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Items: 9


Closing and Opening Holes in the Glycan Shield of HIV-1 Envelope Glycoprotein SOSIP Trimers Can Redirect the Neutralizing Antibody Response to the Newly Unmasked Epitopes.

Ringe RP, Pugach P, Cottrell CA, LaBranche CC, Seabright GE, Ketas TJ, Ozorowski G, Kumar S, Schorcht A, van Gils MJ, Crispin M, Montefiori DC, Wilson IA, Ward AB, Sanders RW, Klasse PJ, Moore JP.

J Virol. 2019 Feb 5;93(4). pii: e01656-18. doi: 10.1128/JVI.01656-18. Print 2019 Feb 15.


Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen.

Struwe WB, Chertova E, Allen JD, Seabright GE, Watanabe Y, Harvey DJ, Medina-Ramirez M, Roser JD, Smith R, Westcott D, Keele BF, Bess JW Jr, Sanders RW, Lifson JD, Moore JP, Crispin M.

Cell Rep. 2018 Aug 21;24(8):1958-1966.e5. doi: 10.1016/j.celrep.2018.07.080.


Structure of the Lassa virus glycan shield provides a model for immunological resistance.

Watanabe Y, Raghwani J, Allen JD, Seabright GE, Li S, Moser F, Huiskonen JT, Strecker T, Bowden TA, Crispin M.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7320-7325. doi: 10.1073/pnas.1803990115. Epub 2018 Jun 25.


Signature of Antibody Domain Exchange by Native Mass Spectrometry and Collision-Induced Unfolding.

Watanabe Y, Vasiljevic S, Allen JD, Seabright GE, Duyvesteyn HME, Doores KJ, Crispin M, Struwe WB.

Anal Chem. 2018 Jun 19;90(12):7325-7331. doi: 10.1021/acs.analchem.8b00573. Epub 2018 May 25.


Isomer Information from Ion Mobility Separation of High-Mannose Glycan Fragments.

Harvey DJ, Seabright GE, Vasiljevic S, Crispin M, Struwe WB.

J Am Soc Mass Spectrom. 2018 May;29(5):972-988. doi: 10.1007/s13361-018-1890-5. Epub 2018 Mar 5.


Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein.

Behrens AJ, Vasiljevic S, Pritchard LK, Harvey DJ, Andev RS, Krumm SA, Struwe WB, Cupo A, Kumar A, Zitzmann N, Seabright GE, Kramer HB, Spencer DI, Royle L, Lee JH, Klasse PJ, Burton DR, Wilson IA, Ward AB, Sanders RW, Moore JP, Doores KJ, Crispin M.

Cell Rep. 2016 Mar 22;14(11):2695-706. doi: 10.1016/j.celrep.2016.02.058. Epub 2016 Mar 10.


Redirecting adenoviruses to tumour cells using therapeutic antibodies: Generation of a versatile human bispecific adaptor.

Vasiljevic S, Beale EV, Bonomelli C, Easthope IS, Pritchard LK, Seabright GE, Caputo AT, Scanlan CN, Dalziel M, Crispin M.

Mol Immunol. 2015 Dec;68(2 Pt A):234-43. doi: 10.1016/j.molimm.2015.08.014. Epub 2015 Sep 29.


Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies.

Pritchard LK, Spencer DI, Royle L, Bonomelli C, Seabright GE, Behrens AJ, Kulp DW, Menis S, Krumm SA, Dunlop DC, Crispin DJ, Bowden TA, Scanlan CN, Ward AB, Schief WR, Doores KJ, Crispin M.

Nat Commun. 2015 Jun 24;6:7479. doi: 10.1038/ncomms8479.


Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers.

Pritchard LK, Vasiljevic S, Ozorowski G, Seabright GE, Cupo A, Ringe R, Kim HJ, Sanders RW, Doores KJ, Burton DR, Wilson IA, Ward AB, Moore JP, Crispin M.

Cell Rep. 2015 Jun 16;11(10):1604-13. doi: 10.1016/j.celrep.2015.05.017. Epub 2015 Jun 4.

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