Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 445

1.

Mining for Oxysterols in Cyp7b1-/- Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5.

Meljon A, Crick PJ, Yutuc E, Yau JL, Seckl JR, Theofilopoulos S, Arenas E, Wang Y, Griffiths WJ.

Biomolecules. 2019 Apr 13;9(4). pii: E149. doi: 10.3390/biom9040149.

2.

Predictors of Nephrolithiasis, Osteoporosis, and Mortality in Primary Hyperparathyroidism.

Reid LJ, Muthukrishnan B, Patel D, Seckl JR, Gibb FW.

J Clin Endocrinol Metab. 2019 Sep 1;104(9):3692-3700. doi: 10.1210/jc.2018-02483.

PMID:
30916764
3.

Predicting outcomes and complications following radioiodine therapy in Graves' thyrotoxicosis.

Aung ET, Zammitt NN, Dover AR, Strachan MWJ, Seckl JR, Gibb FW.

Clin Endocrinol (Oxf). 2019 Jan;90(1):192-199. doi: 10.1111/cen.13873. Epub 2018 Oct 25.

PMID:
30291728
4.

Presentation, diagnostic assessment and surgical outcomes in primary hyperparathyroidism: a single centre's experience.

Reid L, Muthukrishnan B, Patel D, Crane M, Akyol M, Thomson A, Seckl JR, Gibb FW.

Endocr Connect. 2018 Aug 23. pii: EC-18-0195. doi: 10.1530/EC-18-0195. [Epub ahead of print]

5.

Corrigendum: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.

Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MTG, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S.

Nat Med. 2018 Apr 10;24(4):525. doi: 10.1038/nm0418-525e.

PMID:
29634685
6.

Midlife stress alters memory and mood-related behaviors in old age: Role of locally activated glucocorticoids.

Wheelan N, Kenyon CJ, Harris AP, Cairns C, Al Dujaili E, Seckl JR, Yau JLW.

Psychoneuroendocrinology. 2018 Mar;89:13-22. doi: 10.1016/j.psyneuen.2017.12.018. Epub 2017 Dec 23.

7.

11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation.

Verma M, Kipari TMJ, Zhang Z, Man TY, Forster T, Homer NZM, Seckl JR, Holmes MC, Chapman KE.

Brain Behav Immun. 2018 Mar;69:223-234. doi: 10.1016/j.bbi.2017.11.015. Epub 2017 Nov 21.

8.

Macrophage 11β-HSD-1 deficiency promotes inflammatory angiogenesis.

Zhang Z, Coutinho AE, Man TY, Kipari TMJ, Hadoke PWF, Salter DM, Seckl JR, Chapman KE.

J Endocrinol. 2017 Sep;234(3):291-299. doi: 10.1530/JOE-17-0223. Epub 2017 Jul 4.

9.

Overexpression of Mineralocorticoid Receptors in the Mouse Forebrain Partly Alleviates the Effects of Chronic Early Life Stress on Spatial Memory, Neurogenesis and Synaptic Function in the Dentate Gyrus.

Kanatsou S, Karst H, Kortesidou D, van den Akker RA, den Blaauwen J, Harris AP, Seckl JR, Krugers HJ, Joels M.

Front Cell Neurosci. 2017 May 29;11:132. doi: 10.3389/fncel.2017.00132. eCollection 2017.

10.

Maternal Licorice Consumption During Pregnancy and Pubertal, Cognitive, and Psychiatric Outcomes in Children.

Räikkönen K, Martikainen S, Pesonen AK, Lahti J, Heinonen K, Pyhälä R, Lahti M, Tuovinen S, Wehkalampi K, Sammallahti S, Kuula L, Andersson S, Eriksson JG, Ortega-Alonso A, Reynolds RM, Strandberg TE, Seckl JR, Kajantie E.

Am J Epidemiol. 2017 Mar 1;185(5):317-328. doi: 10.1093/aje/kww172.

PMID:
28158597
11.

Räikkönen et al. Respond to "Maternal Stress and Offspring Health".

