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Items: 19

1.

The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a.

Rouault AAJ, Rosselli-Murai LK, Hernandez CC, Gimenez LE, Tall GG, Sebag JA.

Sci Signal. 2020 Jan 7;13(613). pii: eaax4569. doi: 10.1126/scisignal.aax4569.

PMID:
31911434
2.

Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice.

Perschbacher KJ, Deng G, Sandgren JA, Walsh JW, Witcher PC, Sapouckey SA, Owens CE, Zhang SY, Scroggins SM, Pearson NA, Devor EJ, Sebag JA, Pierce GL, Fisher RA, Kwitek AE, Santillan DA, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL.

Hypertension. 2020 Feb;75(2):569-579. doi: 10.1161/HYPERTENSIONAHA.119.14056. Epub 2019 Dec 23.

PMID:
31865781
3.

MRAP2 regulates ghrelin receptor signaling and hunger sensing.

Srisai D, Yin TC, Lee AA, Rouault AAJ, Pearson NA, Grobe JL, Sebag JA.

Nat Commun. 2017 Sep 28;8(1):713. doi: 10.1038/s41467-017-00747-6.

4.

Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling.

Rouault AAJ, Lee AA, Sebag JA.

Biochim Biophys Acta Mol Cell Res. 2017 Dec;1864(12):2322-2329. doi: 10.1016/j.bbamcr.2017.09.008. Epub 2017 Sep 20.

5.

Relationship of Cuboid Height to Plantar Ulceration and Other Radiographic Parameters in Midfoot Charcot Neuroarthropathy.

Meyr AJ, Sebag JA.

J Foot Ankle Surg. 2017 Jul - Aug;56(4):748-755. doi: 10.1053/j.jfas.2017.02.007.

PMID:
28633771
6.

Melanocortin Receptor Accessory Proteins (MRAPs): Functions in the melanocortin system and beyond.

Rouault AAJ, Srinivasan DK, Yin TC, Lee AA, Sebag JA.

Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt A):2462-2467. doi: 10.1016/j.bbadis.2017.05.008. Epub 2017 May 9. Review.

7.

The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1.

Chaly AL, Srisai D, Gardner EE, Sebag JA.

Elife. 2016 Feb 1;5. pii: e12397. doi: 10.7554/eLife.12397.

8.

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.

Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD.

Nature. 2015 Apr 2;520(7545):94-8. doi: 10.1038/nature14051. Epub 2015 Jan 19.

9.

Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish.

Sebag JA, Zhang C, Hinkle PM, Bradshaw AM, Cone RD.

Science. 2013 Jul 19;341(6143):278-81. doi: 10.1126/science.1232995.

10.

[G-protein-coupled receptors targeting: the allosteric approach].

Sebag JA, Pantel J.

Med Sci (Paris). 2012 Oct;28(10):845-51. doi: 10.1051/medsci/20122810012. Epub 2012 Oct 12. Review. French.

11.

Functional expression of frog and rainbow trout melanocortin 2 receptors using heterologous MRAP1s.

Liang L, Sebag JA, Eagelston L, Serasinghe MN, Veo K, Reinick C, Angleson J, Hinkle PM, Dores RM.

Gen Comp Endocrinol. 2011 Oct 1;174(1):5-14. doi: 10.1016/j.ygcen.2011.07.005. Epub 2011 Aug 9.

PMID:
21846469
12.

Use of chimeric melanocortin-2 and -4 receptors to identify regions responsible for ligand specificity and dependence on melanocortin 2 receptor accessory protein.

Hinkle PM, Serasinghe MN, Jakabowski A, Sebag JA, Wilson KR, Haskell-Luevano C.

Eur J Pharmacol. 2011 Jun 11;660(1):94-102. doi: 10.1016/j.ejphar.2010.10.113. Epub 2011 Jan 3.

13.

Physiological roles of the melanocortin MC₃ receptor.

Renquist BJ, Lippert RN, Sebag JA, Ellacott KL, Cone RD.

Eur J Pharmacol. 2011 Jun 11;660(1):13-20. doi: 10.1016/j.ejphar.2010.12.025. Epub 2011 Jan 3. Review.

14.
15.

Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking.

Sebag JA, Hinkle PM.

J Biol Chem. 2009 Aug 21;284(34):22641-8. doi: 10.1074/jbc.M109.022400. Epub 2009 Jun 17.

16.

Structure and function of the melanocortin2 receptor accessory protein (MRAP).

Hinkle PM, Sebag JA.

Mol Cell Endocrinol. 2009 Mar 5;300(1-2):25-31. doi: 10.1016/j.mce.2008.10.041. Epub 2008 Nov 6. Review.

17.

Regions of melanocortin 2 (MC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling.

Sebag JA, Hinkle PM.

J Biol Chem. 2009 Jan 2;284(1):610-8. doi: 10.1074/jbc.M804413200. Epub 2008 Nov 3.

18.

Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers.

Sebag JA, Hinkle PM.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20244-9. Epub 2007 Dec 12.

19.

Regulation of endogenous melanocortin-4 receptor expression and signaling by glucocorticoids.

Sebag JA, Hinkle PM.

Endocrinology. 2006 Dec;147(12):5948-55. Epub 2006 Sep 14.

PMID:
16973723

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