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Items: 43

1.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig JA, Pisco JP, Peet C, Dranow DM, Robinson DA, Jansen C, Norcross NR, Vinayak S, Anderson M, Brooks CF, Cooper CA, Damerow S, Delves M, Dowers K, Duffy J, Edwards TE, Hallyburton I, Horst BG, Hulverson MA, Ferguson L, Jiménez-Díaz MB, Jumani RS, Lorimer DD, Love MS, Maher S, Matthews H, McNamara CW, Miller P, O'Neill S, Ojo KK, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz LM, Scullion P, Sharma A, Shepherd SM, Shishikura Y, Simeons FRC, Stebbins EE, Stojanovski L, Straschil U, Tamaki FK, Tamjar J, Torrie LS, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Gamo FJ, Mäser P, Kyle DE, Winzeler EA, Myler PJ, Wyatt PG, Floyd D, Matthews D, Sharma A, Striepen B, Huston CD, Gray DW, Fairlamb AH, Pisliakov AV, Walpole C, Read KD, Van Voorhis WC, Gilbert IH.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7015-7020. doi: 10.1073/pnas.1814685116. Epub 2019 Mar 20.

2.

Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1).

Bell M, Foley D, Naylor C, Wood G, Robinson C, Riley J, Epemolu O, Ellis L, Scullion P, Shishikura Y, Osuna-Cabello M, Ferguson L, Pinto E, Fletcher D, Katz E, McLean WHI, Wyatt P, Read KD, Woodland A.

ACS Med Chem Lett. 2019 Feb 14;10(3):341-347. doi: 10.1021/acsmedchemlett.8b00616. eCollection 2019 Mar 14.

3.

Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1.

Bell M, Foley D, Naylor C, Robinson C, Riley J, Epemolu O, Scullion P, Shishikura Y, Katz E, McLean WHI, Wyatt P, Read KD, Woodland A.

Bioorg Med Chem Lett. 2018 Oct 15;28(19):3255-3259. doi: 10.1016/j.bmcl.2018.07.044. Epub 2018 Jul 30.

4.

A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism.

Roberts AJ, Dunne J, Scullion P, Norval S, Fairlamb AH.

Biochem J. 2018 Aug 30;475(16):2593-2610. doi: 10.1042/BCJ20180232.

5.

Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users.

McKenzie C, Sutcliffe OB, Read KD, Scullion P, Epemolu O, Fletcher D, Helander A, Beck O, Rylski A, Antonides LH, Riley J, Smith SA, Nic Daeid N.

Forensic Toxicol. 2018;36(2):359-374. doi: 10.1007/s11419-018-0413-1. Epub 2018 Apr 5.

6.

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.

Cleghorn LAT, Ray PC, Odingo J, Kumar A, Wescott H, Korkegian A, Masquelin T, Lopez Moure A, Wilson C, Davis S, Huggett M, Turner P, Smith A, Epemolu O, Zuccotto F, Riley J, Scullion P, Shishikura Y, Ferguson L, Rullas J, Guijarro L, Read KD, Green SR, Hipskind P, Parish T, Wyatt PG.

J Med Chem. 2018 Aug 9;61(15):6592-6608. doi: 10.1021/acs.jmedchem.8b00172. Epub 2018 Jul 26.

7.

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.

Murugesan D, Ray PC, Bayliss T, Prosser GA, Harrison JR, Green K, Soares de Melo C, Feng TS, Street LJ, Chibale K, Warner DF, Mizrahi V, Epemolu O, Scullion P, Ellis L, Riley J, Shishikura Y, Ferguson L, Osuna-Cabello M, Read KD, Green SR, Lamprecht DA, Finin PM, Steyn AJC, Ioerger TR, Sacchettini J, Rhee KY, Arora K, Barry CE 3rd, Wyatt PG, Boshoff HIM.

ACS Infect Dis. 2018 Jun 8;4(6):954-969. doi: 10.1021/acsinfecdis.7b00275. Epub 2018 Mar 26.

8.

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.

Zhang N, Zoltner M, Leung KF, Scullion P, Hutchinson S, Del Pino RC, Vincent IM, Zhang YK, Freund YR, Alley MRK, Jacobs RT, Read KD, Barrett MP, Horn D, Field MC.

