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Items: 1 to 50 of 163

1.

Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research.

Montano M, Bhasin S, D'Aquila RT, Erlandson KM, Evans WJ, Funderburg NT, Justice A, Ndhlovu LC, Ojikutu B, Pahor M, Pahwa S, Ryan AS, Schrack J, Schultz MB, Sebastiani P, Sinclair DA, Tripp J, Walker B, Womack JA, Yung R, Reeves RK.

AIDS Res Hum Retroviruses. 2019 Sep 23. doi: 10.1089/AID.2019.0130. [Epub ahead of print]

PMID:
31456412
2.

A meta-analysis of genome-wide association studies identifies multiple longevity genes.

Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, Ware EB, Sarnowski C, Smith AV, Seppälä I, Cordell HJ, Dose J, Amin N, Arnold AM, Ayers KL, Barzilai N, Becker EJ, Beekman M, Blanché H, Christensen K, Christiansen L, Collerton JC, Cubaynes S, Cummings SR, Davies K, Debrabant B, Deleuze JF, Duncan R, Faul JD, Franceschi C, Galan P, Gudnason V, Harris TB, Huisman M, Hurme MA, Jagger C, Jansen I, Jylhä M, Kähönen M, Karasik D, Kardia SLR, Kingston A, Kirkwood TBL, Launer LJ, Lehtimäki T, Lieb W, Lyytikäinen LP, Martin-Ruiz C, Min J, Nebel A, Newman AB, Nie C, Nohr EA, Orwoll ES, Perls TT, Province MA, Psaty BM, Raitakari OT, Reinders MJT, Robine JM, Rotter JI, Sebastiani P, Smith J, Sørensen TIA, Taylor KD, Uitterlinden AG, van der Flier W, van der Lee SJ, van Duijn CM, van Heemst D, Vaupel JW, Weir D, Ye K, Zeng Y, Zheng W, Holstege H, Kiel DP, Lunetta KL, Slagboom PE, Murabito JM.

Nat Commun. 2019 Aug 14;10(1):3669. doi: 10.1038/s41467-019-11558-2.

3.

A serum protein signature of APOE genotypes in centenarians.

Sebastiani P, Monti S, Morris M, Gurinovich A, Toshiko T, Andersen SL, Sweigart B, Ferrucci L, Jennings LL, Glass DJ, Perls TT.

Aging Cell. 2019 Aug 5:e13023. doi: 10.1111/acel.13023. [Epub ahead of print]

4.

Heterogeneity of healthy aging: comparing long-lived families across five healthy aging phenotypes of blood pressure, memory, pulmonary function, grip strength, and metabolism.

Marron MM, Wojczynski MK, Minster RL, Boudreau RM, Sebastiani P, Cosentino S, Thyagarajan B, Ukraintseva SV, Schupf N, Christensen K, Feitosa M, Perls T, Zmuda JM, Newman AB; Long Life Family Study.

Geroscience. 2019 Jul 22. doi: 10.1007/s11357-019-00086-y. [Epub ahead of print]

PMID:
31332674
5.

Genetic associations with age of menopause in familial longevity.

Bae H, Lunetta KL, Murabito JM, Andersen SL, Schupf N, Perls T, Sebastiani P; Long Life Family Study.

Menopause. 2019 Oct;26(10):1204-1212. doi: 10.1097/GME.0000000000001367.

PMID:
31188284
6.

Prevalence, Incidence and Risk Factors for Overall, Physical and Cognitive Independence among those from exceptionally long-lived families: The Long Life Family Study.

Santanasto AJ, Marron MM, Boudreau RM, Feitosa MF, Wojczynski MK, Arbeev KG, Thyagarajan B, Schupf N, Stallard E, Sebastiani P, Cosentino S, Christensen K, Newman AB.

J Gerontol A Biol Sci Med Sci. 2019 May 14. pii: glz124. doi: 10.1093/gerona/glz124. [Epub ahead of print]

PMID:
31086986
7.

Correction to: The Novel C5aR Antagonist DF3016A Protects Neurons Against Ischemic Neuroinflammatory Injury.

Brandolini L, Grannonico M, Bianchini G, Colanardi A, Sebastiani P, Paladini A, Piroli A, Allegretti M, Varrassi G, Di Loreto S.

Neurotox Res. 2019 Aug;36(2):439. doi: 10.1007/s12640-019-00049-3.

