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Items: 1 to 50 of 119

1.

Decreased Fecal Bacterial Diversity and Altered Microbiome in Children Colonized With Clostridium difficile.

Chen LA, Hourigan SK, Grigoryan Z, Gao Z, Clemente JC, Rideout JR, Chirumamilla S, Rabidazeh S, Saeed S, Elson CO, Oliva-Hemker M, Blaser MJ, Sears CL.

J Pediatr Gastroenterol Nutr. 2018 Dec 11. doi: 10.1097/MPG.0000000000002210. [Epub ahead of print]

PMID:
30540709
2.

Non-toxigenic Bacteroides fragilis (NTBF) administration reduces bacteria-driven chronic colitis and tumor development independent of polysaccharide A.

Chan JL, Wu S, Geis AL, Chan GV, Gomes TAM, Beck SE, Wu X, Fan H, Tam AJ, Chung L, Ding H, Wang H, Pardoll DM, Housseau F, Sears CL.

Mucosal Immunol. 2018 Oct 2. doi: 10.1038/s41385-018-0085-5. [Epub ahead of print]

PMID:
30279518
3.

Roles for Interleukin 17 and Adaptive Immunity in Pathogenesis of Colorectal Cancer.

Hurtado CG, Wan F, Housseau F, Sears CL.

Gastroenterology. 2018 Dec;155(6):1706-1715. doi: 10.1053/j.gastro.2018.08.056. Epub 2018 Sep 13. Review.

PMID:
30218667
4.

The Contributions of Physician-Scientists Within Divisions of Infectious Diseases.

Sears CL.

J Infect Dis. 2018 Aug 14;218(suppl_1):S16-S19. doi: 10.1093/infdis/jiy206.

PMID:
30124976
5.

Development and Optimization of Metagenomic Next-Generation Sequencing Methods for Cerebrospinal Fluid Diagnostics.

Simner PJ, Miller HB, Breitwieser FP, Pinilla Monsalve G, Pardo CA, Salzberg SL, Sears CL, Thomas DL, Eberhart CG, Carroll KC.

J Clin Microbiol. 2018 Aug 27;56(9). pii: e00472-18. doi: 10.1128/JCM.00472-18. Print 2018 Sep.

PMID:
29976594
6.

Gut Microbial-Related Choline Metabolite Trimethylamine-N-Oxide Is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection.

Shan Z, Clish CB, Hua S, Scott JM, Hanna DB, Burk RD, Haberlen SA, Shah SJ, Margolick JB, Sears CL, Post WS, Landay AL, Lazar JM, Hodis HN, Anastos K, Kaplan RC, Qi Q.

J Infect Dis. 2018 Sep 22;218(9):1474-1479. doi: 10.1093/infdis/jiy356.

PMID:
29912352
7.

Malaria and the Microbiome: A Systematic Review.

Ippolito MM, Denny JE, Langelier C, Sears CL, Schmidt NW.

Clin Infect Dis. 2018 Nov 28;67(12):1831-1839. doi: 10.1093/cid/ciy374.

PMID:
29701835
8.

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.

Chung L, Orberg ET, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J, Finard BB, Tam AJ, McAllister F, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL, Housseau F.

Cell Host Microbe. 2018 Mar 14;23(3):421. doi: 10.1016/j.chom.2018.02.004. No abstract available.

PMID:
29544099
9.

The who, where and how of fusobacteria and colon cancer.

Sears CL.

Elife. 2018 Mar 13;7. pii: e28434. doi: 10.7554/eLife.28434.

10.

The intestinal microbiome influences checkpoint blockade.

Sears CL, Pardoll DM.

Nat Med. 2018 Mar 6;24(3):254-255. doi: 10.1038/nm.4511. No abstract available.

PMID:
29509750
11.

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.

Dejea CM, Fathi P, Craig JM, Boleij A, Taddese R, Geis AL, Wu X, DeStefano Shields CE, Hechenbleikner EM, Huso DL, Anders RA, Giardiello FM, Wick EC, Wang H, Wu S, Pardoll DM, Housseau F, Sears CL.

Science. 2018 Feb 2;359(6375):592-597. doi: 10.1126/science.aah3648. Epub 2018 Feb 1.

12.

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.

Chung L, Thiele Orberg E, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J, Finard BB, Tam AJ, McAllister F, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL, Housseau F.

Cell Host Microbe. 2018 Feb 14;23(2):203-214.e5. doi: 10.1016/j.chom.2018.01.007. Epub 2018 Feb 1. Erratum in: Cell Host Microbe. 2018 Mar 14;23 (3):421.

