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Items: 1 to 50 of 143

1.

Oral antibiotic use and chronic disease: long-term health impact beyond antimicrobial resistance and Clostridioides difficile.

Queen J, Zhang J, Sears CL.

Gut Microbes. 2020 Feb 9:1-12. doi: 10.1080/19490976.2019.1706425. [Epub ahead of print]

PMID:
32037950
2.

To The Editor.

Sears CL, Del Rio C, Malani P.

J Infect Dis. 2019 Dec 31. pii: jiz689. doi: 10.1093/infdis/jiz689. [Epub ahead of print] No abstract available.

PMID:
31943038
3.

Human Colon Mucosal Biofilms and Murine Host Communicate via Altered mRNA and microRNA Expression during Cancer.

Tomkovich S, Gharaibeh RZ, Dejea CM, Pope JL, Jiang J, Winglee K, Gauthier J, Newsome RC, Yang Y, Fodor AA, Schmittgen TD, Sears CL, Jobin C.

mSystems. 2020 Jan 14;5(1). pii: e00451-19. doi: 10.1128/mSystems.00451-19.

4.

Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin.

Metz P, Tjan MJH, Wu S, Pervaiz M, Hermans S, Shettigar A, Sears CL, Ritschel T, Dutilh BE, Boleij A.

Front Cell Infect Microbiol. 2019 Oct 25;9:364. doi: 10.3389/fcimb.2019.00364. eCollection 2019.

5.

Fecal Transplant in Children With Clostridioides difficile Gives Sustained Reduction in Antimicrobial Resistance and Potential Pathogen Burden.

Hourigan SK, Ahn M, Gibson KM, Pérez-Losada M, Felix G, Weidner M, Leibowitz I, Niederhuber JE, Sears CL, Crandall KA, Oliva-Hemker M.

Open Forum Infect Dis. 2019 Aug 26;6(10):ofz379. doi: 10.1093/ofid/ofz379. eCollection 2019 Oct.

6.

Charting the Path Forward: Development, Goals and Initiatives of the 2019 Infectious Diseases of America Strategic Plan.

Sears CL, File TM, Alexander BD, McQuillen DP, MacIntyre AT, Allen UD, Colasanti JA, Siddiqui J, Reveles KR, Busky C; Infectious Diseases Society of America (IDSA) Board of Directors.

Clin Infect Dis. 2019 Nov 27;69(12):e1-e7. doi: 10.1093/cid/ciz1040.

PMID:
31620782
7.

Impact of the microbiome on checkpoint inhibitor treatment in patients with non-small cell lung cancer and melanoma.

Shaikh FY, Gills JJ, Sears CL.

EBioMedicine. 2019 Oct;48:642-647. doi: 10.1016/j.ebiom.2019.08.076. Epub 2019 Oct 6. Review.

8.

Transmission and clearance of potential procarcinogenic bacteria during fecal microbiota transplantation for recurrent Clostridioides difficile.

Drewes JL, Corona A, Sanchez U, Fan Y, Hourigan SK, Weidner M, Sidhu SD, Simner PJ, Wang H, Timp W, Oliva-Hemker M, Sears CL.

JCI Insight. 2019 Oct 3;4(19). pii: 130848. doi: 10.1172/jci.insight.130848.

9.

Immunopathologic Stratification of Colorectal Cancer for Checkpoint Blockade Immunotherapy.

Llosa NJ, Luber B, Siegel N, Awan AH, Oke T, Zhu Q, Bartlett BR, Aulakh LK, Thompson ED, Jaffee EM, Durham JN, Sears CL, Le DT, Diaz LA Jr, Pardoll DM, Wang H, Housseau F, Anders RA.

Cancer Immunol Res. 2019 Oct;7(10):1574-1579. doi: 10.1158/2326-6066.CIR-18-0927. Epub 2019 Aug 22.

PMID:
31439614
10.

Inclusion, Diversity, Access, and Equity: Perspectives for Infectious Diseases.

Sears CL, Del Rio C, Malani P.

J Infect Dis. 2019 Aug 20;220(Supplement_2):S27-S29. doi: 10.1093/infdis/jiz125. No abstract available.

PMID:
31430379
11.

Oral antibiotic use and risk of colorectal cancer in the United Kingdom, 1989-2012: a matched case-control study.

