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Items: 1 to 50 of 149

1.

Two-Year Results After AAV2-Mediated Gene Therapy for Choroideremia: The Alberta Experience.

Dimopoulos IS, Hoang SC, Radziwon A, Binczyk NM, Seabra MC, MacLaren RE, Somani R, Tennant MTS, MacDonald IM.

Am J Ophthalmol. 2018 Jun 27;193:130-142. doi: 10.1016/j.ajo.2018.06.011. [Epub ahead of print]

PMID:
29940166
2.

Melanin Transferred to Keratinocytes Resides in Nondegradative Endocytic Compartments.

Correia MS, Moreiras H, Pereira FJC, Neto MV, Festas TC, Tarafder AK, Ramalho JS, Seabra MC, Barral DC.

J Invest Dermatol. 2018 Mar;138(3):637-646. doi: 10.1016/j.jid.2017.09.042. Epub 2017 Oct 24.

PMID:
29074272
3.

Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli.

Alexander M, Ramstead AG, Bauer KM, Lee SH, Runtsch MC, Wallace J, Huffaker TB, Larsen DK, Tolmachova T, Seabra MC, Round JL, Ward DM, O'Connell RM.

J Immunol. 2017 Nov 15;199(10):3559-3570. doi: 10.4049/jimmunol.1700904. Epub 2017 Oct 4.

PMID:
28978688
4.

Visual Acuity after Retinal Gene Therapy for Choroideremia.

Edwards TL, Jolly JK, Groppe M, Barnard AR, Cottriall CL, Tolmachova T, Black GC, Webster AR, Lotery AJ, Holder GE, Xue K, Downes SM, Simunovic MP, Seabra MC, MacLaren RE.

N Engl J Med. 2016 May 19;374(20):1996-8. doi: 10.1056/NEJMc1509501. Epub 2016 Apr 27. No abstract available.

5.

Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells.

Wankel B, Ouyang J, Guo X, Hadjiolova K, Miller J, Liao Y, Tham DK, Romih R, Andrade LR, Gumper I, Simon JP, Sachdeva R, Tolmachova T, Seabra MC, Fukuda M, Schaeren-Wiemers N, Hong WJ, Sabatini DD, Wu XR, Kong X, Kreibich G, Rindler MJ, Sun TT.

Mol Biol Cell. 2016 May 15;27(10):1621-34. doi: 10.1091/mbc.E15-04-0230. Epub 2016 Mar 23.

6.

Correction: A Role for Na+,K+-ATPase α1 in Regulating Rab27a Localisation on Melanosomes.

Booth AE, Tarafder AK, Hume AN, Recchi C, Seabra MC.

PLoS One. 2016 Feb 3;11(2):e0148719. doi: 10.1371/journal.pone.0148719. eCollection 2016. No abstract available.

7.

Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment.

Burgoyne T, Meschede IP, Burden JJ, Bailly M, Seabra MC, Futter CE.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15922-7. doi: 10.1073/pnas.1509285113. Epub 2015 Dec 14.

8.

Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease).

Wavre-Shapton ST, Calvi AA, Turmaine M, Seabra MC, Cutler DF, Futter CE, Mitchison HM.

Hum Mol Genet. 2015 Dec 15;24(24):7060-74. doi: 10.1093/hmg/ddv406. Epub 2015 Oct 8.

9.

Host cell autophagy contributes to Plasmodium liver development.

Thieleke-Matos C, Lopes da Silva M, Cabrita-Santos L, Portal MD, Rodrigues IP, Zuzarte-Luis V, Ramalho JS, Futter CE, Mota MM, Barral DC, Seabra MC.

Cell Microbiol. 2016 Mar;18(3):437-50. doi: 10.1111/cmi.12524. Epub 2015 Nov 4.

PMID:
26399761
10.

Rab27a GTPase modulates L-type Ca2+ channel function via interaction with the II-III linker of CaV1.3 subunit.

Reichhart N, Markowski M, Ishiyama S, Wagner A, Crespo-Garcia S, Schorb T, Ramalho JS, Milenkovic VM, Föckler R, Seabra MC, Strauß O.

Cell Signal. 2015 Nov;27(11):2231-40. doi: 10.1016/j.cellsig.2015.07.023. Epub 2015 Jul 31.

PMID:
26235199
11.

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin.

Alexander M, Hu R, Runtsch MC, Kagele DA, Mosbruger TL, Tolmachova T, Seabra MC, Round JL, Ward DM, O'Connell RM.

