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Items: 1 to 50 of 224

1.

Correction: Modeling differentiation-state transitions linked to therapeutic escape in triple-negative breast cancer.

Chapman MP, Risom T, Aswani AJ, Langer EM, Sears RC, Tomlin CJ.

PLoS Comput Biol. 2019 Oct 9;15(10):e1007441. doi: 10.1371/journal.pcbi.1007441. eCollection 2019 Oct.

2.

Mission Possible: Advances in MYC Therapeutic Targeting in Cancer.

Allen-Petersen BL, Sears RC.

BioDrugs. 2019 Oct;33(5):539-553. doi: 10.1007/s40259-019-00370-5. Review.

3.

The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance.

Beltran H, Hruszkewycz A, Scher HI, Hildesheim J, Isaacs J, Yu EY, Kelly K, Lin D, Dicker A, Arnold J, Hecht T, Wicha M, Sears R, Rowley D, White R, Gulley JL, Lee J, Diaz Meco M, Small EJ, Shen M, Knudsen K, Goodrich DW, Lotan T, Zoubeidi A, Sawyers CL, Rudin CM, Loda M, Thompson T, Rubin MA, Tawab-Amiri A, Dahut W, Nelson PS.

Clin Cancer Res. 2019 Jul 30. doi: 10.1158/1078-0432.CCR-19-1423. [Epub ahead of print]

PMID:
31363002
4.

Innate αβ T Cells Mediate Antitumor Immunity by Orchestrating Immunogenic Macrophage Programming.

Hundeyin M, Kurz E, Mishra A, Rossi JAK, Liudahl SM, Leis KR, Mehrotra H, Kim M, Torres LE, Ogunsakin A, Link J, Sears RC, Sivagnanam S, Goecks J, Islam KMS, Dolgalev I, Savadkar S, Wang W, Aykut B, Leinwand J, Diskin B, Adam S, Israr M, Gelas M, Lish J, Chin K, Farooq MS, Wadowski B, Wu J, Shah S, Adeegbe DO, Pushalkar S, Vasudevaraja V, Saxena D, Wong KK, Coussens LM, Miller G.

Cancer Discov. 2019 Sep;9(9):1288-1305. doi: 10.1158/2159-8290.CD-19-0161. Epub 2019 Jul 2.

PMID:
31266770
5.

Mindfulness-based cognitive therapy for children and adolescents with anxiety disorders at-risk for bipolar disorder: A psychoeducation waitlist controlled pilot trial.

Cotton S, Kraemer KM, Sears RW, Strawn JR, Wasson RS, McCune N, Welge J, Blom TJ, Durling M, Delbello MP.

Early Interv Psychiatry. 2019 Jul 2. doi: 10.1111/eip.12848. [Epub ahead of print]

PMID:
31264800
6.

WashU Epigenome Browser update 2019.

Li D, Hsu S, Purushotham D, Sears RL, Wang T.

Nucleic Acids Res. 2019 Jul 2;47(W1):W158-W165. doi: 10.1093/nar/gkz348.

7.

BioID as a Tool for Protein-Proximity Labeling in Living Cells.

Sears RM, May DG, Roux KJ.

Methods Mol Biol. 2019;2012:299-313. doi: 10.1007/978-1-4939-9546-2_15.

PMID:
31161514
8.

Repair of nuclear ruptures requires barrier-to-autointegration factor.

Halfmann CT, Sears RM, Katiyar A, Busselman BW, Aman LK, Zhang Q, O'Bryan CS, Angelini TE, Lele TP, Roux KJ.

J Cell Biol. 2019 Jul 1;218(7):2136-2149. doi: 10.1083/jcb.201901116. Epub 2019 May 30.

PMID:
31147383
9.

Decline in abundance and apparent survival rates of fin whales (Balaenoptera physalus) in the northern Gulf of St. Lawrence.

Schleimer A, Ramp C, Delarue J, Carpentier A, Bérubé M, Palsbøll PJ, Sears R, Hammond PS.

Ecol Evol. 2019 Mar 15;9(7):4231-4244. doi: 10.1002/ece3.5055. eCollection 2019 Apr.

10.

The use of protein phosphatase 2A activators in combination therapies for pancreas cancer.

Allen-Petersen BL, Sears RC.

Oncotarget. 2019 Mar 12;10(21):2008-2009. doi: 10.18632/oncotarget.26772. eCollection 2019 Mar 12. No abstract available.

11.

Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma.

