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A Pictorial Ultrasound Essay of Gestational Trophoblastic Disease.

Cavoretto P, Cioffi R, Mangili G, Petrone M, Bergamini A, Rabaiotti E, Valsecchi L, Candiani M, Seckl MJ.

J Ultrasound Med. 2019 Aug 29. doi: 10.1002/jum.15119. [Epub ahead of print] Review.


Emergency Etoposide-Cisplatin (Em-EP) for patients with germ cell tumours (GCT) and trophoblastic neoplasia (TN).

Chan Wah Hak C, Coyle C, Kocache A, Short D, Sarwar N, Seckl MJ, Gonzalez MA.

BMC Cancer. 2019 Aug 5;19(1):770. doi: 10.1186/s12885-019-5968-7.


When to stop human chorionic gonadotrophin (hCG) surveillance after treatment with chemotherapy for gestational trophoblastic neoplasia (GTN): A national analysis on over 4,000 patients.

Balachandran K, Salawu A, Ghorani E, Kaur B, Sebire NJ, Short D, Harvey R, Hancock B, Tidy J, Singh K, Sarwar N, Winter MC, Seckl MJ.

Gynecol Oncol. 2019 Oct;155(1):8-12. doi: 10.1016/j.ygyno.2019.07.024. Epub 2019 Jul 30.


A case of intraplacental gestational choriocarcinoma; characterised by the methylation pattern of the early placenta and an absence of driver mutations.

Savage P, Monk D, Hernandez Mora JR, van der Westhuizen N, Rauw J, Tinker A, Robinson W, Song Q, Seckl MJ, Fisher RA.

BMC Cancer. 2019 Jul 29;19(1):744. doi: 10.1186/s12885-019-5906-8.


Tumor growth suppression using a combination of taxol-based therapy and GSK3 inhibition in non-small cell lung cancer.

O'Flaherty L, Shnyder SD, Cooper PA, Cross SJ, Wakefield JG, Pardo OE, Seckl MJ, Tavaré JM.

PLoS One. 2019 Apr 10;14(4):e0214610. doi: 10.1371/journal.pone.0214610. eCollection 2019.


Challenges in the diagnosis and treatment of gestational trophoblastic neoplasia worldwide.

Braga A, Mora P, de Melo AC, Nogueira-Rodrigues A, Amim-Junior J, Rezende-Filho J, Seckl MJ.

World J Clin Oncol. 2019 Feb 24;10(2):28-37. doi: 10.5306/wjco.v10.i2.28.


Intensified therapies improve survival and identification of novel prognostic factors for placental-site and epithelioid trophoblastic tumours.

Froeling FEM, Ramaswami R, Papanastasopoulos P, Kaur B, Sebire NJ, Short D, Fisher RA, Sarwar N, Wells M, Singh K, Ellis L, Horsman JM, Winter MC, Tidy J, Hancock BW, Seckl MJ.

Br J Cancer. 2019 Mar;120(6):587-594. doi: 10.1038/s41416-019-0402-0. Epub 2019 Feb 22.


The results of treatment with high-dose chemotherapy and peripheral blood stem cell support for gestational trophoblastic neoplasia.

Frijstein MM, Lok CAR, Short D, Singh K, Fisher RA, Hancock BW, Tidy JA, Sarwar N, Kanfer E, Winter MC, Savage PM, Seckl MJ.

Eur J Cancer. 2019 Mar;109:162-171. doi: 10.1016/j.ejca.2018.12.033. Epub 2019 Feb 4.


Tumoral pulmonary hypertension.

Price LC, Seckl MJ, Dorfmüller P, Wort SJ.

Eur Respir Rev. 2019 Feb 6;28(151). pii: 180065. doi: 10.1183/16000617.0065-2018. Print 2019 Mar 31. Review.


Do we need post-pregnancy screening with human chorionic gonadotrophin after previous hydatidiform mole to identify patients with recurrent gestational trophoblastic disease?

Earp KE, Hancock BW, Short D, Harvey RA, Fisher RA, Drew D, Sarwar N, Tidy JA, Winter MC, Chien P, Seckl MJ.

