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Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling.

Hasan S, Rahman WU, Sebo P, Osicka R.

Toxins (Basel). 2019 Jun 20;11(6). pii: E362. doi: 10.3390/toxins11060362.


Rapid Purification of Endotoxin-Free RTX Toxins.

Stanek O, Masin J, Osicka R, Jurnecka D, Osickova A, Sebo P.

Toxins (Basel). 2019 Jun 12;11(6). pii: E336. doi: 10.3390/toxins11060336.


Residues 529 to 549 participate in membrane penetration and pore-forming activity of the Bordetella adenylate cyclase toxin.

Roderova J, Osickova A, Sukova A, Mikusova G, Fiser R, Sebo P, Osicka R, Masin J.

Sci Rep. 2019 Apr 8;9(1):5758. doi: 10.1038/s41598-019-42200-2.


A prospective observational study of the main features of nocturnal leg cramps in primary care.

Sebo P, Haller D, Cerutti B, Maisonneuve H.

Swiss Med Wkly. 2019 Mar 24;149:w20048. doi: 10.4414/smw.2019.20048. eCollection 2019 Mar 11.


What is the profile of older drivers considered medically unfit to drive? A cross-sectional survey in Western Switzerland.

Sebo P, Vaucher P, Haller D, Huber P, Mueller Y, Favrat B.

Swiss Med Wkly. 2018 Nov 18;148:w14684. doi: 10.4414/smw.2018.14684. eCollection 2018 Nov 5.


General practitioners' perspectives on the use of nonpharmacological home remedies in two regions in Switzerland and France.

Sebo P, Haller D, Sommer J, Excoffier S, Gaboreau Y, Maisonneuve H.

Swiss Med Wkly. 2018 Oct 28;148:w14676. doi: 10.4414/smw.2018.14676. eCollection 2018 Oct 22.


Comparative genomics of Czech vaccine strains of Bordetella pertussis.

Dienstbier A, Pouchnik D, Wildung M, Amman F, Hofacker IL, Parkhill J, Holubova J, Sebo P, Vecerek B.

Pathog Dis. 2018 Oct 1;76(7). doi: 10.1093/femspd/fty071.


Prophylactic and therapeutic inhibition of allergic airway inflammation by probiotic Escherichia coli O83.

Zwicker C, Sarate P, Drinić M, Ambroz K, Korb E, Smole U, Köhler C, Wilson MS, Kozakova H, Sebo P, Kverka M, Wiedermann U, Schabussova I.

J Allergy Clin Immunol. 2018 Dec;142(6):1987-1990.e7. doi: 10.1016/j.jaci.2018.07.029. Epub 2018 Aug 17. No abstract available.


Bordetella pertussis and Bordetella bronchiseptica filamentous hemagglutinins are processed at different sites.

Jurnecka D, Man P, Sebo P, Bumba L.

FEBS Open Bio. 2018 Jun 20;8(8):1256-1266. doi: 10.1002/2211-5463.12474. eCollection 2018 Aug.


Adherence to guidelines when evaluating fitness-to-drive in the elderly: a practice review of Swiss physicians.

Sebo P, Haller DM, Favrat B, Huber P, Mueller Y, Vaucher P.

Swiss Med Wkly. 2018 Jul 9;148:w14632. doi: 10.4414/smw.2018.14632. eCollection 2018. Review.


A guide to polarized airway epithelial models for studies of host-pathogen interactions.

Hasan S, Sebo P, Osicka R.

FEBS J. 2018 Dec;285(23):4343-4358. doi: 10.1111/febs.14582. Epub 2018 Jul 2. Review.


Phospholipase A activity of adenylate cyclase toxin?

Masin J, Osicka R, Bumba L, Sebo P.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2489-E2490. doi: 10.1073/pnas.1722588115. Epub 2018 Feb 21. No abstract available.


Bordetella pertussis Adenylate Cyclase Toxin Disrupts Functional Integrity of Bronchial Epithelial Layers.

Hasan S, Kulkarni NN, Asbjarnarson A, Linhartova I, Osicka R, Sebo P, Gudmundsson GH.

