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Age-Related Vascular Dysfunction: What Registered Dietitian Nutritionists Need to Know.

Johnson SA, Litwin NS, Seals DR.

J Acad Nutr Diet. 2019 Jun 3. pii: S2212-2672(18)32071-9. doi: 10.1016/j.jand.2019.03.016. [Epub ahead of print] No abstract available.


Aerobic exercise training and vascular function with aging in healthy men and women.

Seals DR, Nagy EE, Moreau KL.

J Physiol. 2019 May 11. doi: 10.1113/JP277764. [Epub ahead of print]


Apocynin and Tempol Ameliorate Dietary Sodium-Induced Declines in Cutaneous Microvascular Function in Salt Resistant Humans.

Ramick MG, Brian MS, Matthews EL, Patik JC, Seals DR, Lennon SL, Farquhar WB, Edwards DG.

Am J Physiol Heart Circ Physiol. 2019 May 10. doi: 10.1152/ajpheart.00786.2018. [Epub ahead of print]


The Historical Context and Scientific Legacy of John O. Holloszy.

Hagberg JM, Coyle EF, Baldwin KM, Cartee GD, Fontana L, Joyner MJ, Kirwan JP, Seals DR, Weiss EP.

J Appl Physiol (1985). 2019 Feb 7. doi: 10.1152/japplphysiol.00669.2018. [Epub ahead of print]


Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice.

Brunt VE, Gioscia-Ryan RA, Richey JJ, Zigler MC, Cuevas LM, Gonzalez A, Vázquez-Baeza Y, Battson ML, Smithson AT, Gilley AD, Ackermann G, Neilson AP, Weir T, Davy KP, Knight R, Seals DR.

J Physiol. 2019 May;597(9):2361-2378. doi: 10.1113/JP277336. Epub 2019 Feb 27.


Habitual aerobic exercise and circulating proteomic patterns in healthy adults: relation to indicators of healthspan.

Santos-Parker JR, Santos-Parker KS, McQueen MB, Martens CR, Seals DR.

J Appl Physiol (1985). 2018 Nov 1;125(5):1646-1659. doi: 10.1152/japplphysiol.00458.2018. Epub 2018 Sep 20.


Healthy lifestyle-based approaches for successful vascular aging.

Rossman MJ, LaRocca TJ, Martens CR, Seals DR.

J Appl Physiol (1985). 2018 Dec 1;125(6):1888-1900. doi: 10.1152/japplphysiol.00521.2018. Epub 2018 Sep 13.


Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue.

Ballak DB, Li S, Cavalli G, Stahl JL, Tengesdal IW, van Diepen JA, Klück V, Swartzwelter B, Azam T, Tack CJ, Stienstra R, Mandrup-Poulsen T, Seals DR, Dinarello CA.

J Biol Chem. 2018 Sep 14;293(37):14224-14236. doi: 10.1074/jbc.RA118.003698. Epub 2018 Jul 13.


Curcumin supplementation and motor-cognitive function in healthy middle-aged and older adults.

Santos-Parker JR, Lubieniecki KL, Rossman MJ, Van Ark HJ, Bassett CJ, Strahler TR, Chonchol MB, Justice JN, Seals DR.

Nutr Healthy Aging. 2018 Jun 15;4(4):323-333. doi: 10.3233/NHA-170029.


Amino acid and lipid associated plasma metabolomic patterns are related to healthspan indicators with ageing.

Johnson LC, Martens CR, Santos-Parker JR, Bassett CJ, Strahler TR, Cruickshank-Quinn C, Reisdorph N, McQueen MB, Seals DR.

Clin Sci (Lond). 2018 Aug 30;132(16):1765-1777. doi: 10.1042/CS20180409. Print 2018 Aug 31.


Vascular aging.

Seals DR, Alexander LM.

J Appl Physiol (1985). 2018 Dec 1;125(6):1841-1842. doi: 10.1152/japplphysiol.00448.2018. Epub 2018 Jun 7. No abstract available.


Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults.

Rossman MJ, Santos-Parker JR, Steward CAC, Bispham NZ, Cuevas LM, Rosenberg HL, Woodward KA, Chonchol M, Gioscia-Ryan RA, Murphy MP, Seals DR.