Eur J Obstet Gynecol Reprod Biol. 2019 Mar;234:117-119. doi: 10.1016/j.ejogrb.2018.12.029. Epub 2019 Jan 6.


Is there uniformity in definitions and treatment of gestational trophoblastic disease in Europe?

Frijstein MM, Lok CAR, Coulter J, van Trommel NE, Ten Kate-Booij MJ, Golfier F, Seckl MJ, Massuger LFAG.

Int J Gynecol Cancer. 2019 Jan;29(1):108-112. doi: 10.1136/ijgc-2018-000028.


Management and prognostic factors of epithelioid trophoblastic tumors: Results from the International Society for the Study of Trophoblastic Diseases database.

Frijstein MM, Lok CAR, van Trommel NE, Ten Kate-Booij MJ, Massuger LFAG, van Werkhoven E, Kaur B, Tidy JA, Sarwar N, Golfier F, Winter MC, Hancock BW, Seckl MJ; all the contributors to the ISSTD PSTT/ETT database.

Gynecol Oncol. 2019 Feb;152(2):361-367. doi: 10.1016/j.ygyno.2018.11.015. Epub 2018 Nov 22.


Update on the diagnosis and management of gestational trophoblastic disease.

Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L.

Int J Gynaecol Obstet. 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615.


Targeting autophagy sensitises lung cancer cells to Src family kinase inhibitors.

Rupniewska E, Roy R, Mauri FA, Liu X, Kaliszczak M, Bellezza G, Cagini L, Barbareschi M, Ferrero S, Tommasi AM, Aboagye E, Seckl MJ, Pardo OE.

Oncotarget. 2018 Jun 8;9(44):27346-27362. doi: 10.18632/oncotarget.25213. eCollection 2018 Jun 8.


Does a human chorionic gonadotropin level of over 20,000 IU/L four weeks after uterine evacuation for complete hydatidiform mole constitute an indication for chemotherapy for gestational trophoblastic neoplasia?

Braga A, Biscaro A, do Amaral Giordani JM, Viggiano M, Elias KM, Berkowitz RS, Seckl MJ.

Eur J Obstet Gynecol Reprod Biol. 2018 Apr;223:50-55. doi: 10.1016/j.ejogrb.2018.02.001. Epub 2018 Feb 15. Review.


What is the optimal duration of human chorionic gonadotrophin surveillance following evacuation of a molar pregnancy? A retrospective analysis on over 20,000 consecutive patients.

Coyle C, Short D, Jackson L, Sebire NJ, Kaur B, Harvey R, Savage PM, Seckl MJ.

Gynecol Oncol. 2018 Feb;148(2):254-257. doi: 10.1016/j.ygyno.2017.12.008. Epub 2017 Dec 9.


Pembrolizumab is effective for drug-resistant gestational trophoblastic neoplasia.

Ghorani E, Kaur B, Fisher RA, Short D, Joneborg U, Carlson JW, Akarca A, Marafioti T, Quezada SA, Sarwar N, Seckl MJ.

Lancet. 2017 Nov 25;390(10110):2343-2345. doi: 10.1016/S0140-6736(17)32894-5. No abstract available.


Increased human Chorionic Gonadotropin levels five years before diagnosis of an ovarian dysgerminoma.

Cormio G, Seckl MJ, Loizzi V, Resta L, Cicinelli E.

Eur J Obstet Gynecol Reprod Biol. 2018 Jan;220:138-139. doi: 10.1016/j.ejogrb.2017.11.008. Epub 2017 Nov 10. No abstract available.


Rare ovarian tumours: Epidemiology, treatment challenges in and outside a network setting.

Ray-Coquard I, Trama A, Seckl MJ, Fotopoulou C, Pautier P, Pignata S, Kristensen G, Mangili G, Falconer H, Massuger L, Sehouli J, Pujade-Lauraine E, Lorusso D, Amant F, Rokkones E, Vergote I, Ledermann JA; RARECARENet Working Group.