Wang J, Merino DM, Light N, Murphy BL, Wang YD, Guo X, Hodges AP, Chau LQ, Liu KW, Dhall G, Asgharzadeh S, Kiehna EN, Shirey RJ, Janda KD, Taylor MD, Malkin D, Ellison DW, VandenBerg SR, Eberhart CG, Sears RC, Roussel MF, Gilbertson RJ, Wechsler-Reya RJ.

Cancer Res. 2019 May 1;79(9):2208-2219. doi: 10.1158/0008-5472.CAN-18-2565. Epub 2019 Mar 18.

PMID:
30885981
12.

Modeling differentiation-state transitions linked to therapeutic escape in triple-negative breast cancer.

Chapman MP, Risom T, Aswani AJ, Langer EM, Sears RC, Tomlin CJ.

PLoS Comput Biol. 2019 Mar 11;15(3):e1006840. doi: 10.1371/journal.pcbi.1006840. eCollection 2019 Mar. Erratum in: PLoS Comput Biol. 2019 Oct 9;15(10):e1007441.

13.

A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression.

Auciello FR, Bulusu V, Oon C, Tait-Mulder J, Berry M, Bhattacharyya S, Tumanov S, Allen-Petersen BL, Link J, Kendsersky ND, Vringer E, Schug M, Novo D, Hwang RF, Evans RM, Nixon C, Dorrell C, Morton JP, Norman JC, Sears RC, Kamphorst JJ, Sherman MH.

Cancer Discov. 2019 May;9(5):617-627. doi: 10.1158/2159-8290.CD-18-1212. Epub 2019 Mar 5.

PMID:
30837243
14.

Fin whale (Balaenoptera physalus) mitogenomics: A cautionary tale of defining sub-species from mitochondrial sequence monophyly.

Cabrera AA, Hoekendijk JPA, Aguilar A, Barco SG, Berrow S, Bloch D, Borrell A, Cunha HA, Dalla Rosa L, Dias CP, Gauffier P, Hao W, Landry S, Larsen F, Martín V, Mizroch S, Oosting T, Øien N, Pampoulie C, Panigada S, Prieto R, Ramp C, Rivera-Léon V, Robbins J, Ryan C, Schall E, Sears R, Silva MA, Urbán J, Wenzel FW, Palsbøll PJ, Bérubé M.

Mol Phylogenet Evol. 2019 Jun;135:86-97. doi: 10.1016/j.ympev.2019.02.003. Epub 2019 Feb 13.

15.

Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting.

Langer EM, Allen-Petersen BL, King SM, Kendsersky ND, Turnidge MA, Kuziel GM, Riggers R, Samatham R, Amery TS, Jacques SL, Sheppard BC, Korkola JE, Muschler JL, Thibault G, Chang YH, Gray JW, Presnell SC, Nguyen DG, Sears RC.

Cell Rep. 2019 Jan 15;26(3):608-623.e6. doi: 10.1016/j.celrep.2018.12.090.

16.

GRB7 dependent proliferation of basal-like, HER-2 positive human breast cancer cell lines is mediated in part by HER-1 signaling.

Luoh SW, Wagoner W, Wang X, Hu Z, Lai X, Chin K, Sears R, Ramsey E.

Mol Carcinog. 2019 May;58(5):699-707. doi: 10.1002/mc.22963. Epub 2019 Jan 28.

17.

Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma.

Allen-Petersen BL, Risom T, Feng Z, Wang Z, Jenny ZP, Thoma MC, Pelz KR, Morton JP, Sansom OJ, Lopez CD, Sheppard B, Christensen DJ, Ohlmeyer M, Narla G, Sears RC.

Cancer Res. 2019 Jan 1;79(1):209-219. doi: 10.1158/0008-5472.CAN-18-0717. Epub 2018 Nov 2.

PMID:
30389701
18.

Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals.

Su Y, Pelz C, Huang T, Torkenczy K, Wang X, Cherry A, Daniel CJ, Liang J, Nan X, Dai MS, Adey A, Impey S, Sears RC.

Genes Dev. 2018 Nov 1;32(21-22):1398-1419. doi: 10.1101/gad.314377.118. Epub 2018 Oct 26.

19.

A principled method to identify individual differences and behavioral shifts in signaled active avoidance.

Krypotos AM, Moscarello JM, Sears RM, LeDoux JE, Galatzer-Levy I.

Learn Mem. 2018 Oct 15;25(11):564-568. doi: 10.1101/lm.047399.118. Print 2018 Nov.

PMID:
30322888
20.

