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Items: 25


Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab.

Hernandez LD, Kroh HK, Hsieh E, Yang X, Beaumont M, Sheth PR, DiNunzio E, Rutherford SA, Ohi MD, Ermakov G, Xiao L, Secore S, Karczewski J, Racine F, Mayhood T, Fischer P, Sher X, Gupta P, Lacy DB, Therien AG.

J Mol Biol. 2017 Apr 7;429(7):1030-1044. doi: 10.1016/j.jmb.2017.02.010. Epub 2017 Feb 21.


Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains.

Secore S, Wang S, Doughtry J, Xie J, Miezeiewski M, Rustandi RR, Horton M, Xoconostle R, Wang B, Lancaster C, Kristopeit A, Wang SC, Christanti S, Vitelli S, Gentile MP, Goerke A, Skinner J, Strable E, Thiriot DS, Bodmer JL, Heinrichs JH.

PLoS One. 2017 Jan 26;12(1):e0170640. doi: 10.1371/journal.pone.0170640. eCollection 2017.


Design and Purification of Subunit Vaccines for Prevention of Clostridium difficile Infection.

Karczewski J, Bodmer JL, Cook JC, Xoconostle RF, Nahas DD, Joyce JG, Heinrichs JH, Secore S.

Methods Mol Biol. 2016;1403:385-96. doi: 10.1007/978-1-4939-3387-7_20.


Toxicity assessment of Clostridium difficile toxins in rodent models and protection of vaccination.

Wang S, Rustandi RR, Lancaster C, Hong LG, Thiriot DS, Xie J, Secore S, Kristopeit A, Wang SC, Heinrichs JH.

Vaccine. 2016 Mar 4;34(10):1319-23. doi: 10.1016/j.vaccine.2015.11.026. Epub 2015 Nov 21.


An in vitro culture model to study the dynamics of colonic microbiota in Syrian golden hamsters and their susceptibility to infection with Clostridium difficile.

Miezeiewski M, Schnaufer T, Muravsky M, Wang S, Caro-Aguilar I, Secore S, Thiriot DS, Hsu C, Rogers I, DeSantis T, Kuczynski J, Probst AJ, Chehoud C, Steger R, Warrington J, Bodmer JL, Heinrichs JH.

ISME J. 2015 Feb;9(2):321-32. doi: 10.1038/ismej.2014.127. Epub 2014 Jul 18.


Detecting and preventing reversion to toxicity for a formaldehyde-treated C. difficile toxin B mutant.

Wang B, Wang S, Rustandi RR, Wang F, Mensch CD, Hong L, Kristopeit A, Secore S, Dornadula G, Kanavage A, Heinrichs JH, Mach H, Blue JT, Thiriot DS.

Vaccine. 2015 Jan 1;33(1):252-9. doi: 10.1016/j.vaccine.2014.06.032. Epub 2014 Jun 18.


Mechanism of action and epitopes of Clostridium difficile toxin B-neutralizing antibody bezlotoxumab revealed by X-ray crystallography.

Orth P, Xiao L, Hernandez LD, Reichert P, Sheth PR, Beaumont M, Yang X, Murgolo N, Ermakov G, DiNunzio E, Racine F, Karczewski J, Secore S, Ingram RN, Mayhood T, Strickland C, Therien AG.

J Biol Chem. 2014 Jun 27;289(26):18008-21. doi: 10.1074/jbc.M114.560748. Epub 2014 May 12.


Development of a recombinant toxin fragment vaccine for Clostridium difficile infection.

Karczewski J, Zorman J, Wang S, Miezeiewski M, Xie J, Soring K, Petrescu I, Rogers I, Thiriot DS, Cook JC, Chamberlin M, Xoconostle RF, Nahas DD, Joyce JG, Bodmer JL, Heinrichs JH, Secore S.

Vaccine. 2014 May 19;32(24):2812-8. doi: 10.1016/j.vaccine.2014.02.026. Epub 2014 Mar 21.


Development and optimization of a high-throughput assay to measure neutralizing antibodies against Clostridium difficile binary toxin.

Xie J, Horton M, Zorman J, Antonello JM, Zhang Y, Arnold BA, Secore S, Xoconostle R, Miezeiewski M, Wang S, Price CE, Thiriot D, Goerke A, Gentile MP, Skinner JM, Heinrichs JH.

Clin Vaccine Immunol. 2014 May;21(5):689-97. doi: 10.1128/CVI.00038-14. Epub 2014 Mar 12.


Development and optimization of a novel assay to measure neutralizing antibodies against Clostridium difficile toxins.

Xie J, Zorman J, Indrawati L, Horton M, Soring K, Antonello JM, Zhang Y, Secore S, Miezeiewski M, Wang S, Kanavage AD, Skinner JM, Rogers I, Bodmer JL, Heinrichs JH.

Clin Vaccine Immunol. 2013 Apr;20(4):517-25. doi: 10.1128/CVI.00549-12. Epub 2013 Feb 6.


A fully human monoclonal antibody to Staphylococcus aureus iron regulated surface determinant B (IsdB) with functional activity in vitro and in vivo.

Ebert T, Smith S, Pancari G, Clark D, Hampton R, Secore S, Towne V, Fan H, Wang XM, Wu X, Ernst R, Harvey BR, Finnefrock AC, Wang F, Tan C, Durr E, Cope L, Anderson A, An Z, McNeely T.

