Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 61


A bipartite sorting signal ensures specificity of retromer complex in membrane protein recycling.

Suzuki SW, Chuang YS, Li M, Seaman MNJ, Emr SD.

J Cell Biol. 2019 Sep 2;218(9):2876-2886. doi: 10.1083/jcb.201901019. Epub 2019 Jul 23.


Retromer and Its Role in Regulating Signaling at Endosomes.

Seaman MNJ.

Prog Mol Subcell Biol. 2018;57:137-149. doi: 10.1007/978-3-319-96704-2_5. Review.


Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex.

Seaman MNJ, Mukadam AS, Breusegem SY.

J Cell Sci. 2018 Jun 21;131(12). pii: jcs217398. doi: 10.1242/jcs.217398.


Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing.

Mukadam AS, Breusegem SY, Seaman MNJ.

Cell Mol Life Sci. 2018 Jul;75(14):2613-2625. doi: 10.1007/s00018-018-2752-9. Epub 2018 Jan 24.


Retromer and the cation-independent mannose 6-phosphate receptor-Time for a trial separation?

Seaman MNJ.

Traffic. 2018 Feb;19(2):150-152. doi: 10.1111/tra.12542. Epub 2017 Dec 21. Review.


Calnuc Function in Endosomal Sorting of Lysosomal Receptors.

Larkin H, Costantino S, Seaman MN, Lavoie C.

Traffic. 2016 Apr;17(4):416-32. doi: 10.1111/tra.12374. Epub 2016 Feb 12.


De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease.

Rovelet-Lecrux A, Charbonnier C, Wallon D, Nicolas G, Seaman MN, Pottier C, Breusegem SY, Mathur PP, Jenardhanan P, Le Guennec K, Mukadam AS, Quenez O, Coutant S, Rousseau S, Richard AC, Boland A, Deleuze JF, Frebourg T, Hannequin D, Campion D; CNR-MAJ collaborators.

Mol Psychiatry. 2015 Sep;20(9):1046-56. doi: 10.1038/mp.2015.100. Epub 2015 Jul 21.


Retromer-mediated endosomal protein sorting: The role of unstructured domains.

Mukadam AS, Seaman MN.

FEBS Lett. 2015 Sep 14;589(19 Pt A):2620-6. doi: 10.1016/j.febslet.2015.05.052. Epub 2015 Jun 10. Review.


Genome-wide RNAi screen reveals a role for multipass membrane proteins in endosome-to-golgi retrieval.

Breusegem SY, Seaman MNJ.

Cell Rep. 2014 Dec 11;9(5):1931-1945. doi: 10.1016/j.celrep.2014.10.053. Epub 2014 Nov 20.


Analysis of the Retromer complex-WASH complex interaction illuminates new avenues to explore in Parkinson disease.

Seaman MNj, Freeman CL.

Commun Integr Biol. 2014 Jun 13;7:e29483. doi: 10.4161/cib.29483. eCollection 2014.


VPS35 Parkinson mutation impairs autophagy via WASH.

Zavodszky E, Seaman MN, Rubinsztein DC.

Cell Cycle. 2014;13(14):2155-6. doi: 10.4161/cc.29734. Epub 2014 Jun 25. No abstract available.


VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface.

Hesketh GG, Pérez-Dorado I, Jackson LP, Wartosch L, Schäfer IB, Gray SR, McCoy AJ, Zeldin OB, Garman EF, Harbour ME, Evans PR, Seaman MNJ, Luzio JP, Owen DJ.

Dev Cell. 2014 Jun 9;29(5):591-606. doi: 10.1016/j.devcel.2014.04.010. Epub 2014 May 22.


Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy.

Zavodszky E, Seaman MN, Moreau K, Jimenez-Sanchez M, Breusegem SY, Harbour ME, Rubinsztein DC.

Nat Commun. 2014 May 13;5:3828. doi: 10.1038/ncomms4828.


RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation.

Freeman CL, Hesketh G, Seaman MN.

J Cell Sci. 2014 May 1;127(Pt 9):2053-70. doi: 10.1242/jcs.144659. Epub 2014 Mar 18.


Image-based and biochemical assays to investigate endosomal protein sorting.

Breusegem SY, Seaman MN.