PMID:
31062231
8.

The Novel C5aR Antagonist DF3016A Protects Neurons Against Ischemic Neuroinflammatory Injury.

Brandolini L, Grannonico M, Bianchini G, Colanardi A, Sebastiani P, Paladini A, Piroli A, Allegretti M, Varrassi G, Di Loreto S.

Neurotox Res. 2019 Jul;36(1):163-174. doi: 10.1007/s12640-019-00026-w. Epub 2019 Apr 5. Erratum in: Neurotox Res. 2019 May 6;:.

9.

CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features.

Kartha VK, Sebastiani P, Kern JG, Zhang L, Varelas X, Monti S.

Front Genet. 2019 Feb 19;10:121. doi: 10.3389/fgene.2019.00121. eCollection 2019.

10.

A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity.

Marron MM, Miljkovic I, Boudreau RM, Christensen K, Feitosa MF, Lee JH, Sebastiani P, Thyagarajan B, Wojczynski MK, Zmuda JM, Newman AB; Long Life Family Study.

Metabolism. 2019 May;94:28-38. doi: 10.1016/j.metabol.2019.01.010. Epub 2019 Jan 30.

PMID:
30710575
11.

FTO rs9939609 Gene Polymorphism and Obesity: Lack of Association in Kidney Transplantation.

Piancatelli D, Maccarone D, Sebastiani P, Colanardi A, Iesari S, Clemente K, Lai Q, Pisani F.

Transplant Proc. 2019 Jan - Feb;51(1):164-166. doi: 10.1016/j.transproceed.2018.04.080. Epub 2018 Jun 30.

PMID:
30655132
12.

PopCluster: an algorithm to identify genetic variants with ethnicity-dependent effects.

Gurinovich A, Bae H, Farrell JJ, Andersen SL, Monti S, Puca A, Atzmon G, Barzilai N, Perls TT, Sebastiani P.

Bioinformatics. 2019 Sep 1;35(17):3046-3054. doi: 10.1093/bioinformatics/btz017.

PMID:
30624692
13.

Sex Differences in Genetic Associations With Longevity.

Zeng Y, Nie C, Min J, Chen H, Liu X, Ye R, Chen Z, Bai C, Xie E, Yin Z, Lv Y, Lu J, Li J, Ni T, Bolund L, Land KC, Yashin A, O'Rand AM, Sun L, Yang Z, Tao W, Gurinovich A, Franceschi C, Xie J, Gu J, Hou Y, Liu X, Xu X, Robine JM, Deelen J, Sebastiani P, Slagboom E, Perls T, Hauser E, Gottschalk W, Tan Q, Christensen K, Shi X, Lutz M, Tian XL, Yang H, Vaupel J.

JAMA Netw Open. 2018 Aug;1(4):e181670. doi: 10.1001/jamanetworkopen.2018.1670. Epub 2018 Aug 24.

14.

APOE Alleles and Extreme Human Longevity.

Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, Andersen SL, Villa F, Atzmon G, Christensen K, Arai Y, Barzilai N, Puca A, Christiansen L, Hirose N, Perls TT.

J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):44-51. doi: 10.1093/gerona/gly174.

15.

Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring.

Andersen SL, Sweigart B, Sebastiani P, Drury J, Sidlowski S, Perls TT.

J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):108-113. doi: 10.1093/gerona/gly141.

16.

Biomarker signatures of sickle cell disease severity.

Du M, Van Ness S, Gordeuk V, Nouraie SM, Nekhai S, Gladwin M, Steinberg MH, Sebastiani P.

Blood Cells Mol Dis. 2018 Sep;72:1-9. doi: 10.1016/j.bcmd.2018.05.001. Epub 2018 May 16.

17.

Inflammatory signatures distinguish metabolic health in African American women with obesity.

Denis GV, Sebastiani P, Bertrand KA, Strissel KJ, Tran AH, Slama J, Medina ND, Andrieu G, Palmer JR.

PLoS One. 2018 May 8;13(5):e0196755. doi: 10.1371/journal.pone.0196755. eCollection 2018.

18.

Purpose in Life Among Centenarian Offspring.

Marone S, Bloore K, Sebastiani P, Flynn C, Leonard B, Whitaker K, Mostowy M, Perls T, Andersen SL.

