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Items: 1 to 50 of 116

1.

Effects of pioglitazone and fenofibrate co-administration on bone biomechanics and histomorphometry in ovariectomized rats.

Smith SY, Samadfam R, Chouinard L, Awori M, Bénardeau A, Bauss F, Guldberg RE, Sebokova E, Wright MB.

J Bone Miner Metab. 2015 Nov;33(6):625-41. doi: 10.1007/s00774-014-0632-4. Epub 2014 Dec 23.

PMID:
25534548
2.

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.

Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH.

Nat Med. 2015 Jan;21(1):27-36. doi: 10.1038/nm.3761. Epub 2014 Dec 8.

PMID:
25485909
3.

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.

Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, DiMarchi RD, Tschöp MH.

Sci Transl Med. 2013 Oct 30;5(209):209ra151. doi: 10.1126/scitranslmed.3007218.

4.

Effects of the dual PPAR-α/γ agonist aleglitazar on glycaemic control and organ protection in the Zucker diabetic fatty rat.

Bénardeau A, Verry P, Atzpodien EA, Funk JM, Meyer M, Mizrahi J, Winter M, Wright MB, Uhles S, Sebokova E.

Diabetes Obes Metab. 2013 Feb;15(2):164-74. doi: 10.1111/dom.12006. Epub 2012 Oct 3.

PMID:
22958363
5.

Combination treatment with pioglitazone and fenofibrate attenuates pioglitazone-mediated acceleration of bone loss in ovariectomized rats.

Samadfam R, Awori M, Bénardeau A, Bauss F, Sebokova E, Wright M, Smith SY.

J Endocrinol. 2012 Feb;212(2):179-86. doi: 10.1530/JOE-11-0356. Epub 2011 Nov 7.

PMID:
22062085
6.

Rhesus macaques develop metabolic syndrome with reversible vascular dysfunction responsive to pioglitazone.

Zhang X, Zhang R, Raab S, Zheng W, Wang J, Liu N, Zhu T, Xue L, Song Z, Mao J, Li K, Zhang H, Zhang Y, Han C, Ding Y, Wang H, Hou N, Liu Y, Shang S, Li C, Sebokova E, Cheng H, Huang PL.

Circulation. 2011 Jul 5;124(1):77-86. doi: 10.1161/CIRCULATIONAHA.110.990333. Epub 2011 Jun 20.

7.

Effects of aleglitazar, a balanced dual peroxisome proliferator-activated receptor α/γ agonist on glycemic and lipid parameters in a primate model of the metabolic syndrome.

Hansen BC, Tigno XT, Bénardeau A, Meyer M, Sebokova E, Mizrahi J.

Cardiovasc Diabetol. 2011 Jan 20;10:7. doi: 10.1186/1475-2840-10-7.

8.

Taspoglutide, a novel human once-weekly GLP-1 analogue, protects pancreatic β-cells in vitro and preserves islet structure and function in the Zucker diabetic fatty rat in vivo.

Uhles S, Wang H, Bénardeau A, Prummer M, Brecheisen M, Sewing S, Tobalina L, Bosco D, Wollheim CB, Migliorini C, Sebokova E.

Diabetes Obes Metab. 2011 Apr;13(4):326-36. doi: 10.1111/j.1463-1326.2010.01352.x.

PMID:
21205124
9.

Taspoglutide, a novel human once-weekly analogue of glucagon-like peptide-1, improves glucose homeostasis and body weight in the Zucker diabetic fatty rat.

Sebokova E, Bénardeau A, Sprecher U, Sewing S, Tobalina L, Migliorini C.

Diabetes Obes Metab. 2010 Aug;12(8):674-82. doi: 10.1111/j.1463-1326.2010.01207.x.

PMID:
20590744
10.

Taspoglutide, an analog of human glucagon-like Peptide-1 with enhanced stability and in vivo potency.

Sebokova E, Christ AD, Wang H, Sewing S, Dong JZ, Taylor J, Cawthorne MA, Culler MD.

Endocrinology. 2010 Jun;151(6):2474-82. doi: 10.1210/en.2009-1459. Epub 2010 Apr 9.

PMID:
20382695
11.

High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail.

Ukropec J, Radikova Z, Huckova M, Koska J, Kocan A, Sebokova E, Drobna B, Trnovec T, Susienkova K, Labudova V, Gasperikova D, Langer P, Klimes I.

Diabetologia. 2010 May;53(5):899-906. doi: 10.1007/s00125-010-1683-2. Epub 2010 Feb 25.

PMID:
20182860
12.

Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors.