Zhang J, Haines C, Watson AJM, Hart AR, Platt MJ, Pardoll DM, Cosgrove SE, Gebo KA, Sears CL.

Gut. 2019 Nov;68(11):1971-1978. doi: 10.1136/gutjnl-2019-318593. Epub 2019 Aug 19.

PMID:
31427405
12.

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes.

Riquelme E, Zhang Y, Zhang L, Montiel M, Zoltan M, Dong W, Quesada P, Sahin I, Chandra V, San Lucas A, Scheet P, Xu H, Hanash SM, Feng L, Burks JK, Do KA, Peterson CB, Nejman D, Tzeng CD, Kim MP, Sears CL, Ajami N, Petrosino J, Wood LD, Maitra A, Straussman R, Katz M, White JR, Jenq R, Wargo J, McAllister F.

Cell. 2019 Aug 8;178(4):795-806.e12. doi: 10.1016/j.cell.2019.07.008.

PMID:
31398337
13.

Changes in Gut Microbiome after Bariatric Surgery Versus Medical Weight Loss in a Pilot Randomized Trial.

Lee CJ, Florea L, Sears CL, Maruthur N, Potter JJ, Schweitzer M, Magnuson T, Clark JM.

Obes Surg. 2019 Oct;29(10):3239-3245. doi: 10.1007/s11695-019-03976-4.

PMID:
31256356
14.

Induction of the metal transporter ZIP8 by interferon gamma in intestinal epithelial cells: Potential role of metal dyshomeostasis in Crohn's disease.

Melia JMP, Lin R, Xavier RJ, Thompson RB, Fu D, Wan F, Sears CL, Donowitz M.

Biochem Biophys Res Commun. 2019 Jul 23;515(2):325-331. doi: 10.1016/j.bbrc.2019.05.137. Epub 2019 May 29.

PMID:
31151823
15.

A Summary of the Fight Colorectal Cancer Working Meeting: Exploring Risk Factors and Etiology of Sporadic Early-Age Onset Colorectal Cancer.

Dwyer AJ, Murphy CC, Boland CR, Garcia R, Hampel H, Limburg P, Lowery J, Zauber AG, Waring S, Worrall S, Perea J, Siegel R, Lee J, Molmenti C, Sears CL, Buckhaults P, Hayes R, Hussan H, de Miranda N, Palles C, Diaz L, Song M, Cercek A, Lieu CH, Patel SG, Karlitz JJ, Cao Y, Demb J, Blatchford P, Risendal B, Weltzien E, Wali A, Daschner P, Loomans-Kropp H, Flores R, Levell CL, Wehling K, Martin J, Pesmen C, Kuchar V, Soisson R, Davis A, Ahnen D.

Gastroenterology. 2019 Aug;157(2):280-288. doi: 10.1053/j.gastro.2019.04.049. Epub 2019 May 13. No abstract available.

PMID:
31095950
16.

Gut microbiome and its role in obesity and insulin resistance.

Lee CJ, Sears CL, Maruthur N.

Ann N Y Acad Sci. 2020 Feb;1461(1):37-52. doi: 10.1111/nyas.14107. Epub 2019 May 14. Review.

PMID:
31087391
17.

Intratumoral Adaptive Immunosuppression and Type 17 Immunity in Mismatch Repair Proficient Colorectal Tumors.

Llosa NJ, Luber B, Tam AJ, Smith KN, Siegel N, Awan AH, Fan H, Oke T, Zhang J, Domingue J, Engle EL, Roberts CA, Bartlett BR, Aulakh LK, Thompson ED, Taube JM, Durham JN, Sears CL, Le DT, Diaz LA, Pardoll DM, Wang H, Anders RA, Housseau F.

Clin Cancer Res. 2019 Sep 1;25(17):5250-5259. doi: 10.1158/1078-0432.CCR-19-0114. Epub 2019 May 6.

PMID:
31061070
18.

The Impact of Human Immunodeficiency Virus Infection on Gut Microbiota α-Diversity: An Individual-level Meta-analysis.

Tuddenham SA, Koay WLA, Zhao N, White JR, Ghanem KG, Sears CL; HIV Microbiome Re-analysis Consortium .

Clin Infect Dis. 2020 Feb 3;70(4):615-627. doi: 10.1093/cid/ciz258.

PMID:
30921452
19.

Epigenetic Changes Induced by Bacteroides fragilis Toxin.

