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Items: 35


The relationship of REL proto-oncogene to pathobiology and chemoresistance in follicular and transformed follicular lymphoma.

Hu X, Baytak E, Li J, Akman B, Okay K, Hu G, Scuto A, Zhang W, Küçük C.

Leuk Res. 2017 Mar;54:30-38. doi: 10.1016/j.leukres.2017.01.001. Epub 2017 Jan 9.


Combined copy number and mutation analysis identifies oncogenic pathways associated with transformation of follicular lymphoma.

Bouska A, Zhang W, Gong Q, Iqbal J, Scuto A, Vose J, Ludvigsen M, Fu K, Weisenburger DD, Greiner TC, Gascoyne RD, Rosenwald A, Ott G, Campo E, Rimsza LM, Delabie J, Jaffe ES, Braziel RM, Connors JM, Wu CI, Staudt LM, D'Amore F, McKeithan TW, Chan WC.

Leukemia. 2017 Jan;31(1):83-91. doi: 10.1038/leu.2016.175. Epub 2016 Jun 16.


Cyclin D1 depletion induces DNA damage in mantle cell lymphoma lines.

Mohanty S, Mohanty A, Sandoval N, Tran T, Bedell V, Wu J, Scuto A, Murata-Collins J, Weisenburger DD, Ngo VN.

Leuk Lymphoma. 2017 Mar;58(3):676-688. doi: 10.1080/10428194.2016.1198958. Epub 2016 Jun 24.


Data supporting the role of electric field and electrode material on the improvement of the ageing effects in hydrogenated amorphous silicon solar cells.

Scuto A, Valenti L, Pierro S, Foti M, Gerardi C, Battaglia A, Lombardo S.

Data Brief. 2015 Jul 23;4:518-23. doi: 10.1016/j.dib.2015.07.020. eCollection 2015 Sep.


Carbamates: A study on genotoxic, cytotoxic, and apoptotic effects induced in Chinese hamster ovary (CHO-K1) cells.

Soloneski S, Kujawski M, Scuto A, Larramendy ML.

Toxicol In Vitro. 2015 Aug;29(5):834-44. doi: 10.1016/j.tiv.2015.03.011. Epub 2015 Mar 24.


Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells.

Küçük C, Jiang B, Hu X, Zhang W, Chan JK, Xiao W, Lack N, Alkan C, Williams JC, Avery KN, Kavak P, Scuto A, Sen E, Gaulard P, Staudt L, Iqbal J, Zhang W, Cornish A, Gong Q, Yang Q, Sun H, d'Amore F, Leppä S, Liu W, Fu K, de Leval L, McKeithan T, Chan WC.

Nat Commun. 2015 Jan 14;6:6025. doi: 10.1038/ncomms7025.


Targeting JAK1/STAT3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer.

Wen W, Liang W, Wu J, Kowolik CM, Buettner R, Scuto A, Hsieh MY, Hong H, Brown CE, Forman SJ, Horne D, Morgan R, Wakabayashi M, Dellinger TH, Han ES, Yim JH, Jove R.

Mol Cancer Ther. 2014 Dec;13(12):3037-48. doi: 10.1158/1535-7163.MCT-14-0077. Epub 2014 Oct 15.


SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells.

Scuto A, Kirschbaum M, Buettner R, Kujawski M, Cermak JM, Atadja P, Jove R.

Cell Death Dis. 2013 May 16;4:e635. doi: 10.1038/cddis.2013.159.


DNA damage kinetics and apoptosis in ivermectin-treated Chinese hamster ovary cells.

Molinari G, Kujawski M, Scuto A, Soloneski S, Larramendy ML.

J Appl Toxicol. 2013 Nov;33(11):1260-7. doi: 10.1002/jat.2782. Epub 2012 Sep 7.


S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma.

Liu Y, Deng J, Wang L, Lee H, Armstrong B, Scuto A, Kowolik C, Weiss LM, Forman S, Yu H.

Blood. 2012 Aug 16;120(7):1458-65. doi: 10.1182/blood-2011-12-399030. Epub 2012 Jun 28.


Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling.

