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Items: 1 to 50 of 129

1.

A summary of the Fight Colorectal Cancer working meeting: exploring risk factors and etiology of sporadic early-age onset colorectal cancer.

Dwyer AJ, Murphy CC, Boland CR, Garcia R, Hampel H, Limburg P, Lowery J, Zauber AG, Waring S, Worrall S, Perea J, Siegel R, Lee J, Molmenti C, Sears CL, Buckhaults P, Hayes R, Hussan H, de Miranda N, Palles C, Diaz L, Song M, Cercek A, Lieu CH, Patel SG, Karlitz JJ, Cao Y, Demb J, Blatchford P, Risendal B, Weltzien E, Wali A, Daschner P, Loomans-Kropp H, R F, Levell CL, Wehling K, Martin J, Pesmen C, Kuchar V, Soisson R, Davis A, Ahnen D.

Gastroenterology. 2019 May 13. pii: S0016-5085(19)40882-2. doi: 10.1053/j.gastro.2019.04.049. [Epub ahead of print] No abstract available.

PMID:
31095950
2.

Gut microbiome and its role in obesity and insulin resistance.

Lee CJ, Sears CL, Maruthur N.

Ann N Y Acad Sci. 2019 May 14. doi: 10.1111/nyas.14107. [Epub ahead of print] Review.

PMID:
31087391
3.

INTRATUMORAL ADAPTIVE IMMUNOSUPPRESSION AND TYPE 17 IMMUNITY IN MISMATCH REPAIR PROFICIENT COLORECTAL TUMORS.

Llosa NJ, Luber B, Tam AJ, Smith KN, Siegel N, Awan AH, Fan H, Oke T, Zhang J, Domingue J, Engle EL, Roberts CA, Bartlett BR, Aulakh LK, Thompson ED, Taube JM, Durham JN, Sears CL, Le DT, Diaz LA, Pardoll DM, Wang H, Anders R, Housseau F.

Clin Cancer Res. 2019 May 6. pii: clincanres.0114.2019. doi: 10.1158/1078-0432.CCR-19-0114. [Epub ahead of print]

PMID:
31061070
4.

The Impact of HIV Infection on Gut Microbiota Alpha-Diversity: An Individual Level Meta-analysis.

Tuddenham SA, Koay WLA, Zhao N, White JR, Ghanem KG, Sears CL; HIV Microbiome Re-analysis Consortium.

Clin Infect Dis. 2019 Mar 28. pii: ciz258. doi: 10.1093/cid/ciz258. [Epub ahead of print]

PMID:
30921452
5.

Epigenetic changes induced by Bacteroides fragilis toxin (BFT).

Allen J, Hao S, Sears CL, Timp W.

Infect Immun. 2019 Mar 18. pii: IAI.00447-18. doi: 10.1128/IAI.00447-18. [Epub ahead of print]

PMID:
30885929
6.

Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic.

Tomkovich S, Dejea CM, Winglee K, Drewes JL, Chung L, Housseau F, Pope JL, Gauthier J, Sun X, Mühlbauer M, Liu X, Fathi P, Anders RA, Besharati S, Perez-Chanona E, Yang Y, Ding H, Wu X, Wu S, White JR, Gharaibeh RZ, Fodor AA, Wang H, Pardoll DM, Jobin C, Sears CL.

J Clin Invest. 2019 Mar 11;130:1699-1712. doi: 10.1172/JCI124196. eCollection 2019 Mar 11.

7.

Correction to: persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1.

Smith KN, Llosa NJ, Cottrell TR, Siegel N, Fan H, Suri P, Chan HY, Guo H, Oke T, Awan AH, Verde F, Danilova L, Anagnostou V, Tam AJ, Luber BS, Bartlett BR, Aulakh LK, Sidhom JW, Zhu Q, Sears CL, Cope L, Sharfman WH, Thompson ED, Riemer J, Marrone KA, Naidoo J, Velculescu VE, Forde PM, Vogelstein B, Kinzler KW, Papadopoulos N, Durham JN, Wang H, Le DT, Justesen S, Taube JM, Diaz LA Jr, Brahmer JR, Pardoll DM, Anders RA, Housseau F.

J Immunother Cancer. 2019 Mar 6;7(1):63. doi: 10.1186/s40425-019-0547-7.