Eur J Surg Oncol. 2019 Jan;45(1):67-74. doi: 10.1016/j.ejso.2017.09.025. Epub 2017 Nov 3. Review.


Emerging roles of hnRNPA1 in modulating malignant transformation.

Roy R, Huang Y, Seckl MJ, Pardo OE.

Wiley Interdiscip Rev RNA. 2017 Nov;8(6). doi: 10.1002/wrna.1431. Epub 2017 Aug 8. Review.


Experiences of Women With Gestational Trophoblastic Neoplasia Treated With High-Dose Chemotherapy and Stem Cell Transplantation: A Qualitative Study.

Singh K, Warnock C, Ireson J, Strickland S, Short D, Seckl MJ, Hancock BW.

Oncol Nurs Forum. 2017 May 1;44(3):375-383. doi: 10.1188/17.ONF.375-383.


Can the FIGO 2000 scoring system for gestational trophoblastic neoplasia be simplified? A new retrospective analysis from a nationwide dataset.

Eysbouts YK, Ottevanger PB, Massuger LFAG, IntHout J, Short D, Harvey R, Kaur B, Sebire NJ, Sarwar N, Sweep FCGJ, Seckl MJ.

Ann Oncol. 2017 Aug 1;28(8):1856-1861. doi: 10.1093/annonc/mdx211.


18F FDG positron-emission tomography findings of gliomatosis peritonei: A case report and review of the literature.

Lavoie JM, Lacroix-Poisson F, Hoang LN, Wilson DC, Seckl MJ, Tinker AV.

Gynecol Oncol Rep. 2017 Mar 27;20:105-107. doi: 10.1016/j.gore.2017.03.018. eCollection 2017 May.


Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine.

Poursaitidis I, Wang X, Crighton T, Labuschagne C, Mason D, Cramer SL, Triplett K, Roy R, Pardo OE, Seckl MJ, Rowlinson SW, Stone E, Lamb RF.

Cell Rep. 2017 Mar 14;18(11):2547-2556. doi: 10.1016/j.celrep.2017.02.054.


Type I interferons modulate methotrexate resistance in gestational trophoblastic neoplasia.

Elias KM, Harvey RA, Hasselblatt KT, Seckl MJ, Berkowitz RS.

Am J Reprod Immunol. 2017 Jun;77(6). doi: 10.1111/aji.12666. Epub 2017 Mar 14.


Multicenter, Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Pravastatin Added to First-Line Standard Chemotherapy in Small-Cell Lung Cancer (LUNGSTAR).

Seckl MJ, Ottensmeier CH, Cullen M, Schmid P, Ngai Y, Muthukumar D, Thompson J, Harden S, Middleton G, Fife KM, Crosse B, Taylor P, Nash S, Hackshaw A.

J Clin Oncol. 2017 May 10;35(14):1506-1514. doi: 10.1200/JCO.2016.69.7391. Epub 2017 Feb 27.


15years of progress in gestational trophoblastic disease: Scoring, standardization, and salvage.

Brown J, Naumann RW, Seckl MJ, Schink J.

Gynecol Oncol. 2017 Jan;144(1):200-207. doi: 10.1016/j.ygyno.2016.08.330. Epub 2016 Oct 13. Review.


Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer.

Li H, Stokes W, Chater E, Roy R, de Bruin E, Hu Y, Liu Z, Smit EF, Heynen GJ, Downward J, Seckl MJ, Wang Y, Tang H, Pardo OE.

Cell Discov. 2016 Sep 27;2:16031. eCollection 2016.


Power Doppler Quantification in Assessing Gestational Trophoblastic Neoplasia.

Li Y, Tang MX, Agarwal R, Patel D, Eckersley RJ, Barrois G, Roddie ME, Dayal L, Savage PM, Seckl MJ, Lim A.

Ultraschall Med. 2018 Apr;39(2):206-212. doi: 10.1055/s-0041-111065. Epub 2016 Aug 16.


Anti-Müllerian Hormone in Patients Treated with Chemotherapy for Gestational Trophoblastic Neoplasia Does Not Predict Short-Term Fertility.

