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Items: 1 to 50 of 307

1.

Comprehensive autophagy evaluation in cardiac diseases models.

Kaludercic N, Maiuri MC, Kaushik S, Fernández ÁF, de Bruijn J, Castoldi F, Chen Y, Ito J, Mukai R, Murakawa T, Nah J, Pietrocola F, Saito T, Sebti S, Semenzato M, Tsansizi L, Sciarretta S, Madrigal-Matute J.

Cardiovasc Res. 2019 Aug 27. pii: cvz233. doi: 10.1093/cvr/cvz233. [Epub ahead of print]

PMID:
31504266
2.

A Phase I Study of GGTI-2418 (Geranylgeranyl Transferase I Inhibitor) in Patients with Advanced Solid Tumors.

Karasic TB, Chiorean EG, Sebti SM, O'Dwyer PJ.

Target Oncol. 2019 Aug 1. doi: 10.1007/s11523-019-00661-5. [Epub ahead of print]

PMID:
31372813
3.

Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs.

Francois RA, Zhang A, Husain K, Wang C, Hutchinson S, Kongnyuy M, Batra SK, Coppola D, Sebti SM, Malafa MP.

Cancer Cell Int. 2019 Jul 22;19:189. doi: 10.1186/s12935-019-0876-0. eCollection 2019.

4.

Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors.

Kazi A, Xiang S, Yang H, Chen L, Kennedy P, Ayaz M, Fletcher S, Cummings C, Lawrence HR, Beato F, Kang Y, Kim MP, Delitto A, Underwood PW, Fleming JB, Trevino JG, Hamilton AD, Sebti SM.

Clin Cancer Res. 2019 Jun 21. doi: 10.1158/1078-0432.CCR-18-3399. [Epub ahead of print]

PMID:
31227505
5.

GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors.

Kazi A, Xiang S, Yang H, Delitto D, Trevino J, Jiang RHY, Ayaz M, Lawrence HR, Kennedy P, Sebti SM.

Nat Commun. 2018 Dec 4;9(1):5154. doi: 10.1038/s41467-018-07644-6.

6.

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine.

Carbone M, Amelio I, Affar EB, Brugarolas J, Cannon-Albright LA, Cantley LC, Cavenee WK, Chen Z, Croce CM, Andrea A, Gandara D, Giorgi C, Jia W, Lan Q, Mak TW, Manley JL, Mikoshiba K, Onuchic JN, Pass HI, Pinton P, Prives C, Rothman N, Sebti SM, Turkson J, Wu X, Yang H, Yu H, Melino G.

Cell Death Differ. 2018 Nov;25(11):1885-1904. doi: 10.1038/s41418-018-0213-5. Epub 2018 Oct 15. Review.

PMID:
30323273
7.

Author Correction: Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.

Fernández ÁF, Sebti S, Wei Y, Zou Z, Shi M, McMillan KL, He C, Ting T, Liu Y, Chiang WC, Marciano DK, Schiattarella GG, Bhagat G, Moe OW, Hu MC, Levine B.

Nature. 2018 Sep;561(7723):E30. doi: 10.1038/s41586-018-0270-4.

PMID:
29921925
8.

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.

Fernández ÁF, Sebti S, Wei Y, Zou Z, Shi M, McMillan KL, He C, Ting T, Liu Y, Chiang WC, Marciano DK, Schiattarella GG, Bhagat G, Moe OW, Hu MC, Levine B.

Nature. 2018 Jun;558(7708):136-140. doi: 10.1038/s41586-018-0162-7. Epub 2018 May 30. Erratum in: Nature. 2018 Sep;561(7723):E30.

9.

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.

Kuchay S, Giorgi C, Simoneschi D, Pagan J, Missiroli S, Saraf A, Florens L, Washburn MP, Collazo-Lorduy A, Castillo-Martin M, Cordon-Cardo C, Sebti SM, Pinton P, Pagano M.

Nature. 2017 Jun 22;546(7659):554-558. doi: 10.1038/nature22965. Epub 2017 Jun 14.

10.

Combined HMG-COA reductase and prenylation inhibition in treatment of CCM.

Nishimura S, Mishra-Gorur K, Park J, Surovtseva YV, Sebti SM, Levchenko A, Louvi A, Gunel M.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5503-5508. doi: 10.1073/pnas.1702942114. Epub 2017 May 12.

11.

δ-Tocotrienol, a natural form of vitamin E, inhibits pancreatic cancer stem-like cells and prevents pancreatic cancer metastasis.

Husain K, Centeno BA, Coppola D, Trevino J, Sebti SM, Malafa MP.

Oncotarget. 2017 May 9;8(19):31554-31567. doi: 10.18632/oncotarget.15767.

12.

Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Treg and antitumor CTL function.