Hypertension. 2018 Jun;71(6):1056-1063. doi: 10.1161/HYPERTENSIONAHA.117.10787. Epub 2018 Apr 16.


Keynote lecture: strategies for optimal cardiovascular aging.

Seals DR, Brunt VE, Rossman MJ.

Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H183-H188. doi: 10.1152/ajpheart.00734.2017. Epub 2018 Apr 13.


Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults.

Martens CR, Denman BA, Mazzo MR, Armstrong ML, Reisdorph N, McQueen MB, Chonchol M, Seals DR.

Nat Commun. 2018 Mar 29;9(1):1286. doi: 10.1038/s41467-018-03421-7.


Strategies for Achieving Healthy Vascular Aging.

Nowak KL, Rossman MJ, Chonchol M, Seals DR.

Hypertension. 2018 Mar;71(3):389-402. doi: 10.1161/HYPERTENSIONAHA.117.10439. Epub 2018 Jan 8. Review. No abstract available.


Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice.

Gioscia-Ryan RA, Battson ML, Cuevas LM, Eng JS, Murphy MP, Seals DR.

J Appl Physiol (1985). 2018 May 1;124(5):1194-1202. doi: 10.1152/japplphysiol.00670.2017. Epub 2017 Oct 26.


Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function.

Rossman MJ, Kaplon RE, Hill SD, McNamara MN, Santos-Parker JR, Pierce GL, Seals DR, Donato AJ.

Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H890-H895. doi: 10.1152/ajpheart.00416.2017. Epub 2017 Sep 29.


Cholecalciferol, Calcitriol, and Vascular Function in CKD: A Randomized, Double-Blind Trial.

Kendrick J, Andrews E, You Z, Moreau K, Nowak KL, Farmer-Bailey H, Seals DR, Chonchol M.

Clin J Am Soc Nephrol. 2017 Sep 7;12(9):1438-1446. doi: 10.2215/CJN.01870217. Epub 2017 Aug 7.


Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions.

Raizada MK, Joe B, Bryan NS, Chang EB, Dewhirst FE, Borisy GG, Galis ZS, Henderson W, Jose PA, Ketchum CJ, Lampe JW, Pepine CJ, Pluznick JL, Raj D, Seals DR, Gioscia-Ryan RA, Tang WHW, Oh YS.

Hypertension. 2017 Jul 31. pii: HYPERTENSIONAHA.117.09699. doi: 10.1161/HYPERTENSIONAHA.117.09699. [Epub ahead of print] Review. No abstract available.


A viewpoint on considering physiological principles to study stress resistance and resilience with aging.

Miller BF, Seals DR, Hamilton KL.

Ageing Res Rev. 2017 Sep;38:1-5. doi: 10.1016/j.arr.2017.06.004. Epub 2017 Jul 1. Review.


Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice.

Pagliassotti MJ, Estrada AL, Hudson WM, Wei Y, Wang D, Seals DR, Zigler ML, LaRocca TJ.

J Nutr Biochem. 2017 Jul;45:15-23. doi: 10.1016/j.jnutbio.2017.02.022. Epub 2017 Apr 6.


Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance.

Cavalli G, Justice JN, Boyle KE, D'Alessandro A, Eisenmesser EZ, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Garlanda C, Mantovani A, Seals DR, Dagna L, Joosten LA, Ballak DB, Dinarello CA.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2313-2318. doi: 10.1073/pnas.1619011114. Epub 2017 Feb 13.


Reductions in central arterial compliance with age are related to sympathetic vasoconstrictor nerve activity in healthy men.

Tanaka H, Dinenno FA, Seals DR.

Hypertens Res. 2017 May;40(5):493-495. doi: 10.1038/hr.2016.182. Epub 2017 Jan 19.


Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress.

Santos-Parker JR, Strahler TR, Bassett CJ, Bispham NZ, Chonchol MB, Seals DR.

Aging (Albany NY). 2017 Jan 3;9(1):187-208. doi: 10.18632/aging.101149.


Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice.