Räikkönen K, Martikainen S, Pesonen AK, Lahti J, Heinonen K, Pyhälä R, Lahti M, Tuovinen S, Wehkalampi K, Sammallahti S, Kuula L, Andersson S, Eriksson JG, Ortega-Alonso A, Reynolds RM, Strandberg TE, Seckl JR, Kajantie E.

Am J Epidemiol. 2017 Mar 1;185(5):333-334. doi: 10.1093/aje/kww174. No abstract available.

PMID:
28158390
12.

Dynamic Changes in DNA Methylation Occur during the First Year of Life in Preterm Infants.

Piyasena C, Cartier J, Provençal N, Wiechmann T, Khulan B, Sunderesan R, Menon G, Seckl JR, Reynolds RM, Binder EB, Drake AJ.

Front Endocrinol (Lausanne). 2016 Dec 15;7:158. doi: 10.3389/fendo.2016.00158. eCollection 2016. Erratum in: Front Endocrinol (Lausanne). 2018 Feb 27;9:47.

13.

Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™).

Webster SP, McBride A, Binnie M, Sooy K, Seckl JR, Andrew R, Pallin TD, Hunt HJ, Perrior TR, Ruffles VS, Ketelbey JW, Boyd A, Walker BR.

Br J Pharmacol. 2017 Mar;174(5):396-408. doi: 10.1111/bph.13699. Epub 2017 Jan 25.

14.

11β-hydroxysteroid dehydrogenase-1 deficiency alters the gut microbiome response to Western diet.

Johnson JS, Opiyo MN, Thomson M, Gharbi K, Seckl JR, Heger A, Chapman KE.

J Endocrinol. 2017 Feb;232(2):273-283. Epub 2016 Nov 24.

16.

Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.

Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S.

Nat Med. 2016 Jul;22(7):771-9. doi: 10.1038/nm.4115. Epub 2016 Jun 6. Erratum in: Nat Med. 2018 Apr 10;24(4):525.

17.

Thyrotropin Receptor Antibody Levels at Diagnosis and After Thionamide Course Predict Graves' Disease Relapse.

Tun NN, Beckett G, Zammitt NN, Strachan MW, Seckl JR, Gibb FW.

Thyroid. 2016 Aug;26(8):1004-9. doi: 10.1089/thy.2016.0017. Epub 2016 Jul 6.

PMID:
27266892
18.

Pravastatin ameliorates placental vascular defects, fetal growth, and cardiac function in a model of glucocorticoid excess.

Wyrwoll CS, Noble J, Thomson A, Tesic D, Miller MR, Rog-Zielinska EA, Moran CM, Seckl JR, Chapman KE, Holmes MC.

Proc Natl Acad Sci U S A. 2016 May 31;113(22):6265-70. doi: 10.1073/pnas.1520356113. Epub 2016 May 16.

19.

11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice.

Coutinho AE, Kipari TM, Zhang Z, Esteves CL, Lucas CD, Gilmour JS, Webster SP, Walker BR, Hughes J, Savill JS, Seckl JR, Rossi AG, Chapman KE.

Endocrinology. 2016 Jul;157(7):2928-36. doi: 10.1210/en.2016-1118. Epub 2016 May 4.

20.

Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension.

Evans LC, Ivy JR, Wyrwoll C, McNairn JA, Menzies RI, Christensen TH, Al-Dujaili EA, Kenyon CJ, Mullins JJ, Seckl JR, Holmes MC, Bailey MA.

Circulation. 2016 Apr 5;133(14):1360-70. doi: 10.1161/CIRCULATIONAHA.115.019341. Epub 2016 Mar 7.

21.

Effects of Mineralocorticoid Receptor Overexpression on Anxiety and Memory after Early Life Stress in Female Mice.

Kanatsou S, Ter Horst JP, Harris AP, Seckl JR, Krugers HJ, Joëls M.

Front Behav Neurosci. 2016 Jan 26;9:374. doi: 10.3389/fnbeh.2015.00374. eCollection 2015.

