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Items: 29


Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance.

Chen K, Luan X, Liu Q, Wang J, Chang X, Snijders AM, Mao JH, Secombe J, Dan Z, Chen JH, Wang Z, Dong X, Qiu C, Chang X, Zhang D, Celniker SE, Liu X.

Cell Host Microbe. 2019 Apr 10;25(4):537-552.e8. doi: 10.1016/j.chom.2019.02.003. Epub 2019 Mar 19.


The Histone Demethylase KDM5 Is Essential for Larval Growth in Drosophila.

Drelon C, Belalcazar HM, Secombe J.

Genetics. 2018 Jul;209(3):773-787. doi: 10.1534/genetics.118.301004. Epub 2018 May 15.


A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5.

Zamurrad S, Hatch HAM, Drelon C, Belalcazar HM, Secombe J.

Cell Rep. 2018 Feb 27;22(9):2359-2369. doi: 10.1016/j.celrep.2018.02.018.


Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodelling.

Navarro-Costa P, McCarthy A, PrudĂȘncio P, Greer C, Guilgur LG, Becker JD, Secombe J, Rangan P, Martinho RG.

Nat Commun. 2016 Aug 10;7:12331. doi: 10.1038/ncomms12331.


The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif.

Liu X, Secombe J.

Cell Rep. 2015 Dec 15;13(10):2219-31. doi: 10.1016/j.celrep.2015.11.007. Epub 2015 Dec 7.


KDM5 interacts with Foxo to modulate cellular levels of oxidative stress.

Liu X, Greer C, Secombe J.

PLoS Genet. 2014 Oct 16;10(10):e1004676. doi: 10.1371/journal.pgen.1004676. eCollection 2014 Oct.


The Drosophila ubiquitin-specific protease Puffyeye regulates dMyc-mediated growth.

Li L, Anderson S, Secombe J, Eisenman RN.

Development. 2013 Dec;140(23):4776-87. doi: 10.1242/dev.096941. Epub 2013 Oct 30.


Myc-dependent genome instability and lifespan in Drosophila.

Greer C, Lee M, Westerhof M, Milholland B, Spokony R, Vijg J, Secombe J.

PLoS One. 2013 Sep 6;8(9):e74641. doi: 10.1371/journal.pone.0074641. eCollection 2013.


Myc in stem cell behaviour: insights from Drosophila.

Quinn LM, Secombe J, Hime GR.

Adv Exp Med Biol. 2013;786:269-85. doi: 10.1007/978-94-007-6621-1_15. Review.


Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.

DiTacchio L, Le HD, Vollmers C, Hatori M, Witcher M, Secombe J, Panda S.

Science. 2011 Sep 30;333(6051):1881-5. doi: 10.1126/science.1206022.


Essential functions of the histone demethylase lid.

Li L, Greer C, Eisenman RN, Secombe J.

PLoS Genet. 2010 Nov 24;6(11):e1001221. doi: 10.1371/journal.pgen.1001221.


Addressing cultural safety in the classroom.

Secombe J, Roeters H.

Nurs N Z. 2010 Aug;16(7):22. No abstract available.


Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye.

Grzeschik NA, Amin N, Secombe J, Brumby AM, Richardson HE.

Dev Biol. 2007 Nov 1;311(1):106-23. Epub 2007 Aug 17.


The function and regulation of the JARID1 family of histone H3 lysine 4 demethylases: the Myc connection.

Secombe J, Eisenman RN.

Cell Cycle. 2007 Jun 1;6(11):1324-8. Epub 2007 Jun 14. Review.


The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth.

Secombe J, Li L, Carlos L, Eisenman RN.

Genes Dev. 2007 Mar 1;21(5):537-51. Epub 2007 Feb 20.


The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster.

Loo LW, Secombe J, Little JT, Carlos LS, Yost C, Cheng PF, Flynn EM, Edgar BA, Eisenman RN.

Mol Cell Biol. 2005 Aug;25(16):7078-91.


A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila.

Brumby A, Secombe J, Horsfield J, Coombe M, Amin N, Coates D, Saint R, Richardson H.

Genetics. 2004 Sep;168(1):227-51.


Myc: a weapon of mass destruction.

Secombe J, Pierce SB, Eisenman RN.

Cell. 2004 Apr 16;117(2):153-6. Review.


Drosophila cyclin E interacts with components of the Brahma complex.

Brumby AM, Zraly CB, Horsfield JA, Secombe J, Saint R, Dingwall AK, Richardson H.

EMBO J. 2002 Jul 1;21(13):3377-89.


Bronchoalveolar lavage fluid urea as a measure of pulmonary permeability in healthy smokers.

Ward C, Thien F, Secombe J, Gollant S, Walters EH.

Eur Respir J. 2000 Feb;15(2):285-90.


decapentaplegic is required for arrest in G1 phase during Drosophila eye development.

Horsfield J, Penton A, Secombe J, Hoffman FM, Richardson H.

Development. 1998 Dec;125(24):5069-78.


Suppression of noradrenaline spillover by the dopamine prodrug gamma-L-glutamyl-L-dopa: a central effect?

McGrath BP, Wang ZQ, Shimizu K, Way D, Secombe J.

Hypertens Res. 1995 Jun;18 Suppl 1:S113-8.


Sympatho-inhibitory effects of gamma-l-glutamyl-l-dopa are not mediated by activation of dopamine-2 receptors in conscious rabbits.

Wang ZQ, Shimizu K, Way D, Secombe J, McGrath BP.

Zhongguo Yao Li Xue Bao. 1995 May;16(3):193-7.


Complement levels and exposure in the hypobaric chamber.

Brook WH, Secombe J, Seychell D.

Aviat Space Environ Med. 1995 May;66(5):415-7.


Sympatho-inhibitory effects of r-l-glutamyl-l-dopa in conscious rabbits.

Wang ZQ, Shimizu K, Way D, Secombe J, McGrath BP.

Zhongguo Yao Li Xue Bao. 1994 Jan;15(1):17-21.


The dopamine prodrug, gludopa, decreases both renal and extrarenal noradrenaline spillover in conscious rabbits.

Wang ZQ, Shimizu K, Way D, Secombe J, McGrath BP.

Clin Exp Pharmacol Physiol. 1993 May;20(5):365-8.


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