8.
9.

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1.

Smith KN, Llosa NJ, Cottrell TR, Siegel N, Fan H, Suri P, Chan HY, Guo H, Oke T, Awan AH, Verde F, Danilova L, Anagnostou V, Tam AJ, Luber BS, Bartlett BR, Aulakh LK, Sidhom JW, Zhu Q, Sears CL, Cope L, Sharfman WH, Thompson ED, Riemer J, Marrone KA, Naidoo J, Velculescu VE, Forde PM, Vogelstein B, Kinzler KW, Papadopoulos N, Durham JN, Wang H, Le DT, Justesen S, Taube JM, Diaz LA Jr, Brahmer JR, Pardoll DM, Anders RA, Housseau F.

J Immunother Cancer. 2019 Feb 11;7(1):40. doi: 10.1186/s40425-018-0492-x. Erratum in: J Immunother Cancer. 2019 Mar 6;7(1):63.

10.

Erratum: Author Correction: High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia.

Drewes JL, White JR, Dejea CM, Fathi P, Iyadorai T, Vadivelu J, Roslani AC, Wick EC, Mongodin EF, Loke MF, Thulasi K, Gan HM, Goh KL, Chong HY, Kumar S, Wanyiri JW, Sears CL.

NPJ Biofilms Microbiomes. 2019 Jan 9;5:2. doi: 10.1038/s41522-018-0078-x. eCollection 2019.

11.

Decreased Fecal Bacterial Diversity and Altered Microbiome in Children Colonized With Clostridium difficile.

Chen LA, Hourigan SK, Grigoryan Z, Gao Z, Clemente JC, Rideout JR, Chirumamilla S, Rabidazeh S, Saeed S, Elson CO, Oliva-Hemker M, Blaser MJ, Sears CL.

J Pediatr Gastroenterol Nutr. 2019 Apr;68(4):502-508. doi: 10.1097/MPG.0000000000002210.

PMID:
30540709
12.

Non-toxigenic Bacteroides fragilis (NTBF) administration reduces bacteria-driven chronic colitis and tumor development independent of polysaccharide A.

Chan JL, Wu S, Geis AL, Chan GV, Gomes TAM, Beck SE, Wu X, Fan H, Tam AJ, Chung L, Ding H, Wang H, Pardoll DM, Housseau F, Sears CL.

Mucosal Immunol. 2019 Jan;12(1):164-177. doi: 10.1038/s41385-018-0085-5. Epub 2018 Oct 2.

13.

Roles for Interleukin 17 and Adaptive Immunity in Pathogenesis of Colorectal Cancer.

Hurtado CG, Wan F, Housseau F, Sears CL.

Gastroenterology. 2018 Dec;155(6):1706-1715. doi: 10.1053/j.gastro.2018.08.056. Epub 2018 Sep 13. Review.

14.

The Contributions of Physician-Scientists Within Divisions of Infectious Diseases.

Sears CL.

J Infect Dis. 2018 Aug 14;218(suppl_1):S16-S19. doi: 10.1093/infdis/jiy206.

PMID:
30124976
15.

Development and Optimization of Metagenomic Next-Generation Sequencing Methods for Cerebrospinal Fluid Diagnostics.

Simner PJ, Miller HB, Breitwieser FP, Pinilla Monsalve G, Pardo CA, Salzberg SL, Sears CL, Thomas DL, Eberhart CG, Carroll KC.

J Clin Microbiol. 2018 Aug 27;56(9). pii: e00472-18. doi: 10.1128/JCM.00472-18. Print 2018 Sep.

16.

Gut Microbial-Related Choline Metabolite Trimethylamine-N-Oxide Is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection.

Shan Z, Clish CB, Hua S, Scott JM, Hanna DB, Burk RD, Haberlen SA, Shah SJ, Margolick JB, Sears CL, Post WS, Landay AL, Lazar JM, Hodis HN, Anastos K, Kaplan RC, Qi Q.

J Infect Dis. 2018 Sep 22;218(9):1474-1479. doi: 10.1093/infdis/jiy356.

PMID:
29912352
17.

Malaria and the Microbiome: A Systematic Review.

Ippolito MM, Denny JE, Langelier C, Sears CL, Schmidt NW.