Infect Immun. 2018 Feb 20;86(3). pii: e00445-17. doi: 10.1128/IAI.00445-17. Print 2018 Mar.


Phosphoproteomics of cAMP signaling of Bordetella adenylate cyclase toxin in mouse dendritic cells.

Novák J, Fabrik I, Linhartová I, Link M, Černý O, Stulík J, Šebo P.

Sci Rep. 2017 Nov 24;7(1):16298. doi: 10.1038/s41598-017-14501-x.


How do general practitioners put preventive care recommendations into practice? A cross-sectional study in Switzerland and France.

Sebo P, Cerutti B, Fournier JP, Rat C, Rougerie F, Senn N, Haller DM, Maisonneuve H.

BMJ Open. 2017 Oct 6;7(10):e017958. doi: 10.1136/bmjopen-2017-017958.


Structure-Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes.

Novak J, Cerny O, Osickova A, Linhartova I, Masin J, Bumba L, Sebo P, Osicka R.

Toxins (Basel). 2017 Sep 24;9(10). pii: E300. doi: 10.3390/toxins9100300. Review.


Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity.

Fedele G, Schiavoni I, Adkins I, Klimova N, Sebo P.

Toxins (Basel). 2017 Sep 21;9(10). pii: E293. doi: 10.3390/toxins9100293. Review.


Overview of preventive practices provided by primary care physicians: A cross-sectional study in Switzerland and France.

Sebo P, Maisonneuve H, Cerutti B, Fournier JP, Senn N, Rat C, Haller DM.

PLoS One. 2017 Sep 5;12(9):e0184032. doi: 10.1371/journal.pone.0184032. eCollection 2017.


The conserved tyrosine residue 940 plays a key structural role in membrane interaction of Bordetella adenylate cyclase toxin.

Masin J, Roderova J, Osickova A, Novak P, Bumba L, Fiser R, Sebo P, Osicka R.

Sci Rep. 2017 Aug 24;7(1):9330. doi: 10.1038/s41598-017-09575-6.


General practitioners' views and preferences about quality improvement feedback in preventive care: a cross-sectional study in Switzerland and France.

Sebo P, Maisonneuve H, Fournier JP, Senn N, Haller DM.

Implement Sci. 2017 Jul 26;12(1):95. doi: 10.1186/s13012-017-0623-7.


Corrigendum: A Universal Influenza Vaccine Can Lead to Disease Exacerbation or Viral Control Depending on Delivery Strategies.

Bernelin-Cottet C, Deloizy C, Stanek O, Barc C, Bouguyon E, Urien C, Boulesteix O, Pezant J, Richard CA, Moudjou M, Costa BD, Jouneau L, Chevalier C, Leclerc C, Sebo P, Bertho N, Schwartz-Cornil I.

Front Immunol. 2017 Jul 18;8:831. doi: 10.3389/fimmu.2017.00831. eCollection 2017.


Accuracy of anthropometric measurements by general practitioners in overweight and obese patients.

Sebo P, Herrmann FR, Haller DM.

BMC Obes. 2017 Jun 29;4:23. doi: 10.1186/s40608-017-0158-0. eCollection 2017.


Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis.

Skopova K, Tomalova B, Kanchev I, Rossmann P, Svedova M, Adkins I, Bibova I, Tomala J, Masin J, Guiso N, Osicka R, Sedlacek R, Kovar M, Sebo P.

Infect Immun. 2017 May 23;85(6). pii: e00937-16. doi: 10.1128/IAI.00937-16. Print 2017 Jun.


Rates, Delays, and Completeness of General Practitioners' Responses to a Postal Versus Web-Based Survey: A Randomized Trial.

Sebo P, Maisonneuve H, Cerutti B, Fournier JP, Senn N, Haller DM.

J Med Internet Res. 2017 Mar 22;19(3):e83. doi: 10.2196/jmir.6308.


Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif.

Wald T, Spoutil F, Osickova A, Prochazkova M, Benada O, Kasparek P, Bumba L, Klein OD, Sedlacek R, Sebo P, Prochazka J, Osicka R.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1641-E1650. doi: 10.1073/pnas.1615334114. Epub 2017 Feb 14.