Betts BC, Veerapathran A, Pidala J, Yang H, Horna P, Walton K, Cubitt CL, Gunawan S, Lawrence HR, Lawrence NJ, Sebti SM, Anasetti C.

Sci Transl Med. 2017 Jan 11;9(372). pii: eaai8269. doi: 10.1126/scitranslmed.aai8269.

13.

A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation.

Kim D, Sun M, He L, Zhou QH, Chen J, Sun XM, Bepler G, Sebti SM, Cheng JQ.

J Biol Chem. 2016 Oct 21;291(43):22856. No abstract available.

14.

Protein Prenylation Constitutes an Endogenous Brake on Axonal Growth.

Li H, Kuwajima T, Oakley D, Nikulina E, Hou J, Yang WS, Lowry ER, Lamas NJ, Amoroso MW, Croft GF, Hosur R, Wichterle H, Sebti S, Filbin MT, Stockwell B, Henderson CE.

Cell Rep. 2016 Jul 12;16(2):545-558. doi: 10.1016/j.celrep.2016.06.013. Epub 2016 Jun 30.

15.

A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal Neoplasia.

Springett GM, Husain K, Neuger A, Centeno B, Chen DT, Hutchinson TZ, Lush RM, Sebti S, Malafa MP.

EBioMedicine. 2015 Nov 14;2(12):1987-95. doi: 10.1016/j.ebiom.2015.11.025. eCollection 2015 Dec.

16.

Triciribine Phosphate Monohydrate, an AKT Inhibitor, Enhances Gemcitabine Activity in Pancreatic Cancer Cells.

Kim R, Yamauchi T, Husain K, Sebti S, Malafa M.

Anticancer Res. 2015 Sep;35(9):4599-604.

PMID:
26254348
17.

Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.

Bach AS, Derocq D, Laurent-Matha V, Montcourrier P, Sebti S, Orsetti B, Theillet C, Gongora C, Pattingre S, Ibing E, Roger P, Linares LK, Reinheckel T, Meurice G, Kaiser FJ, Gespach C, Liaudet-Coopman E.

Oncotarget. 2015 Sep 29;6(29):28084-103. doi: 10.18632/oncotarget.4394.

18.

EGR-1/Bax pathway plays a role in vitamin E δ-tocotrienol-induced apoptosis in pancreatic cancer cells.

Wang C, Husain K, Zhang A, Centeno BA, Chen DT, Tong Z, Sebti SM, Malafa MP.

J Nutr Biochem. 2015 Aug;26(8):797-807. doi: 10.1016/j.jnutbio.2015.02.008. Epub 2015 Apr 1.

19.

Randomized, Placebo-Controlled Trial of Green Tea Catechins for Prostate Cancer Prevention.

Kumar NB, Pow-Sang J, Egan KM, Spiess PE, Dickinson S, Salup R, Helal M, McLarty J, Williams CR, Schreiber F, Parnes HL, Sebti S, Kazi A, Kang L, Quinn G, Smith T, Yue B, Diaz K, Chornokur G, Crocker T, Schell MJ.

Cancer Prev Res (Phila). 2015 Oct;8(10):879-87. doi: 10.1158/1940-6207.CAPR-14-0324. Epub 2015 Apr 14.

20.

Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated with Estrogen Receptor-Negative Subtypes and Poor Prognosis.

Tang H, Sebti S, Titone R, Zhou Y, Isidoro C, Ross TS, Hibshoosh H, Xiao G, Packer M, Xie Y, Levine B.

EBioMedicine. 2015 Mar;2(3):255-263.

21.

CD4+ T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response.

Betts BC, Sagatys EM, Veerapathran A, Lloyd MC, Beato F, Lawrence HR, Yue B, Kim J, Sebti SM, Anasetti C, Pidala J.

J Leukoc Biol. 2015 Apr;97(4):807-19. doi: 10.1189/jlb.5A1114-532RR. Epub 2015 Feb 6.

22.

Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.

Li R, Cheng C, Balasis ME, Liu Y, Garner TP, Daniel KG, Li J, Qin Y, Gavathiotis E, Sebti SM.

Eur J Med Chem. 2015 Jan 27;90:315-331. doi: 10.1016/j.ejmech.2014.11.035. Epub 2014 Nov 20.

23.

Experimental Design-Based Response Surface Methodology Optimization for Synthesis of β-Mercapto Carbonyl Derivatives as Antimycobacterial Drugs Catalyzed by Calcium Pyrophosphate.

Abrouki Y, Anouzla A, Loukili H, Bennazha J, Lotfi R, Rayadh A, Bahlaoui MA, Sebti S, Zakarya D, Zahouily M.

Int J Med Chem. 2014;2014:586437. doi: 10.1155/2014/586437. Epub 2014 Mar 6.

24.

Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation.

Tecleab A, Zhang X, Sebti SM.