Clin Infect Dis. 2018 Nov 28;67(12):1831-1839. doi: 10.1093/cid/ciy374.

PMID:
29701835
18.

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.

Chung L, Orberg ET, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J, Finard BB, Tam AJ, McAllister F, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL, Housseau F.

Cell Host Microbe. 2018 Mar 14;23(3):421. doi: 10.1016/j.chom.2018.02.004. No abstract available.

19.

The who, where and how of fusobacteria and colon cancer.

Sears CL.

Elife. 2018 Mar 13;7. pii: e28434. doi: 10.7554/eLife.28434.

20.

The intestinal microbiome influences checkpoint blockade.

Sears CL, Pardoll DM.

Nat Med. 2018 Mar 6;24(3):254-255. doi: 10.1038/nm.4511. No abstract available.

21.

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.

Dejea CM, Fathi P, Craig JM, Boleij A, Taddese R, Geis AL, Wu X, DeStefano Shields CE, Hechenbleikner EM, Huso DL, Anders RA, Giardiello FM, Wick EC, Wang H, Wu S, Pardoll DM, Housseau F, Sears CL.

Science. 2018 Feb 2;359(6375):592-597. doi: 10.1126/science.aah3648. Epub 2018 Feb 1.

22.

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.

Chung L, Thiele Orberg E, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J, Finard BB, Tam AJ, McAllister F, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL, Housseau F.

Cell Host Microbe. 2018 Feb 14;23(2):203-214.e5. doi: 10.1016/j.chom.2018.01.007. Epub 2018 Feb 1. Erratum in: Cell Host Microbe. 2018 Mar 14;23 (3):421.

23.

High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia.

Drewes JL, White JR, Dejea CM, Fathi P, Iyadorai T, Vadivelu J, Roslani AC, Wick EC, Mongodin EF, Loke MF, Thulasi K, Gan HM, Goh KL, Chong HY, Kumar S, Wanyiri JW, Sears CL.

NPJ Biofilms Microbiomes. 2017 Nov 29;3:34. doi: 10.1038/s41522-017-0040-3. eCollection 2017. Erratum in: NPJ Biofilms Microbiomes. 2019 Jan 9;5:2.

24.

A Blueprint to Advance Colorectal Cancer Immunotherapies.

Le DT, Hubbard-Lucey VM, Morse MA, Heery CR, Dwyer A, Marsilje TH, Brodsky AN, Chan E, Deming DA, Diaz LA Jr, Fridman WH, Goldberg RM, Hamilton SR, Housseau F, Jaffee EM, Kang SP, Krishnamurthi SS, Lieu CH, Messersmith W, Sears CL, Segal NH, Yang A, Moss RA, Cha E, O'Donnell-Tormey J, Roach N, Davis AQ, McAbee K, Worrall S, Benson AB.

Cancer Immunol Res. 2017 Nov;5(11):942-949. doi: 10.1158/2326-6066.CIR-17-0375. Epub 2017 Oct 16.

25.

Microbiota dysbiosis in select human cancers: Evidence of association and causality.

Chen J, Domingue JC, Sears CL.

Semin Immunol. 2017 Aug;32:25-34. doi: 10.1016/j.smim.2017.08.001. Epub 2017 Aug 16. Review.

26.

Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis.

Maiuri AR, Peng M, Podicheti R, Sriramkumar S, Kamplain CM, Rusch DB, DeStefano Shields CE, Sears CL, O'Hagan HM.

Cancer Res. 2017 Jul 1;77(13):3467-3478. doi: 10.1158/0008-5472.CAN-17-0056. Epub 2017 May 18. Erratum in: Cancer Res. 2018 Jan 15;78(2):584.

27.

Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation.

Fu K, Sun X, Wier EM, Hodgson A, Liu Y, Sears CL, Wan F.

Elife. 2016 Jul 25;5. pii: e15018. doi: 10.7554/eLife.15018.

28.

Sporadic colorectal cancer: microbial contributors to disease prevention, development and therapy.

Drewes JL, Housseau F, Sears CL.

Br J Cancer. 2016 Jul 26;115(3):273-80. doi: 10.1038/bjc.2016.189. Epub 2016 Jul 5. Review.

29.