Ghorani E, Ramaswami R, Smith RJ, Savage PM, Seckl MJ.

J Reprod Med. 2016 May-Jun;61(5-6):205-9.


Molecular genotyping of placental site and epithelioid trophoblastic tumours; female predominance.

Zhao S, Sebire NJ, Kaur B, Seckl MJ, Fisher RA.

Gynecol Oncol. 2016 Sep;142(3):501-7. doi: 10.1016/j.ygyno.2016.05.033. Epub 2016 Jul 4.


Risk of recurrent molar pregnancies following complete and partial hydatidiform moles.

Eagles N, Sebire NJ, Short D, Savage PM, Seckl MJ, Fisher RA.

Hum Reprod. 2016 Jun;31(6):1379. doi: 10.1093/humrep/dew079. Epub 2016 Apr 12. No abstract available.


Nemo-like kinase regulates the expression of vascular endothelial growth factor (VEGF) in alveolar epithelial cells.

Ke H, Masoumi KC, Ahlqvist K, Seckl MJ, Rydell-Törmänen K, Massoumi R.

Sci Rep. 2016 Apr 1;6:23987. doi: 10.1038/srep23987.


Intraplacental choriocarcinoma: Systematic review and management guidance.

Jiao L, Ghorani E, Sebire NJ, Seckl MJ.

Gynecol Oncol. 2016 Jun;141(3):624-631. doi: 10.1016/j.ygyno.2016.03.026. Epub 2016 Apr 6. Review.


Circulating Cell Free DNA in the Diagnosis of Trophoblastic Tumors.

Openshaw MR, Harvey RA, Sebire NJ, Kaur B, Sarwar N, Seckl MJ, Fisher RA.

EBioMedicine. 2015 Dec 29;4:146-52. doi: 10.1016/j.ebiom.2015.12.022. eCollection 2016 Feb.


miR-515-5p controls cancer cell migration through MARK4 regulation.

Pardo OE, Castellano L, Munro CE, Hu Y, Mauri F, Krell J, Lara R, Pinho FG, Choudhury T, Frampton AE, Pellegrino L, Pshezhetskiy D, Wang Y, Waxman J, Seckl MJ, Stebbing J.

EMBO Rep. 2016 Apr;17(4):570-84. doi: 10.15252/embr.201540970. Epub 2016 Feb 10.


Abnormal villous morphology mimicking a hydatidiform mole associated with paternal trisomy of chromosomes 3,7,8 and unipaternal disomy of chromosome 11.

Sebire NJ, May PC, Kaur B, Seckl MJ, Fisher RA.

Diagn Pathol. 2016 Feb 4;11:20. doi: 10.1186/s13000-016-0471-9.


Late spontaneous resolution of persistent molar pregnancy.

Taylor F, Short D, Harvey R, Winter MC, Tidy J, Hancock BW, Savage PM, Sarwar N, Seckl MJ, Coleman RE.

BJOG. 2016 Jun;123(7):1175-81. doi: 10.1111/1471-0528.13867. Epub 2016 Jan 15.


Hormonal contraceptive use before hCG remission does not increase the risk of gestational trophoblastic neoplasia following complete hydatidiform mole: a historical database review.

Braga A, Maestá I, Short D, Savage P, Harvey R, Seckl MJ.

BJOG. 2016 Jul;123(8):1330-5. doi: 10.1111/1471-0528.13617. Epub 2015 Oct 7.


Update on the diagnosis and management of gestational trophoblastic disease.

Ngan HY, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR.

Int J Gynaecol Obstet. 2015 Oct;131 Suppl 2:S123-6. doi: 10.1016/j.ijgo.2015.06.008. No abstract available.


Risk of recurrent molar pregnancies following complete and partial hydatidiform moles.

Eagles N, Sebire NJ, Short D, Savage PM, Seckl MJ, Fisher RA.

Hum Reprod. 2015 Sep;30(9):2055-63. doi: 10.1093/humrep/dev169. Epub 2015 Jul 22. Erratum in: Hum Reprod. 2016 Jun;31(6):1379.