PLoS Pathog. 2018 Feb 9;14(2):e1006850. doi: 10.1371/journal.ppat.1006850. eCollection 2018 Feb.

9.

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi.

Brand S, Ko EJ, Viayna E, Thompson S, Spinks D, Thomas M, Sandberg L, Francisco AF, Jayawardhana S, Smith VC, Jansen C, De Rycker M, Thomas J, MacLean L, Osuna-Cabello M, Riley J, Scullion P, Stojanovski L, Simeons FRC, Epemolu O, Shishikura Y, Crouch SD, Bakshi TS, Nixon CJ, Reid IH, Hill AP, Underwood TZ, Hindley SJ, Robinson SA, Kelly JM, Fiandor JM, Wyatt PG, Marco M, Miles TJ, Read KD, Gilbert IH.

J Med Chem. 2017 Sep 14;60(17):7284-7299. doi: 10.1021/acs.jmedchem.7b00463. Epub 2017 Aug 27.

10.

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, Riley J, Epemolu O, Norval S, Snavely T, Robertson GT, Rubin EJ, Ioerger TR, Sirgel FA, van der Merwe R, van Helden PD, Keller P, Böttger EC, Karakousis PC, Lenaerts AJ, Sacchettini JC.

Cell. 2017 Jul 13;170(2):249-259.e25. doi: 10.1016/j.cell.2017.06.025. Epub 2017 Jun 29.

11.

A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome.

Tatham MH, Cole C, Scullion P, Wilkie R, Westwood NJ, Stark LA, Hay RT.

Mol Cell Proteomics. 2017 Feb;16(2):310-326. doi: 10.1074/mcp.O116.065219. Epub 2016 Dec 2.

12.

Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM.

Varshney D, Petit AP, Bueren-Calabuig JA, Jansen C, Fletcher DA, Peggie M, Weidlich S, Scullion P, Pisliakov AV, Cowling VH.

Nucleic Acids Res. 2016 Dec 1;44(21):10423-10436. Epub 2016 Jul 15.

13.

Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis.

Brand S, Norcross NR, Thompson S, Harrison JR, Smith VC, Robinson DA, Torrie LS, McElroy SP, Hallyburton I, Norval S, Scullion P, Stojanovski L, Simeons FR, van Aalten D, Frearson JA, Brenk R, Fairlamb AH, Ferguson MA, Wyatt PG, Gilbert IH, Read KD.

J Med Chem. 2014 Dec 11;57(23):9855-69. doi: 10.1021/jm500809c. Epub 2014 Nov 20.

14.

Injury risk to specific body regions of pedestrians in frontal vehicle crashes modeled by empirical, in-depth accident data.

Helmer T, Ebner A, Samaha RR, Scullion P, Kates R.

Stapp Car Crash J. 2010 Nov;54:93-117.

PMID:
21512905
15.

A reexamination of the small overlap frontal crash.

Scullion P, Morgan RM, Mohan P, Kan CD, Shanks K, Jin W, Tangirala R.

Ann Adv Automot Med. 2010;54:137-48.

16.

6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors.

Cai J, Baugh M, Black D, Long C, Jonathan Bennett D, Dempster M, Fradera X, Gillespie J, Andrews F, Boucharens S, Bruin J, Cameron KS, Cumming I, Hamilton W, Jones PS, Kaptein A, Kinghorn E, Maidment M, Martin I, Mitchell A, Rankovic Z, Robinson J, Scullion P, Uitdehaag JC, Vink P, Westwood P, van Zeeland M, van Berkom L, Bastiani M, Meulemans T.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4350-4. doi: 10.1016/j.bmcl.2010.06.072. Epub 2010 Jun 17.

PMID:
20598883
17.

2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors.

Cai J, Bennett DJ, Rankovic Z, Dempster M, Fradera X, Gillespie J, Cumming I, Finlay W, Baugh M, Boucharens S, Bruin J, Cameron KS, Hamilton W, Kerr J, Kinghorn E, McGarry G, Robinson J, Scullion P, Uitdehaag JC, van Zeeland M, Potin D, Saniere L, Fouquet A, Chevallier F, Deronzier H, Dorleans C, Nicolai E.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4447-50. doi: 10.1016/j.bmcl.2010.06.049. Epub 2010 Jun 15.

PMID:
20594841
18.

Models of disability: their influence in nursing and potential role in challenging discrimination.

