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Items: 1 to 50 of 85

1.

Microphysiological Engineering of Self-Assembled and Perfusable Microvascular Beds for the Production of Vascularized Three-Dimensional Human Microtissues.

Paek J, Park SE, Lu Q, Park KT, Cho M, Oh JM, Kwon KW, Yi YS, Song JW, Edelstein HI, Ishibashi J, Yang W, Myerson JW, Kiseleva RY, Aprelev P, Hood ED, Stambolian D, Seale P, Muzykantov VR, Huh D.

ACS Nano. 2019 Jul 23;13(7):7627-7643. doi: 10.1021/acsnano.9b00686. Epub 2019 Jun 18.

PMID:
31194909
2.

A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate.

Wang W, Ishibashi J, Trefely S, Shao M, Cowan AJ, Sakers A, Lim HW, O'Connor S, Doan MT, Cohen P, Baur JA, King MT, Veech RL, Won KJ, Rabinowitz JD, Snyder NW, Gupta RK, Seale P.

Cell Metab. 2019 Jul 2;30(1):174-189.e5. doi: 10.1016/j.cmet.2019.05.005. Epub 2019 May 30.

PMID:
31155495
3.

Identification of a mesenchymal progenitor cell hierarchy in adipose tissue.

Merrick D, Sakers A, Irgebay Z, Okada C, Calvert C, Morley MP, Percec I, Seale P.

Science. 2019 Apr 26;364(6438). pii: eaav2501. doi: 10.1126/science.aav2501.

PMID:
31023895
4.

Transcriptional Control of Brown and Beige Fat Development and Function.

Shapira SN, Seale P.

Obesity (Silver Spring). 2019 Jan;27(1):13-21. doi: 10.1002/oby.22334. Review.

5.

Stepping Up Human Beige Fat Cell Production.

Yang W, Seale P.

Cell Rep. 2018 Dec 11;25(11):2935-2936. doi: 10.1016/j.celrep.2018.11.091.

PMID:
30540928
Free Article
6.

Interrogation of nonconserved human adipose lincRNAs identifies a regulatory role of linc-ADAL in adipocyte metabolism.

Zhang X, Xue C, Lin J, Ferguson JF, Weiner A, Liu W, Han Y, Hinkle C, Li W, Jiang H, Gosai S, Hachet M, Garcia BA, Gregory BD, Soccio RE, Hogenesch JB, Seale P, Li M, Reilly MP.

Sci Transl Med. 2018 Jun 20;10(446). pii: eaar5987. doi: 10.1126/scitranslmed.aar5987.

7.

Enhancing brown fat with NFIA.

Shapira SN, Seale P.

Nat Cell Biol. 2017 Aug 31;19(9):1006-1007. doi: 10.1038/ncb3591.

8.

Neonatal GLP1R activation limits adult adiposity by durably altering hypothalamic architecture.

Rozo AV, Babu DA, Suen PA, Groff DN, Seeley RJ, Simmons RA, Seale P, Ahima RS, Stoffers DA.

Mol Metab. 2017 May 15;6(7):748-759. doi: 10.1016/j.molmet.2017.05.006. eCollection 2017 Jul.

9.

Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge.

Emmett MJ, Lim HW, Jager J, Richter HJ, Adlanmerini M, Peed LC, Briggs ER, Steger DJ, Ma T, Sims CA, Baur JA, Pei L, Won KJ, Seale P, Gerhart-Hines Z, Lazar MA.

Nature. 2017 Jun 22;546(7659):544-548. doi: 10.1038/nature22819. Epub 2017 Jun 14.

10.

EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex.

Shapira SN, Lim HW, Rajakumari S, Sakers AP, Ishibashi J, Harms MJ, Won KJ, Seale P.

Genes Dev. 2017 Apr 1;31(7):660-673. doi: 10.1101/gad.294405.116. Epub 2017 Apr 20.

11.

PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing.

Kissig M, Ishibashi J, Harms MJ, Lim HW, Stine RR, Won KJ, Seale P.

