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2001 1
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2012 10
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104 results

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Page 1
Intestinal SEC16B modulates obesity by regulating chylomicron metabolism.
Shi R, Lu W, Tian Y, Wang B. Shi R, et al. Mol Metab. 2023 Apr;70:101693. doi: 10.1016/j.molmet.2023.101693. Epub 2023 Feb 14. Mol Metab. 2023. PMID: 36796587 Free PMC article.
However, the function of SEC16B in vivo, especially in lipid metabolism, has not been investigated. ...CONCLUSIONS: Our studies demonstrated that intestinal SEC16B is required for dietary lipid absorption in mice. These results revealed that SEC16B plays impo …
However, the function of SEC16B in vivo, especially in lipid metabolism, has not been investigated. ...CONCLUSIONS: Our studies demon …
Bi-allelic mutation in SEC16B alters collagen trafficking and increases ER stress.
El-Gazzar A, Voraberger B, Rauch F, Mairhofer M, Schmidt K, Guillemyn B, Mitulović G, Reiterer V, Haun M, Mayr MM, Mayr JA, Kimeswenger S, Drews O, Saraff V, Shaw N, Fratzl-Zelman N, Symoens S, Farhan H, Högler W. El-Gazzar A, et al. EMBO Mol Med. 2023 Apr 11;15(4):e16834. doi: 10.15252/emmm.202216834. Epub 2023 Mar 14. EMBO Mol Med. 2023. PMID: 36916446 Free PMC article.
Consequently, patient fibroblasts exhibited ER stress, enhanced autophagosome formation, and higher levels of apoptosis. Transfection of wild-type SEC16B into patient cells rescued the collagen trafficking. Mechanistically, we show that the defect is a consequence of reduc …
Consequently, patient fibroblasts exhibited ER stress, enhanced autophagosome formation, and higher levels of apoptosis. Transfection of wil …
Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells.
Yonekawa S, Furuno A, Baba T, Fujiki Y, Ogasawara Y, Yamamoto A, Tagaya M, Tani K. Yonekawa S, et al. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12746-51. doi: 10.1073/pnas.1103283108. Epub 2011 Jul 18. Proc Natl Acad Sci U S A. 2011. PMID: 21768384 Free PMC article.
Here, we reveal an unexpected role of Sec16B in the biogenesis of mammalian peroxisomes. When overexpressed, Sec16B was targeted to the entire ER, whereas Sec16A was mostly cytosolic. Concomitant with the overexpression of Sec16B, peroxisomal membrane biogene …
Here, we reveal an unexpected role of Sec16B in the biogenesis of mammalian peroxisomes. When overexpressed, Sec16B was target …
Transcriptional regulation of the ER stress-inducible gene Sec16B in Neuro2a cells.
Oh-Hashi K, Kohno H, Hirata Y. Oh-Hashi K, et al. Mol Cell Biochem. 2021 Jan;476(1):35-44. doi: 10.1007/s11010-020-03883-8. Epub 2020 Aug 19. Mol Cell Biochem. 2021. PMID: 32815086
Sec16B mRNA was induced by treatment with the ER stress-inducing reagents thapsigargin (Tg) and brefeldin A in a time-dependent manner. In the genomic sequence of the mouse Sec16B gene, we found an unfolded protein response element (UPRE), which is well conserved be
Sec16B mRNA was induced by treatment with the ER stress-inducing reagents thapsigargin (Tg) and brefeldin A in a time-dependent manne
A genome-wide association study of bitter and sweet beverage consumption.
Zhong VW, Kuang A, Danning RD, Kraft P, van Dam RM, Chasman DI, Cornelis MC. Zhong VW, et al. Hum Mol Genet. 2019 Jul 15;28(14):2449-2457. doi: 10.1093/hmg/ddz061. Hum Mol Genet. 2019. PMID: 31046077 Free PMC article.
Sub-phenotype analyses targeting the alcohol, caffeine and sweetener components of beverages yielded additional loci: (i) four loci for bitter alcoholic beverages (GCKR, KLB, ADH1B and AGBL2); (ii) five loci for bitter non-alcoholic beverages (ANXA9, AHR, POR, CYP1A1/2 and CSDC2) …