J Biol Chem. 2014 Nov 7;289(45):31296-309. doi: 10.1074/jbc.M114.565796. Epub 2014 Sep 10.

25.

Imidazo[1,2-a]pyridine-based peptidomimetics as inhibitors of Akt.

Kim YB, Kang CW, Ranatunga S, Yang H, Sebti SM, Del Valle JR.

Bioorg Med Chem Lett. 2014 Oct 1;24(19):4650-4653. doi: 10.1016/j.bmcl.2014.08.040. Epub 2014 Aug 28.

26.

Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim.

Cheng C, Liu Y, Balasis ME, Garner TP, Li J, Simmons NL, Berndt N, Song H, Pan L, Qin Y, Nicolaou KC, Gavathiotis E, Sebti SM, Li R.

Mar Drugs. 2014 Jul 29;12(8):4311-25. doi: 10.3390/md12084311.

27.

Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours.

Zhang X, Blaskovich MA, Forinash KD, Sebti SM.

Br J Cancer. 2014 Aug 26;111(5):894-902. doi: 10.1038/bjc.2014.349. Epub 2014 Jul 1.

28.

Identification of novel inhibitors that disrupt STAT3-DNA interaction from a γ-AApeptide OBOC combinatorial library.

Teng P, Zhang X, Wu H, Qiao Q, Sebti SM, Cai J.

Chem Commun (Camb). 2014 Aug 14;50(63):8739-42. doi: 10.1039/c4cc03909b. Epub 2014 Jun 25.

29.

Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation.

Yang H, Lawrence HR, Kazi A, Gevariya H, Patel R, Luo Y, Rix U, Schonbrunn E, Lawrence NJ, Sebti SM.

Oncotarget. 2014 May 30;5(10):2947-61.

30.

BAG6/BAT3 modulates autophagy by affecting EP300/p300 intracellular localization.

Sebti S, Prébois C, Pérez-Gracia E, Bauvy C, Desmots F, Pirot N, Gongora C, Bach AS, Hubberstey AV, Palissot V, Berchem G, Codogno P, Linares LK, Liaudet-Coopman E, Pattingre S.

Autophagy. 2014 Jul;10(7):1341-2. doi: 10.4161/auto.28979. Epub 2014 May 15.

31.

Cyclic marinopyrrole derivatives as disruptors of Mcl-1 and Bcl-x(L) binding to Bim.

Cheng C, Liu Y, Balasis ME, Simmons NL, Li J, Song H, Pan L, Qin Y, Nicolaou KC, Sebti SM, Li R.

Mar Drugs. 2014 Mar 7;12(3):1335-48. doi: 10.3390/md12031335.

32.

BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy.

Sebti S, Prébois C, Pérez-Gracia E, Bauvy C, Desmots F, Pirot N, Gongora C, Bach AS, Hubberstey AV, Palissot V, Berchem G, Codogno P, Linares LK, Liaudet-Coopman E, Pattingre S.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4115-20. doi: 10.1073/pnas.1313618111. Epub 2014 Mar 3.

33.

Discovery of PI-1840, a novel noncovalent and rapidly reversible proteasome inhibitor with anti-tumor activity.

Kazi A, Ozcan S, Tecleab A, Sun Y, Lawrence HR, Sebti SM.

J Biol Chem. 2014 Apr 25;289(17):11906-15. doi: 10.1074/jbc.M113.533950. Epub 2014 Feb 25.

34.

Lysophosphatidic acid acyltransferase beta regulates mTOR signaling.

Blaskovich MA, Yendluri V, Lawrence HR, Lawrence NJ, Sebti SM, Springett GM.

PLoS One. 2013 Oct 31;8(10):e78632. doi: 10.1371/journal.pone.0078632. eCollection 2013.

35.

Selective disruption of rb-raf-1 kinase interaction inhibits pancreatic adenocarcinoma growth irrespective of gemcitabine sensitivity.

Treviño JG, Verma M, Singh S, Pillai S, Zhang D, Pernazza D, Sebti SM, Lawrence NJ, Centeno BA, Chellappan SP.

Mol Cancer Ther. 2013 Dec;12(12):2722-34. doi: 10.1158/1535-7163.MCT-12-0719. Epub 2013 Oct 9.

36.

Development of new N-Arylbenzamides as STAT3 Dimerization Inhibitors.

Urlam MK, Pireddu R, Ge Y, Zhang X, Sun Y, Lawrence HR, Guida WC, Sebti SM, Lawrence NJ.

Medchemcomm. 2013 Jun;4(6):932-941.

37.

Phase I clinical, pharmacokinetic, and pharmacodynamic study of the Akt-inhibitor triciribine phosphate monohydrate in patients with advanced hematologic malignancies.