EMBO J. 2017 Jun 1;36(11):1528-1542. doi: 10.15252/embj.201695588. Epub 2017 Apr 13.

12.

Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice.

Soccio RE, Li Z, Chen ER, Foong YH, Benson KK, Dispirito JR, Mullican SE, Emmett MJ, Briggs ER, Peed LC, Dzeng RK, Medina CJ, Jolivert JF, Kissig M, Rajapurkar SR, Damle M, Lim HW, Won KJ, Seale P, Steger DJ, Lazar MA.

J Clin Invest. 2017 Apr 3;127(4):1451-1462. doi: 10.1172/JCI91211. Epub 2017 Feb 27.

13.

Regeneration of fat cells from myofibroblasts during wound healing.

Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, Hsi TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G.

Science. 2017 Feb 17;355(6326):748-752. doi: 10.1126/science.aai8792. Epub 2017 Jan 5.

14.

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue.

Wada S, Neinast M, Jang C, Ibrahim YH, Lee G, Babu A, Li J, Hoshino A, Rowe GC, Rhee J, Martina JA, Puertollano R, Blenis J, Morley M, Baur JA, Seale P, Arany Z.

Genes Dev. 2016 Nov 15;30(22):2551-2564. Epub 2016 Dec 2.

15.

Activation of β3-adrenoceptors increases in vivo free fatty acid uptake and utilization in brown but not white fat depots in high-fat-fed rats.

Warner A, Kjellstedt A, Carreras A, Böttcher G, Peng XR, Seale P, Oakes N, Lindén D.

Am J Physiol Endocrinol Metab. 2016 Dec 1;311(6):E901-E910. doi: 10.1152/ajpendo.00204.2016. Epub 2016 Oct 25.

16.

Control of brown and beige fat development.

Wang W, Seale P.

Nat Rev Mol Cell Biol. 2016 Nov;17(11):691-702. doi: 10.1038/nrm.2016.96. Epub 2016 Aug 24. Review.

17.

Lack of AKT in adipocytes causes severe lipodystrophy.

Shearin AL, Monks BR, Seale P, Birnbaum MJ.

Mol Metab. 2016 May 13;5(7):472-479. doi: 10.1016/j.molmet.2016.05.006. eCollection 2016 Jul.

18.

SnapShot: Brown and Beige Adipose Thermogenesis.

Kissig M, Shapira SN, Seale P.

Cell. 2016 Jun 30;166(1):258-258.e1. doi: 10.1016/j.cell.2016.06.038.

19.

Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program.

Shao M, Ishibashi J, Kusminski CM, Wang QA, Hepler C, Vishvanath L, MacPherson KA, Spurgin SB, Sun K, Holland WL, Seale P, Gupta RK.

Cell Metab. 2016 Jun 14;23(6):1167-1184. doi: 10.1016/j.cmet.2016.04.023. Epub 2016 May 26.

20.

Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue.

Tran CM, Mukherjee S, Ye L, Frederick DW, Kissig M, Davis JG, Lamming DW, Seale P, Baur JA.

Diabetes. 2016 Apr;65(4):927-41. doi: 10.2337/db15-0502. Epub 2016 Feb 8.

21.

EBF2 promotes the recruitment of beige adipocytes in white adipose tissue.

Stine RR, Shapira SN, Lim HW, Ishibashi J, Harms M, Won KJ, Seale P.

Mol Metab. 2015 Nov 14;5(1):57-65. doi: 10.1016/j.molmet.2015.11.001. eCollection 2016 Jan.

22.

Brown and Beige Fat: Physiological Roles beyond Heat Generation.

Kajimura S, Spiegelman BM, Seale P.

Cell Metab. 2015 Oct 6;22(4):546-59. doi: 10.1016/j.cmet.2015.09.007. Review.

23.

Single-cell transcriptomics and functional target validation of brown adipocytes show their complex roles in metabolic homeostasis.

Spaethling JM, Sanchez-Alavez M, Lee J, Xia FC, Dueck H, Wang W, Fisher SA, Sul JY, Seale P, Kim J, Bartfai T, Eberwine J.