Methods Enzymol. 2014;534:155-78. doi: 10.1016/B978-0-12-397926-1.00009-3.


Response to letter by Insall.

Seaman MN, Gautreau A, Billadeau DD.

Trends Cell Biol. 2013 Nov;23(11):520-1. doi: 10.1016/j.tcb.2013.07.012. Epub 2013 Aug 26. No abstract available.


An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome.

Allison R, Lumb JH, Fassier C, Connell JW, Ten Martin D, Seaman MN, Hazan J, Reid E.

J Cell Biol. 2013 Aug 5;202(3):527-43. doi: 10.1083/jcb.201211045. Epub 2013 Jul 29.


Retromer-mediated endosomal protein sorting: all WASHed up!

Seaman MN, Gautreau A, Billadeau DD.

Trends Cell Biol. 2013 Nov;23(11):522-8. doi: 10.1016/j.tcb.2013.04.010. Epub 2013 May 28. Review.


The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα.

Ryder PV, Vistein R, Gokhale A, Seaman MN, Puthenveedu MA, Faundez V.

Mol Biol Cell. 2013 Jul;24(14):2269-84. doi: 10.1091/mbc.E13-02-0088. Epub 2013 May 15.


Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer.

Helfer E, Harbour ME, Henriot V, Lakisic G, Sousa-Blin C, Volceanov L, Seaman MNJ, Gautreau A.

Biol Cell. 2013 May;105(5):191-207. doi: 10.1111/boc.201200038. Epub 2013 Mar 7.


N-acetylation and phosphorylation of Sec complex subunits in the ER membrane.

Soromani C, Zeng N, Hollemeyer K, Heinzle E, Klein MC, Tretter T, Seaman MN, Römisch K.

BMC Cell Biol. 2012 Dec 13;13:34. doi: 10.1186/1471-2121-13-34.


Rab7 mutants associated with Charcot-Marie-Tooth disease cause delayed growth factor receptor transport and altered endosomal and nuclear signaling.

BasuRay S, Mukherjee S, Romero EG, Seaman MN, Wandinger-Ness A.

J Biol Chem. 2013 Jan 11;288(2):1135-49. doi: 10.1074/jbc.M112.417766. Epub 2012 Nov 27.


The retromer complex - endosomal protein recycling and beyond.

Seaman MN.

J Cell Sci. 2012 Oct 15;125(Pt 20):4693-702. doi: 10.1242/jcs.103440. Epub 2012 Nov 12. Review.


The hereditary spastic paraplegia protein strumpellin: characterisation in neurons and of the effect of disease mutations on WASH complex assembly and function.

Freeman C, Seaman MN, Reid E.

Biochim Biophys Acta. 2013 Jan;1832(1):160-73. doi: 10.1016/j.bbadis.2012.10.011. Epub 2012 Oct 23.


Identification of Alzheimer disease-associated variants in genes that regulate retromer function.

Vardarajan BN, Bruesegem SY, Harbour ME, Inzelberg R, Friedland R, St George-Hyslop P, Seaman MN, Farrer LA.

Neurobiol Aging. 2012 Sep;33(9):2231.e15-2231.e30. doi: 10.1016/j.neurobiolaging.2012.04.020. Epub 2012 Jun 5. Erratum in: Neurobiol Aging. 2013 Jul;34(7):1923. Inzelberg, Rivka [added]; Friedland, Robert [added].


Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35.

Harbour ME, Breusegem SY, Seaman MN.

Biochem J. 2012 Feb 15;442(1):209-20. doi: 10.1042/BJ20111761.


Evolutionary variations of VPS29, and their implications for the heteropentameric model of retromer.

Harbour ME, Seaman MN.

Commun Integr Biol. 2011 Sep;4(5):619-22. doi: 10.4161/cib.4.5.16855. Epub 2011 Sep 1.


The fifth adaptor protein complex.

Hirst J, Barlow LD, Francisco GC, Sahlender DA, Seaman MN, Dacks JB, Robinson MS.

PLoS Biol. 2011 Oct;9(10):e1001170. doi: 10.1371/journal.pbio.1001170. Epub 2011 Oct 11. Erratum in: PLoS Biol. 2012 Mar;10(3). doi: 10.1371/annotation/89dff893-c156-44bb-a731-bfcc91843583.


VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins.

Swarbrick JD, Shaw DJ, Chhabra S, Ghai R, Valkov E, Norwood SJ, Seaman MN, Collins BM.

PLoS One. 2011;6(5):e20420. doi: 10.1371/journal.pone.0020420. Epub 2011 May 24.


The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics.

Harbour ME, Breusegem SY, Antrobus R, Freeman C, Reid E, Seaman MN.

J Cell Sci. 2010 Nov 1;123(Pt 21):3703-17. doi: 10.1242/jcs.071472. Epub 2010 Oct 5.


Ricin toxin hits a retrograde roadblock.

Seaman MN, Peden AA.

Cell. 2010 Apr 16;141(2):222-4. doi: 10.1016/j.cell.2010.03.044.


A screen for endocytic motifs.

Kozik P, Francis RW, Seaman MN, Robinson MS.

Traffic. 2010 Jun;11(6):843-55. doi: 10.1111/j.1600-0854.2010.01056.x. Epub 2010 Mar 4.


Enhanced SnapShot: endosome-to-golgi retrieval.

Seaman MN.

Cell. 2009 Dec 11;139(6):1198-1198.e1. doi: 10.1016/j.cell.2009.11.040. No abstract available.


Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.

Seaman MN, Harbour ME, Tattersall D, Read E, Bright N.

J Cell Sci. 2009 Jul 15;122(Pt 14):2371-82. doi: 10.1242/jcs.048686. Epub 2009 Jun 16.


Loss of the Batten disease gene CLN3 prevents exit from the TGN of the mannose 6-phosphate receptor.

Metcalf DJ, Calvi AA, Seaman MNj, Mitchison HM, Cutler DF.

Traffic. 2008 Nov;9(11):1905-14. doi: 10.1111/j.1600-0854.2008.00807.x. Epub 2008 Aug 4.


Endosome protein sorting: motifs and machinery.

Seaman MN.

Cell Mol Life Sci. 2008 Sep;65(18):2842-58. doi: 10.1007/s00018-008-8354-1. Review.


Structure of Vps26B and mapping of its interaction with the retromer protein complex.

Collins BM, Norwood SJ, Kerr MC, Mahony D, Seaman MN, Teasdale RD, Owen DJ.

Traffic. 2008 Mar;9(3):366-79. Epub 2007 Dec 11.


Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment.

Chibalina MV, Seaman MN, Miller CC, Kendrick-Jones J, Buss F.

J Cell Sci. 2007 Dec 15;120(Pt 24):4278-88. Epub 2007 Nov 20.


EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval.

Gokool S, Tattersall D, Seaman MN.

Traffic. 2007 Dec;8(12):1873-86. Epub 2007 Oct 7.


Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex.

Gokool S, Tattersall D, Reddy JV, Seaman MN.

Biochem J. 2007 Dec 1;408(2):287-95.


The role of cargo proteins in GGA recruitment.

Hirst J, Seaman MN, Buschow SI, Robinson MS.

Traffic. 2007 May;8(5):594-604.


Endosome sorting: GSE complex minds the Gap.

Seaman MN.

Nat Cell Biol. 2006 Jul;8(7):648-9. No abstract available.


Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly.

Collins BM, Skinner CF, Watson PJ, Seaman MN, Owen DJ.

Nat Struct Mol Biol. 2005 Jul;12(7):594-602. Epub 2005 Jun 19.


Recycle your receptors with retromer.

Seaman MN.

Trends Cell Biol. 2005 Feb;15(2):68-75. Review.


Clathrin-mediated endocytosis in AP-2-depleted cells.

Motley A, Bright NA, Seaman MN, Robinson MS.

J Cell Biol. 2003 Sep 1;162(5):909-18.


Relationships between contaminant levels in marine sediments and their biological effects on embryos of oysters, Crassostrea gigas.

Geffard O, Budzinski H, His E, Seaman MN, Garrigues P.

Environ Toxicol Chem. 2002 Nov;21(11):2310-8.


Identification of the functional domains of yeast sorting nexins Vps5p and Vps17p.

Seaman MN, Williams HP.

Mol Biol Cell. 2002 Aug;13(8):2826-40.

Supplemental Content

Loading ...
Support Center