J Gerontol B Psychol Sci Soc Sci. 2018 Mar 7. doi: 10.1093/geronb/gby023. [Epub ahead of print]

PMID:
29522128
19.

Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice.

Sebastiani A, Gölz C, Sebastiani PG, Bobkiewicz W, Behl C, Mittmann T, Thal SC, Engelhard K.

Front Neurosci. 2017 Dec 19;11:678. doi: 10.3389/fnins.2017.00678. eCollection 2017.

20.

Manual and Automated Procedures for Compiling a Very Large Sample of Centenarian Pedigrees.

Nebbia G, Nussbaum L, Helmkamp A, Andersen S, Perls T, Sebastiani P.

N Am Actuar J. 2018;22(4):591-599. doi: 10.1080/10920277.2018.1462716. Epub 2018 Sep 27.

21.

Assortative Mating by Ethnicity in Longevous Families.

Sebastiani P, Gurinovich A, Bae H, Andersen SL, Perls TT.

Front Genet. 2017 Nov 21;8:186. doi: 10.3389/fgene.2017.00186. eCollection 2017.

22.

HLA Typing and Celiac Disease in Moroccans.

Piancatelli D, Ben El Barhdadi I, Oumhani K, Sebastiani P, Colanardi A, Essaid A.

Med Sci (Basel). 2017 Jan 6;5(1). pii: E2. doi: 10.3390/medsci5010002.

23.

Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies.

Bae H, Gurinovich A, Malovini A, Atzmon G, Andersen SL, Villa F, Barzilai N, Puca A, Perls TT, Sebastiani P.

J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1439-1447. doi: 10.1093/gerona/glx124.

24.

Relationships Among Obesity, Type 2 Diabetes, and Plasma Cytokines in African American Women.

Denis GV, Sebastiani P, Andrieu G, Tran AH, Strissel KJ, Lombardi FL, Palmer JR.

Obesity (Silver Spring). 2017 Nov;25(11):1916-1920. doi: 10.1002/oby.21943. Epub 2017 Aug 25.

25.

A novel healthy blood pressure phenotype in the Long Life Family Study.

Marron MM, Singh J, Boudreau RM, Christensen K, Cosentino S, Feitosa MF, Minster RL, Perls T, Schupf N, Sebastiani P, Ukraintseva S, Wojczynski MK, Newman AB.

J Hypertens. 2018 Jan;36(1):43-53. doi: 10.1097/HJH.0000000000001514.

26.

A phased SNP-based classification of sickle cell anemia HBB haplotypes.

Shaikho EM, Farrell JJ, Alsultan A, Qutub H, Al-Ali AK, Figueiredo MS, Chui DHK, Farrer LA, Murphy GJ, Mostoslavsky G, Sebastiani P, Steinberg MH.

BMC Genomics. 2017 Aug 11;18(1):608. doi: 10.1186/s12864-017-4013-y.

27.

Genetic determinants of HbF in Saudi Arabian and African Benin haplotype sickle cell anemia.

Shaikho EM, Farrell JJ, Alsultan A, Sebastiani P, Steinberg MH.

Am J Hematol. 2017 Sep;92(9):E555-E557. doi: 10.1002/ajh.24822. Epub 2017 Jul 19. No abstract available.

28.

Uroplakin 3a+ Cells Are a Distinctive Population of Epithelial Progenitors that Contribute to Airway Maintenance and Post-injury Repair.

Guha A, Deshpande A, Jain A, Sebastiani P, Cardoso WV.

Cell Rep. 2017 Apr 11;19(2):246-254. doi: 10.1016/j.celrep.2017.03.051.

29.

Four Genome-Wide Association Studies Identify New Extreme Longevity Variants.

Sebastiani P, Gurinovich A, Bae H, Andersen S, Malovini A, Atzmon G, Villa F, Kraja AT, Ben-Avraham D, Barzilai N, Puca A, Perls TT.

J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1453-1464. doi: 10.1093/gerona/glx027.

30.

Limitations and risks of meta-analyses of longevity studies.

Sebastiani P, Bae H, Gurinovich A, Soerensen M, Puca A, Perls TT.

Mech Ageing Dev. 2017 Jul;165(Pt B):139-146. doi: 10.1016/j.mad.2017.01.008. Epub 2017 Jan 28. Review.

31.

A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells.