FASEB J. 2016 Jan;30(1):81-92. doi: 10.1096/fj.15-273797. Epub 2015 Aug 24.

PMID:
26304220
24.

Multidrug-resistant tuberculosis in New South Wales, Australia, 1999-2010: a case series report.

Roberts-Witteveen A, Reinten T, Christensen A, Sintchenko V, Seale P, Lowbridge C.

Int J Tuberc Lung Dis. 2015 Jul;19(7):850-6. doi: 10.5588/ijtld.14.0575.

PMID:
26056113
25.

Deep sequencing reveals cell-type-specific patterns of single-cell transcriptome variation.

Dueck H, Khaladkar M, Kim TK, Spaethling JM, Francis C, Suresh S, Fisher SA, Seale P, Beck SG, Bartfai T, Kuhn B, Eberwine J, Kim J.

Genome Biol. 2015 Jun 9;16:122. doi: 10.1186/s13059-015-0683-4.

26.

Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation.

Seale P.

Diabetes. 2015 Jul;64(7):2369-75. doi: 10.2337/db15-0203. Epub 2015 Jun 7. Review.

27.

The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin.

DiPilato LM, Ahmad F, Harms M, Seale P, Manganiello V, Birnbaum MJ.

Mol Cell Biol. 2015 Aug;35(16):2752-60. doi: 10.1128/MCB.00422-15. Epub 2015 Jun 1.

28.

PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program.

Harms MJ, Lim HW, Ho Y, Shapira SN, Ishibashi J, Rajakumari S, Steger DJ, Lazar MA, Won KJ, Seale P.

Genes Dev. 2015 Feb 1;29(3):298-307. doi: 10.1101/gad.252734.114.

29.

Functions of Prdm16 in thermogenic fat cells.

Ishibashi J, Seale P.

Temperature (Austin). 2015 Mar 17;2(1):65-72. doi: 10.4161/23328940.2014.974444. eCollection 2015 Jan-Mar. Review.

30.

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.

Brestoff JR, Kim BS, Saenz SA, Stine RR, Monticelli LA, Sonnenberg GF, Thome JJ, Farber DL, Lutfy K, Seale P, Artis D.

Nature. 2015 Mar 12;519(7542):242-6. doi: 10.1038/nature14115. Epub 2014 Dec 22.

31.

Thermogenic activity of UCP1 in human white fat-derived beige adipocytes.

Bartesaghi S, Hallen S, Huang L, Svensson PA, Momo RA, Wallin S, Carlsson EK, Forslöw A, Seale P, Peng XR.

Mol Endocrinol. 2015 Jan;29(1):130-9. doi: 10.1210/me.2014-1295.

32.

Ebf2 is a selective marker of brown and beige adipogenic precursor cells.

Wang W, Kissig M, Rajakumari S, Huang L, Lim HW, Won KJ, Seale P.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14466-71. doi: 10.1073/pnas.1412685111. Epub 2014 Sep 2.

33.

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis.

Lim MA, Bence KK, Sandesara I, Andreux P, Auwerx J, Ishibashi J, Seale P, Kalb RG.

Hum Mol Genet. 2014 Sep 15;23(18):4995-5008. doi: 10.1093/hmg/ddu214. Epub 2014 May 15.

34.

Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.

Harms MJ, Ishibashi J, Wang W, Lim HW, Goyama S, Sato T, Kurokawa M, Won KJ, Seale P.

Cell Metab. 2014 Apr 1;19(4):593-604. doi: 10.1016/j.cmet.2014.03.007.

35.

p107 is a crucial regulator for determining the adipocyte lineage fate choices of stem cells.

De Sousa M, Porras DP, Perry CG, Seale P, Scimè A.

Stem Cells. 2014 May;32(5):1323-36. doi: 10.1002/stem.1637.

36.

Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.

Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM.

Cell. 2014 Jan 16;156(1-2):304-16. doi: 10.1016/j.cell.2013.12.021.

37.

The nuclear receptor Rev-erbα controls circadian thermogenic plasticity.