Boehringer M, Fischer H, Hennig M, Hunziker D, Huwyler J, Kuhn B, Loeffler BM, Luebbers T, Mattei P, Narquizian R, Sebokova E, Sprecher U, Wessel HP.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1106-8. doi: 10.1016/j.bmcl.2009.12.025. Epub 2009 Dec 6.

PMID:
20031408
13.

Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

Mattei P, Boehringer M, Di Giorgio P, Fischer H, Hennig M, Huwyler J, Koçer B, Kuhn B, Loeffler BM, Macdonald A, Narquizian R, Rauber E, Sebokova E, Sprecher U.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1109-13. doi: 10.1016/j.bmcl.2009.12.024. Epub 2009 Dec 6.

PMID:
20031405
14.

Medium-chain fatty acids ameliorate insulin resistance caused by high-fat diets in rats.

Wein S, Wolffram S, Schrezenmeir J, Gasperiková D, Klimes I, Seböková E.

Diabetes Metab Res Rev. 2009 Feb;25(2):185-94. doi: 10.1002/dmrr.925.

PMID:
19219861
15.

Increased thyroid volume, prevalence of thyroid antibodies and impaired fasting glucose in young adults from organochlorine cocktail polluted area: outcome of transgenerational transmission?

Langer P, Kocan A, Tajtáková M, Koska J, Rádiková Z, Ksinantová L, Imrich R, Hucková M, Drobná B, Gasperíková D, Seböková E, Klimes I.

Chemosphere. 2008 Oct;73(7):1145-50. doi: 10.1016/j.chemosphere.2008.06.067. Epub 2008 Sep 14.

PMID:
18790515
16.

Possible effects of environmental nitrates and toxic organochlorines on human thyroid in highly polluted areas in Slovakia.

Rádiková Z, Tajtáková M, Kocan A, Trnovec T, Seböková E, Klimes I, Langer P.

Thyroid. 2008 Mar;18(3):353-62. doi: 10.1089/thy.2007.0182.

PMID:
18298316
17.

Reduced plaque formation induced by rosiglitazone in an STZ-diabetes mouse model of atherosclerosis is associated with downregulation of adhesion molecules.

Tikellis C, Jandeleit-Dahm KA, Sheehy K, Murphy A, Chin-Dusting J, Kling D, Sebokova E, Cooper ME, Mizrahi J, Woollard KJ.

Atherosclerosis. 2008 Jul;199(1):55-64. Epub 2008 Feb 21.

PMID:
18093596
18.

Lipoprotein lipase HindIII polymorphism influences HDL-cholesterol levels in statin-treated patients with coronary artery disease.

Javorský M, Gasperíková D, Ukropec J, Sedláková B, Riecanský I, Krizanová O, Seböková E, Dobríková M, Klimes I, Tkác I.

Wien Klin Wochenschr. 2007;119(15-16):476-82.

PMID:
17721767
19.

Possible effects of persistent organochlorinated pollutants cocktail on thyroid hormone levels and pituitary-thyroid interrelations.

Langer P, Kocan A, Tajtáková M, Rádiková Z, Petrík J, Koska J, Ksinantová L, Imrich R, Hucková M, Chovancová J, Drobná B, Jursa S, Bergman A, Athanasiadou M, Hovander L, Gasperíková D, Trnovec T, Seböková E, Klimes I.

Chemosphere. 2007 Nov;70(1):110-8. Epub 2007 Aug 10.

PMID:
17692893
20.

Thyroid ultrasound volume, structure and function after long-term high exposure of large population to polychlorinated biphenyls, pesticides and dioxin.

Langer P, Tajtáková M, Kocan A, Petrík J, Koska J, Ksinantová L, Rádiková Z, Ukropec J, Imrich R, Hucková M, Chovancová J, Drobná B, Jursa S, Vlcek M, Bergman A, Athanasiadou M, Hovander L, Shishiba Y, Trnovec T, Seböková E, Klimes I.

Chemosphere. 2007 Aug;69(1):118-27. Epub 2007 May 29.

PMID:
17537484
21.

Concerted action of leptin in regulation of fatty acid oxidation in skeletal muscle and liver.

Wein S, Ukropec J, Gasperíková D, Klimes I, Seböková E.

Exp Clin Endocrinol Diabetes. 2007 Apr;115(4):244-51.

PMID:
17479441
22.

Dipeptidyl peptidase IV inhibitors: the next generation of new promising therapies for the management of type 2 diabetes.

Sebokova E, Christ AD, Boehringer M, Mizrahi J.

Curr Top Med Chem. 2007;7(6):547-55. Review.

PMID:
17352676
23.