13.

High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia.

Drewes JL, White JR, Dejea CM, Fathi P, Iyadorai T, Vadivelu J, Roslani AC, Wick EC, Mongodin EF, Loke MF, Thulasi K, Gan HM, Goh KL, Chong HY, Kumar S, Wanyiri JW, Sears CL.

NPJ Biofilms Microbiomes. 2017 Nov 29;3:34. doi: 10.1038/s41522-017-0040-3. eCollection 2017.

14.

A Blueprint to Advance Colorectal Cancer Immunotherapies.

Le DT, Hubbard-Lucey VM, Morse MA, Heery CR, Dwyer A, Marsilje TH, Brodsky AN, Chan E, Deming DA, Diaz LA Jr, Fridman WH, Goldberg RM, Hamilton SR, Housseau F, Jaffee EM, Kang SP, Krishnamurthi SS, Lieu CH, Messersmith W, Sears CL, Segal NH, Yang A, Moss RA, Cha E, O'Donnell-Tormey J, Roach N, Davis AQ, McAbee K, Worrall S, Benson AB.

Cancer Immunol Res. 2017 Nov;5(11):942-949. doi: 10.1158/2326-6066.CIR-17-0375. Epub 2017 Oct 16.

15.

Microbiota dysbiosis in select human cancers: Evidence of association and causality.

Chen J, Domingue JC, Sears CL.

Semin Immunol. 2017 Aug;32:25-34. doi: 10.1016/j.smim.2017.08.001. Epub 2017 Aug 16. Review.

16.

Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis.

Maiuri AR, Peng M, Podicheti R, Sriramkumar S, Kamplain CM, Rusch DB, DeStefano Shields CE, Sears CL, O'Hagan HM.

Cancer Res. 2017 Jul 1;77(13):3467-3478. doi: 10.1158/0008-5472.CAN-17-0056. Epub 2017 May 18. Erratum in: Cancer Res. 2018 Jan 15;78(2):584.

17.

Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation.

Fu K, Sun X, Wier EM, Hodgson A, Liu Y, Sears CL, Wan F.

Elife. 2016 Jul 25;5. pii: e15018. doi: 10.7554/eLife.15018.

18.

Sporadic colorectal cancer: microbial contributors to disease prevention, development and therapy.

Drewes JL, Housseau F, Sears CL.

Br J Cancer. 2016 Jul 26;115(3):273-80. doi: 10.1038/bjc.2016.189. Epub 2016 Jul 5. Review.

19.

Next-generation sequencing in neuropathologic diagnosis of infections of the nervous system.

Salzberg SL, Breitwieser FP, Kumar A, Hao H, Burger P, Rodriguez FJ, Lim M, Quiñones-Hinojosa A, Gallia GL, Tornheim JA, Melia MT, Sears CL, Pardo CA.

Neurol Neuroimmunol Neuroinflamm. 2016 Jun 13;3(4):e251. doi: 10.1212/NXI.0000000000000251. eCollection 2016 Aug.

20.

The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis.

Thiele Orberg E, Fan H, Tam AJ, Dejea CM, Destefano Shields CE, Wu S, Chung L, Finard BB, Wu X, Fathi P, Ganguly S, Fu J, Pardoll DM, Sears CL, Housseau F.

Mucosal Immunol. 2017 Mar;10(2):421-433. doi: 10.1038/mi.2016.53. Epub 2016 Jun 15.

21.

Do biofilms confer a pro-carcinogenic state?

Dejea CM, Sears CL.

Gut Microbes. 2016;7(1):54-7. doi: 10.1080/19490976.2015.1121363.

22.

Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment.

DeStefano Shields CE, Van Meerbeke SW, Housseau F, Wang H, Huso DL, Casero RA Jr, O'Hagan HM, Sears CL.

J Infect Dis. 2016 Jul 1;214(1):122-9. doi: 10.1093/infdis/jiw069. Epub 2016 Feb 21.

23.

Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis.

Housseau F, Wu S, Wick EC, Fan H, Wu X, Llosa NJ, Smith KN, Tam A, Ganguly S, Wanyiri JW, Iyadorai T, Malik AA, Roslani AC, Vadivelu JS, Van Meerbeke S, Huso DL, Pardoll DM, Sears CL.

Cancer Res. 2016 Apr 15;76(8):2115-24. doi: 10.1158/0008-5472.CAN-15-0749. Epub 2016 Feb 15.

24.

Brief Report: Intestinal Microbiota-Produced Trimethylamine-N-Oxide and Its Association With Coronary Stenosis and HIV Serostatus.