A Universal Influenza Vaccine Can Lead to Disease Exacerbation or Viral Control Depending on Delivery Strategies.

Bernelin-Cottet C, Deloizy C, Stanek O, Barc C, Bouguyon E, Urien C, Boulesteix O, Pezant J, Richard CA, Moudjou M, Da Costa B, Jouneau L, Chevalier C, Leclerc C, Sebo P, Bertho N, Schwartz-Cornil I.

Front Immunol. 2016 Dec 26;7:641. doi: 10.3389/fimmu.2016.00641. eCollection 2016. Erratum in: Front Immunol. 2017 Jul 18;8:831.


cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity.

Cerny O, Anderson KE, Stephens LR, Hawkins PT, Sebo P.

J Immunol. 2017 Feb 1;198(3):1285-1296. doi: 10.4049/jimmunol.1601309. Epub 2016 Dec 30.


Negatively charged residues of the segment linking the enzyme and cytolysin moieties restrict the membrane-permeabilizing capacity of adenylate cyclase toxin.

Masin J, Osickova A, Sukova A, Fiser R, Halada P, Bumba L, Linhartova I, Osicka R, Sebo P.

Sci Rep. 2016 Sep 1;6:29137. doi: 10.1038/srep29137.


Alternatives to HIST for acellular pertussis vaccines: progress and challenges in replacement.

Arciniega J, Wagner L, Prymula R, Sebo P, Isbrucker R, Descampe B, Chapsal JM, Costanzo A, Hendriksen C, Hoonaker M, Nelson S, Lidster K, Casey W, Allen D.

Pharmeur Bio Sci Notes. 2016;2015:82-96.


Expanding the tools for identifying mononuclear phagocyte subsets in swine: Reagents to porcine CD11c and XCR1.

Deloizy C, Bouguyon E, Fossum E, Sebo P, Osicka R, Bole A, Pierres M, Biacchesi S, Dalod M, Bogen B, Bertho N, Schwartz-Cornil I.

Dev Comp Immunol. 2016 Dec;65:31-40. doi: 10.1016/j.dci.2016.06.015. Epub 2016 Jun 21.


Calcium-Driven Folding of RTX Domain β-Rolls Ratchets Translocation of RTX Proteins through Type I Secretion Ducts.

Bumba L, Masin J, Macek P, Wald T, Motlova L, Bibova I, Klimova N, Bednarova L, Veverka V, Kachala M, Svergun DI, Barinka C, Sebo P.

Mol Cell. 2016 Apr 7;62(1):47-62. doi: 10.1016/j.molcel.2016.03.018.


Proteome analysis of Bordetella pertussis isolated from human macrophages.

Lamberti Y, Cafiero JH, Surmann K, Valdez H, Holubova J, Večerek B, Sebo P, Schmidt F, Völker U, Rodriguez ME.

J Proteomics. 2016 Mar 16;136:55-67. doi: 10.1016/j.jprot.2016.02.002. Epub 2016 Feb 10.


Editorial: Why still study bacterial toxins in the third millennium?

Frisan T, Sebo P.

Pathog Dis. 2016 Apr;74(3). pii: ftw009. doi: 10.1093/femspd/ftw009. Epub 2016 Jan 26. No abstract available.


Transmembrane segments of complement receptor 3 do not participate in cytotoxic activities but determine receptor structure required for action of Bordetella adenylate cyclase toxin.

Wald T, Osickova A, Masin J, Liskova PM, Petry-Podgorska I, Matousek T, Sebo P, Osicka R.

Pathog Dis. 2016 Apr;74(3). pii: ftw008. doi: 10.1093/femspd/ftw008. Epub 2016 Jan 21.


Biocompatible Size-Defined Dendrimer-Albumin Binding Protein Hybrid Materials as a Versatile Platform for Biomedical Applications.

Maly J, Stanek O, Frolik J, Maly M, Ennen F, Appelhans D, Semeradtova A, Wrobel D, Stofik M, Knapova T, Kuchar M, Stastna LC, Cermak J, Sebo P, Maly P.

