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Items: 1 to 50 of 173

1.

Differential modulation of innate immune responses in human primary cells by influenza A viruses carrying human or avian non-structural 1 proteins.

Monteagudo PL, Muñoz-Moreno R, Fribourg M, Potla U, Mena I, Marjanovic N, Hartmann BM, Sealfon SC, García-Sastre A, Ramos I, Fernández-Sesma A.

J Virol. 2019 Oct 9. pii: JVI.00999-19. doi: 10.1128/JVI.00999-19. [Epub ahead of print]

2.

Spatio-temporal dynamics of Host-Virus competition: A model study of influenza A.

Whitman J, Dhanji A, Hayot F, Sealfon SC, Jayaprakash C.

J Theor Biol. 2020 Jan 7;484:110026. doi: 10.1016/j.jtbi.2019.110026. Epub 2019 Sep 28.

PMID:
31574283
3.

Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1.

Ramos I, Smith G, Ruf-Zamojski F, Martínez-Romero C, Fribourg M, Carbajal EA, Hartmann BM, Nair VD, Marjanovic N, Monteagudo PL, DeJesus VA, Mutetwa T, Zamojski M, Tan GS, Jayaprakash C, Zaslavsky E, Albrecht RA, Sealfon SC, García-Sastre A, Fernandez-Sesma A.

J Virol. 2019 Sep 30;93(20). pii: e00559-19. doi: 10.1128/JVI.00559-19. Print 2019 Oct 15.

4.

Pathway-level information extractor (PLIER) for gene expression data.

Mao W, Zaslavsky E, Hartmann BM, Sealfon SC, Chikina M.

Nat Methods. 2019 Jul;16(7):607-610. doi: 10.1038/s41592-019-0456-1. Epub 2019 Jun 27.

PMID:
31249421
5.

Cytogenetic, Genomic, and Functional Characterization of Pituitary Gonadotrope Cell Lines.

Ruf-Zamojski F, Ge Y, Pincas H, Shan J, Song Y, Hines N, Kelley K, Montagna C, Nair P, Toufaily C, Bernard DJ, Mellon PL, Nair V, Turgeon JL, Sealfon SC.

J Endocr Soc. 2019 Mar 25;3(5):902-920. doi: 10.1210/js.2019-00064. eCollection 2019 May 1.

6.

Interpretation of an individual functional genomics experiment guided by massive public data.

Lee YS, Wong AK, Tadych A, Hartmann BM, Park CY, DeJesus VA, Ramos I, Zaslavsky E, Sealfon SC, Troyanskaya OG.

Nat Methods. 2018 Dec;15(12):1049-1052. doi: 10.1038/s41592-018-0218-5. Epub 2018 Nov 26.

PMID:
30478325
7.

Single-cell stabilization method identifies gonadotrope transcriptional dynamics and pituitary cell type heterogeneity.

Ruf-Zamojski F, Ge Y, Nair V, Zamojski M, Pincas H, Toufaily C, Tome-Garcia J, Stoeckius M, Stephenson W, Smith GR, Bernard DJ, Tsankova NM, Hartmann BM, Fribourg M, Smibert P, Swerdlow H, Turgeon JL, Sealfon SC.

Nucleic Acids Res. 2018 Nov 30;46(21):11370-11380. doi: 10.1093/nar/gky991.

8.

Ex vivo human HSC expansion requires coordination of cellular reprogramming with mitochondrial remodeling and p53 activation.

Papa L, Zimran E, Djedaini M, Ge Y, Ozbek U, Sebra R, Sealfon SC, Hoffman R.

Blood Adv. 2018 Oct 23;2(20):2766-2779. doi: 10.1182/bloodadvances.2018024273.

9.

Correction: Elucidation of molecular kinetic schemes from macroscopic traces using system identification.

Fribourg M, Logothetis DE, González-Maeso J, Sealfon SC, Galocha-Iragüen B, Las-Heras Andrés F, Brezina V.

PLoS Comput Biol. 2018 Oct 16;14(10):e1006539. doi: 10.1371/journal.pcbi.1006539. eCollection 2018 Oct.

10.

High resolution annotation of zebrafish transcriptome using long-read sequencing.

Nudelman G, Frasca A, Kent B, Sadler KC, Sealfon SC, Walsh MJ, Zaslavsky E.

Genome Res. 2018 Sep;28(9):1415-1425. doi: 10.1101/gr.223586.117. Epub 2018 Jul 30.

11.

Tellurium notebooks-An environment for reproducible dynamical modeling in systems biology.

Medley JK, Choi K, König M, Smith L, Gu S, Hellerstein J, Sealfon SC, Sauro HM.

PLoS Comput Biol. 2018 Jun 15;14(6):e1006220. doi: 10.1371/journal.pcbi.1006220. eCollection 2018 Jun.