Nam S, Scuto A, Yang F, Chen W, Park S, Yoo HS, Konig H, Bhatia R, Cheng X, Merz KH, Eisenbrand G, Jove R.

Mol Oncol. 2012 Jun;6(3):276-83. doi: 10.1016/j.molonc.2012.02.002. Epub 2012 Feb 17.


Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-ĸB signaling, and synergizes with an ERK inhibitor.

Yang F, Jove V, Chang S, Hedvat M, Liu L, Buettner R, Tian Y, Scuto A, Wen W, Yip ML, Van Meter T, Yen Y, Jove R.

Cancer Biol Ther. 2012 Apr;13(6):349-57. doi: 10.4161/cbt.19239. Epub 2012 Apr 1.


Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480.

Xin H, Herrmann A, Reckamp K, Zhang W, Pal S, Hedvat M, Zhang C, Liang W, Scuto A, Weng S, Morosini D, Cao ZA, Zinda M, Figlin R, Huszar D, Jove R, Yu H.

Cancer Res. 2011 Nov 1;71(21):6601-10. doi: 10.1158/0008-5472.CAN-11-1217. Epub 2011 Sep 15.


6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells.

Liu L, Nam S, Tian Y, Yang F, Wu J, Wang Y, Scuto A, Polychronopoulos P, Magiatis P, Skaltsounis L, Jove R.

Cancer Res. 2011 Jun 1;71(11):3972-9. doi: 10.1158/0008-5472.CAN-10-3852. Epub 2011 May 24.


STAT3 inhibition is a therapeutic strategy for ABC-like diffuse large B-cell lymphoma.

Scuto A, Kujawski M, Kowolik C, Krymskaya L, Wang L, Weiss LM, Digiusto D, Yu H, Forman S, Jove R.

Cancer Res. 2011 May 1;71(9):3182-8. doi: 10.1158/0008-5472.CAN-10-2380. Epub 2011 Apr 26.


Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels.

Kretzner L, Scuto A, Dino PM, Kowolik CM, Wu J, Ventura P, Jove R, Forman SJ, Yen Y, Kirschbaum MH.

Cancer Res. 2011 Jun 1;71(11):3912-20. doi: 10.1158/0008-5472.CAN-10-2259. Epub 2011 Apr 18.


The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival.

Scuto A, Krejci P, Popplewell L, Wu J, Wang Y, Kujawski M, Kowolik C, Xin H, Chen L, Wang Y, Kretzner L, Yu H, Wilcox WR, Yen Y, Forman S, Jove R.

Leukemia. 2011 Mar;25(3):538-50. doi: 10.1038/leu.2010.289. Epub 2010 Dec 17.


Targeting STAT3 in adoptively transferred T cells promotes their in vivo expansion and antitumor effects.

Kujawski M, Zhang C, Herrmann A, Reckamp K, Scuto A, Jensen M, Deng J, Forman S, Figlin R, Yu H.

Cancer Res. 2010 Dec 1;70(23):9599-610. doi: 10.1158/0008-5472.CAN-10-1293. Epub 2010 Nov 30.


Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3.

Yang F, Brown C, Buettner R, Hedvat M, Starr R, Scuto A, Schroeder A, Jensen M, Jove R.

Mol Cancer Ther. 2010 Apr;9(4):953-62. doi: 10.1158/1535-7163.MCT-09-0947. Epub 2010 Apr 6.


In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses.

Kortylewski M, Swiderski P, Herrmann A, Wang L, Kowolik C, Kujawski M, Lee H, Scuto A, Liu Y, Yang C, Deng J, Soifer HS, Raubitschek A, Forman S, Rossi JJ, Pardoll DM, Jove R, Yu H.

Nat Biotechnol. 2009 Oct;27(10):925-32. doi: 10.1038/nbt.1564. Epub 2009 Sep 13.


The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells.

Scuto A, Kirschbaum M, Kowolik C, Kretzner L, Juhasz A, Atadja P, Pullarkat V, Bhatia R, Forman S, Yen Y, Jove R.

Blood. 2008 May 15;111(10):5093-100. doi: 10.1182/blood-2007-10-117762. Epub 2008 Mar 18.