Park S, Gianotti-Sommer A, Molina-Estevez FJ, Vanuytsel K, Skvir N, Leung A, Rozelle SS, Shaikho EM, Weir I, Jiang Z, Luo HY, Chui DHK, Figueiredo MS, Alsultan A, Al-Ali A, Sebastiani P, Steinberg MH, Mostoslavsky G, Murphy GJ.

Stem Cell Reports. 2017 Apr 11;8(4):1076-1085. doi: 10.1016/j.stemcr.2016.12.017. Epub 2017 Jan 19.

32.

The comparative safety of buprenorphine versus methadone in pregnancy-what about confounding?

Brogly SB, Saia K, Hernández-Diaz S, Werler M, Sebastiani P.

Addiction. 2016 Dec;111(12):2130-2131. doi: 10.1111/add.13551. No abstract available.

33.

Biomarker signatures of aging.

Sebastiani P, Thyagarajan B, Sun F, Schupf N, Newman AB, Montano M, Perls TT.

Aging Cell. 2017 Apr;16(2):329-338. doi: 10.1111/acel.12557. Epub 2017 Jan 6.

34.

Telomere length is longer in women with late maternal age.

Fagan E, Sun F, Bae H, Elo I, Andersen SL, Lee J, Christensen K, Thyagarajan B, Sebastiani P, Perls T, Honig LS, Schupf N; Long Life Family Study.

Menopause. 2017 May;24(5):497-501. doi: 10.1097/GME.0000000000000795.

35.

Age and Sex Distributions of Age-Related Biomarker Values in Healthy Older Adults from the Long Life Family Study.

Sebastiani P, Thyagarajan B, Sun F, Honig LS, Schupf N, Cosentino S, Feitosa MF, Wojczynski M, Newman AB, Montano M, Perls TT.

J Am Geriatr Soc. 2016 Nov;64(11):e189-e194. doi: 10.1111/jgs.14522. Epub 2016 Oct 26.

36.

A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia.

Vathipadiekal V, Farrell JJ, Wang S, Edward HL, Shappell H, Al-Rubaish AM, Al-Muhanna F, Naserullah Z, Alsuliman A, Qutub HO, Simkin I, Farrer LA, Jiang Z, Luo HY, Huang S, Mostoslavsky G, Murphy GJ, Patra PK, Chui DH, Alsultan A, Al-Ali AK, Sebastiani P, Steinberg MH.

Am J Hematol. 2016 Nov;91(11):1118-1122. doi: 10.1002/ajh.24527. Epub 2016 Aug 22.

37.

Detection of Significant Groups in Hierarchical Clustering by Resampling.

Sebastiani P, Perls TT.

Front Genet. 2016 Aug 8;7:144. doi: 10.3389/fgene.2016.00144. eCollection 2016.

38.

Compression of Morbidity Is Observed Across Cohorts with Exceptional Longevity.

Ismail K, Nussbaum L, Sebastiani P, Andersen S, Perls T, Barzilai N, Milman S.

J Am Geriatr Soc. 2016 Aug;64(8):1583-91. doi: 10.1111/jgs.14222. Epub 2016 Jul 5.

39.

Variants of ZBTB7A (LRF) and its β-globin gene cluster binding motifs in sickle cell anemia.

Shaikho EM, Habara AH, Alsultan A, Al-Rubaish AM, Al-Muhanna F, Naserullah Z, Alsuliman A, Qutub HO, Patra PK, Sebastiani P, Baltrusaitis K, Farrell JJ, Jiang Z, Luo HY, Chui DH, Al-Ali AK, Steinberg MH.

Blood Cells Mol Dis. 2016 Jul;59:49-51. doi: 10.1016/j.bcmd.2016.04.001. Epub 2016 Apr 13. No abstract available.

40.

Homozygosity for a haplotype in the HBG2-OR51B4 region is exclusive to Arab-Indian haplotype sickle cell anemia.

Vathipadiekal V, Alsultan A, Baltrusaitis K, Farrell JJ, Al-Rubaish AM, Al-Muhanna F, Naserullah Z, Suliman A, Patra PK, Milton JN, Farrer LA, Chui DH, Al-Ali AK, Sebastiani P, Steinberg MH.

Am J Hematol. 2016 Jun;91(6):E308-11. doi: 10.1002/ajh.24368. Epub 2016 Apr 28. No abstract available.

41.

Learning Bayesian Networks from Correlated Data.