22.

Correction: Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity.

Kanatsou S, Fearey BC, Kuil LE, Lucassen PJ, Harris AP, Seckl JR, Krugers H, Joels M.

PLoS One. 2015 Dec 18;10(12):e0145706. doi: 10.1371/journal.pone.0145706. eCollection 2015. No abstract available.

23.

Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity.

Kanatsou S, Fearey BC, Kuil LE, Lucassen PJ, Harris AP, Seckl JR, Krugers H, Joels M.

PLoS One. 2015 Nov 23;10(11):e0142012. doi: 10.1371/journal.pone.0142012. eCollection 2015. Erratum in: PLoS One. 2015;10(12):e0145706.

24.

Decreased Npas4 and Arc mRNA Levels in the Hippocampus of Aged Memory-Impaired Wild-Type But Not Memory Preserved 11β-HSD1 Deficient Mice.

Qiu J, Dunbar DR, Noble J, Cairns C, Carter R, Kelly V, Chapman KE, Seckl JR, Yau JL.

J Neuroendocrinol. 2016 Jan;28(1). doi: 10.1111/jne.12339.

25.

Cardiomyocyte and Vascular Smooth Muscle-Independent 11β-Hydroxysteroid Dehydrogenase 1 Amplifies Infarct Expansion, Hypertrophy, and the Development of Heart Failure After Myocardial Infarction in Male Mice.

White CI, Jansen MA, McGregor K, Mylonas KJ, Richardson RV, Thomson A, Moran CM, Seckl JR, Walker BR, Chapman KE, Gray GA.

Endocrinology. 2016 Jan;157(1):346-57. doi: 10.1210/en.2015-1630. Epub 2015 Oct 14.

26.

Decreased maternal hypothalamic-pituitary-adrenal axis activity in very severely obese pregnancy: Associations with birthweight and gestation at delivery.

Stirrat LI, O'Reilly JR, Barr SM, Andrew R, Riley SC, Howie AF, Bowman M, Smith R, Lewis JG, Denison FC, Forbes S, Seckl JR, Walker BR, Norman JE, Reynolds RM.

Psychoneuroendocrinology. 2016 Jan;63:135-43. doi: 10.1016/j.psyneuen.2015.09.019. Epub 2015 Sep 25.

PMID:
26444587
27.

Hypothalamic-pituitary-adrenal axis dysregulation and cortisol activity in obesity: A systematic review.

Incollingo Rodriguez AC, Epel ES, White ML, Standen EC, Seckl JR, Tomiyama AJ.

Psychoneuroendocrinology. 2015 Dec;62:301-18. doi: 10.1016/j.psyneuen.2015.08.014. Epub 2015 Aug 21. Review.

PMID:
26356039
28.

Dynamics of DNA methylation at IGF2 in preterm and term infants during the first year of life: an observational study.

Piyasena C, Cartier J, Khulan B, French K, Menon G, Seckl JR, Reynolds RM, Drake AJ.

Lancet. 2015 Feb 26;385 Suppl 1:S81. doi: 10.1016/S0140-6736(15)60396-8.

PMID:
26312903
29.

Sex-Differences in the Metabolic Health of Offspring of Parents with Diabetes: A Record-Linkage Study.

Aldhous MC, Reynolds RM, Campbell A, Linksted P, Lindsay RS, Smith BH, Seckl JR, Porteous DJ, Norman JE; Generation Scotland.

PLoS One. 2015 Aug 26;10(8):e0134883. doi: 10.1371/journal.pone.0134883. eCollection 2015.

30.

Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease.

Sooy K, Noble J, McBride A, Binnie M, Yau JL, Seckl JR, Walker BR, Webster SP.

Endocrinology. 2015 Dec;156(12):4592-603. doi: 10.1210/en.2015-1395. Epub 2015 Aug 25.

31.

Overexpression of mineralocorticoid receptors does not affect memory and anxiety-like behavior in female mice.

Kanatsou S, Kuil LE, Arp M, Oitzl MS, Harris AP, Seckl JR, Krugers HJ, Joels M.