Hum Antibodies. 2010;19(4):113-28. doi: 10.3233/HAB-2010-0235.


Selection and characterization of murine monoclonal antibodies to Staphylococcus aureus iron-regulated surface determinant B with functional activity in vitro and in vivo.

Brown M, Kowalski R, Zorman J, Wang XM, Towne V, Zhao Q, Secore S, Finnefrock AC, Ebert T, Pancari G, Isett K, Zhang Y, Anderson AS, Montgomery D, Cope L, McNeely T.

Clin Vaccine Immunol. 2009 Aug;16(8):1095-104. doi: 10.1128/CVI.00085-09. Epub 2009 Jun 24.


Serologic assay to quantify human immunoglobulin G antibodies to the Staphylococcus aureus iron surface determinant B antigen.

Raedler MD, Heyne S, Wagner E, Shalkowski SK, Secore S, Anderson AS, Cook J, Cope L, McNeely T, Retzlaff M, Shanter J, Rubinstein LJ, Green T, Kartsonis N, Esser MT.

Clin Vaccine Immunol. 2009 May;16(5):739-48. doi: 10.1128/CVI.00478-08. Epub 2009 Mar 25.


A novel Staphylococcus aureus vaccine: iron surface determinant B induces rapid antibody responses in rhesus macaques and specific increased survival in a murine S. aureus sepsis model.

Kuklin NA, Clark DJ, Secore S, Cook J, Cope LD, McNeely T, Noble L, Brown MJ, Zorman JK, Wang XM, Pancari G, Fan H, Isett K, Burgess B, Bryan J, Brownlow M, George H, Meinz M, Liddell ME, Kelly R, Schultz L, Montgomery D, Onishi J, Losada M, Martin M, Ebert T, Tan CY, Schofield TL, Nagy E, Meineke A, Joyce JG, Kurtz MB, Caulfield MJ, Jansen KU, McClements W, Anderson AS.

Infect Immun. 2006 Apr;74(4):2215-23.


Toward engineering skeletal muscle to release peptide hormone from the human pre-proinsulin gene.

Bartlett RJ, Denis M, Secore SL, Alejandro R, Ricordi C.

Transplant Proc. 1998 Mar;30(2):451. No abstract available.


Use of biolistic particle accelerator to introduce genes into isolated islets of Langerhans.

Bartlett RJ, Secore SL, Bottino R, Fernandez L, Inverardi L, Ricordi C.

Transplant Proc. 1997 Jun;29(4):2201-2. No abstract available.


Toward the biologic release of human insulin from skeletal muscle.

Bartlett RJ, Secore SL, Denis M, Fernandez L, Tzakis A, Alejandro R, Ricordi C.

Transplant Proc. 1997 Jun;29(4):2199-200. No abstract available.


Mutation segregation and rapid carrier detection of X-linked muscular dystrophy in dogs.

Bartlett RJ, Winand NJ, Secore SL, Singer JT, Fletcher S, Wilton S, Bogan DJ, Metcalf-Bogan JR, Bartlett WT, Howell JM, Cooper BJ, Kornegay JN.

Am J Vet Res. 1996 May;57(5):650-4.


Expression of a fluorescent reporter gene in skeletal muscle cells from a virus-based vector: implications for diabetes treatment.

Bartlett RJ, Singer JT, Shean MK, Weindler FW, Secore SL.

Transplant Proc. 1995 Dec;27(6):3344. No abstract available.


An error in dystrophin mRNA processing in golden retriever muscular dystrophy, an animal homologue of Duchenne muscular dystrophy.

Sharp NJ, Kornegay JN, Van Camp SD, Herbstreith MH, Secore SL, Kettle S, Hung WY, Constantinou CD, Dykstra MJ, Roses AD, et al.

Genomics. 1992 May;13(1):115-21.


A StuI polymorphism on chromosome 3p14.1-14.2 (D3S622) defined by two polymorphic StuI sites 2.4 kb apart.

Secore SL, Walker AP, Herbstreith MH, Siddique T, Jeffers AJ, DeShields TR, Speer MC, Pericak-Vance MA, Golembieski WA, Smith DI, et al.

Nucleic Acids Res. 1991 Nov 25;19(22):6349. No abstract available.


D21S194, a jump clone from D21S16.

Walker AP, Collins FS, Siddique T, Yamaoka LH, Herbstreith MH, Pericak-Vance MA, Secore SL, Hung WY, Goate AM, Hardy JA, et al.

Nucleic Acids Res. 1990 Apr 11;18(7):1931. No abstract available.


Inherited deletion at Duchenne dystrophy locus in normal male.

Bartlett RJ, Walker AP, Laing NG, Koh J, Secore SL, Speer MC, Pericak-Vance M, Hung WY, Yamaoka LH, Siddique T, et al.

Lancet. 1989 Mar 4;1(8636):496-7. No abstract available.


A Bgl II polymorphism detected by LDR152 [D19S19].

Walker AP, Bartlett RJ, Yamaoka LH, Secore SL, Lee JE, Gilbert J, Herbstreith M, Pericak-Vance MA, Hung WY, Roses AD.

Nucleic Acids Res. 1988 Sep 26;16(18):9063. No abstract available.

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