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Items: 23


Treatment with a CD40 Antagonist Antibody Reverses Severe Proteinuria and Loss of Saliva Production and Restores Glomerular Morphology in Murine Systemic Lupus Erythematosus.

Perper SJ, Westmoreland SV, Karman J, Twomey R, Seagal J, Wang R, McRae BL, Clarke SH.

J Immunol. 2019 Jul 1;203(1):58-75. doi: 10.4049/jimmunol.1900043. Epub 2019 May 20.


BCR-dependent lineage plasticity in mature B cells.

Graf R, Seagal J, Otipoby KL, Lam KP, Ayoub S, Zhang B, Sander S, Chu VT, Rajewsky K.

Science. 2019 Feb 15;363(6428):748-753. doi: 10.1126/science.aau8475.


Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade.

Pai CS, Huang JT, Lu X, Simons DM, Park C, Chang A, Tamaki W, Liu E, Roybal KT, Seagal J, Chen M, Hagihara K, Wei XX, DuPage M, Kwek SS, Oh DY, Daud A, Tsai KK, Wu C, Zhang L, Fasso M, Sachidanandam R, Jayaprakash A, Lin I, Casbon AJ, Kinsbury GA, Fong L.

Immunity. 2019 Feb 19;50(2):477-492.e8. doi: 10.1016/j.immuni.2019.01.006. Epub 2019 Feb 5.


Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity.

Pai CS, Simons DM, Lu X, Evans M, Wei J, Wang YH, Chen M, Huang J, Park C, Chang A, Wang J, Westmoreland S, Beam C, Banach D, Bowley D, Dong F, Seagal J, Ritacco W, Richardson PL, Mitra S, Lynch G, Bousquet P, Mankovich J, Kingsbury G, Fong L.

J Clin Invest. 2019 Jan 2;129(1):349-363. doi: 10.1172/JCI123391. Epub 2018 Dec 10.


IL-36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis.

Su Z, Paulsboe S, Wetter J, Salte K, Kannan A, Mathew S, Horowitz A, Gerstein C, Namovic M, Todorović V, Seagal J, Edelmayer RM, Viner M, Rinaldi L, Zhou L, Leys L, Huang S, Wang L, Sadhukhan R, Honore P, McGaraughty S, Scott VE.

Exp Dermatol. 2019 Feb;28(2):113-120. doi: 10.1111/exd.13841. Epub 2018 Dec 21.


A novel allele for inducible Cre expression in germinal center B cells.

Weber T, Seagal J, Winkler W, Wirtz T, Chu VT, Rajewsky K.

Eur J Immunol. 2019 Jan;49(1):192-194. doi: 10.1002/eji.201847863. Epub 2018 Nov 20.


Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation.

Patterson HC, Kraus M, Wang D, Shahsafaei A, Henderson JM, Seagal J, Otipoby KL, Thai TH, Rajewsky K.

J Immunol. 2011 Sep 15;187(6):2853-8. doi: 10.4049/jimmunol.1101143. Epub 2011 Aug 12.


Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma.

Calado DP, Zhang B, Srinivasan L, Sasaki Y, Seagal J, Unitt C, Rodig S, Kutok J, Tarakhovsky A, Schmidt-Supprian M, Rajewsky K.

Cancer Cell. 2010 Dec 14;18(6):580-9. doi: 10.1016/j.ccr.2010.11.024.


A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2.

Izhak L, Wildbaum G, Zohar Y, Anunu R, Klapper L, Elkeles A, Seagal J, Yefenof E, Ayalon-Soffer M, Karin N.

J Immunol. 2009 Jul 1;183(1):732-9. doi: 10.4049/jimmunol.0802746. Epub 2009 Jun 17.


Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis.

Hao Z, Duncan GS, Seagal J, Su YW, Hong C, Haight J, Chen NJ, Elia A, Wakeham A, Li WY, Liepa J, Wood GA, Casola S, Rajewsky K, Mak TW.

Immunity. 2008 Oct 17;29(4):615-27. doi: 10.1016/j.immuni.2008.07.016. Epub 2008 Oct 2.


LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1.

Rastelli J, Hömig-Hölzel C, Seagal J, Müller W, Hermann AC, Rajewsky K, Zimber-Strobl U.

Blood. 2008 Feb 1;111(3):1448-55. Epub 2007 Nov 15.


IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta.

Waisman A, Kraus M, Seagal J, Ghosh S, Melamed D, Song J, Sasaki Y, Classen S, Lutz C, Brombacher F, Nitschke L, Rajewsky K.

J Exp Med. 2007 Apr 16;204(4):747-58. Epub 2007 Apr 9.


Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting.

Casola S, Cattoretti G, Uyttersprot N, Koralov SB, Seagal J, Hao Z, Waisman A, Egert A, Ghitza D, Rajewsky K.

Proc Natl Acad Sci U S A. 2006 May 9;103(19):7396-401. Epub 2006 May 1. Erratum in: Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2025. Segal, Jane [corrected to Seagal, Jane].


Generation and selection of an IgG-driven autoimmune repertoire during B-lymphopoiesis in Igmicro-deficient/lpr mice.

Seagal J, Edry E, Naftali H, Melamed D.

Int Immunol. 2004 Jul;16(7):905-13. Epub 2004 May 17.


A fail-safe mechanism for negative selection of isotype-switched B cell precursors is regulated by the Fas/FasL pathway.

Seagal J, Edry E, Keren Z, Leider N, Benny O, Machluf M, Melamed D.

J Exp Med. 2003 Nov 17;198(10):1609-19.


Increased plasma cell frequency and accumulation of abnormal syndecan-1plus T-cells in Igmu-deficient/lpr mice.

Seagal J, Leider N, Wildbaum G, Karin N, Melamed D.

Int Immunol. 2003 Sep;15(9):1045-52.


Selection events in directing B cell development.

Seagal J, Melamed D.

Histol Histopathol. 2003 Apr;18(2):519-27. doi: 10.14670/HH-18.519. Review.


Role of receptor revision in forming a B cell repertoire.

Seagal J, Melamed D.

Clin Immunol. 2002 Oct;105(1):1-8. Review. No abstract available.


Vascular endothelial growth factor and angiopoietin in liver regeneration.

Kraizer Y, Mawasi N, Seagal J, Paizi M, Assy N, Spira G.

Biochem Biophys Res Commun. 2001 Sep 14;287(1):209-15.


Use of human CD4 transgenic mice for studying immunogenicity of HIV-1 envelope protein gp120.

Seagal J, Spectorman E, Gershoni JM, Denisova GF.

Transgenic Res. 2001 Apr;10(2):113-20.


Forming a story: the health benefits of narrative.

Pennebaker JW, Seagal JD.

J Clin Psychol. 1999 Oct;55(10):1243-54.


Effects of disclosure of traumatic events on illness behavior among psychiatric prison inmates.

Richards JM, Beal WE, Seagal JD, Pennebaker JW.

J Abnorm Psychol. 2000 Feb;109(1):156-60.


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