Macromol Biosci. 2016 Apr;16(4):553-66. doi: 10.1002/mabi.201500332. Epub 2016 Jan 8.


Bordetella pertussis filamentous hemagglutinin itself does not trigger anti-inflammatory interleukin-10 production by human dendritic cells.

Villarino Romero R, Hasan S, Faé K, Holubova J, Geurtsen J, Schwarzer M, Wiertsema S, Osicka R, Poolman J, Sebo P.

Int J Med Microbiol. 2016 Jan;306(1):38-47. doi: 10.1016/j.ijmm.2015.11.003. Epub 2015 Nov 30.


Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3.

Osicka R, Osickova A, Hasan S, Bumba L, Cerny J, Sebo P.

Elife. 2015 Dec 9;4:e10766. doi: 10.7554/eLife.10766.


Pore-formation by adenylate cyclase toxoid activates dendritic cells to prime CD8+ and CD4+ T cells.

Svedova M, Masin J, Fiser R, Cerny O, Tomala J, Freudenberg M, Tuckova L, Kovar M, Dadaglio G, Adkins I, Sebo P.

Immunol Cell Biol. 2016 Apr;94(4):322-33. doi: 10.1038/icb.2015.87. Epub 2015 Oct 6.


Bordetella adenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzyme.

Masin J, Osicka R, Bumba L, Sebo P.

Pathog Dis. 2015 Nov;73(8):ftv075. doi: 10.1093/femspd/ftv075. Epub 2015 Sep 20. Review.


cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL-Bax pro-apoptotic cascade in phagocytes.

Ahmad JN, Cerny O, Linhartova I, Masin J, Osicka R, Sebo P.

Cell Microbiol. 2016 Mar;18(3):384-98. doi: 10.1111/cmi.12519. Epub 2015 Oct 7.


What are patients' expectations about the organization of their primary care physicians' practices?

Sebo P, Herrmann FR, Bovier P, Haller DM.

BMC Health Serv Res. 2015 Aug 14;15:328. doi: 10.1186/s12913-015-0985-y.


How do GPs in Switzerland perceive their patients' satisfaction and expectations? An observational study.

Sebo P, Herrmann FR, Haller DM.

BMJ Open. 2015 Jun 10;5(6):e007085. doi: 10.1136/bmjopen-2014-007085.


Redesigning protein cavities as a strategy for increasing affinity in protein-protein interaction: interferon- γ receptor 1 as a model.

Černý J, Biedermannová L, Mikulecký P, Zahradník J, Charnavets T, Šebo P, Schneider B.

Biomed Res Int. 2015;2015:716945. doi: 10.1155/2015/716945. Epub 2015 Apr 28.


Bordetella pertussis Adenylate Cyclase Toxin Blocks Induction of Bactericidal Nitric Oxide in Macrophages through cAMP-Dependent Activation of the SHP-1 Phosphatase.

Cerny O, Kamanova J, Masin J, Bibova I, Skopova K, Sebo P.

J Immunol. 2015 May 15;194(10):4901-13. doi: 10.4049/jimmunol.1402941. Epub 2015 Apr 15.


Accuracy of doctors' anthropometric measurements in general practice.

Sebo P, Haller D, Pechère-Bertschi A, Bovier P, Herrmann F.

Swiss Med Wkly. 2015 Feb 21;145:w14115. doi: 10.4414/smw.2015.14115. eCollection 2015.


Interaction of Bordetella adenylate cyclase toxin with complement receptor 3 involves multivalent glycan binding.

Hasan S, Osickova A, Bumba L, Novák P, Sebo P, Osicka R.

FEBS Lett. 2015 Jan 30;589(3):374-9. doi: 10.1016/j.febslet.2014.12.023. Epub 2014 Dec 29.


Filamentous hemagglutinin of Bordetella pertussis: a key adhesin with immunomodulatory properties?

Villarino Romero R, Osicka R, Sebo P.

Future Microbiol. 2014;9(12):1339-60. doi: 10.2217/fmb.14.77. Review.


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