Allen J, Hao S, Sears CL, Timp W.

Infect Immun. 2019 May 21;87(6). pii: e00447-18. doi: 10.1128/IAI.00447-18. Print 2019 Jun.

20.

Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic.

Tomkovich S, Dejea CM, Winglee K, Drewes JL, Chung L, Housseau F, Pope JL, Gauthier J, Sun X, Mühlbauer M, Liu X, Fathi P, Anders RA, Besharati S, Perez-Chanona E, Yang Y, Ding H, Wu X, Wu S, White JR, Gharaibeh RZ, Fodor AA, Wang H, Pardoll DM, Jobin C, Sears CL.

J Clin Invest. 2019 Mar 11;130:1699-1712. doi: 10.1172/JCI124196. eCollection 2019 Mar 11.

21.

Correction to: persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1.

Smith KN, Llosa NJ, Cottrell TR, Siegel N, Fan H, Suri P, Chan HY, Guo H, Oke T, Awan AH, Verde F, Danilova L, Anagnostou V, Tam AJ, Luber BS, Bartlett BR, Aulakh LK, Sidhom JW, Zhu Q, Sears CL, Cope L, Sharfman WH, Thompson ED, Riemer J, Marrone KA, Naidoo J, Velculescu VE, Forde PM, Vogelstein B, Kinzler KW, Papadopoulos N, Durham JN, Wang H, Le DT, Justesen S, Taube JM, Diaz LA Jr, Brahmer JR, Pardoll DM, Anders RA, Housseau F.

J Immunother Cancer. 2019 Mar 6;7(1):63. doi: 10.1186/s40425-019-0547-7.

22.
23.

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1.

Smith KN, Llosa NJ, Cottrell TR, Siegel N, Fan H, Suri P, Chan HY, Guo H, Oke T, Awan AH, Verde F, Danilova L, Anagnostou V, Tam AJ, Luber BS, Bartlett BR, Aulakh LK, Sidhom JW, Zhu Q, Sears CL, Cope L, Sharfman WH, Thompson ED, Riemer J, Marrone KA, Naidoo J, Velculescu VE, Forde PM, Vogelstein B, Kinzler KW, Papadopoulos N, Durham JN, Wang H, Le DT, Justesen S, Taube JM, Diaz LA Jr, Brahmer JR, Pardoll DM, Anders RA, Housseau F.

J Immunother Cancer. 2019 Feb 11;7(1):40. doi: 10.1186/s40425-018-0492-x. Erratum in: J Immunother Cancer. 2019 Mar 6;7(1):63.

24.

Erratum: Author Correction: High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia.

Drewes JL, White JR, Dejea CM, Fathi P, Iyadorai T, Vadivelu J, Roslani AC, Wick EC, Mongodin EF, Loke MF, Thulasi K, Gan HM, Goh KL, Chong HY, Kumar S, Wanyiri JW, Sears CL.

NPJ Biofilms Microbiomes. 2019 Jan 9;5:2. doi: 10.1038/s41522-018-0078-x. eCollection 2019.

25.

Decreased Fecal Bacterial Diversity and Altered Microbiome in Children Colonized With Clostridium difficile.

Chen LA, Hourigan SK, Grigoryan Z, Gao Z, Clemente JC, Rideout JR, Chirumamilla S, Rabidazeh S, Saeed S, Elson CO, Oliva-Hemker M, Blaser MJ, Sears CL.

J Pediatr Gastroenterol Nutr. 2019 Apr;68(4):502-508. doi: 10.1097/MPG.0000000000002210.

PMID:
30540709
26.

Non-toxigenic Bacteroides fragilis (NTBF) administration reduces bacteria-driven chronic colitis and tumor development independent of polysaccharide A.

Chan JL, Wu S, Geis AL, Chan GV, Gomes TAM, Beck SE, Wu X, Fan H, Tam AJ, Chung L, Ding H, Wang H, Pardoll DM, Housseau F, Sears CL.

Mucosal Immunol. 2019 Jan;12(1):164-177. doi: 10.1038/s41385-018-0085-5. Epub 2018 Oct 2.

27.

Roles for Interleukin 17 and Adaptive Immunity in Pathogenesis of Colorectal Cancer.

Hurtado CG, Wan F, Housseau F, Sears CL.