Next-generation sequencing in neuropathologic diagnosis of infections of the nervous system.

Salzberg SL, Breitwieser FP, Kumar A, Hao H, Burger P, Rodriguez FJ, Lim M, Quiñones-Hinojosa A, Gallia GL, Tornheim JA, Melia MT, Sears CL, Pardo CA.

Neurol Neuroimmunol Neuroinflamm. 2016 Jun 13;3(4):e251. doi: 10.1212/NXI.0000000000000251. eCollection 2016 Aug.

30.

The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis.

Thiele Orberg E, Fan H, Tam AJ, Dejea CM, Destefano Shields CE, Wu S, Chung L, Finard BB, Wu X, Fathi P, Ganguly S, Fu J, Pardoll DM, Sears CL, Housseau F.

Mucosal Immunol. 2017 Mar;10(2):421-433. doi: 10.1038/mi.2016.53. Epub 2016 Jun 15.

31.

Do biofilms confer a pro-carcinogenic state?

Dejea CM, Sears CL.

Gut Microbes. 2016;7(1):54-7. doi: 10.1080/19490976.2015.1121363.

32.

Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment.

DeStefano Shields CE, Van Meerbeke SW, Housseau F, Wang H, Huso DL, Casero RA Jr, O'Hagan HM, Sears CL.

J Infect Dis. 2016 Jul 1;214(1):122-9. doi: 10.1093/infdis/jiw069. Epub 2016 Feb 21.

33.

Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis.

Housseau F, Wu S, Wick EC, Fan H, Wu X, Llosa NJ, Smith KN, Tam A, Ganguly S, Wanyiri JW, Iyadorai T, Malik AA, Roslani AC, Vadivelu JS, Van Meerbeke S, Huso DL, Pardoll DM, Sears CL.

Cancer Res. 2016 Apr 15;76(8):2115-24. doi: 10.1158/0008-5472.CAN-15-0749. Epub 2016 Feb 15.

34.

Brief Report: Intestinal Microbiota-Produced Trimethylamine-N-Oxide and Its Association With Coronary Stenosis and HIV Serostatus.

Miller PE, Haberlen SA, Brown TT, Margolick JB, DiDonato JA, Hazen SL, Witt MD, Kingsley LA, Palella FJ Jr, Budoff M, Jacobson LP, Post WS, Sears CL.

J Acquir Immune Defic Syndr. 2016 May 1;72(1):114-8. doi: 10.1097/QAI.0000000000000937.

35.

Clostridium difficile Infection in Pediatric Inflammatory Bowel Disease.

Hourigan SK, Sears CL, Oliva-Hemker M.

Inflamm Bowel Dis. 2016 Apr;22(4):1020-5. doi: 10.1097/MIB.0000000000000666. Review.

36.

The intestinal microbiome and health.

Tuddenham S, Sears CL.

Curr Opin Infect Dis. 2015 Oct;28(5):464-70. doi: 10.1097/QCO.0000000000000196. Review.

37.

Regulatory T-cell Response to Enterotoxigenic Bacteroides fragilis Colonization Triggers IL17-Dependent Colon Carcinogenesis.

Geis AL, Fan H, Wu X, Wu S, Huso DL, Wolfe JL, Sears CL, Pardoll DM, Housseau F.

Cancer Discov. 2015 Oct;5(10):1098-109. doi: 10.1158/2159-8290.CD-15-0447. Epub 2015 Jul 22.

38.

Microbiome changes associated with sustained eradication of Clostridium difficile after single faecal microbiota transplantation in children with and without inflammatory bowel disease.

Hourigan SK, Chen LA, Grigoryan Z, Laroche G, Weidner M, Sears CL, Oliva-Hemker M.

Aliment Pharmacol Ther. 2015 Sep;42(6):741-52. doi: 10.1111/apt.13326. Epub 2015 Jul 21.

39.

Metabolism links bacterial biofilms and colon carcinogenesis.

Johnson CH, Dejea CM, Edler D, Hoang LT, Santidrian AF, Felding BH, Ivanisevic J, Cho K, Wick EC, Hechenbleikner EM, Uritboonthai W, Goetz L, Casero RA Jr, Pardoll DM, White JR, Patti GJ, Sears CL, Siuzdak G.