Miller PE, Haberlen SA, Brown TT, Margolick JB, DiDonato JA, Hazen SL, Witt MD, Kingsley LA, Palella FJ Jr, Budoff M, Jacobson LP, Post WS, Sears CL.

J Acquir Immune Defic Syndr. 2016 May 1;72(1):114-8. doi: 10.1097/QAI.0000000000000937.

25.

Clostridium difficile Infection in Pediatric Inflammatory Bowel Disease.

Hourigan SK, Sears CL, Oliva-Hemker M.

Inflamm Bowel Dis. 2016 Apr;22(4):1020-5. doi: 10.1097/MIB.0000000000000666. Review.

26.

The intestinal microbiome and health.

Tuddenham S, Sears CL.

Curr Opin Infect Dis. 2015 Oct;28(5):464-70. doi: 10.1097/QCO.0000000000000196. Review.

27.

Regulatory T-cell Response to Enterotoxigenic Bacteroides fragilis Colonization Triggers IL17-Dependent Colon Carcinogenesis.

Geis AL, Fan H, Wu X, Wu S, Huso DL, Wolfe JL, Sears CL, Pardoll DM, Housseau F.

Cancer Discov. 2015 Oct;5(10):1098-109. doi: 10.1158/2159-8290.CD-15-0447. Epub 2015 Jul 22.

28.

Microbiome changes associated with sustained eradication of Clostridium difficile after single faecal microbiota transplantation in children with and without inflammatory bowel disease.

Hourigan SK, Chen LA, Grigoryan Z, Laroche G, Weidner M, Sears CL, Oliva-Hemker M.

Aliment Pharmacol Ther. 2015 Sep;42(6):741-52. doi: 10.1111/apt.13326. Epub 2015 Jul 21.

29.

Metabolism links bacterial biofilms and colon carcinogenesis.

Johnson CH, Dejea CM, Edler D, Hoang LT, Santidrian AF, Felding BH, Ivanisevic J, Cho K, Wick EC, Hechenbleikner EM, Uritboonthai W, Goetz L, Casero RA Jr, Pardoll DM, White JR, Patti GJ, Sears CL, Siuzdak G.

Cell Metab. 2015 Jun 2;21(6):891-7. doi: 10.1016/j.cmet.2015.04.011. Epub 2015 May 7.

30.

Microbiota organization is a distinct feature of proximal colorectal cancers.

Dejea CM, Wick EC, Hechenbleikner EM, White JR, Mark Welch JL, Rossetti BJ, Peterson SN, Snesrud EC, Borisy GG, Lazarev M, Stein E, Vadivelu J, Roslani AC, Malik AA, Wanyiri JW, Goh KL, Thevambiga I, Fu K, Wan F, Llosa N, Housseau F, Romans K, Wu X, McAllister FM, Wu S, Vogelstein B, Kinzler KW, Pardoll DM, Sears CL.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18321-6. doi: 10.1073/pnas.1406199111. Epub 2014 Dec 8.

31.

The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints.

Llosa NJ, Cruise M, Tam A, Wicks EC, Hechenbleikner EM, Taube JM, Blosser RL, Fan H, Wang H, Luber BS, Zhang M, Papadopoulos N, Kinzler KW, Vogelstein B, Sears CL, Anders RA, Pardoll DM, Housseau F.

Cancer Discov. 2015 Jan;5(1):43-51. doi: 10.1158/2159-8290.CD-14-0863. Epub 2014 Oct 30.

32.

The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients.

Boleij A, Hechenbleikner EM, Goodwin AC, Badani R, Stein EM, Lazarev MG, Ellis B, Carroll KC, Albesiano E, Wick EC, Platz EA, Pardoll DM, Sears CL.

Clin Infect Dis. 2015 Jan 15;60(2):208-15. doi: 10.1093/cid/ciu787. Epub 2014 Oct 9.

33.

John G. Bartlett: a transformative, visionary leader of Johns Hopkins Infectious Diseases.

Auwaerter PG, Quinn TC, Sears CL, Thomas DL.

Clin Infect Dis. 2014 Sep 15;59 Suppl 2:S61-2. doi: 10.1093/cid/ciu440. No abstract available.

PMID:
25151478
34.

Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis.

Sears CL, Geis AL, Housseau F.

J Clin Invest. 2014 Oct;124(10):4166-72. doi: 10.1172/JCI72334. Epub 2014 Aug 8. Review.

35.

Microbiota and immune responses in colon cancer: more to learn.

McAllister F, Housseau F, Sears CL.