Sub-phenotype analyses targeting the alcohol, caffeine and sweetener components of beverages yielded additional loci: (i) four loci for bitt …
Female-Specific Susceptibility Locus in BOC and SEC16B are Associated with Adolescent Idiopathic Scoliosis.
Dai Z, Wang Y, Wu Z, Feng Z, Sun X, Qiu Y, Cheng JC, Xu L, Zhu Z. Dai Z, et al. Spine (Phila Pa 1976). 2021 Nov 15;46(22):E1178-E1184. doi: 10.1097/BRS.0000000000004098. Spine (Phila Pa 1976). 2021. PMID: 33958541
CONCLUSION: Female-specific variants in BOC and SEC16B were associated with AIS. Expression of BOC and SEC16B was significantly lower in AIS patients. The role of BOC and SEC16B in the development of AIS is worthy of further investigation.Level of Evidence: 3 …
CONCLUSION: Female-specific variants in BOC and SEC16B were associated with AIS. Expression of BOC and SEC16B was significantl …
Characterization of human Sec16B: indications of specialized, non-redundant functions.
Budnik A, Heesom KJ, Stephens DJ. Budnik A, et al. Sci Rep. 2011;1:77. doi: 10.1038/srep00077. Epub 2011 Aug 30. Sci Rep. 2011. PMID: 22355596 Free PMC article.
In humans two isoforms of Sec16 are present, the larger Sec16A and the smaller Sec16B. Nevertheless, the functional differences between the two isoforms are ill-defined. Here we describe characterization of the localization and dynamics of Sec16B relative to Sec16A, …
In humans two isoforms of Sec16 are present, the larger Sec16A and the smaller Sec16B. Nevertheless, the functional differences betwe …
Dual function of Sec16B: Endoplasmic reticulum-derived protein secretion and peroxisome biogenesis in mammalian cells.
Tani K, Tagaya M, Yonekawa S, Baba T. Tani K, et al. Cell Logist. 2011 Jul;1(4):164-167. doi: 10.4161/cl.1.4.18341. Epub 2011 Jul 1. Cell Logist. 2011. PMID: 22279616 Free PMC article.
We recently demonstrated that Sec16B, but not Sec16A, regulates the transport of peroxisomal biogenesis factors from the ER to peroxisomes in mammalian cells. The C-terminal region of Sec16B, which is not conserved in Sec16A, is required for this function. ...
We recently demonstrated that Sec16B, but not Sec16A, regulates the transport of peroxisomal biogenesis factors from the ER to peroxi …
Genetic variants in SEC16B are associated with body composition in black South Africans.
Sahibdeen V, Crowther NJ, Soodyall H, Hendry LM, Munthali RJ, Hazelhurst S, Choudhury A, Norris SA, Ramsay M, Lombard Z. Sahibdeen V, et al. Nutr Diabetes. 2018 Jul 19;8(1):43. doi: 10.1038/s41387-018-0050-0. Nutr Diabetes. 2018. PMID: 30026463 Free PMC article.

Measurements included body mass index (BMI), waist and hip circumference, waist-to-hip ratio (WHR), total fat mass, total lean mass and percentage fat mass (PFM). RESULTS: SNPs in several gene loci, including SEC16B (P(adj) < 9.48 10(-7)), NEGR1 (P(adj) < 1.64 10(-6)

Measurements included body mass index (BMI), waist and hip circumference, waist-to-hip ratio (WHR), total fat mass, total lean mass and perc …
[Association between SEC16B polymorphisms and body mass index variation or risk of obesity: a Meta-analysis].
Fu LW, Zhang MX, Gao LW, Mi J. Fu LW, et al. Zhonghua Liu Xing Bing Xue Za Zhi. 2016 Sep 10;37(9):1288-1295. doi: 10.3760/cma.j.issn.0254-6450.2016.09.021. Zhonghua Liu Xing Bing Xue Za Zhi. 2016. PMID: 27655580 Chinese.
Objective: To systematically evaluate the associations between SEC16B polymorphisms and body mass index (BMI) or risk of obesity in different ethnic populations. ...There were no significant differences among subgroups of ethnicity, different age groups and literatures wit …
Objective: To systematically evaluate the associations between SEC16B polymorphisms and body mass index (BMI) or risk of obesity in d …
104 results