Nat Commun. 2015 Jun 18;6:7321. doi: 10.1038/ncomms8321.

12.

Impact of the serum- and glucocorticoid-inducible kinase 1 on platelet dense granule biogenesis and secretion.

Walker B, Schmid E, Russo A, Schmidt EM, Burk O, Münzer P, Velic A, Macek B, Schaller M, Schwab M, Seabra MC, Gawaz M, Lang F, Borst O.

J Thromb Haemost. 2015 Jul;13(7):1325-34. doi: 10.1111/jth.12998. Epub 2015 Jun 12.

13.

Choroideremia.

MacDonald IM, Hume S, Chan S, Seabra MC.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018.
2003 Feb 21 [updated 2015 Feb 26].

14.

Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL.

Burgoyne T, O'Connor MN, Seabra MC, Cutler DF, Futter CE.

J Cell Sci. 2015 Apr 1;128(7):1400-7. doi: 10.1242/jcs.164400. Epub 2015 Feb 17.

15.

A role for Rab27 in neutrophil chemotaxis and lung recruitment.

Singh RK, Furze RC, Birrell MA, Rankin SM, Hume AN, Seabra MC.

BMC Cell Biol. 2014 Oct 31;15:39. doi: 10.1186/s12860-014-0039-z.

16.

MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells.

Okoye IS, Coomes SM, Pelly VS, Czieso S, Papayannopoulos V, Tolmachova T, Seabra MC, Wilson MS.

Immunity. 2014 Sep 18;41(3):503. doi: 10.1016/j.immuni.2014.08.008. Epub 2014 Sep 18. No abstract available.

17.

Melanoma goes on a diet to get moving: toning down phagocytic Rab7 expression helps melanoma to metastasise.

Hume AN, Seabra MC.

Pigment Cell Melanoma Res. 2014 Nov;27(6):1012-3. doi: 10.1111/pcmr.12310. Epub 2014 Sep 18. No abstract available.

PMID:
25141997
18.

Phagosome maturation during endosome interaction revealed by partial rhodopsin processing in retinal pigment epithelium.

Wavre-Shapton ST, Meschede IP, Seabra MC, Futter CE.

J Cell Sci. 2014 Sep 1;127(Pt 17):3852-61. doi: 10.1242/jcs.154757. Epub 2014 Jul 29.

19.

A role for Na+,K+-ATPase α1 in regulating Rab27a localisation on melanosomes.

Booth AE, Tarafder AK, Hume AN, Recchi C, Seabra MC.

PLoS One. 2014 Jul 22;9(7):e102851. doi: 10.1371/journal.pone.0102851. eCollection 2014. Erratum in: PLoS One. 2016;11(2):e0148719.

20.

MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells.

Okoye IS, Coomes SM, Pelly VS, Czieso S, Papayannopoulos V, Tolmachova T, Seabra MC, Wilson MS.

Immunity. 2014 Jul 17;41(1):89-103. doi: 10.1016/j.immuni.2014.05.019.

21.

Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection.

Thieleke-Matos C, da Silva ML, Cabrita-Santos L, Pires CF, Ramalho JS, Ikonomov O, Seixas E, Shisheva A, Seabra MC, Barral DC.

Traffic. 2014 Oct;15(10):1066-82. doi: 10.1111/tra.12190. Epub 2014 Aug 21.

22.

Haff disease associated with the ingestion of the freshwater fish Mylossoma duriventre (pacu-manteiga).

Tolesani Júnior O, Roderjan CN, do Carmo Neto E, Ponte MM, Seabra MC, Knibel MF.

Rev Bras Ter Intensiva. 2013 Oct-Dec;25(4):348-51. doi: 10.5935/0103-507X.20130058. English, Portuguese.

23.

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial.

MacLaren RE, Groppe M, Barnard AR, Cottriall CL, Tolmachova T, Seymour L, Clark KR, During MJ, Cremers FP, Black GC, Lotery AJ, Downes SM, Webster AR, Seabra MC.

Lancet. 2014 Mar 29;383(9923):1129-37. doi: 10.1016/S0140-6736(13)62117-0. Epub 2014 Jan 16.

24.

Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis.

Tarafder AK, Bolasco G, Correia MS, Pereira FJC, Iannone L, Hume AN, Kirkpatrick N, Picardo M, Torrisi MR, Rodrigues IP, Ramalho JS, Futter CE, Barral DC, Seabra MC.