SUMO protease SENP1 deSUMOylates and stabilizes c-Myc.

Sun XX, Chen Y, Su Y, Wang X, Chauhan KM, Liang J, Daniel CJ, Sears RC, Dai MS.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):10983-10988. doi: 10.1073/pnas.1802932115. Epub 2018 Oct 10.

21.

Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer.

Risom T, Langer EM, Chapman MP, Rantala J, Fields AJ, Boniface C, Alvarez MJ, Kendsersky ND, Pelz CR, Johnson-Camacho K, Dobrolecki LE, Chin K, Aswani AJ, Wang NJ, Califano A, Lewis MT, Tomlin CJ, Spellman PT, Adey A, Gray JW, Sears RC.

Nat Commun. 2018 Sep 19;9(1):3815. doi: 10.1038/s41467-018-05729-w.

22.

Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups.

Archer TC, Ehrenberger T, Mundt F, Gold MP, Krug K, Mah CK, Mahoney EL, Daniel CJ, LeNail A, Ramamoorthy D, Mertins P, Mani DR, Zhang H, Gillette MA, Clauser K, Noble M, Tang LC, Pierre-François J, Silterra J, Jensen J, Tamayo P, Korshunov A, Pfister SM, Kool M, Northcott PA, Sears RC, Lipton JO, Carr SA, Mesirov JP, Pomeroy SL, Fraenkel E.

Cancer Cell. 2018 Sep 10;34(3):396-410.e8. doi: 10.1016/j.ccell.2018.08.004.

23.

MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network.

Brudvig JJ, Cain JT, Sears RM, Schmidt-Grimminger GG, Wittchen ES, Adler KB, Ghashghaei HT, Weimer JM.

Sci Rep. 2018 Sep 5;8(1):13278. doi: 10.1038/s41598-018-31578-0.

24.

Modelling distributed crewing in commercial aircraft with STAMP for a rapid decompression hazard.

Revell KMA, Allison C, Sears R, Stanton NA.

Ergonomics. 2019 Feb;62(2):156-170. doi: 10.1080/00140139.2018.1514467. Epub 2018 Oct 29.

PMID:
30185116
25.

Serum Biomarker Signature-Based Liquid Biopsy for Diagnosis of Early-Stage Pancreatic Cancer.

Mellby LD, Nyberg AP, Johansen JS, Wingren C, Nordestgaard BG, Bojesen SE, Mitchell BL, Sheppard BC, Sears RC, Borrebaeck CAK.

J Clin Oncol. 2018 Oct 1;36(28):2887-2894. doi: 10.1200/JCO.2017.77.6658. Epub 2018 Aug 14.

26.

Primary brain calcification: an international study reporting novel variants and associated phenotypes.

Ramos EM, Carecchio M, Lemos R, Ferreira J, Legati A, Sears RL, Hsu SC, Panteghini C, Magistrelli L, Salsano E, Esposito S, Taroni F, Richard AC, Tranchant C, Anheim M, Ayrignac X, Goizet C, Vidailhet M, Maltete D, Wallon D, Frebourg T, Pimentel L, Geschwind DH, Vanakker O, Galasko D, Fogel BL, Innes AM, Ross A, Dobyns WB, Alcantara D, O'Driscoll M, Hannequin D, Campion D; French PFBC study group, Oliveira JR, Garavaglia B, Coppola G, Nicolas G.

Eur J Hum Genet. 2018 Oct;26(10):1462-1477. doi: 10.1038/s41431-018-0185-4. Epub 2018 Jun 28.

27.

Peripheral blood gene expression reveals an inflammatory transcriptomic signature in Friedreich's ataxia patients.

Nachun D, Gao F, Isaacs C, Strawser C, Yang Z, Dokuru D, Van Berlo V, Sears R, Farmer J, Perlman S, Lynch DR, Coppola G.

Hum Mol Genet. 2018 Sep 1;27(17):2965-2977. doi: 10.1093/hmg/ddy198.

28.

Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer.

McClinch K, Avelar RA, Callejas D, Izadmehr S, Wiredja D, Perl A, Sangodkar J, Kastrinsky DB, Schlatzer D, Cooper M, Kiselar J, Stachnik A, Yao S, Hoon D, McQuaid D, Zaware N, Gong Y, Brautigan DL, Plymate SR, Sprenger CCT, Oh WK, Levine AC, Kirschenbaum A, Sfakianos JP, Sears R, DiFeo A, Ioannou Y, Ohlmeyer M, Narla G, Galsky MD.