Front Behav Neurosci. 2015 Jul 14;9:182. doi: 10.3389/fnbeh.2015.00182. eCollection 2015.

32.

Maternal depressive symptoms during pregnancy, placental expression of genes regulating glucocorticoid and serotonin function and infant regulatory behaviors.

Räikkönen K, Pesonen AK, O'Reilly JR, Tuovinen S, Lahti M, Kajantie E, Villa P, Laivuori H, Hämäläinen E, Seckl JR, Reynolds RM.

Psychol Med. 2015 Nov;45(15):3217-26. doi: 10.1017/S003329171500121X. Epub 2015 Jun 22.

PMID:
26096463
33.

Placental 5-methylcytosine and 5-hydroxymethylcytosine patterns associate with size at birth.

Piyasena C, Reynolds RM, Khulan B, Seckl JR, Menon G, Drake AJ.

Epigenetics. 2015;10(8):692-7. doi: 10.1080/15592294.2015.1062963.

34.

Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography.

Kirkby NS, Low L, Wu J, Miller E, Seckl JR, Walker BR, Webb DJ, Hadoke PW.

J Vis Exp. 2015 May 26;(99):e50627. doi: 10.3791/50627.

35.

Fetal brain 11β-hydroxysteroid dehydrogenase type 2 selectively determines programming of adult depressive-like behaviors and cognitive function, but not anxiety behaviors in male mice.

Wyrwoll C, Keith M, Noble J, Stevenson PL, Bombail V, Crombie S, Evans LC, Bailey MA, Wood E, Seckl JR, Holmes MC.

Psychoneuroendocrinology. 2015 Sep;59:59-70. doi: 10.1016/j.psyneuen.2015.05.003. Epub 2015 May 18.

36.

Estrogens protect male mice from obesity complications and influence glucocorticoid metabolism.

Dakin RS, Walker BR, Seckl JR, Hadoke PW, Drake AJ.

Int J Obes (Lond). 2015 Oct;39(10):1539-47. doi: 10.1038/ijo.2015.102. Epub 2015 Jun 2.

37.

Maternal depressive symptoms throughout pregnancy are associated with increased placental glucocorticoid sensitivity.

Reynolds RM, Pesonen AK, O'Reilly JR, Tuovinen S, Lahti M, Kajantie E, Villa PM, Laivuori H, Hämäläinen E, Seckl JR, Räikkönen K.

Psychol Med. 2015 Jul;45(10):2023-30. doi: 10.1017/S003329171400316X. Epub 2015 Jan 28.

PMID:
25628053
38.

Diurnal and stress-induced intra-hippocampal corticosterone rise attenuated in 11β-HSD1-deficient mice: a microdialysis study in young and aged mice.

Yau JL, Noble J, Kenyon CJ, Ludwig M, Seckl JR.

Eur J Neurosci. 2015 Mar;41(6):787-92. doi: 10.1111/ejn.12836. Epub 2015 Jan 23.

39.

5α-Reduced neurosteroids sex-dependently reverse central prenatal programming of neuroendocrine stress responses in rats.

Brunton PJ, Donadio MV, Yao ST, Greenwood M, Seckl JR, Murphy D, Russell JA.

J Neurosci. 2015 Jan 14;35(2):666-77. doi: 10.1523/JNEUROSCI.5104-13.2015.

40.

Short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged mice.

Wheelan N, Webster SP, Kenyon CJ, Caughey S, Walker BR, Holmes MC, Seckl JR, Yau JL.

Neuropharmacology. 2015 Apr;91:71-6. doi: 10.1016/j.neuropharm.2014.12.005. Epub 2014 Dec 11.

41.

Adipocyte pseudohypoxia suppresses lipolysis and facilitates benign adipose tissue expansion.

Michailidou Z, Morton NM, Moreno Navarrete JM, West CC, Stewart KJ, Fernández-Real JM, Schofield CJ, Seckl JR, Ratcliffe PJ.