Gastroenterology. 2018 Dec;155(6):1706-1715. doi: 10.1053/j.gastro.2018.08.056. Epub 2018 Sep 13. Review.

28.

The Contributions of Physician-Scientists Within Divisions of Infectious Diseases.

Sears CL.

J Infect Dis. 2018 Aug 14;218(suppl_1):S16-S19. doi: 10.1093/infdis/jiy206.

PMID:
30124976
29.

Development and Optimization of Metagenomic Next-Generation Sequencing Methods for Cerebrospinal Fluid Diagnostics.

Simner PJ, Miller HB, Breitwieser FP, Pinilla Monsalve G, Pardo CA, Salzberg SL, Sears CL, Thomas DL, Eberhart CG, Carroll KC.

J Clin Microbiol. 2018 Aug 27;56(9). pii: e00472-18. doi: 10.1128/JCM.00472-18. Print 2018 Sep.

30.

Gut Microbial-Related Choline Metabolite Trimethylamine-N-Oxide Is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection.

Shan Z, Clish CB, Hua S, Scott JM, Hanna DB, Burk RD, Haberlen SA, Shah SJ, Margolick JB, Sears CL, Post WS, Landay AL, Lazar JM, Hodis HN, Anastos K, Kaplan RC, Qi Q.

J Infect Dis. 2018 Sep 22;218(9):1474-1479. doi: 10.1093/infdis/jiy356.

31.

Malaria and the Microbiome: A Systematic Review.

Ippolito MM, Denny JE, Langelier C, Sears CL, Schmidt NW.

Clin Infect Dis. 2018 Nov 28;67(12):1831-1839. doi: 10.1093/cid/ciy374.

32.

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.

Chung L, Orberg ET, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J, Finard BB, Tam AJ, McAllister F, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL, Housseau F.

Cell Host Microbe. 2018 Mar 14;23(3):421. doi: 10.1016/j.chom.2018.02.004. No abstract available.

33.

The who, where and how of fusobacteria and colon cancer.

Sears CL.

Elife. 2018 Mar 13;7. pii: e28434. doi: 10.7554/eLife.28434.

34.

The intestinal microbiome influences checkpoint blockade.

Sears CL, Pardoll DM.

Nat Med. 2018 Mar 6;24(3):254-255. doi: 10.1038/nm.4511. No abstract available.

35.

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.

Dejea CM, Fathi P, Craig JM, Boleij A, Taddese R, Geis AL, Wu X, DeStefano Shields CE, Hechenbleikner EM, Huso DL, Anders RA, Giardiello FM, Wick EC, Wang H, Wu S, Pardoll DM, Housseau F, Sears CL.

Science. 2018 Feb 2;359(6375):592-597. doi: 10.1126/science.aah3648. Epub 2018 Feb 1.

36.

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.

Chung L, Thiele Orberg E, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J, Finard BB, Tam AJ, McAllister F, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL, Housseau F.

Cell Host Microbe. 2018 Feb 14;23(2):203-214.e5. doi: 10.1016/j.chom.2018.01.007. Epub 2018 Feb 1. Erratum in: Cell Host Microbe. 2018 Mar 14;23 (3):421.

37.

High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia.

Drewes JL, White JR, Dejea CM, Fathi P, Iyadorai T, Vadivelu J, Roslani AC, Wick EC, Mongodin EF, Loke MF, Thulasi K, Gan HM, Goh KL, Chong HY, Kumar S, Wanyiri JW, Sears CL.

NPJ Biofilms Microbiomes. 2017 Nov 29;3:34. doi: 10.1038/s41522-017-0040-3. eCollection 2017. Erratum in: NPJ Biofilms Microbiomes. 2019 Jan 9;5:2.

38.

A Blueprint to Advance Colorectal Cancer Immunotherapies.

Le DT, Hubbard-Lucey VM, Morse MA, Heery CR, Dwyer A, Marsilje TH, Brodsky AN, Chan E, Deming DA, Diaz LA Jr, Fridman WH, Goldberg RM, Hamilton SR, Housseau F, Jaffee EM, Kang SP, Krishnamurthi SS, Lieu CH, Messersmith W, Sears CL, Segal NH, Yang A, Moss RA, Cha E, O'Donnell-Tormey J, Roach N, Davis AQ, McAbee K, Worrall S, Benson AB.