Gioscia-Ryan RA, Battson ML, Cuevas LM, Zigler MC, Sindler AL, Seals DR.

Aging (Albany NY). 2016 Nov 22;8(11):2897-2914. doi: 10.18632/aging.101099.


Habitual aerobic exercise does not protect against micro- or macrovascular endothelial dysfunction in healthy estrogen-deficient postmenopausal women.

Santos-Parker JR, Strahler TR, Vorwald VM, Pierce GL, Seals DR.

J Appl Physiol (1985). 2017 Jan 1;122(1):11-19. doi: 10.1152/japplphysiol.00732.2016. Epub 2016 Nov 10.


Nutrition and other lifestyle influences on arterial aging.

LaRocca TJ, Martens CR, Seals DR.

Ageing Res Rev. 2017 Oct;39:106-119. doi: 10.1016/j.arr.2016.09.002. Epub 2016 Sep 28. Review.


Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways.

Lesniewski LA, Seals DR, Walker AE, Henson GD, Blimline MW, Trott DW, Bosshardt GC, LaRocca TJ, Lawson BR, Zigler MC, Donato AJ.

Aging Cell. 2017 Feb;16(1):17-26. doi: 10.1111/acel.12524. Epub 2016 Sep 22.


Practical alternatives to chronic caloric restriction for optimizing vascular function with ageing.

Martens CR, Seals DR.

J Physiol. 2016 Dec 15;594(24):7177-7195. doi: 10.1113/JP272348. Epub 2016 Nov 29. Review.


Adding value to a graduate physiology seminar by focusing on public communication skills.

LaRocca TJ, Justice JN, Seals DR, Martens CR.

Adv Physiol Educ. 2016 Sep;40(3):365-9. doi: 10.1152/advan.00183.2015. No abstract available.


Oral trehalose supplementation improves resistance artery endothelial function in healthy middle-aged and older adults.

Kaplon RE, Hill SD, Bispham NZ, Santos-Parker JR, Nowlan MJ, Snyder LL, Chonchol M, LaRocca TJ, McQueen MB, Seals DR.

Aging (Albany NY). 2016 Jun;8(6):1167-83. doi: 10.18632/aging.100962.


Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice.

de Picciotto NE, Gano LB, Johnson LC, Martens CR, Sindler AL, Mills KF, Imai S, Seals DR.

Aging Cell. 2016 Jun;15(3):522-30. doi: 10.1111/acel.12461. Epub 2016 Mar 11.


Estimated aortic stiffness is independently associated with cardiac baroreflex sensitivity in humans: role of ageing and habitual endurance exercise.

Pierce GL, Harris SA, Seals DR, Casey DP, Barlow PB, Stauss HM.

J Hum Hypertens. 2016 Sep;30(9):513-20. doi: 10.1038/jhh.2016.3. Epub 2016 Feb 25.


Improved motor and cognitive performance with sodium nitrite supplementation is related to small metabolite signatures: a pilot trial in middle-aged and older adults.

Justice JN, Johnson LC, DeVan AE, Cruickshank-Quinn C, Reisdorph N, Bassett CJ, Evans TD, Brooks FA, Bryan NS, Chonchol MB, Giordano T, McQueen MB, Seals DR.

Aging (Albany NY). 2015 Nov;7(11):1004-21.


Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults.

DeVan AE, Johnson LC, Brooks FA, Evans TD, Justice JN, Cruickshank-Quinn C, Reisdorph N, Bryan NS, McQueen MB, Santos-Parker JR, Chonchol MB, Bassett CJ, Sindler AL, Giordano T, Seals DR.

J Appl Physiol (1985). 2016 Feb 15;120(4):416-25. doi: 10.1152/japplphysiol.00879.2015. Epub 2015 Nov 25.


Reduced large elastic artery stiffness with regular aerobic exercise in middle-aged and older adults: potential role of suppressed nuclear factor κ B signalling.

Jablonski KL, Donato AJ, Fleenor BS, Nowlan MJ, Walker AE, Kaplon RE, Ballak DB, Seals DR.

J Hypertens. 2015 Dec;33(12):2477-82. doi: 10.1097/HJH.0000000000000742.


