infect Dis. 2014 May 1;209(9):1382-92. doi: 10.1093/infdis/jit576. Epub 2013 Nov 7.

30.

Characterization of transcription factor phenotypes within antigen-specific CD4+ T cells using qualitative multiplex single-cell RT-PCR.

Phetsouphanh C, Xu Y, Amin J, Seddiki N, Procopio F, Sekaly RP, Zaunders JJ, Kelleher AD.

PLoS One. 2013 Oct 4;8(10):e74946. doi: 10.1371/journal.pone.0074946. eCollection 2013.

31.

Membrane-bound oxygen reductases of the anaerobic sulfate-reducing Desulfovibrio vulgaris Hildenborough: roles in oxygen defence and electron link with periplasmic hydrogen oxidation.

Ramel F, Amrani A, Pieulle L, Lamrabet O, Voordouw G, Seddiki N, Brèthes D, Company M, Dolla A, Brasseur G.

Microbiology. 2013 Dec;159(Pt 12):2663-73. doi: 10.1099/mic.0.071282-0. Epub 2013 Oct 1.

PMID:
24085836
32.

The majority of HIV type 1 DNA in circulating CD4+ T lymphocytes is present in non-gut-homing resting memory CD4+ T cells.

McBride K, Xu Y, Bailey M, Seddiki N, Suzuki K, Murray JM, Gao Y, Yan C, Cooper DA, Kelleher AD, Koelsch KK, Zaunders J.

AIDS Res Hum Retroviruses. 2013 Oct;29(10):1330-9. doi: 10.1089/AID.2012.0351.

33.

Regulatory T cells negatively affect IL-2 production of effector T cells through CD39/adenosine pathway in HIV infection.

Jenabian MA, Seddiki N, Yatim A, Carriere M, Hulin A, Younas M, Ghadimi E, Kök A, Routy JP, Tremblay A, Sévigny J, Lelievre JD, Levy Y.

PLoS Pathog. 2013;9(4):e1003319. doi: 10.1371/journal.ppat.1003319. Epub 2013 Apr 25.

34.

The microRNA-9/B-lymphocyte-induced maturation protein-1/IL-2 axis is differentially regulated in progressive HIV infection.

Seddiki N, Phetsouphanh C, Swaminathan S, Xu Y, Rao S, Li J, Sutcliffe EL, Denyer G, Finlayson R, Gelgor L, Cooper DA, Zaunders J, Kelleher AD.

Eur J Immunol. 2013 Feb;43(2):510-20. doi: 10.1002/eji.201242695. Epub 2012 Dec 18.

35.

miR-155 is differentially expressed in Treg subsets, which may explain expression level differences of miR-155 in HIV-1 infected patients.

Seddiki N, Swaminathan S, Phetsouphanh C, Kelleher AD.

Blood. 2012 Jun 28;119(26):6396-7. doi: 10.1182/blood-2012-02-412874. No abstract available.

PMID:
22745300
36.

Structural engineering of a phage lysin that targets gram-negative pathogens.

Lukacik P, Barnard TJ, Keller PW, Chaturvedi KS, Seddiki N, Fairman JW, Noinaj N, Kirby TL, Henderson JP, Steven AC, Hinnebusch BJ, Buchanan SK.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9857-62. doi: 10.1073/pnas.1203472109. Epub 2012 Jun 7.

37.

Differential regulation of the Let-7 family of microRNAs in CD4+ T cells alters IL-10 expression.

Swaminathan S, Suzuki K, Seddiki N, Kaplan W, Cowley MJ, Hood CL, Clancy JL, Murray DD, Méndez C, Gelgor L, Anderson B, Roth N, Cooper DA, Kelleher AD.

J Immunol. 2012 Jun 15;188(12):6238-46. doi: 10.4049/jimmunol.1101196. Epub 2012 May 14.

38.

Progressive activation of CD127+132- recent thymic emigrants into terminally differentiated CD127-132+ T-cells in HIV-1 infection.

Sasson SC, Zaunders JJ, Seddiki N, Bailey M, McBride K, Koelsch KK, Merlin KM, Smith DE, Cooper DA, Kelleher AD.

PLoS One. 2012;7(2):e31148. doi: 10.1371/journal.pone.0031148. Epub 2012 Feb 13.

39.

A novel assay for detection of hepatitis C virus-specific effector CD4(+) T cells via co-expression of CD25 and CD134.

Keoshkerian E, Helbig K, Beard M, Zaunders J, Seddiki N, Kelleher A, Hampartzoumian T, Zekry A, Lloyd AR.

J Immunol Methods. 2012 Jan 31;375(1-2):148-58. doi: 10.1016/j.jim.2011.10.004. Epub 2011 Oct 12.