Cancer Res. 2018 Apr 15;78(8):2065-2080. doi: 10.1158/0008-5472.CAN-17-0123. Epub 2018 Jan 22.

29.

Feasibility, Acceptability, and Preliminary Effectiveness of a 4-week Mindfulness-Based Cognitive Therapy Protocol for Hospital Employees.

Luberto CM, Wasson RS, Kraemer KM, Sears RW, Hueber C, Cotton S.

Mindfulness (N Y). 2017 Dec;8(6):1522-1531. doi: 10.1007/s12671-017-0718-x. Epub 2017 Apr 1.

30.

The ubiquitin-specific protease USP36 is a conserved histone H2B deubiquitinase.

DeVine T, Sears RC, Dai MS.

Biochem Biophys Res Commun. 2018 Jan 15;495(3):2363-2368. doi: 10.1016/j.bbrc.2017.12.107. Epub 2017 Dec 20.

31.

The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model.

Janghorban M, Langer EM, Wang X, Zachman D, Daniel CJ, Hooper J, Fleming WH, Agarwal A, Sears RC.

PLoS One. 2017 Nov 30;12(11):e0188910. doi: 10.1371/journal.pone.0188910. eCollection 2017.

32.

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.

Farrell AS, Joly MM, Allen-Petersen BL, Worth PJ, Lanciault C, Sauer D, Link J, Pelz C, Heiser LM, Morton JP, Muthalagu N, Hoffman MT, Manning SL, Pratt ED, Kendsersky ND, Egbukichi N, Amery TS, Thoma MC, Jenny ZP, Rhim AD, Murphy DJ, Sansom OJ, Crawford HC, Sheppard BC, Sears RC.

Nat Commun. 2017 Nov 23;8(1):1728. doi: 10.1038/s41467-017-01967-6.

33.

ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells.

Langer EM, Kendsersky ND, Daniel CJ, Kuziel GM, Pelz C, Murphy KM, Capecchi MR, Sears RC.

Oncogene. 2018 Feb 22;37(8):1005-1019. doi: 10.1038/onc.2017.356. Epub 2017 Oct 30.

34.

Noradrenergic Regulation of Central Amygdala in Aversive Pavlovian-to-Instrumental Transfer.

Campese VD, Soroeta JM, Vazey EM, Aston-Jones G, LeDoux JE, Sears RM.

eNeuro. 2017 Oct 24;4(5). pii: ENEURO.0224-17.2017. doi: 10.1523/ENEURO.0224-17.2017. eCollection 2017 Sep-Oct.

35.

Tissue-specific DNA methylation is conserved across human, mouse, and rat, and driven by primary sequence conservation.

Zhou J, Sears RL, Xing X, Zhang B, Li D, Rockweiler NB, Jang HS, Choudhary MNK, Lee HJ, Lowdon RF, Arand J, Tabers B, Gu CC, Cicero TJ, Wang T.

BMC Genomics. 2017 Sep 12;18(1):724. doi: 10.1186/s12864-017-4115-6.

36.

Characterization of the amplificatory effect of norepinephrine in the acquisition of Pavlovian threat associations.

Díaz-Mataix L, Piper WT, Schiff HC, Roberts CH, Campese VD, Sears RM, LeDoux JE.

Learn Mem. 2017 Aug 16;24(9):432-439. doi: 10.1101/lm.044412.116. Print 2017 Sep.

37.

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.

Sangodkar J, Perl A, Tohme R, Kiselar J, Kastrinsky DB, Zaware N, Izadmehr S, Mazhar S, Wiredja DD, O'Connor CM, Hoon D, Dhawan NS, Schlatzer D, Yao S, Leonard D, Borczuk AC, Gokulrangan G, Wang L, Svenson E, Farrington CC, Yuan E, Avelar RA, Stachnik A, Smith B, Gidwani V, Giannini HM, McQuaid D, McClinch K, Wang Z, Levine AC, Sears RC, Chen EY, Duan Q, Datt M, Haider S, Ma'ayan A, DiFeo A, Sharma N, Galsky MD, Brautigan DL, Ioannou YA, Xu W, Chance MR, Ohlmeyer M, Narla G.

J Clin Invest. 2017 Jun 1;127(6):2081-2090. doi: 10.1172/JCI89548. Epub 2017 May 15.

38.

Epigenomic Inactivation of RasGAPs Activates RAS Signaling in a Subset of Luminal B Breast Cancers.

Sears R, Gray JW.

Cancer Discov. 2017 Feb;7(2):131-133. doi: 10.1158/2159-8290.CD-16-1423.