Comparative Approaches to Understanding the Relation Between Aging and Physical Function.

Justice JN, Cesari M, Seals DR, Shively CA, Carter CS.

J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1243-53. doi: 10.1093/gerona/glv035. Epub 2015 Apr 23. Review.


Effect of dietary sodium restriction on human urinary metabolomic profiles.

Jablonski KL, Klawitter J, Chonchol M, Bassett CJ, Racine ML, Seals DR.

Clin J Am Soc Nephrol. 2015 Jul 7;10(7):1227-34. doi: 10.2215/CJN.11531114. Epub 2015 Apr 21.


Oral nitrite therapy improves vascular function in diabetic mice.

Sindler AL, Cox-York K, Reese L, Bryan NS, Seals DR, Gentile CL.

Diab Vasc Dis Res. 2015 May;12(3):221-4. doi: 10.1177/1479164114565628. Epub 2015 Feb 12.


Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity.

Seals DR, Justice JN, LaRocca TJ.

J Physiol. 2016 Apr 15;594(8):2001-24. doi: 10.1113/jphysiol.2014.282665. Epub 2015 Mar 11. Review.


Aerobic exercise and other healthy lifestyle factors that influence vascular aging.

Santos-Parker JR, LaRocca TJ, Seals DR.

Adv Physiol Educ. 2014 Dec;38(4):296-307. doi: 10.1152/advan.00088.2014. Review.


Sodium nitrite supplementation improves motor function and skeletal muscle inflammatory profile in old male mice.

Justice JN, Gioscia-Ryan RA, Johnson LC, Battson ML, de Picciotto NE, Beck HJ, Jiang H, Sindler AL, Bryan NS, Enoka RM, Seals DR.

J Appl Physiol (1985). 2015 Jan 15;118(2):163-9. doi: 10.1152/japplphysiol.00608.2014. Epub 2014 Nov 6.


The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice.

Gano LB, Donato AJ, Pasha HM, Hearon CM Jr, Sindler AL, Seals DR.

Am J Physiol Heart Circ Physiol. 2014 Dec 15;307(12):H1754-63. doi: 10.1152/ajpheart.00377.2014. Epub 2014 Oct 17.


Translational geroscience: emphasizing function to achieve optimal longevity.

Seals DR, Melov S.

Aging (Albany NY). 2014 Sep;6(9):718-30.


Mitochondrial quality control and age-associated arterial stiffening.

LaRocca TJ, Hearon CM Jr, Henson GD, Seals DR.

Exp Gerontol. 2014 Oct;58:78-82. doi: 10.1016/j.exger.2014.07.008. Epub 2014 Jul 14.


You're only as old as your arteries: translational strategies for preserving vascular endothelial function with aging.

Seals DR, Kaplon RE, Gioscia-Ryan RA, LaRocca TJ.

Physiology (Bethesda). 2014 Jul;29(4):250-64. doi: 10.1152/physiol.00059.2013. Review.


Assessment of vascular function in patients with chronic kidney disease.

Jablonski KL, Decker E, Perrenoud L, Kendrick J, Chonchol M, Seals DR, Jalal D.

J Vis Exp. 2014 Jun 16;(88). doi: 10.3791/51478.


Prevention of age-related endothelial dysfunction by habitual aerobic exercise in healthy humans: possible role of nuclear factor κB.

Walker AE, Kaplon RE, Pierce GL, Nowlan MJ, Seals DR.

Clin Sci (Lond). 2014 Dec;127(11):645-54. doi: 10.1042/CS20140030.


Edward F. Adolph Distinguished Lecture: The remarkable anti-aging effects of aerobic exercise on systemic arteries.

Seals DR.

J Appl Physiol (1985). 2014 Sep 1;117(5):425-39. doi: 10.1152/japplphysiol.00362.2014. Epub 2014 May 22. Review.


Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice.

Gioscia-Ryan RA, LaRocca TJ, Sindler AL, Zigler MC, Murphy MP, Seals DR.

J Physiol. 2014 Jun 15;592(12):2549-61. doi: 10.1113/jphysiol.2013.268680. Epub 2014 Mar 24.

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