J Invest Dermatol. 2014 Apr;134(4):1056-1066. doi: 10.1038/jid.2013.432. Epub 2013 Oct 18.

25.

Expression of OA1 limits the fusion of a subset of MVBs with lysosomes - a mechanism potentially involved in the initial biogenesis of melanosomes.

Burgoyne T, Jolly R, Martin-Martin B, Seabra MC, Piccirillo R, Schiaffino MV, Futter CE.

J Cell Sci. 2013 Nov 15;126(Pt 22):5143-52. doi: 10.1242/jcs.128561. Epub 2013 Sep 4. Erratum in: J Cell Sci. 2014 Feb 1;127(Pt 3):700.

26.

An essential role for Rab27a GTPase in eosinophil exocytosis.

Kim JD, Willetts L, Ochkur S, Srivastava N, Hamburg R, Shayeganpour A, Seabra MC, Lee JJ, Moqbel R, Lacy P.

J Leukoc Biol. 2013 Dec;94(6):1265-74. doi: 10.1189/jlb.0812431. Epub 2013 Aug 28.

27.

Clinical utility gene card for: choroideremia.

Moosajee M, Ramsden SC, Black GC, Seabra MC, Webster AR.

Eur J Hum Genet. 2014 Apr;22(4). doi: 10.1038/ejhg.2013.183. Epub 2013 Aug 21. No abstract available.

28.

Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy.

Kirsten ML, Baron RA, Seabra MC, Ces O.

Mol Membr Biol. 2013 Jul;30(4):303-14. doi: 10.3109/09687688.2013.818725.

PMID:
23815289
29.

Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo.

Tolmachova T, Tolmachov OE, Barnard AR, de Silva SR, Lipinski DM, Walker NJ, Maclaren RE, Seabra MC.

J Mol Med (Berl). 2013 Jul;91(7):825-37. doi: 10.1007/s00109-013-1006-4. Epub 2013 Jun 12.

30.

Rab and Arf proteins in genetic diseases.

Seixas E, Barros M, Seabra MC, Barral DC.

Traffic. 2013 Aug;14(8):871-85. doi: 10.1111/tra.12072. Epub 2013 Apr 29. Review.

31.

Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium.

Wavre-Shapton ST, Tolmachova T, Lopes da Silva M, Futter CE, Seabra MC.

PLoS One. 2013;8(2):e57769. doi: 10.1371/journal.pone.0057769. Epub 2013 Feb 27. Erratum in: PLoS One. 2013;8(5). doi:10.1371/annotation/83a88285-e6a0-41fb-ae67-4315c21e5090. da Silva, Mafalda Lopes [corrected to Lopes da Silva, Mafalda].

32.

Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion.

Singh RK, Mizuno K, Wasmeier C, Wavre-Shapton ST, Recchi C, Catz SD, Futter C, Tolmachova T, Hume AN, Seabra MC.

FEBS J. 2013 Feb;280(3):892-903. doi: 10.1111/febs.12081. Epub 2013 Jan 2.

33.

Novel functions for Rab GTPases in multiple aspects of tumour progression.

Recchi C, Seabra MC.

Biochem Soc Trans. 2012 Dec 1;40(6):1398-403. doi: 10.1042/BST20120199. Review.

34.

Rab27a and melanosomes: a model to investigate the membrane targeting of Rabs.

Booth AE, Seabra MC, Hume AN.

Biochem Soc Trans. 2012 Dec 1;40(6):1383-8. doi: 10.1042/BST20120200.

PMID:
23176485
35.

Bacteria and protozoa differentially modulate the expression of Rab proteins.

Seixas E, Ramalho JS, Mota LJ, Barral DC, Seabra MC.

PLoS One. 2012;7(7):e39858. doi: 10.1371/journal.pone.0039858. Epub 2012 Jul 20.

36.

Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression.

Bobrie A, Krumeich S, Reyal F, Recchi C, Moita LF, Seabra MC, Ostrowski M, Théry C.

Cancer Res. 2012 Oct 1;72(19):4920-30. doi: 10.1158/0008-5472.CAN-12-0925. Epub 2012 Aug 3.

37.

An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue.

Hendrix A, Lambein K, Westbroek W, Seabra MC, Cocquyt V, Pauwels P, Bracke M, Gespach C, De Wever O.

Int J Dev Biol. 2012;56(5):363-8. doi: 10.1387/ijdb.120008ah.

38.

The host endocytic pathway is essential for Plasmodium berghei late liver stage development.