Gerhart-Hines Z, Feng D, Emmett MJ, Everett LJ, Loro E, Briggs ER, Bugge A, Hou C, Ferrara C, Seale P, Pryma DA, Khurana TS, Lazar MA.

Nature. 2013 Nov 21;503(7476):410-413. doi: 10.1038/nature12642. Epub 2013 Oct 27.

38.

Brown and beige fat: development, function and therapeutic potential.

Harms M, Seale P.

Nat Med. 2013 Oct;19(10):1252-63. doi: 10.1038/nm.3361. Epub 2013 Sep 29. Review.

PMID:
24100998
39.

Brown adipose tissue biology and therapeutic potential.

Seale P.

Front Endocrinol (Lausanne). 2013 Mar 19;4:14. doi: 10.3389/fendo.2013.00014. eCollection 2013. No abstract available.

40.

EBF2 determines and maintains brown adipocyte identity.

Rajakumari S, Wu J, Ishibashi J, Lim HW, Giang AH, Won KJ, Reed RR, Seale P.

Cell Metab. 2013 Apr 2;17(4):562-74. doi: 10.1016/j.cmet.2013.01.015. Epub 2013 Mar 14.

41.

MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16.

Yin H, Pasut A, Soleimani VD, Bentzinger CF, Antoun G, Thorn S, Seale P, Fernando P, van Ijcken W, Grosveld F, Dekemp RA, Boushel R, Harper ME, Rudnicki MA.

Cell Metab. 2013 Feb 5;17(2):210-24. doi: 10.1016/j.cmet.2013.01.004.

42.

Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.

Derecka M, Gornicka A, Koralov SB, Szczepanek K, Morgan M, Raje V, Sisler J, Zhang Q, Otero D, Cichy J, Rajewsky K, Shimoda K, Poli V, Strobl B, Pellegrini S, Harris TE, Seale P, Russell AP, McAinch AJ, O'Brien PE, Keller SR, Croniger CM, Kordula T, Larner AC.

Cell Metab. 2012 Dec 5;16(6):814-24. doi: 10.1016/j.cmet.2012.11.005.

43.

An Evi1-C/EBPβ complex controls peroxisome proliferator-activated receptor γ2 gene expression to initiate white fat cell differentiation.

Ishibashi J, Firtina Z, Rajakumari S, Wood KH, Conroe HM, Steger DJ, Seale P.

Mol Cell Biol. 2012 Jun;32(12):2289-99. doi: 10.1128/MCB.06529-11. Epub 2012 Apr 2.

44.

Orexin turns up the heat on obesity.

Seale P.

Cell Metab. 2011 Oct 5;14(4):441-2. doi: 10.1016/j.cmet.2011.09.007.

45.

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.

Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM.

J Clin Invest. 2011 Jan;121(1):96-105. doi: 10.1172/JCI44271. Epub 2010 Dec 1.

46.

Transcriptional control of brown adipocyte development and thermogenesis.

Seale P.

Int J Obes (Lond). 2010 Oct;34 Suppl 1:S17-22. doi: 10.1038/ijo.2010.178.

PMID:
20935660
47.

Validity of a continuous metabolic risk score as an index for modeling metabolic syndrome in adolescents.

Okosun IS, Lyn R, Davis-Smith M, Eriksen M, Seale P.

Ann Epidemiol. 2010 Nov;20(11):843-51. doi: 10.1016/j.annepidem.2010.08.001.

PMID:
20933191
48.

Medicine. Beige can be slimming.

Ishibashi J, Seale P.

Science. 2010 May 28;328(5982):1113-4. doi: 10.1126/science.1190816. Epub 2010 May 6. No abstract available.

49.

Transcriptional control of brown fat development.

Kajimura S, Seale P, Spiegelman BM.

Cell Metab. 2010 Apr 7;11(4):257-62. doi: 10.1016/j.cmet.2010.03.005. Review.

50.

Transcriptional control of preadipocyte determination by Zfp423.

Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM.

Nature. 2010 Mar 25;464(7288):619-23. doi: 10.1038/nature08816. Epub 2010 Mar 3.

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