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Items: 33

1.

Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis.

Regan Anderson TM, Ma S, Perez Kerkvliet C, Peng Y, Helle TM, Krutilina RI, Raj GV, Cidlowski JA, Ostrander JH, Schwertfeger KL, Seagroves TN, Lange CA.

Mol Cancer Res. 2018 Jul 10. doi: 10.1158/1541-7786.MCR-18-0410. [Epub ahead of print]

PMID:
29991529
2.

Correction: The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer.

Fatima I, El-Ayachi I, Taotao L, Angeles Lillo M, Krutilina RI, Seagroves TN, Radaszkiewicz TW, Hutnan M, Bryja V, Krum SA, Rivas F, Miranda-Carboni GA.

PLoS One. 2018 May 17;13(5):e0197796. doi: 10.1371/journal.pone.0197796. eCollection 2018.

3.

Fluorescence-Activated Cell Sorting of Murine Mammary Cancer Stem-Like Cell Subpopulations with HIF Activity.

Brooks DL, Seagroves TN.

Methods Mol Biol. 2018;1742:247-263. doi: 10.1007/978-1-4939-7665-2_22.

PMID:
29330806
4.

Chromatin Immunoprecipitation of HIF-α in Breast Tumor Cells Using Wild Type and Loss of Function Models.

Brooks DL, Seagroves TN.

Methods Mol Biol. 2018;1742:67-79. doi: 10.1007/978-1-4939-7665-2_7.

PMID:
29330791
5.

The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer.

Fatima I, El-Ayachi I, Taotao L, Lillo MA, Krutilina R, Seagroves TN, Radaszkiewicz TW, Hutnan M, Bryja V, Krum SA, Rivas F, Miranda-Carboni GA.

PLoS One. 2017 Dec 27;12(12):e0189864. doi: 10.1371/journal.pone.0189864. eCollection 2017. Erratum in: PLoS One. 2018 May 17;13(5):e0197796.

6.

Bisphenol A Induces Sox2 in ER+ Breast Cancer Stem-Like Cells.

Lillo MA, Nichols C, Seagroves TN, Miranda-Carboni GA, Krum SA.

Horm Cancer. 2017 Apr;8(2):90-99. doi: 10.1007/s12672-017-0286-5. Epub 2017 Feb 27.

7.

Methylparaben stimulates tumor initiating cells in ER+ breast cancer models.

Lillo MA, Nichols C, Perry C, Runke S, Krutilina R, Seagroves TN, Miranda-Carboni GA, Krum SA.

J Appl Toxicol. 2017 Apr;37(4):417-425. doi: 10.1002/jat.3374. Epub 2016 Sep 1.

8.

SMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathway.

Sethuraman A, Brown M, Seagroves TN, Wu ZH, Pfeffer LM, Fan M.

Breast Cancer Res. 2016 Aug 5;18(1):81. doi: 10.1186/s13058-016-0738-9.

9.

ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models.

Brooks DL, Schwab LP, Krutilina R, Parke DN, Sethuraman A, Hoogewijs D, Schörg A, Gotwald L, Fan M, Wenger RH, Seagroves TN.

Mol Cancer. 2016 Mar 22;15:26. doi: 10.1186/s12943-016-0510-x.

10.

Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer.

Regan Anderson TM, Ma SH, Raj GV, Cidlowski JA, Helle TM, Knutson TP, Krutilina RI, Seagroves TN, Lange CA.

Cancer Res. 2016 Mar 15;76(6):1653-63. doi: 10.1158/0008-5472.CAN-15-2510. Epub 2016 Jan 29.

11.

Assessment of the Tumorigenic Potential of Spontaneously Immortalized and hTERT-Immortalized Cultured Dental Pulp Stem Cells.

Wilson R, Urraca N, Skobowiat C, Hope KA, Miravalle L, Chamberlin R, Donaldson M, Seagroves TN, Reiter LT.

Stem Cells Transl Med. 2015 Aug;4(8):905-12. doi: 10.5966/sctm.2014-0196. Epub 2015 Jun 1.

12.

mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer.

Sodi VL, Khaku S, Krutilina R, Schwab LP, Vocadlo DJ, Seagroves TN, Reginato MJ.

Mol Cancer Res. 2015 May;13(5):923-33. doi: 10.1158/1541-7786.MCR-14-0536. Epub 2015 Jan 30.

13.

Benzimidazole analogs as potent hypoxia inducible factor inhibitors: synthesis, biological evaluation, and profiling drug-like properties.

Chen J, Wang J, Schwab LP, Park KT, Seagroves TN, Jennings LK, Miller DD, Li W.

Anticancer Res. 2014 Aug;34(8):3891-904.

14.

MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cancers.

Krutilina R, Sun W, Sethuraman A, Brown M, Seagroves TN, Pfeffer LM, Ignatova T, Fan M.

Breast Cancer Res. 2014 Jul 28;16(4):R78. doi: 10.1186/bcr3693.

15.

The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways.

Slominski A, Kim TK, Brożyna AA, Janjetovic Z, Brooks DL, Schwab LP, Skobowiat C, Jóźwicki W, Seagroves TN.

