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Items: 22


Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8α+ dendritic cells.

Parekh VV, Pabbisetty SK, Wu L, Sebzda E, Martinez J, Zhang J, Van Kaer L.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6371-E6380. doi: 10.1073/pnas.1706504114. Epub 2017 Jul 17.


A Distinct Lung-Interstitium-Resident Memory CD8(+) T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection.

Gilchuk P, Hill TM, Guy C, McMaster SR, Boyd KL, Rabacal WA, Lu P, Shyr Y, Kohlmeier JE, Sebzda E, Green DR, Joyce S.

Cell Rep. 2016 Aug 16;16(7):1800-9. doi: 10.1016/j.celrep.2016.07.037. Epub 2016 Aug 4.


Peripheral tolerance can be modified by altering KLF2-regulated Treg migration.

Pabbisetty SK, Rabacal W, Volanakis EJ, Parekh VV, Olivares-Villagómez D, Cendron D, Boyd KL, Van Kaer L, Sebzda E.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4662-70. doi: 10.1073/pnas.1605849113. Epub 2016 Jul 26.


Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival.

Rabacal W, Pabbisetty SK, Hoek KL, Cendron D, Guo Y, Maseda D, Sebzda E.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5370-5. doi: 10.1073/pnas.1521491113. Epub 2016 Apr 25.


KLF2 is a rate-limiting transcription factor that can be targeted to enhance regulatory T-cell production.

Pabbisetty SK, Rabacal W, Maseda D, Cendron D, Collins PL, Hoek KL, Parekh VV, Aune TM, Sebzda E.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9579-84. doi: 10.1073/pnas.1323493111. Epub 2014 Jun 16.


Follicular B cell trafficking within the spleen actively restricts humoral immune responses.

Hoek KL, Gordy LE, Collins PL, Parekh VV, Aune TM, Joyce S, Thomas JW, Van Kaer L, Sebzda E.

Immunity. 2010 Aug 27;33(2):254-65. doi: 10.1016/j.immuni.2010.07.016. Epub 2010 Aug 5.


Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling.

Bertozzi CC, Schmaier AA, Mericko P, Hess PR, Zou Z, Chen M, Chen CY, Xu B, Lu MM, Zhou D, Sebzda E, Santore MT, Merianos DJ, Stadtfeld M, Flake AW, Graf T, Skoda R, Maltzman JS, Koretzky GA, Kahn ML.

Blood. 2010 Jul 29;116(4):661-70. doi: 10.1182/blood-2010-02-270876. Epub 2010 Apr 2.


Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns.

Sebzda E, Zou Z, Lee JS, Wang T, Kahn ML.

Nat Immunol. 2008 Mar;9(3):292-300. doi: 10.1038/ni1565. Epub 2008 Feb 3.


Klf2 is an essential regulator of vascular hemodynamic forces in vivo.

Lee JS, Yu Q, Shin JT, Sebzda E, Bertozzi C, Chen M, Mericko P, Stadtfeld M, Zhou D, Cheng L, Graf T, MacRae CA, Lepore JJ, Lo CW, Kahn ML.

Dev Cell. 2006 Dec;11(6):845-57.


Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development.

Sebzda E, Hibbard C, Sweeney S, Abtahian F, Bezman N, Clemens G, Maltzman JS, Cheng L, Liu F, Turner M, Tybulewicz V, Koretzky GA, Kahn ML.

Dev Cell. 2006 Sep;11(3):349-61.


Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.

Abtahian F, Bezman N, Clemens R, Sebzda E, Cheng L, Shattil SJ, Kahn ML, Koretzky GA.

Mol Cell Biol. 2006 Sep;26(18):6936-49.


In vivo beta1 integrin function requires phosphorylation-independent regulation by cytoplasmic tyrosines.

Chen H, Zou Z, Sarratt KL, Zhou D, Zhang M, Sebzda E, Hammer DA, Kahn ML.

Genes Dev. 2006 Apr 15;20(8):927-32.


Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

Abtahian F, Guerriero A, Sebzda E, Lu MM, Zhou R, Mocsai A, Myers EE, Huang B, Jackson DG, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, Kahn ML.

Science. 2003 Jan 10;299(5604):247-51.


Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling.

Sebzda E, Bracke M, Tugal T, Hogg N, Cantrell DA.

Nat Immunol. 2002 Mar;3(3):251-8. Epub 2002 Feb 11.


Identification of a cross-reactive self ligand in virus-mediated autoimmunity.

Ohteki T, Hessel A, Bachmann MF, Zakarian A, Sebzda E, Tsao MS, McKall-Faienza K, Odermatt B, Ohashi PS.

Eur J Immunol. 1999 Sep;29(9):2886-96.


Selection of the T cell repertoire.

Sebzda E, Mariathasan S, Ohteki T, Jones R, Bachmann MF, Ohashi PS.

Annu Rev Immunol. 1999;17:829-74. Review.


Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner.

Sebzda E, Choi M, Fung-Leung WP, Mak TW, Ohashi PS.

Immunity. 1997 May;6(5):643-53.


Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo.

Speiser DE, Sebzda E, Ohteki T, Bachmann MF, Pfeffer K, Mak TW, Ohashi PS.

Eur J Immunol. 1996 Dec;26(12):3055-60.


T cell responses are governed by avidity and co-stimulatory thresholds.

Bachmann MF, Sebzda E, Kündig TM, Shahinian A, Speiser DE, Mak TW, Ohashi PS.

Eur J Immunol. 1996 Sep;26(9):2017-22.


Duration of TCR stimulation determines costimulatory requirement of T cells.

Kündig TM, Shahinian A, Kawai K, Mittrücker HW, Sebzda E, Bachmann MF, Mak TW, Ohashi PS.

Immunity. 1996 Jul;5(1):41-52.


Mature T cell reactivity altered by peptide agonist that induces positive selection.

Sebzda E, Kündig TM, Thomson CT, Aoki K, Mak SY, Mayer JP, Zamborelli T, Nathenson SG, Ohashi PS.

J Exp Med. 1996 Mar 1;183(3):1093-104.


Positive and negative thymocyte selection induced by different concentrations of a single peptide.

Sebzda E, Wallace VA, Mayer J, Yeung RS, Mak TW, Ohashi PS.

Science. 1994 Mar 18;263(5153):1615-8.


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