Bae H, Monti S, Montano M, Steinberg MH, Perls TT, Sebastiani P.

Sci Rep. 2016 May 5;6:25156. doi: 10.1038/srep25156.

42.

Kidney Transplantation, Polymorphisms of IL-18, and Other Pro-Inflammatory Genes and Late Post-Transplant Outcome.

Piancatelli D, Maccarone D, Colanardi A, Sebastiani P, Clemente K, Iesari S, Di Pietro V, Lai Q, Famulari A, Pisani F.

Transplant Proc. 2016 Mar;48(2):323-5. doi: 10.1016/j.transproceed.2016.02.010.

PMID:
27109946
43.

Familial Risk for Exceptional Longevity.

Sebastiani P, Andersen SL, McIntosh AI, Nussbaum L, Stevenson MD, Pierce L, Xia S, Salance K, Perls TT.

N Am Actuar J. 2016 Jan 1;20(1):57-64. Epub 2015 Oct 7.

44.

Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease.

Liu L, Pertsemlidis A, Ding LH, Story MD, Steinberg MH, Sebastiani P, Hoppe C, Ballas SK, Pace BS.

Exp Biol Med (Maywood). 2016 Apr;241(7):706-18. doi: 10.1177/1535370216642047. Epub 2016 Mar 27.

45.

Novel loci and pathways significantly associated with longevity.

Zeng Y, Nie C, Min J, Liu X, Li M, Chen H, Xu H, Wang M, Ni T, Li Y, Yan H, Zhang JP, Song C, Chi LQ, Wang HM, Dong J, Zheng GY, Lin L, Qian F, Qi Y, Liu X, Cao H, Wang Y, Zhang L, Li Z, Zhou Y, Wang Y, Lu J, Li J, Qi M, Bolund L, Yashin A, Land KC, Gregory S, Yang Z, Gottschalk W, Tao W, Wang J, Wang J, Xu X, Bae H, Nygaard M, Christiansen L, Christensen K, Franceschi C, Lutz MW, Gu J, Tan Q, Perls T, Sebastiani P, Deelen J, Slagboom E, Hauser E, Xu H, Tian XL, Yang H, Vaupel JW.

Sci Rep. 2016 Feb 25;6:21243. doi: 10.1038/srep21243.

46.

Fast Room Temperature Very Low Field-Magnetic Resonance Imaging System Compatible with MagnetoEncephaloGraphy Environment.

Galante A, Sinibaldi R, Conti A, De Luca C, Catallo N, Sebastiani P, Pizzella V, Romani GL, Sotgiu A, Della Penna S.

PLoS One. 2015 Dec 2;10(12):e0142701. doi: 10.1371/journal.pone.0142701. eCollection 2015.

47.

Posttraumatic Propofol Neurotoxicity Is Mediated via the Pro-Brain-Derived Neurotrophic Factor-p75 Neurotrophin Receptor Pathway in Adult Mice.

Sebastiani A, Granold M, Ditter A, Sebastiani P, Gölz C, Pöttker B, Luh C, Schaible EV, Radyushkin K, Timaru-Kast R, Werner C, Schäfer MK, Engelhard K, Moosmann B, Thal SC.

Crit Care Med. 2016 Feb;44(2):e70-82. doi: 10.1097/CCM.0000000000001284.

PMID:
26317567
48.

Bayesian Polynomial Regression Models to Fit Multiple Genetic Models for Quantitative Traits.

Bae H, Perls T, Steinberg M, Sebastiani P.

Bayesian Anal. 2015 Mar;10(1):53-74.

49.

Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease.

Zhang X, Zhang W, Saraf SL, Nouraie M, Han J, Gowhari M, Hassan J, Miasnikova G, Sergueeva A, Nekhai S, Kittles R, Machado RF, Garcia JG, Gladwin MT, Steinberg MH, Sebastiani P, McClain DA, Gordeuk VR.

Hum Genet. 2015 Aug;134(8):895-904. doi: 10.1007/s00439-015-1572-3. Epub 2015 May 30.

50.

Temporal gene expression profiling of the rat knee joint capsule during immobilization-induced joint contractures.

Wong K, Sun F, Trudel G, Sebastiani P, Laneuville O.

BMC Musculoskelet Disord. 2015 May 26;16:125. doi: 10.1186/s12891-015-0588-0.

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