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Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.

Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K, Cheng X, Cawthorne E, Coleman ML, Crockford TL, Davies B, Dow LE, Goldin R, Kranc K, Kudo H, Lawson H, McAuliffe J, Milward K, Scudamore CL, Soilleux E, Issa F, Ratcliffe PJ, Pugh CW.

J Clin Invest. 2019 Jun 4;130:3640-3656. doi: 10.1172/JCI124099.


Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function.

Hurcombe JA, Hartley P, Lay AC, Ni L, Bedford JJ, Leader JP, Singh S, Murphy A, Scudamore CL, Marquez E, Barrington AF, Pinto V, Marchetti M, Wong LF, Uney J, Saleem MA, Mathieson PW, Patel S, Walker RJ, Woodgett JR, Quaggin SE, Welsh GI, Coward RJM.

Nat Commun. 2019 Jan 24;10(1):403. doi: 10.1038/s41467-018-08235-1.


Modelling invasive group A streptococcal disease using bioluminescence.

Lamb LE, Zhi X, Alam F, Pyzio M, Scudamore CL, Wiles S, Sriskandan S.

BMC Microbiol. 2018 Jun 19;18(1):60. doi: 10.1186/s12866-018-1200-1.


Tracking preleukemic cells in vivo to reveal the sequence of molecular events in radiation leukemogenesis.

Verbiest T, Finnon R, Brown N, Cruz-Garcia L, Finnon P, O'Brien G, Ross E, Bouffler S, Scudamore CL, Badie C.

Leukemia. 2018 Jun;32(6):1435-1444. doi: 10.1038/s41375-018-0085-1. Epub 2018 Mar 3.


Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.

Bilanges B, Alliouachene S, Pearce W, Morelli D, Szabadkai G, Chung YL, Chicanne G, Valet C, Hill JM, Voshol PJ, Collinson L, Peddie C, Ali K, Ghazaly E, Rajeeve V, Trichas G, Srinivas S, Chaussade C, Salamon RS, Backer JM, Scudamore CL, Whitehead MA, Keaney EP, Murphy LO, Semple RK, Payrastre B, Tooze SA, Vanhaesebroeck B.

Nat Commun. 2017 Nov 27;8(1):1804. doi: 10.1038/s41467-017-01969-4.


Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

Berenjeno IM, Piñeiro R, Castillo SD, Pearce W, McGranahan N, Dewhurst SM, Meniel V, Birkbak NJ, Lau E, Sansregret L, Morelli D, Kanu N, Srinivas S, Graupera M, Parker VER, Montgomery KG, Moniz LS, Scudamore CL, Phillips WA, Semple RK, Clarke A, Swanton C, Vanhaesebroeck B.

Nat Commun. 2017 Nov 24;8(1):1773. doi: 10.1038/s41467-017-02002-4.


Radiosensitization In Vivo by Histone Deacetylase Inhibition with No Increase in Early Normal Tissue Radiation Toxicity.

Groselj B, Ruan JL, Scott H, Gorrill J, Nicholson J, Kelly J, Anbalagan S, Thompson J, Stratford MRL, Jevons SJ, Hammond EM, Scudamore CL, Kerr M, Kiltie AE.

Mol Cancer Ther. 2018 Feb;17(2):381-392. doi: 10.1158/1535-7163.MCT-17-0011. Epub 2017 Aug 24.


Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues.

Al-Jazzar A, Javaheri B, Prideaux M, Boyde A, Scudamore CL, Cherifi C, Hay E, Hopkinson M, Boyd M, Cohen-Solal M, Farquharson C, Pitsillides AA.

Int J Mol Sci. 2016 Dec 26;18(1). pii: E29. doi: 10.3390/ijms18010029.


The Influence of the CTIP Polymorphism, Q418P, on Homologous Recombination and Predisposition to Radiation-Induced Tumorigenesis (mainly rAML) in Mice.

Patel A, Anderson J, Kraft D, Finnon R, Finnon P, Scudamore CL, Manning G, Bulman R, Brown N, Bouffler S, O'Neill P, Badie C.

Radiat Res. 2016 Dec;186(6):638-649. doi: 10.1667/RR14495.1. Epub 2016 Nov 21.


Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles.

Elshorbagy AK, Jernerén F, Scudamore CL, McMurray F, Cater H, Hough T, Cox R, Refsum H.

PLoS One. 2016 Oct 27;11(10):e0163214. doi: 10.1371/journal.pone.0163214. eCollection 2016.


Developing a Collaborative Agenda for Humanities and Social Scientific Research on Laboratory Animal Science and Welfare.

Davies GF, Greenhough BJ, Hobson-West P, Kirk RG, Applebee K, Bellingan LC, Berdoy M, Buller H, Cassaday HJ, Davies K, Diefenbacher D, Druglitrø T, Escobar MP, Friese C, Herrmann K, Hinterberger A, Jarrett WJ, Jayne K, Johnson AM, Johnson ER, Konold T, Leach MC, Leonelli S, Lewis DI, Lilley EJ, Longridge ER, McLeod CM, Miele M, Nelson NC, Ormandy EH, Pallett H, Poort L, Pound P, Ramsden E, Roe E, Scalway H, Schrader A, Scotton CJ, Scudamore CL, Smith JA, Whitfield L, Wolfensohn S.

PLoS One. 2016 Jul 18;11(7):e0158791. doi: 10.1371/journal.pone.0158791. eCollection 2016.


Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice.

Alliouachene S, Bilanges B, Chaussade C, Pearce W, Foukas LC, Scudamore CL, Moniz LS, Vanhaesebroeck B.

Diabetologia. 2016 Jul;59(7):1503-1512. doi: 10.1007/s00125-016-3963-y. Epub 2016 Apr 30.