Cancer Immunol Res. 2017 Nov;5(11):942-949. doi: 10.1158/2326-6066.CIR-17-0375. Epub 2017 Oct 16.

39.

Microbiota dysbiosis in select human cancers: Evidence of association and causality.

Chen J, Domingue JC, Sears CL.

Semin Immunol. 2017 Aug;32:25-34. doi: 10.1016/j.smim.2017.08.001. Epub 2017 Aug 16. Review.

40.

Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis.

Maiuri AR, Peng M, Podicheti R, Sriramkumar S, Kamplain CM, Rusch DB, DeStefano Shields CE, Sears CL, O'Hagan HM.

Cancer Res. 2017 Jul 1;77(13):3467-3478. doi: 10.1158/0008-5472.CAN-17-0056. Epub 2017 May 18. Erratum in: Cancer Res. 2018 Jan 15;78(2):584.

41.

Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation.

Fu K, Sun X, Wier EM, Hodgson A, Liu Y, Sears CL, Wan F.

Elife. 2016 Jul 25;5. pii: e15018. doi: 10.7554/eLife.15018.

42.

Sporadic colorectal cancer: microbial contributors to disease prevention, development and therapy.

Drewes JL, Housseau F, Sears CL.

Br J Cancer. 2016 Jul 26;115(3):273-80. doi: 10.1038/bjc.2016.189. Epub 2016 Jul 5. Review.

43.

Next-generation sequencing in neuropathologic diagnosis of infections of the nervous system.

Salzberg SL, Breitwieser FP, Kumar A, Hao H, Burger P, Rodriguez FJ, Lim M, Quiñones-Hinojosa A, Gallia GL, Tornheim JA, Melia MT, Sears CL, Pardo CA.

Neurol Neuroimmunol Neuroinflamm. 2016 Jun 13;3(4):e251. doi: 10.1212/NXI.0000000000000251. eCollection 2016 Aug.

44.

The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis.

Thiele Orberg E, Fan H, Tam AJ, Dejea CM, Destefano Shields CE, Wu S, Chung L, Finard BB, Wu X, Fathi P, Ganguly S, Fu J, Pardoll DM, Sears CL, Housseau F.

Mucosal Immunol. 2017 Mar;10(2):421-433. doi: 10.1038/mi.2016.53. Epub 2016 Jun 15.

45.

Do biofilms confer a pro-carcinogenic state?

Dejea CM, Sears CL.

Gut Microbes. 2016;7(1):54-7. doi: 10.1080/19490976.2015.1121363.

46.

Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment.

DeStefano Shields CE, Van Meerbeke SW, Housseau F, Wang H, Huso DL, Casero RA Jr, O'Hagan HM, Sears CL.

J Infect Dis. 2016 Jul 1;214(1):122-9. doi: 10.1093/infdis/jiw069. Epub 2016 Feb 21.

47.

Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis.

Housseau F, Wu S, Wick EC, Fan H, Wu X, Llosa NJ, Smith KN, Tam A, Ganguly S, Wanyiri JW, Iyadorai T, Malik AA, Roslani AC, Vadivelu JS, Van Meerbeke S, Huso DL, Pardoll DM, Sears CL.

Cancer Res. 2016 Apr 15;76(8):2115-24. doi: 10.1158/0008-5472.CAN-15-0749. Epub 2016 Feb 15.

48.

Brief Report: Intestinal Microbiota-Produced Trimethylamine-N-Oxide and Its Association With Coronary Stenosis and HIV Serostatus.

Miller PE, Haberlen SA, Brown TT, Margolick JB, DiDonato JA, Hazen SL, Witt MD, Kingsley LA, Palella FJ Jr, Budoff M, Jacobson LP, Post WS, Sears CL.

J Acquir Immune Defic Syndr. 2016 May 1;72(1):114-8. doi: 10.1097/QAI.0000000000000937.

49.

Clostridium difficile Infection in Pediatric Inflammatory Bowel Disease.

Hourigan SK, Sears CL, Oliva-Hemker M.

Inflamm Bowel Dis. 2016 Apr;22(4):1020-5. doi: 10.1097/MIB.0000000000000666. Review.

50.

The intestinal microbiome and health.

Tuddenham S, Sears CL.

Curr Opin Infect Dis. 2015 Oct;28(5):464-70. doi: 10.1097/QCO.0000000000000196. Review.

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