12.

Regulatory Architecture of the LβT2 Gonadotrope Cell Underlying the Response to Gonadotropin-Releasing Hormone.

Ruf-Zamojski F, Fribourg M, Ge Y, Nair V, Pincas H, Zaslavsky E, Nudelman G, Tuminello SJ, Watanabe H, Turgeon JL, Sealfon SC.

Front Endocrinol (Lausanne). 2018 Feb 14;9:34. doi: 10.3389/fendo.2018.00034. eCollection 2018.

13.

Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death.

Hartmann BM, Albrecht RA, Zaslavsky E, Nudelman G, Pincas H, Marjanovic N, Schotsaert M, Martínez-Romero C, Fenutria R, Ingram JP, Ramos I, Fernandez-Sesma A, Balachandran S, García-Sastre A, Sealfon SC.

Nat Commun. 2017 Dec 5;8(1):1931. doi: 10.1038/s41467-017-02035-9.

14.

Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency.

Stern E, Ruf-Zamojski F, Zalepa-King L, Pincas H, Choi SG, Peskin CS, Hayot F, Turgeon JL, Sealfon SC.

J Biol Chem. 2017 Jun 9;292(23):9815-9829. doi: 10.1074/jbc.M117.783886. Epub 2017 Apr 6.

15.

Multiscale Modeling of Complex Formation and CD80 Depletion during Immune Synapse Development.

Sugár IP, Das J, Jayaprakash C, Sealfon SC.

Biophys J. 2017 Mar 14;112(5):997-1009. doi: 10.1016/j.bpj.2016.12.052.

16.

Elucidation of molecular kinetic schemes from macroscopic traces using system identification.

Fribourg M, Logothetis DE, González-Maeso J, Sealfon SC, Galocha-Iragüen B, Las-Heras Andrés F, Brezina V.

PLoS Comput Biol. 2017 Feb 13;13(2):e1005376. doi: 10.1371/journal.pcbi.1005376. eCollection 2017 Feb. Erratum in: PLoS Comput Biol. 2018 Oct 16;14(10):e1006539.

17.

Solving Immunology?

Vodovotz Y, Xia A, Read EL, Bassaganya-Riera J, Hafler DA, Sontag E, Wang J, Tsang JS, Day JD, Kleinstein SH, Butte AJ, Altman MC, Hammond R, Sealfon SC.

Trends Immunol. 2017 Feb;38(2):116-127. doi: 10.1016/j.it.2016.11.006. Epub 2016 Dec 13. Review.

18.

Characterization of Gonadotrope Secretoproteome Identifies Neurosecretory Protein VGF-derived Peptide Suppression of Follicle-stimulating Hormone Gene Expression.

Choi SG, Wang Q, Jia J, Chikina M, Pincas H, Dolios G, Sasaki K, Wang R, Minamino N, Salton SR, Sealfon SC.

J Biol Chem. 2016 Sep 30;291(40):21322-21334. Epub 2016 Jul 27.

19.

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus.

Nogusa S, Thapa RJ, Dillon CP, Liedmann S, Oguin TH 3rd, Ingram JP, Rodriguez DA, Kosoff R, Sharma S, Sturm O, Verbist K, Gough PJ, Bertin J, Hartmann BM, Sealfon SC, Kaiser WJ, Mocarski ES, López CB, Thomas PG, Oberst A, Green DR, Balachandran S.

Cell Host Microbe. 2016 Jul 13;20(1):13-24. doi: 10.1016/j.chom.2016.05.011. Epub 2016 Jun 16.

20.

MOCCASIN: converting MATLAB ODE models to SBML.

Gómez HF, Hucka M, Keating SM, Nudelman G, Iber D, Sealfon SC.

Bioinformatics. 2016 Jun 15;32(12):1905-6. doi: 10.1093/bioinformatics/btw056. Epub 2016 Feb 9.

21.

Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells.

Baki L, Fribourg M, Younkin J, Eltit JM, Moreno JL, Park G, Vysotskaya Z, Narahari A, Sealfon SC, Gonzalez-Maeso J, Logothetis DE.

Pflugers Arch. 2016 May;468(5):775-93. doi: 10.1007/s00424-015-1780-7. Epub 2016 Jan 16.

22.

Interactive Big Data Resource to Elucidate Human Immune Pathways and Diseases.

Gorenshteyn D, Zaslavsky E, Fribourg M, Park CY, Wong AK, Tadych A, Hartmann BM, Albrecht RA, García-Sastre A, Kleinstein SH, Troyanskaya OG, Sealfon SC.

Immunity. 2015 Sep 15;43(3):605-14. doi: 10.1016/j.immuni.2015.08.014. Epub 2015 Sep 8.

23.