RbAp48 regulates cytoskeletal organization and morphology by increasing K-Ras activity and signaling through mitogen-activated protein kinase.

Scuto A, Zhang H, Zhao H, Rivera M, Yeatman TJ, Jove R, Torres-Roca JF.

Cancer Res. 2007 Nov 1;67(21):10317-24.


Prediction of radiation sensitivity using a gene expression classifier.

Torres-Roca JF, Eschrich S, Zhao H, Bloom G, Sung J, McCarthy S, Cantor AB, Scuto A, Li C, Zhang S, Jove R, Yeatman T.

Cancer Res. 2005 Aug 15;65(16):7169-76.


Action of prolactin, IFN-gamma, TNF-alpha and LPS on heme oxygenase-1 expression and VEGF release in human monocytes/macrophages.

Malaguarnera L, Imbesi R, Di Rosa M, Scuto A, Castrogiovanni P, Messina A, Sanfilippo S.

Int Immunopharmacol. 2005 Aug;5(9):1458-69.


Survivin expression in chronic myeloid leukemia.

Conte E, Stagno F, Guglielmo P, Scuto A, Consoli C, Messina A.

Cancer Lett. 2005 Jul 8;225(1):105-10. Epub 2004 Dec 7.


Interferon-gamma, tumor necrosis factor-alpha, and lipopolysaccharide promote chitotriosidase gene expression in human macrophages.

Malaguarnera L, Musumeci M, Di Rosa M, Scuto A, Musumeci S.

J Clin Lab Anal. 2005;19(3):128-32.


Effect of interferon-gamma, interleukin-10, lipopolysaccharide and tumor necrosis factor-alpha on chitotriosidase synthesis in human macrophages.

Di Rosa M, Musumeci M, Scuto A, Musumeci S, Malaguarnera L.

Clin Chem Lab Med. 2005;43(5):499-502.


Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.

George P, Bali P, Annavarapu S, Scuto A, Fiskus W, Guo F, Sigua C, Sondarva G, Moscinski L, Atadja P, Bhalla K.

Blood. 2005 Feb 15;105(4):1768-76. Epub 2004 Oct 28.


Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells.

Guo F, Sigua C, Bali P, George P, Fiskus W, Scuto A, Annavarapu S, Mouttaki A, Sondarva G, Wei S, Wu J, Djeu J, Bhalla K.

Blood. 2005 Feb 1;105(3):1246-55. Epub 2004 Sep 23.


Prolactin increases HO-1 expression and induces VEGF production in human macrophages.

Malaguarnera L, Imbesi RM, Scuto A, D'Amico F, Licata F, Messina A, Sanfilippo S.

J Cell Biochem. 2004 Sep 1;93(1):197-206.


Superior activity of the combination of histone deacetylase inhibitor LAQ824 and the FLT-3 kinase inhibitor PKC412 against human acute myelogenous leukemia cells with mutant FLT-3.

Bali P, George P, Cohen P, Tao J, Guo F, Sigua C, Vishvanath A, Scuto A, Annavarapu S, Fiskus W, Moscinski L, Atadja P, Bhalla K.

Clin Cancer Res. 2004 Aug 1;10(15):4991-7.


Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3.

George P, Bali P, Cohen P, Tao J, Guo F, Sigua C, Vishvanath A, Fiskus W, Scuto A, Annavarapu S, Moscinski L, Bhalla K.

Cancer Res. 2004 May 15;64(10):3645-52.


rrn operons in Haemophilus parainfluenzae and mosaicism of conserved and species-specific sequences in the 16S-23S rDNA long spacer.

Gianninò V, Rappazzo G, Scuto A, Di Marco O, Privitera A, Santagati M, Stefani S.

Res Microbiol. 2001 Jun;152(5):461-8.


[Esthetic treatment of discolored nonvital teeth].

Messina G, Guccione E, Zaborra G, Scuto A.

Stomatol Mediterr. 1991 Apr-Jun;11(2):95-8. Italian. No abstract available.


[Modern views on treating tooth discoloration from tetracycline].

Bella G, Messina G, Scuto A, Trovato S.

Stomatol Mediterr. 1991 Jan-Mar;11(1):39-45. Italian.


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