39.

Primary auditory cortex regulates threat memory specificity.

Wigestrand MB, Schiff HC, Fyhn M, LeDoux JE, Sears RM.

Learn Mem. 2016 Dec 15;24(1):55-58. doi: 10.1101/lm.044362.116. Print 2017 Jan.

40.

ΔN-ASPP2, a novel isoform of the ASPP2 tumor suppressor, promotes cellular survival.

Van Hook K, Wang Z, Chen D, Nold C, Zhu Z, Anur P, Lee HJ, Yu Z, Sheppard B, Dai MS, Sears R, Spellman P, Lopez CD.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1271-1277. doi: 10.1016/j.bbrc.2016.12.027. Epub 2016 Dec 8.

41.

Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: Implications for the oncoprotein c-MYC.

Mitrugno A, Sylman JL, Ngo AT, Pang J, Sears RC, Williams CD, McCarty OJ.

Am J Physiol Cell Physiol. 2017 Feb 1;312(2):C176-C189. doi: 10.1152/ajpcell.00196.2016. Epub 2016 Nov 30.

42.

β-Adrenergic Receptors Regulate the Acquisition and Consolidation Phases of Aversive Memory Formation Through Distinct, Temporally Regulated Signaling Pathways.

Schiff HC, Johansen JP, Hou M, Bush DE, Smith EK, Klein JE, LeDoux JE, Sears RM.

Neuropsychopharmacology. 2017 Mar;42(4):895-903. doi: 10.1038/npp.2016.238. Epub 2016 Oct 20.

43.

The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm.

LeDoux JE, Moscarello J, Sears R, Campese V.

Mol Psychiatry. 2017 Jan;22(1):24-36. doi: 10.1038/mp.2016.166. Epub 2016 Oct 18. Review.

44.

Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.

Richard NP, Pippa R, Cleary MM, Puri A, Tibbitts D, Mahmood S, Christensen DJ, Jeng S, McWeeney S, Look AT, Chang BH, Tyner JW, Vitek MP, Odero MD, Sears R, Agarwal A.

Oncotarget. 2016 Dec 20;7(51):84214-84227. doi: 10.18632/oncotarget.12394.

45.

Stimulation-induced transient changes in neuronal activity, blood flow and N-acetylaspartate content in rat prefrontal cortex: a chemogenetic fMRS-BOLD study.

Baslow MH, Cain CK, Sears R, Wilson DA, Bachman A, Gerum S, Guilfoyle DN.

NMR Biomed. 2016 Dec;29(12):1678-1687. doi: 10.1002/nbm.3629. Epub 2016 Oct 3.

46.

Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy.

Ramirez LM, Goukasian N, Porat S, Hwang KS, Eastman JA, Hurtz S, Wang B, Vang N, Sears R, Klein E, Coppola G, Apostolova LG.

Neurobiol Aging. 2016 Mar;39:82-9. doi: 10.1016/j.neurobiolaging.2015.10.037. Epub 2015 Nov 6.

PMID:
26923404
47.

MYC is not detected in highly proliferating normal spermatogonia but is coupled with CIP2A in testicular cancers.

Ventelä S, Mäkelä JA, Sears RC, Toppari J, Westermarck J.

Matters (Zur). 2016 Mar;2016. doi: 10.19185/matters.201602000040. Epub 2016 Mar 3.

48.

REEF: Retainable Evaluator Execution Framework.

Weimer M, Chen Y, Chun BG, Condie T, Curino C, Douglas C, Lee Y, Majestro T, Malkhi D, Matusevych S, Myers B, Narayanamurthy S, Ramakrishnan R, Rao S, Sears R, Sezgin B, Wang J.

Proc ACM SIGMOD Int Conf Manag Data. 2015 May-Jun;2015:1343-1355.

49.

Neural Function Before and After Mindfulness-Based Cognitive Therapy in Anxious Adolescents at Risk for Developing Bipolar Disorder.

Strawn JR, Cotton S, Luberto CM, Patino LR, Stahl LA, Weber WA, Eliassen JC, Sears R, DelBello MP.

J Child Adolesc Psychopharmacol. 2016 May;26(4):372-9. doi: 10.1089/cap.2015.0054. Epub 2016 Jan 19.

50.

Deubiquitinating c-Myc: USP36 steps up in the nucleolus.

Sun XX, Sears RC, Dai MS.

Cell Cycle. 2015;14(24):3786-93. doi: 10.1080/15384101.2015.1093713.

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