Cancer J. 2014 May-Jun;20(3):232-6. doi: 10.1097/PPO.0000000000000051. Review.

36.

Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia.

McAllister F, Bailey JM, Alsina J, Nirschl CJ, Sharma R, Fan H, Rattigan Y, Roeser JC, Lankapalli RH, Zhang H, Jaffee EM, Drake CG, Housseau F, Maitra A, Kolls JK, Sears CL, Pardoll DM, Leach SD.

Cancer Cell. 2014 May 12;25(5):621-37. doi: 10.1016/j.ccr.2014.03.014.

37.

Stat3 activation in murine colitis induced by enterotoxigenic Bacteroides fragilis.

Wick EC, Rabizadeh S, Albesiano E, Wu X, Wu S, Chan J, Rhee KJ, Ortega G, Huso DL, Pardoll D, Housseau F, Sears CL.

Inflamm Bowel Dis. 2014 May;20(5):821-34. doi: 10.1097/MIB.0000000000000019.

38.

Microbes, microbiota, and colon cancer.

Sears CL, Garrett WS.

Cell Host Microbe. 2014 Mar 12;15(3):317-28. doi: 10.1016/j.chom.2014.02.007. Review.

39.

Introduction to the special issue highlighting Anaerobe 2012.

Aronoff DM, Marrazzo JM, Sears CL.

Anaerobe. 2013 Dec;24:85-6. doi: 10.1016/j.anaerobe.2013.08.008. Epub 2013 Aug 30. No abstract available.

PMID:
23999247
40.

Clostridium difficile in a HIV-infected cohort: incidence, risk factors, and clinical outcomes.

Haines CF, Moore RD, Bartlett JG, Sears CL, Cosgrove SE, Carroll K, Gebo KA.

AIDS. 2013 Nov 13;27(17):2799-807. doi: 10.1097/01.aids.0000432450.37863.e9.

41.

Bacterial oncogenesis in the colon.

Dejea C, Wick E, Sears CL.

Future Microbiol. 2013 Apr;8(4):445-60. doi: 10.2217/fmb.13.17. Review.

42.

In celebration of Sydney M. Finegold, M.D.: bacteroides fragilis in the colon: the good & the bad.

Sears CL.

Anaerobe. 2012 Apr;18(2):192-6. doi: 10.1016/j.anaerobe.2012.01.005. Epub 2012 Jan 25.

PMID:
22306866
43.

Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.

O'Hagan HM, Wang W, Sen S, Destefano Shields C, Lee SS, Zhang YW, Clements EG, Cai Y, Van Neste L, Easwaran H, Casero RA, Sears CL, Baylin SB.

Cancer Cell. 2011 Nov 15;20(5):606-19. doi: 10.1016/j.ccr.2011.09.012.

44.

Shift from pStat6 to pStat3 predominance is associated with inflammatory bowel disease-associated dysplasia.

Wick EC, LeBlanc RE, Ortega G, Robinson C, Platz E, Pardoll DM, Iacobuzio-Donahue C, Sears CL.

Inflamm Bowel Dis. 2012 Jul;18(7):1267-74. doi: 10.1002/ibd.21908. Epub 2011 Oct 21.

45.

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis.

Goodwin AC, Destefano Shields CE, Wu S, Huso DL, Wu X, Murray-Stewart TR, Hacker-Prietz A, Rabizadeh S, Woster PM, Sears CL, Casero RA Jr.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15354-9. doi: 10.1073/pnas.1010203108. Epub 2011 Aug 29.

46.

Perspective: alpha-bugs, their microbial partners, and the link to colon cancer.

Sears CL, Pardoll DM.

J Infect Dis. 2011 Feb 1;203(3):306-11. doi: 10.1093/jinfdis/jiq061. Epub 2010 Dec 8. No abstract available.

47.

Bacteroides spp. and diarrhea.

Wick EC, Sears CL.

Curr Opin Infect Dis. 2010 Oct;23(5):470-4. doi: 10.1097/QCO.0b013e32833da1eb. Review.

48.

Overactive bladder medication adherence when medication is free to patients.

Sears CL, Lewis C, Noel K, Albright TS, Fischer JR.

J Urol. 2010 Mar;183(3):1077-81. doi: 10.1016/j.juro.2009.11.026. Epub 2010 Jan 21.

PMID:
20092838
49.

IV or not IV? Just one of the antibiotic questions in Whipple's disease.

Sears CL, Cosgrove SE.

Gastroenterology. 2010 Feb;138(2):422-6. doi: 10.1053/j.gastro.2009.12.011. Epub 2009 Dec 22. No abstract available.

PMID:
20034604
50.

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