Formalised consensus of the European Organisation for Treatment of Trophoblastic Diseases on management of gestational trophoblastic diseases.

Bolze PA, Attia J, Massardier J, Seckl MJ, Massuger L, van Trommel N, Niemann I, Hajri T, Schott AM, Golfier F; EOTTD group.

Eur J Cancer. 2015 Sep;51(13):1725-31. doi: 10.1016/j.ejca.2015.05.026. Epub 2015 Jun 16. Review.


DAPK2 regulates oxidative stress in cancer cells by preserving mitochondrial function.

Schlegel CR, Georgiou ML, Misterek MB, Stöcker S, Chater ER, Munro CE, Pardo OE, Seckl MJ, Costa-Pereira AP.

Cell Death Dis. 2015 Mar 5;6:e1671. doi: 10.1038/cddis.2015.31.


Atypical placental site nodule (APSN) and association with malignant gestational trophoblastic disease; a clinicopathologic study of 21 cases.

Kaur B, Short D, Fisher RA, Savage PM, Seckl MJ, Sebire NJ.

Int J Gynecol Pathol. 2015 Mar;34(2):152-8. doi: 10.1097/PGP.0000000000000128.


Brain metastases in gestational trophoblast neoplasia: an update on incidence, management and outcome.

Savage P, Kelpanides I, Tuthill M, Short D, Seckl MJ.

Gynecol Oncol. 2015 Apr;137(1):73-6. doi: 10.1016/j.ygyno.2015.01.530. Epub 2015 Jan 15.


Effects of single-agent and combination chemotherapy for gestational trophoblastic tumors on risks of second malignancy and early menopause.

Savage P, Cooke R, O'Nions J, Krell J, Kwan A, Camarata M, Dancy G, Short D, Seckl MJ, Swerdlow A.

J Clin Oncol. 2015 Feb 10;33(5):472-8. doi: 10.1200/JCO.2014.57.5332. Epub 2014 Dec 29.


A retrospective study to evaluate single agent methotrexate treatment in low risk gestational choriocarcinoma in the United Kingdom.

Taylor F, Short D, Winter MC, Tidy J, Savage PM, Sarwar N, Hancock BW, Seckl MJ, Coleman RE.

Gynecol Oncol. 2015 Feb;136(2):258-63. doi: 10.1016/j.ygyno.2014.12.024. Epub 2014 Dec 24.


Glycogen synthase kinase 3 protein kinase activity is frequently elevated in human non-small cell lung carcinoma and supports tumour cell proliferation.

Vincent EE, Elder DJ, O'Flaherty L, Pardo OE, Dzien P, Phillips L, Morgan C, Pawade J, May MT, Sohail M, Hetzel MR, Seckl MJ, Tavaré JM.

PLoS One. 2014 Dec 8;9(12):e114725. doi: 10.1371/journal.pone.0114725. eCollection 2014.


Gynecologic Cancer Intergroup (GCIG) consensus review for ovarian germ cell tumors.

Brown J, Friedlander M, Backes FJ, Harter P, O'Connor DM, de la Motte Rouge T, Lorusso D, Maenpaa J, Kim JW, Tenney ME, Seckl MJ.

Int J Gynecol Cancer. 2014 Nov;24(9 Suppl 3):S48-54. doi: 10.1097/IGC.0000000000000223. Review.


Trophoblastic disease review for diagnosis and management: a joint report from the International Society for the Study of Trophoblastic Disease, European Organisation for the Treatment of Trophoblastic Disease, and the Gynecologic Cancer InterGroup.

Mangili G, Lorusso D, Brown J, Pfisterer J, Massuger L, Vaughan M, Ngan HY, Golfier F, Sekharan PK, Charry RC, Poveda A, Kim JW, Xiang Y, Berkowtiz R, Seckl MJ.

Int J Gynecol Cancer. 2014 Nov;24(9 Suppl 3):S109-16. doi: 10.1097/IGC.0000000000000294. Review.


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