Comparative analysis of anti-viral transcriptomics reveals novel effects of influenza immune antagonism.

Thakar J, Hartmann BM, Marjanovic N, Sealfon SC, Kleinstein SH.

BMC Immunol. 2015 Aug 14;16:46. doi: 10.1186/s12865-015-0107-y.

24.

Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses.

Hartmann BM, Thakar J, Albrecht RA, Avey S, Zaslavsky E, Marjanovic N, Chikina M, Fribourg M, Hayot F, Schmolke M, Meng H, Wetmur J, García-Sastre A, Kleinstein SH, Sealfon SC.

J Virol. 2015 Oct;89(20):10190-205. doi: 10.1128/JVI.01523-15. Epub 2015 Jul 29.

25.

Understanding multicellular function and disease with human tissue-specific networks.

Greene CS, Krishnan A, Wong AK, Ricciotti E, Zelaya RA, Himmelstein DS, Zhang R, Hartmann BM, Zaslavsky E, Sealfon SC, Chasman DI, FitzGerald GA, Dolinski K, Grosser T, Troyanskaya OG.

Nat Genet. 2015 Jun;47(6):569-76. doi: 10.1038/ng.3259. Epub 2015 Apr 27.

26.

Low-variance RNAs identify Parkinson's disease molecular signature in blood.

Chikina MD, Gerald CP, Li X, Ge Y, Pincas H, Nair VD, Wong AK, Krishnan A, Troyanskaya OG, Raymond D, Saunders-Pullman R, Bressman SB, Yue Z, Sealfon SC.

Mov Disord. 2015 May;30(6):813-21. doi: 10.1002/mds.26205. Epub 2015 Mar 18.

27.

Single-cell analysis shows that paracrine signaling by first responder cells shapes the interferon-β response to viral infection.

Patil S, Fribourg M, Ge Y, Batish M, Tyagi S, Hayot F, Sealfon SC.

Sci Signal. 2015 Feb 10;8(363):ra16. doi: 10.1126/scisignal.2005728.

PMID:
25670204
28.

CellCODE: a robust latent variable approach to differential expression analysis for heterogeneous cell populations.

Chikina M, Zaslavsky E, Sealfon SC.

Bioinformatics. 2015 May 15;31(10):1584-91. doi: 10.1093/bioinformatics/btv015. Epub 2015 Jan 11.

29.

Hybrid Bayesian-rank integration approach improves the predictive power of genomic dataset aggregation.

Badgeley MA, Sealfon SC, Chikina MD.

Bioinformatics. 2015 Jan 15;31(2):209-15. doi: 10.1093/bioinformatics/btu518. Epub 2014 Sep 29.

30.

Growth differentiation factor 9 (GDF9) forms an incoherent feed-forward loop modulating follicle-stimulating hormone β-subunit (FSHβ) gene expression.

Choi SG, Wang Q, Jia J, Pincas H, Turgeon JL, Sealfon SC.

J Biol Chem. 2014 Jun 6;289(23):16164-75. doi: 10.1074/jbc.M113.537696. Epub 2014 Apr 28.

31.

Increasing consistency of disease biomarker prediction across datasets.

Chikina MD, Sealfon SC.

PLoS One. 2014 Apr 16;9(4):e91272. doi: 10.1371/journal.pone.0091272. eCollection 2014.

32.

Combinatorial cytokine code generates anti-viral state in dendritic cells.

Hartmann BM, Marjanovic N, Nudelman G, Moran TM, Sealfon SC.

Front Immunol. 2014 Feb 26;5:73. doi: 10.3389/fimmu.2014.00073. eCollection 2014.

33.

Model of influenza A virus infection: dynamics of viral antagonism and innate immune response.

Fribourg M, Hartmann B, Schmolke M, Marjanovic N, Albrecht RA, García-Sastre A, Sealfon SC, Jayaprakash C, Hayot F.

J Theor Biol. 2014 Jun 21;351:47-57. doi: 10.1016/j.jtbi.2014.02.029. Epub 2014 Mar 2.

34.

Homer1 alternative splicing is regulated by gonadotropin-releasing hormone and modulates gonadotropin gene expression.

Wang Q, Chikina MD, Pincas H, Sealfon SC.

Mol Cell Biol. 2014 May;34(10):1747-56. doi: 10.1128/MCB.01401-13. Epub 2014 Mar 3.

35.

Noise propagation through extracellular signaling leads to fluctuations in gene expression.

Tabbaa OP, Nudelman G, Sealfon SC, Hayot F, Jayaprakash C.

BMC Syst Biol. 2013 Sep 25;7:94. doi: 10.1186/1752-0509-7-94.

36.

Outside the box signaling: secreted factors modulate GnRH receptor-mediated gonadotropin regulation.