PMID:
22019644
40.

CD39/adenosine pathway is involved in AIDS progression.

Nikolova M, Carriere M, Jenabian MA, Limou S, Younas M, Kök A, Huë S, Seddiki N, Hulin A, Delaneau O, Schuitemaker H, Herbeck JT, Mullins JI, Muhtarova M, Bensussan A, Zagury JF, Lelievre JD, Lévy Y.

PLoS Pathog. 2011 Jul;7(7):e1002110. doi: 10.1371/journal.ppat.1002110. Epub 2011 Jul 7.

41.

Chromatin-associated protein kinase C-θ regulates an inducible gene expression program and microRNAs in human T lymphocytes.

Sutcliffe EL, Bunting KL, He YQ, Li J, Phetsouphanh C, Seddiki N, Zafar A, Hindmarsh EJ, Parish CR, Kelleher AD, McInnes RL, Taya T, Milburn PJ, Rao S.

Mol Cell. 2011 Mar 18;41(6):704-19. doi: 10.1016/j.molcel.2011.02.030.

42.

Mapping the interactions between Escherichia coli TolQ transmembrane segments.

Zhang XY, Goemaere EL, Seddiki N, Célia H, Gavioli M, Cascales E, Lloubes R.

J Biol Chem. 2011 Apr 1;286(13):11756-64. doi: 10.1074/jbc.M110.192773. Epub 2011 Feb 1.

43.

IL-7 receptor is expressed on adult pre-B-cell acute lymphoblastic leukemia and other B-cell derived neoplasms and correlates with expression of proliferation and survival markers.

Sasson SC, Smith S, Seddiki N, Zaunders JJ, Bryant A, Koelsch KK, Weatherall C, Munier ML, McGinley C, Yeung J, Mulligan SP, Moore J, Cooper DA, Milliken S, Kelleher AD.

Cytokine. 2010 Apr;50(1):58-68. doi: 10.1016/j.cyto.2009.12.001. Epub 2010 Jan 8.

PMID:
20060740
44.

High levels of human antigen-specific CD4+ T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 (OX40).

Zaunders JJ, Munier ML, Seddiki N, Pett S, Ip S, Bailey M, Xu Y, Brown K, Dyer WB, Kim M, de Rose R, Kent SJ, Jiang L, Breit SN, Emery S, Cunningham AL, Cooper DA, Kelleher AD.

J Immunol. 2009 Aug 15;183(4):2827-36. doi: 10.4049/jimmunol.0803548. Epub 2009 Jul 27.

45.

Immunopathogenesis of immune reconstitution disease in HIV patients responding to antiretroviral therapy.

Kestens L, Seddiki N, Bohjanen PR.

Curr Opin HIV AIDS. 2008 Jul;3(4):419-24. doi: 10.1097/COH.0b013e328302ebbb.

46.

Safety, immunogenicity and efficacy of peptide-pulsed cellular immunotherapy in macaques.

De Rose R, Mason RD, Loh L, Peut V, Smith MZ, Fernandez CS, Alcantara S, Amarasena T, Reece J, Seddiki N, Kelleher AD, Zaunders J, Kent SJ.

J Med Primatol. 2008 Dec;37 Suppl 2:69-78. doi: 10.1111/j.1600-0684.2008.00329.x.

PMID:
19187433
47.

Proliferation of weakly suppressive regulatory CD4+ T cells is associated with over-active CD4+ T-cell responses in HIV-positive patients with mycobacterial immune restoration disease.

Seddiki N, Sasson SC, Santner-Nanan B, Munier M, van Bockel D, Ip S, Marriott D, Pett S, Nanan R, Cooper DA, Zaunders JJ, Kelleher AD.

Eur J Immunol. 2009 Feb;39(2):391-403. doi: 10.1002/eji.200838630.

48.

Low pre-infection levels and loss of central memory CD4+ T cells may predict rapid progression in SIV-infected pigtail macaques.

Mason RD, Rose RD, Seddiki N, Kelleher AD, Kent SJ.

Virology. 2008 Nov 10;381(1):11-5. doi: 10.1016/j.virol.2008.08.042. Epub 2008 Oct 2.

49.

Regulatory T cells in HIV infection: who's suppressing what?

Seddiki N, Kelleher AD.

Curr Infect Dis Rep. 2008 May;10(3):252-8.

PMID:
18510889
50.

Regulatory T cells in HIV infection: who's suppressing what?

Seddiki N, Kelleher AD.

Curr HIV/AIDS Rep. 2008 Feb;5(1):20-6. Review.

PMID:
18417031

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