Fish from industrially polluted freshwater as the main source of organochlorinated pollutants and increased frequency of thyroid disorders and dysglycemia.

Langer P, Kocan A, Tajtaková M, Petrík J, Chovancová J, Drobná B, Jursa S, Rádiková Z, Koska J, Ksinantová L, Hucková M, Imrich R, Wimmerová S, Gasperíková D, Shishiba Y, Trnovec T, Seböková E, Klimes I.

Chemosphere. 2007 Apr;67(9):S379-85. Epub 2007 Jan 11.

PMID:
17222442
24.

Multiple organochlorine pollution and the thyroid.

Langer P, Tajtaková M, Kocan A, Vlcek M, Petrik J, Chovancova J, Drobna B, Jursa S, Pavuk M, Trnovec T, Sebokova E, Klimes I.

Endocr Regul. 2006 Jun;40(2):46-52.

PMID:
17100546
25.

Insulin sensitivity indices: a proposal of cut-off points for simple identification of insulin-resistant subjects.

Radikova Z, Koska J, Huckova M, Ksinantova L, Imrich R, Vigas M, Trnovec T, Langer P, Sebokova E, Klimes I.

Exp Clin Endocrinol Diabetes. 2006 May;114(5):249-56.

PMID:
16804799
26.

A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro.

Burgermeister E, Schnoebelen A, Flament A, Benz J, Stihle M, Gsell B, Rufer A, Ruf A, Kuhn B, Märki HP, Mizrahi J, Sebokova E, Niesor E, Meyer M.

Mol Endocrinol. 2006 Apr;20(4):809-30. Epub 2005 Dec 22.

PMID:
16373399
27.

Human thyroid in the population exposed to high environmental pollution by organochlorinated pollutants for several decades.

Langer P, Kocan A, Tajtakova M, Petrik J, Chovancova J, Drobna B, Jursa S, Pavuk M, Trnovec T, Seböková E, Klimes I.

Endocr Regul. 2005 Jan;39(1):13-20.

PMID:
16107134
28.

Increased thyroid volume and frequency of thyroid disorders signs in schoolchildren from nitrate polluted area.

Tajtáková M, Semanová Z, Tomková Z, Szökeová E, Majoros J, Rádiková Z, Seböková E, Klimes I, Langer P.

Chemosphere. 2006 Jan;62(4):559-64. Epub 2005 Aug 10.

PMID:
16095667
29.

[Epidemiological profile of thyroid volume and disorders in Slovakia].

Tajtáková M, Langer P, Fodor G, Hanzen E, Putz Z, Kost'álová L, Michálek J, Kreze A, Klimes I, Seböková E.

Vnitr Lek. 2000 Nov;46(11):756-63. Slovak.

PMID:
15637890
30.

Mapping of genetic determinants of the sympathoneural response to stress.

Klimes I, Weston K, Gasperíková D, Kovács P, Kvetnanský R, Jezová D, Dixon R, Thompson JR, Seböková E, Samani NJ.

Physiol Genomics. 2005 Jan 20;20(2):183-7. Epub 2004 Nov 16.

PMID:
15547139
31.

Thyroid function and cholesterol level: paradoxical findings in large groups of population with high cholesterol food intake.

Langer P, Kocan A, Tajtakova M, Petrik J, Koska J, Hucková M, Hanzen E, Ksinantova L, Radikova Z, Imrich R, Trnovec T, Blazicek P, Sebokova E, Klimes I.

Endocr Regul. 2003 Sep;37(3):175-80.

PMID:
14986723
32.

The hypotriglyceridemic effect of dietary n-3 FA is associated with increased beta-oxidation and reduced leptin expression.

Ukropec J, Reseland JE, Gasperikova D, Demcakova E, Madsen L, Berge RK, Rustan AC, Klimes I, Drevon CA, Sebökova E.

Lipids. 2003 Oct;38(10):1023-9.

PMID:
14669966
33.

From naturally occurring goitrogens to the effects of anthropogenic endocrine disruptors on the thyroid in Slovakia.

Langer P, Tajtakova M, Kocan A, Trnovec T, Sebokova E, Klimes I.

Bratisl Lek Listy. 2003;104(3):101-7. Review.

PMID:
12940694
35.

Possible effects of polychlorinated biphenyls and organochlorinated pesticides on the thyroid after long-term exposure to heavy environmental pollution.

Langer P, Kocan A, Tajtáková M, Petrík J, Chovancová J, Drobná B, Jursa S, Pavúk M, Koska J, Trnovec T, Seböková E, Klimes I.

J Occup Environ Med. 2003 May;45(5):526-32.