Lopes da Silva M, Thieleke-Matos C, Cabrita-Santos L, Ramalho JS, Wavre-Shapton ST, Futter CE, Barral DC, Seabra MC.

Traffic. 2012 Oct;13(10):1351-63. doi: 10.1111/j.1600-0854.2012.01398.x. Epub 2012 Aug 3.

39.

Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment.

Singh RK, Liao W, Tracey-White D, Recchi C, Tolmachova T, Rankin SM, Hume AN, Seabra MC.

J Cell Sci. 2012 Apr 1;125(Pt 7):1652-6. doi: 10.1242/jcs.100438. Epub 2012 Feb 28.

40.

CHM/REP1 cDNA delivery by lentiviral vectors provides functional expression of the transgene in the retinal pigment epithelium of choroideremia mice.

Tolmachova T, Tolmachov OE, Wavre-Shapton ST, Tracey-White D, Futter CE, Seabra MC.

J Gene Med. 2012 Mar;14(3):158-68. doi: 10.1002/jgm.1652.

PMID:
22228595
41.

Thousands of rab GTPases for the cell biologist.

Diekmann Y, Seixas E, Gouw M, Tavares-Cadete F, Seabra MC, Pereira-Leal JB.

PLoS Comput Biol. 2011 Oct;7(10):e1002217. doi: 10.1371/journal.pcbi.1002217. Epub 2011 Oct 13.

42.

Melanosomes on the move: a model to understand organelle dynamics.

Hume AN, Seabra MC.

Biochem Soc Trans. 2011 Oct;39(5):1191-6. doi: 10.1042/BST0391191. Review.

PMID:
21936787
43.

Semi-automated analysis of organelle movement and membrane content: understanding rab-motor complex transport function.

Hume AN, Wilson MS, Ushakov DS, Ferenczi MA, Seabra MC.

Traffic. 2011 Dec;12(12):1686-701. doi: 10.1111/j.1600-0854.2011.01283.x. Epub 2011 Oct 11.

44.

Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors.

Błażewska KM, Ni F, Haiges R, Kashemirov BA, Coxon FP, Stewart CA, Baron R, Rogers MJ, Seabra MC, Ebetino FH, McKenna CE.

Eur J Med Chem. 2011 Oct;46(10):4820-6. doi: 10.1016/j.ejmech.2011.04.063. Epub 2011 May 7.

PMID:
21889236
45.

Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function.

Taylor A, Mules EH, Seabra MC, Helfrich MH, Rogers MJ, Coxon FP.

Small GTPases. 2011 May;2(3):131-142.

46.

Myosin Va acts in concert with Rab27a and MyRIP to regulate acute von-Willebrand factor release from endothelial cells.

Rojo Pulido I, Nightingale TD, Darchen F, Seabra MC, Cutler DF, Gerke V.

Traffic. 2011 Oct;12(10):1371-82. doi: 10.1111/j.1600-0854.2011.01248.x. Epub 2011 Aug 5.

47.

Rab27a targeting to melanosomes requires nucleotide exchange but not effector binding.

Tarafder AK, Wasmeier C, Figueiredo AC, Booth AE, Orihara A, Ramalho JS, Hume AN, Seabra MC.

Traffic. 2011 Aug;12(8):1056-66. doi: 10.1111/j.1600-0854.2011.01216.x. Epub 2011 Jun 15.

48.

Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland.

Chiang L, Ngo J, Schechter JE, Karvar S, Tolmachova T, Seabra MC, Hume AN, Hamm-Alvarez SF.

Am J Physiol Cell Physiol. 2011 Aug;301(2):C507-21. doi: 10.1152/ajpcell.00355.2010. Epub 2011 Apr 27. Erratum in: Am J Physiol Cell Physiol. 2011 Dec;301(6):C1480.

49.

The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates.

Coxon FP, Taylor A, Stewart CA, Baron R, Seabra MC, Ebetino FH, Rogers MJ.

Bone. 2011 Jul;49(1):111-21. doi: 10.1016/j.bone.2011.03.686. Epub 2011 Mar 21.

PMID:
21419243
50.

Loss of Rab27 function results in abnormal lung epithelium structure in mice.

Bolasco G, Tracey-White DC, Tolmachova T, Thorley AJ, Tetley TD, Seabra MC, Hume AN.

Am J Physiol Cell Physiol. 2011 Mar;300(3):C466-76. doi: 10.1152/ajpcell.00446.2010. Epub 2010 Dec 15.

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