Diabetes. 2015 Mar;64(3):733-45. doi: 10.2337/db14-0233. Epub 2014 Nov 5.

42.

β-Cell-Specific Glucocorticoid Reactivation Attenuates Inflammatory β-Cell Destruction.

Liu X, Turban S, Carter RN, Ahmad S, Ramage L, Webster SP, Walker BR, Seckl JR, Morton NM.

Front Endocrinol (Lausanne). 2014 Oct 14;5:165. doi: 10.3389/fendo.2014.00165. eCollection 2014.

43.

Cholestenoic acids regulate motor neuron survival via liver X receptors.

Theofilopoulos S, Griffiths WJ, Crick PJ, Yang S, Meljon A, Ogundare M, Kitambi SS, Lockhart A, Tuschl K, Clayton PT, Morris AA, Martinez A, Reddy MA, Martinuzzi A, Bassi MT, Honda A, Mizuochi T, Kimura A, Nittono H, De Michele G, Carbone R, Criscuolo C, Yau JL, Seckl JR, Schüle R, Schöls L, Sailer AW, Kuhle J, Fraidakis MJ, Gustafsson JÅ, Steffensen KR, Björkhem I, Ernfors P, Sjövall J, Arenas E, Wang Y.

J Clin Invest. 2014 Nov;124(11):4829-42. doi: 10.1172/JCI68506. Epub 2014 Oct 1.

44.

Epigenomic profiling of men exposed to early-life stress reveals DNA methylation differences in association with current mental state.

Khulan B, Manning JR, Dunbar DR, Seckl JR, Raikkonen K, Eriksson JG, Drake AJ.

Transl Psychiatry. 2014 Sep 23;4:e448. doi: 10.1038/tp.2014.94.

45.

Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice.

Yau JL, Wheelan N, Noble J, Walker BR, Webster SP, Kenyon CJ, Ludwig M, Seckl JR.

Neurobiol Aging. 2015 Jan;36(1):334-43. doi: 10.1016/j.neurobiolaging.2014.07.007. Epub 2014 Jul 15.

46.

Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life.

King V, Norman JE, Seckl JR, Drake AJ.

Reprod Biol Endocrinol. 2014 Aug 1;12:73. doi: 10.1186/1477-7827-12-73.

47.

Increased maternal BMI is associated with infant wheezing in early life: a prospective cohort study.

de Vries A, Reynolds RM, Seckl JR, van der Wal M, Bonsel GJ, Vrijkotte TG.

J Dev Orig Health Dis. 2014 Oct;5(5):351-60. doi: 10.1017/S2040174414000312. Epub 2014 Jun 25.

PMID:
25081820
48.

Elevation of 11β-hydroxysteroid dehydrogenase type 2 activity in Holocaust survivor offspring: evidence for an intergenerational effect of maternal trauma exposure.

Bierer LM, Bader HN, Daskalakis NP, Lehrner AL, Makotkine I, Seckl JR, Yehuda R.

Psychoneuroendocrinology. 2014 Oct;48:1-10. doi: 10.1016/j.psyneuen.2014.06.001. Epub 2014 Jun 7.

49.

Glucocorticoid receptor gene expression in adipose tissue and associated metabolic risk in black and white South African women.

Goedecke JH, Chorell E, Livingstone DE, Stimson RH, Hayes P, Adams K, Dave JA, Victor H, Levitt NS, Kahn SE, Seckl JR, Walker BR, Olsson T.

Int J Obes (Lond). 2015 Feb;39(2):303-11. doi: 10.1038/ijo.2014.94. Epub 2014 May 20.

PMID:
24854429
50.

24S,25-Epoxycholesterol in mouse and rat brain.

Wang Y, Karu K, Meljon A, Turton J, Yau JL, Seckl JR, Wang Y, Griffiths WJ.

Biochem Biophys Res Commun. 2014 Jun 27;449(2):229-34. doi: 10.1016/j.bbrc.2014.05.012. Epub 2014 May 14.

Supplemental Content

Loading ...
Support Center