PMID:
12762077
36.

Iodine deficiency in vegetarians and vegans.

Krajcovicová-Kudlácková M, Bucková K, Klimes I, Seboková E.

Ann Nutr Metab. 2003;47(5):183-5.

PMID:
12748410
37.
38.

Mapping of genetic loci predisposing to hypertriglyceridaemia in the hereditary hypertriglyceridaemic rat: analysis of genetic association with related traits of the insulin resistance syndrome.

Klimes I, Weston K, Kovacs P, Gasperikova D, Jezova D, Kvetnansky R, Thompson JR, Sebokova E, Samani NJ.

Diabetologia. 2003 Mar;46(3):352-8. Epub 2003 Mar 1.

PMID:
12687333
39.

High prevalence of anti-glutamic acid decarboxylase (anti-GAD) antibodies in employees at a polychlorinated biphenyl production factory.

Langer P, Tajtáková M, Guretzki HJ, Kocan A, Petrík J, Chovancová J, Drobná B, Jursa S, Pavúk M, Trnovec T, Seböková E, Klimes I.

Arch Environ Health. 2002 Sep-Oct;57(5):412-5.

PMID:
12641181
40.

Comparison of the extrapancreatic action of gamma-linolenic acid and n-3 PUFAs in the high fat diet-induced insulin resistance [corrected].

Simoncíkova P, Wein S, Gasperikova D, Ukropec J, Certik M, Klimes I, Sebokova E.

Endocr Regul. 2002 Nov;36(4):143-9. Erratum in: Endocr Regul. 2003 Mar;37(1):20.

PMID:
12466014
41.

Lipids and insulin resistance: what we've learned at the Fourth International Smolenice Symposium.

Ravussin E, Klimes I, Seböková E, Howard BV.

Ann N Y Acad Sci. 2002 Jun;967:576-80.

PMID:
12079892
42.

Endocrine regulation of subcutaneous fat metabolism during cold exposure in humans.

Koska J, Ksinantova L, Seböková E, Kvetnansky R, Klimes I, Chrousos G, Pacak K.

Ann N Y Acad Sci. 2002 Jun;967:500-5.

PMID:
12079880
43.

Insulin resistance in the hereditary hypertriglyceridemic rat is associated with an impairment of delta-6 desaturase expression in liver.

Gasperíková D, Demcáková E, Ukropec J, Klimes I, Seböková E.

Ann N Y Acad Sci. 2002 Jun;967:446-53.

PMID:
12079873
44.

Comparison of the extrapancreatic action of BRX-220 and pioglitazone in the high-fat diet-induced insulin resistance.

Seböková E, Kürthy M, Mogyorosi T, Nagy K, Demcáková E, Ukropec J, Koranyi L, Klimes I.

Ann N Y Acad Sci. 2002 Jun;967:424-30.

PMID:
12079870
45.

An increase in peroxisomal fatty acid oxidation is not sufficient to prevent tissue lipid accumulation in hHTg rats.

Ukropec J, Klimes I, Gasperíková D, Demcáková E, Drevon CA, Reseland JE, Seböková E.

Ann N Y Acad Sci. 2002 Jun;967:71-9.

PMID:
12079837
46.

Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance.

Madsen L, Guerre-Millo M, Flindt EN, Berge K, Tronstad KJ, Bergene E, Sebokova E, Rustan AC, Jensen J, Mandrup S, Kristiansen K, Klimes I, Staels B, Berge RK.

J Lipid Res. 2002 May;43(5):742-50.

47.

Nutrient sensing, leptin and insulin action.

Ukropec J, Seböková E, Klimes I.

Arch Physiol Biochem. 2001 Feb;109(1):38-51. Review.

PMID:
11471070
48.

Effects of new hypoglycemic agent A-4166 on lipolysis and lipogenesis in rat adipocytes.

Macho L, Fickova M, Zorad S, Sebokova E, Klimes I.

Endocr Regul. 2000 Sep;34(3):119-26.

PMID:
11074662
49.

Effects of a new hypoglycemic agent A-4166 on glucose metabolism in rat adipocytes and muscle tissues.

Macho L, Ficková M, Zórad S, Seböková E, Klimes I.

Gen Physiol Biophys. 1999 Sep;18(3):293-303.

PMID:
10703745
50.

Defect in long-term activation of phosphatidylinositol 3-kinase by insulin in vivo: studies in insulin-resistant hHTg rats.

Sebokova E, Gasperikova D, Ouwens M, Dorrestijn J, Eckel J, Maasen A, Klimes I.

Endocr Regul. 1999 Jun;33(2):49-54.

PMID:
10467424

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