Sampath D, Malik A, Plunkett W, Nowak B, Williams B, Burton M, Verstovsek S, Faderl S, Garcia-Manero G, List AF, Sebti S, Kantarjian HM, Ravandi F, Lancet JE.

Leuk Res. 2013 Nov;37(11):1461-7. doi: 10.1016/j.leukres.2013.07.034. Epub 2013 Aug 6.

38.

Vitamin E δ-tocotrienol prolongs survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model of pancreatic cancer.

Husain K, Centeno BA, Chen DT, Hingorani SR, Sebti SM, Malafa MP.

Cancer Prev Res (Phila). 2013 Oct;6(10):1074-83. doi: 10.1158/1940-6207.CAPR-13-0157. Epub 2013 Aug 20.

39.

MK-2206, an Akt inhibitor, enhances carboplatinum/paclitaxel efficacy in gastric cancer cell lines.

Almhanna K, Cubitt CL, Zhang S, Kazim S, Husain K, Sullivan D, Sebti S, Malafa M.

Cancer Biol Ther. 2013 Oct 1;14(10):932-6. doi: 10.4161/cbt.25939. Epub 2013 Aug 5.

40.

Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis.

Berndt N, Patel R, Yang H, Balasis ME, Sebti SM.

Cell Cycle. 2013 Jul 1;12(13):2024-32. doi: 10.4161/cc.25043. Epub 2013 Jun 6.

41.

Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.

Schonbrunn E, Betzi S, Alam R, Martin MP, Becker A, Han H, Francis R, Chakrasali R, Jakkaraj S, Kazi A, Sebti SM, Cubitt CL, Gebhard AW, Hazlehurst LA, Tash JS, Georg GI.

J Med Chem. 2013 May 23;56(10):3768-82. doi: 10.1021/jm301234k. Epub 2013 May 6.

42.

Oxadiazole-isopropylamides as potent and noncovalent proteasome inhibitors.

Ozcan S, Kazi A, Marsilio F, Fang B, Guida WC, Koomen J, Lawrence HR, Sebti SM.

J Med Chem. 2013 May 23;56(10):3783-805. doi: 10.1021/jm400221d. Epub 2013 May 13.

43.

Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities.

Patel RA, Liu Y, Wang B, Li R, Sebti SM.

Oncogene. 2014 Jan 30;33(5):550-5. doi: 10.1038/onc.2012.634. Epub 2013 Feb 11.

44.

Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism.

Hodul PJ, Dong Y, Husain K, Pimiento JM, Chen J, Zhang A, Francois R, Pledger WJ, Coppola D, Sebti SM, Chen DT, Malafa MP.

PLoS One. 2013;8(2):e52526. doi: 10.1371/journal.pone.0052526. Epub 2013 Feb 5.

45.

Depletion of K-Ras promotes proteasome degradation of survivin.

Tecleab A, Sebti SM.

Cell Cycle. 2013 Feb 1;12(3):522-32. doi: 10.4161/cc.23407. Epub 2013 Jan 16.

46.

A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation.

Zhang X, Sun Y, Pireddu R, Yang H, Urlam MK, Lawrence HR, Guida WC, Lawrence NJ, Sebti SM.

Cancer Res. 2013 Mar 15;73(6):1922-33. doi: 10.1158/0008-5472.CAN-12-3175. Epub 2013 Jan 15.

47.

Prolonged survival and delayed progression of pancreatic intraepithelial neoplasia in LSL-KrasG12D/+;Pdx-1-Cre mice by vitamin E δ-tocotrienol.

Husain K, Centeno BA, Chen DT, Fulp WJ, Perez M, Zhang Lee G, Luetteke N, Hingorani SR, Sebti SM, Malafa MP.

Carcinogenesis. 2013 Apr;34(4):858-63. doi: 10.1093/carcin/bgt002. Epub 2013 Jan 9.

48.

Poly[(μ(3)-hydrogenphosphato)(4H-1,2,4-triazole-κN(1))zinc].

Aitenneite H, El Bouari A, Sebti S, Saadi M, El Ammari L, Adil K.

Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 1;68(Pt 11):m1426-7. doi: 10.1107/S1600536812044182. Epub 2012 Oct 31.

49.

Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2).

Pireddu R, Forinash KD, Sun NN, Martin MP, Sung SS, Alexander B, Zhu JY, Guida WC, Schönbrunn E, Sebti SM, Lawrence NJ.

Medchemcomm. 2012 Jun 1;3(6):699-709. Epub 2012 Jan 27.

50.

Inhibiting the interaction of cMET and IGF-1R with FAK effectively reduces growth of pancreatic cancer cells in vitro and in vivo.

Ucar DA, Magis AT, He DH, Lawrence NJ, Sebti SM, Kurenova E, Zajac-Kaye M, Zhang J, Hochwald SN.

Anticancer Agents Med Chem. 2013 May;13(4):595-602.

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