Cell Metab. 2015 Jun 2;21(6):891-7. doi: 10.1016/j.cmet.2015.04.011. Epub 2015 May 7.

40.

Microbiota organization is a distinct feature of proximal colorectal cancers.

Dejea CM, Wick EC, Hechenbleikner EM, White JR, Mark Welch JL, Rossetti BJ, Peterson SN, Snesrud EC, Borisy GG, Lazarev M, Stein E, Vadivelu J, Roslani AC, Malik AA, Wanyiri JW, Goh KL, Thevambiga I, Fu K, Wan F, Llosa N, Housseau F, Romans K, Wu X, McAllister FM, Wu S, Vogelstein B, Kinzler KW, Pardoll DM, Sears CL.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18321-6. doi: 10.1073/pnas.1406199111. Epub 2014 Dec 8.

41.

The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints.

Llosa NJ, Cruise M, Tam A, Wicks EC, Hechenbleikner EM, Taube JM, Blosser RL, Fan H, Wang H, Luber BS, Zhang M, Papadopoulos N, Kinzler KW, Vogelstein B, Sears CL, Anders RA, Pardoll DM, Housseau F.

Cancer Discov. 2015 Jan;5(1):43-51. doi: 10.1158/2159-8290.CD-14-0863. Epub 2014 Oct 30.

42.

The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients.

Boleij A, Hechenbleikner EM, Goodwin AC, Badani R, Stein EM, Lazarev MG, Ellis B, Carroll KC, Albesiano E, Wick EC, Platz EA, Pardoll DM, Sears CL.

Clin Infect Dis. 2015 Jan 15;60(2):208-15. doi: 10.1093/cid/ciu787. Epub 2014 Oct 9.

43.

John G. Bartlett: a transformative, visionary leader of Johns Hopkins Infectious Diseases.

Auwaerter PG, Quinn TC, Sears CL, Thomas DL.

Clin Infect Dis. 2014 Sep 15;59 Suppl 2:S61-2. doi: 10.1093/cid/ciu440. No abstract available.

PMID:
25151478
44.

Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis.

Sears CL, Geis AL, Housseau F.

J Clin Invest. 2014 Oct;124(10):4166-72. doi: 10.1172/JCI72334. Epub 2014 Aug 8. Review.

45.

Microbiota and immune responses in colon cancer: more to learn.

McAllister F, Housseau F, Sears CL.

Cancer J. 2014 May-Jun;20(3):232-6. doi: 10.1097/PPO.0000000000000051. Review.

46.

Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia.

McAllister F, Bailey JM, Alsina J, Nirschl CJ, Sharma R, Fan H, Rattigan Y, Roeser JC, Lankapalli RH, Zhang H, Jaffee EM, Drake CG, Housseau F, Maitra A, Kolls JK, Sears CL, Pardoll DM, Leach SD.

Cancer Cell. 2014 May 12;25(5):621-37. doi: 10.1016/j.ccr.2014.03.014.

47.

Stat3 activation in murine colitis induced by enterotoxigenic Bacteroides fragilis.

Wick EC, Rabizadeh S, Albesiano E, Wu X, Wu S, Chan J, Rhee KJ, Ortega G, Huso DL, Pardoll D, Housseau F, Sears CL.

Inflamm Bowel Dis. 2014 May;20(5):821-34. doi: 10.1097/MIB.0000000000000019.

48.

Microbes, microbiota, and colon cancer.

Sears CL, Garrett WS.

Cell Host Microbe. 2014 Mar 12;15(3):317-28. doi: 10.1016/j.chom.2014.02.007. Review.

49.

Introduction to the special issue highlighting Anaerobe 2012.

Aronoff DM, Marrazzo JM, Sears CL.

Anaerobe. 2013 Dec;24:85-6. doi: 10.1016/j.anaerobe.2013.08.008. Epub 2013 Aug 30. No abstract available.

PMID:
23999247
50.

Clostridium difficile in a HIV-infected cohort: incidence, risk factors, and clinical outcomes.

Haines CF, Moore RD, Bartlett JG, Sears CL, Cosgrove SE, Carroll K, Gebo KA.

AIDS. 2013 Nov 13;27(17):2799-807. doi: 10.1097/01.aids.0000432450.37863.e9.

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