Pincas H, Choi SG, Wang Q, Jia J, Turgeon JL, Sealfon SC.

Mol Cell Endocrinol. 2014 Mar 25;385(1-2):56-61. doi: 10.1016/j.mce.2013.08.015. Epub 2013 Aug 28. Review.

37.

Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infection.

Zaslavsky E, Nudelman G, Marquez S, Hershberg U, Hartmann BM, Thakar J, Sealfon SC, Kleinstein SH.

BMC Bioinformatics. 2013;14 Suppl 6:S1. doi: 10.1186/1471-2105-14-S6-S1. Epub 2013 Apr 17.

38.

Chronic treatment with LY341495 decreases 5-HT(2A) receptor binding and hallucinogenic effects of LSD in mice.

Moreno JL, Holloway T, Rayannavar V, Sealfon SC, González-Maeso J.

Neurosci Lett. 2013 Mar 1;536:69-73. doi: 10.1016/j.neulet.2012.12.053. Epub 2013 Jan 16.

39.

β-catenin regulates GnRH-induced FSHβ gene expression.

Wang Q, Chikina M, Zaslavsky E, Pincas H, Sealfon SC.

Mol Endocrinol. 2013 Feb;27(2):224-37. doi: 10.1210/me.2012-1310. Epub 2012 Dec 4.

40.

Mouse dendritic cell (DC) influenza virus infectivity is much lower than that for human DCs and is hemagglutinin subtype dependent.

Hartmann BM, Li W, Jia J, Patil S, Marjanovic N, Martínez-Romero C, Albrecht RA, Hayot F, García-Sastre A, Wetmur JG, Moran TM, Sealfon SC.

J Virol. 2013 Feb;87(3):1916-8. doi: 10.1128/JVI.02980-12. Epub 2012 Nov 28.

41.

Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation.

Braun DA, Fribourg M, Sealfon SC.

J Biol Chem. 2013 Feb 1;288(5):2986-93. doi: 10.1074/jbc.M112.386573. Epub 2012 Nov 19.

42.

Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function.

Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuéllar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, López-Giménez JF, Meana JJ, Benson DL, González-Maeso J.

J Biol Chem. 2012 Dec 28;287(53):44301-19. doi: 10.1074/jbc.M112.413161. Epub 2012 Nov 5.

43.

Involvement of histone demethylase LSD1 in short-time-scale gene expression changes during cell cycle progression in embryonic stem cells.

Nair VD, Ge Y, Balasubramaniyan N, Kim J, Okawa Y, Chikina M, Troyanskaya O, Sealfon SC.

Mol Cell Biol. 2012 Dec;32(23):4861-76. doi: 10.1128/MCB.00816-12. Epub 2012 Oct 1.

44.

Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice.

Moreno JL, Holloway T, Umali A, Rayannavar V, Sealfon SC, González-Maeso J.

Psychopharmacology (Berl). 2013 Jan;225(1):217-26. doi: 10.1007/s00213-012-2809-7. Epub 2012 Jul 28.

45.

Functional selectivity in GPCR heterocomplexes.

González-Maeso J, Sealfon SC.

Mini Rev Med Chem. 2012 Aug;12(9):851-5. Review.

46.

flowPeaks: a fast unsupervised clustering for flow cytometry data via K-means and density peak finding.

Ge Y, Sealfon SC.

Bioinformatics. 2012 Aug 1;28(15):2052-8. doi: 10.1093/bioinformatics/bts300. Epub 2012 May 17.

47.

G proteins and autocrine signaling differentially regulate gonadotropin subunit expression in pituitary gonadotrope.

Choi SG, Jia J, Pfeffer RL, Sealfon SC.

J Biol Chem. 2012 Jun 15;287(25):21550-60. doi: 10.1074/jbc.M112.348607. Epub 2012 May 1.

48.

Computational approaches to understanding dendritic cell responses to influenza virus infection.

Zaslavsky E, Hayot F, Sealfon SC.

Immunol Res. 2012 Dec;54(1-3):160-8. doi: 10.1007/s12026-012-8322-6. Review.

49.

Multi-scale stochastic simulation of diffusion-coupled agents and its application to cell culture simulation.

Shimoni Y, Nudelman G, Hayot F, Sealfon SC.

PLoS One. 2011;6(12):e29298. doi: 10.1371/journal.pone.0029298. Epub 2011 Dec 21.

50.

Optimized amplification and single-cell analysis identify GnRH-mediated activation of Rap1b in primary rat gonadotropes.

Yuen T, Choi SG, Pincas H, Waring DW, Sealfon SC, Turgeon JL.

Mol Cell Endocrinol. 2012 Mar 5;350(1):10-9. doi: 10.1016/j.mce.2011.11.017. Epub 2011 Nov 25.

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