Arch Biochem Biophys. 2014 Dec 1;563:79-93. doi: 10.1016/j.abb.2014.06.030. Epub 2014 Jul 2.

16.

Hypoxia-inducible factor-1α induces ErbB4 signaling in the differentiating mammary gland.

Paatero I, Seagroves TN, Vaparanta K, Han W, Jones FE, Johnson RS, Elenius K.

J Biol Chem. 2014 Aug 8;289(32):22459-69. doi: 10.1074/jbc.M113.533497. Epub 2014 Jun 25.

17.

O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.

Ferrer CM, Lynch TP, Sodi VL, Falcone JN, Schwab LP, Peacock DL, Vocadlo DJ, Seagroves TN, Reginato MJ.

Mol Cell. 2014 Jun 5;54(5):820-31. doi: 10.1016/j.molcel.2014.04.026. Epub 2014 May 22.

18.

Putative role of HIF transcriptional activity in melanocytes and melanoma biology.

Zbytek B, Peacock DL, Seagroves TN, Slominski A.

Dermatoendocrinol. 2013 Apr 1;5(2):239-51. doi: 10.4161/derm.22678. Review.

19.

Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.

Regan Anderson TM, Peacock DL, Daniel AR, Hubbard GK, Lofgren KA, Girard BJ, Schörg A, Hoogewijs D, Wenger RH, Seagroves TN, Lange CA.

Cancer Res. 2013 Sep 15;73(18):5810-20. doi: 10.1158/0008-5472.CAN-13-0523. Epub 2013 Aug 8. Erratum in: Cancer Res. 2013 Nov 1;73(21):6538.

20.

The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance.

Whelan KA, Schwab LP, Karakashev SV, Franchetti L, Johannes GJ, Seagroves TN, Reginato MJ.

J Biol Chem. 2013 May 31;288(22):15865-77. doi: 10.1074/jbc.M112.426999. Epub 2013 Apr 12.

21.

Chemoprevention activity of dipyridamole in the MMTV-PyMT transgenic mouse model of breast cancer.

Wang C, Schwab LP, Fan M, Seagroves TN, Buolamwini JK.

Cancer Prev Res (Phila). 2013 May;6(5):437-47. doi: 10.1158/1940-6207.CAPR-12-0345. Epub 2013 Feb 27.

22.

Anti-matrix metalloproteinase-9 DNAzyme decreases tumor growth in the MMTV-PyMT mouse model of breast cancer.

Hallett MA, Teng B, Hasegawa H, Schwab LP, Seagroves TN, Pourmotabbed T.

Breast Cancer Res. 2013 Feb 13;15(1):R12. doi: 10.1186/bcr3385.

23.

Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer.

Schwab LP, Peacock DL, Majumdar D, Ingels JF, Jensen LC, Smith KD, Cushing RC, Seagroves TN.

Breast Cancer Res. 2012 Jan 7;14(1):R6.

24.

VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis.

Seagroves TN, Peacock DL, Liao D, Schwab LP, Krueger R, Handorf CR, Haase VH, Johnson RS.

Am J Pathol. 2010 May;176(5):2269-82. doi: 10.2353/ajpath.2010.090310. Epub 2010 Apr 9.

25.

Dose-dependent modulation of HIF-1alpha/sima controls the rate of cell migration and invasion in Drosophila ovary border cells.

Doronkin S, Djagaeva I, Nagle ME, Reiter LT, Seagroves TN.

Oncogene. 2010 Feb 25;29(8):1123-34. doi: 10.1038/onc.2009.407. Epub 2009 Dec 7.

PMID:
19966858
26.
27.

Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase.

Reiter LT, Seagroves TN, Bowers M, Bier E.

Hum Mol Genet. 2006 Sep 15;15(18):2825-35. Epub 2006 Aug 11.

28.

HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland.

Seagroves TN, Hadsell D, McManaman J, Palmer C, Liao D, McNulty W, Welm B, Wagner KU, Neville M, Johnson RS.

Development. 2003 Apr;130(8):1713-24.

29.

Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development.

Grimm SL, Seagroves TN, Kabotyanski EB, Hovey RC, Vonderhaar BK, Lydon JP, Miyoshi K, Hennighausen L, Ormandy CJ, Lee AV, Stull MA, Wood TL, Rosen JM.

Mol Endocrinol. 2002 Dec;16(12):2675-91.

PMID:
12456789
30.

IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development.

Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV, Karin M.

Cell. 2001 Dec 14;107(6):763-75.

31.

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

Seagroves TN, Ryan HE, Lu H, Wouters BG, Knapp M, Thibault P, Laderoute K, Johnson RS.

Mol Cell Biol. 2001 May;21(10):3436-44.

32.

C/EBPbeta (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development.

Seagroves TN, Lydon JP, Hovey RC, Vonderhaar BK, Rosen JM.

Mol Endocrinol. 2000 Mar;14(3):359-68.

PMID:
10707954
33.

C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland.

Seagroves TN, Krnacik S, Raught B, Gay J, Burgess-Beusse B, Darlington GJ, Rosen JM.

Genes Dev. 1998 Jun 15;12(12):1917-28.

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