Scullion PA.

J Adv Nurs. 2010 Mar;66(3):697-707. doi: 10.1111/j.1365-2648.2009.05211.x.

PMID:
20423405
20.

Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors.

Rankovic Z, Cai J, Kerr J, Fradera X, Robinson J, Mistry A, Hamilton E, McGarry G, Andrews F, Caulfield W, Cumming I, Dempster M, Waller J, Scullion P, Martin I, Mitchell A, Long C, Baugh M, Westwood P, Kinghorn E, Bruin J, Hamilton W, Uitdehaag J, van Zeeland M, Potin D, Saniere L, Fouquet A, Chevallier F, Deronzier H, Dorleans C, Nicolai E.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1524-7. doi: 10.1016/j.bmcl.2010.01.100. Epub 2010 Jan 25.

PMID:
20149657
21.

Vehicle related factors that influence injury outcome in head-on collisions.

Blum JJ, Scullion P, Morgan RM, Digges K, Kan CD, Park S, Bae H.

Ann Adv Automot Med. 2008 Oct;52:131-40.

22.

A life unlike any other; human rights for some?

Scullion P.

Br J Nurs. 2008 Mar 27-Apr 9;17(6):354-5. No abstract available.

PMID:
18414302
23.

Effective dissemination strategies.

Scullion PA.

Nurse Res. 2002;10(1):65-77. Review.

PMID:
12405007
25.

A new model for the nursing research agenda.

Waine W, Scullion P.

Nurs Manag (Harrow). 2002 May;9(2):18-23. Review. No abstract available.

PMID:
12040605
26.

Equity of access for disabled people.

Scullion P.

Prof Nurse. 2000 Jul;15(10):667-70. Review. No abstract available.

PMID:
12026467
27.

Disabled people as health service employees. How to break down the barriers.

Scullion P.

Nurs Manag (Harrow). 2000 Oct;7(6):8-13. Review. No abstract available.

PMID:
12004389
28.

Enabling disabled people: responsibilities of nurse education.

Scullion P.

Br J Nurs. 2000 Aug 10-Sep 13;9(15):1010-5. Review.

PMID:
11276638
29.

Enabling act.

Scullion P, Jayram R.

Nurs Manag (Harrow). 2000 May;7(2):8-11. No abstract available.

PMID:
11235427
30.

Access to all areas.

Jayram R, Scullion P.

Nurs Manag (Harrow). 2000 Apr;7(1):17-9. Review. No abstract available.

PMID:
11111642
31.

Disability as an equal opportunity issue within nurse education in the UK.

Scullion P.

Nurse Educ Today. 2000 Apr;20(3):199-206. Review.

PMID:
10820574
32.

Nurses can do it.

Scullion P.

Nurs Times. 1999 Jul 7-13;95(27):28. No abstract available.

PMID:
10524124
33.

Phillip Scullion blows the whistle on the press and Glenn Hoddle.

Scullion P.

Nurs Times. 1999 Feb 17-23;95(7):45. No abstract available.

PMID:
10326489
34.
35.

Challenging discrimination against disabled patients.

Scullion P.

Nurs Stand. 1999 Jan 20-26;13(18):37-40.

PMID:
10085902
36.

Recognizing barriers to disabled people.

Scullion P.

Br J Nurs. 1998 May 14-27;7(9):509. No abstract available.

PMID:
9735707
37.

Disability on the agenda.

Scullion P.

Elder Care. 1996 Oct-Nov;8(5):10-2. No abstract available.

PMID:
9077158
38.

Susan's breast reconstruction: a case study and reflective analysis.

Parker J, Scullion P.

Br J Nurs. 1996 Jun 27-Jul 10;5(12):718-23.

PMID:
8718326
40.
41.

Stress and the student nurse in accident and emergency nursing.

Scullion P.

Br J Nurs. 1992 Oct 22-Nov 11;1(12):27-30.

PMID:
1472853
42.

Linking students with ambulance teams.

Scullion P, Holland D.

Nurs Stand. 1992 Jan 8-14;6(15-16):37-40. No abstract available.

PMID:
1739648
43.

Dermatologic review: scalpel technique in removing heloma and hyperkeratosis.

Scullion PG.

J Foot Surg. 1984 Jul-Aug;23(4):344-9.

PMID:
6470433

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