Corrigendum: Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.

Ali K, Soond DR, Piñeiro R, Hagemann T, Pearce W, Lim EL, Bouabe H, Scudamore CL, Hancox T, Maecker H, Friedman L, Turner M, Okkenhaug K, Vanhaesebroeck B.

Nature. 2016 Jul 28;535(7613):580. doi: 10.1038/nature17641. Epub 2016 Apr 6. No abstract available.


Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.

Castillo SD, Tzouanacou E, Zaw-Thin M, Berenjeno IM, Parker VE, Chivite I, Milà-Guasch M, Pearce W, Solomon I, Angulo-Urarte A, Figueiredo AM, Dewhurst RE, Knox RG, Clark GR, Scudamore CL, Badar A, Kalber TL, Foster J, Stuckey DJ, David AL, Phillips WA, Lythgoe MF, Wilson V, Semple RK, Sebire NJ, Kinsler VA, Graupera M, Vanhaesebroeck B.

Sci Transl Med. 2016 Mar 30;8(332):332ra43. doi: 10.1126/scitranslmed.aad9982.


Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity.

Alliouachene S, Bilanges B, Chicanne G, Anderson KE, Pearce W, Ali K, Valet C, Posor Y, Low PC, Chaussade C, Scudamore CL, Salamon RS, Backer JM, Stephens L, Hawkins PT, Payrastre B, Vanhaesebroeck B.

Cell Rep. 2015 Dec 1;13(9):1881-94. doi: 10.1016/j.celrep.2015.10.052. Epub 2015 Nov 19.


Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance.

Hugill AJ, Stewart ME, Yon MA, Probert F, Cox IJ, Hough TA, Scudamore CL, Bentley L, Wall G, Wells SE, Cox RD.

Biol Open. 2015 Oct 2;4(11):1367-75. doi: 10.1242/bio.013342.


Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines.

Scudamore CL, Soilleux EJ, Karp NA, Smith K, Poulsom R, Herrington CS, Day MJ, Brayton CF, Bolon B, Whitelaw B, White ES, Everitt JI, Arends MJ.

J Pathol. 2016 Jan;238(2):359-67. doi: 10.1002/path.4642. Epub 2015 Nov 28. Review.


¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models.

Probert F, Rice P, Scudamore CL, Wells S, Williams R, Hough TA, Cox IJ.

J Proteome Res. 2015 May 1;14(5):2036-45. doi: 10.1021/pr501039k. Epub 2015 Apr 20.


Pharmacological inhibition of FTO.

McMurray F, Demetriades M, Aik W, Merkestein M, Kramer H, Andrew DS, Scudamore CL, Hough TA, Wells S, Ashcroft FM, McDonough MA, Schofield CJ, Cox RD.

PLoS One. 2015 Apr 1;10(4):e0121829. doi: 10.1371/journal.pone.0121829. eCollection 2015.


Histopathological analysis of the respiratory tract.

Scudamore CL, McInnes EF.

Curr Protoc Mouse Biol. 2014 Dec 11;4(4):181-96. doi: 10.1002/9780470942390.mo140094.


Acquiring, recording, and analyzing pathology data from experimental mice: an overview.

Scudamore CL.

Curr Protoc Mouse Biol. 2014 Mar 21;4(1):1-10. doi: 10.1002/9780470942390.mo130200.


Triggered doxorubicin release in solid tumors from thermosensitive liposome-peptide hybrids: Critical parameters and therapeutic efficacy.

Al-Ahmady ZS, Scudamore CL, Kostarelos K.

Int J Cancer. 2015 Aug 1;137(3):731-43. doi: 10.1002/ijc.29430. Epub 2015 Feb 5.


Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread.

Wong PP, Demircioglu F, Ghazaly E, Alrawashdeh W, Stratford MR, Scudamore CL, Cereser B, Crnogorac-Jurcevic T, McDonald S, Elia G, Hagemann T, Kocher HM, Hodivala-Dilke KM.

Cancer Cell. 2015 Jan 12;27(1):123-37. doi: 10.1016/j.ccell.2014.10.015.


Review of approaches to the recording of background lesions in toxicologic pathology studies in rats.

McInnes EF, Scudamore CL.

Toxicol Lett. 2014 Aug 17;229(1):134-43. doi: 10.1016/j.toxlet.2014.06.005. Epub 2014 Jun 21. Review.


Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.

Ali K, Soond DR, Pineiro R, Hagemann T, Pearce W, Lim EL, Bouabe H, Scudamore CL, Hancox T, Maecker H, Friedman L, Turner M, Okkenhaug K, Vanhaesebroeck B.

Nature. 2014 Jun 19;510(7505):407-411. doi: 10.1038/nature13444. Epub 2014 Jun 11. Erratum in: Nature. 2016 Jul 28;535(7613):580.


A simplified necropsy technique for mice: making the most of unscheduled deaths.

Scudamore CL, Busk N, Vowell K.

Lab Anim. 2014 Oct;48(4):342-4. doi: 10.1177/0023677214536555. Epub 2014 May 29.


Integrating pathology into human disease modelling--how to eat the elephant.

Scudamore CL.

Dis Model Mech. 2014 May;7(5):495-7. doi: 10.1242/dmm.016394.


Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.

Maguire S, Estabel J, Ingham N, Pearson S, Ryder E, Carragher DM, Walker N; Sanger MGP Slc25a21 Project Team, Bussell J, Chan WI, Keane TM, Adams DJ, Scudamore CL, Lelliott CJ, Ramírez-Solis R, Karp NA, Steel KP, White JK, Gerdin AK.

PLoS One. 2014 Mar 18;9(3):e91807. doi: 10.1371/journal.pone.0091807. eCollection 2014.


Commentary: the role of the toxicologic pathologist in academia.

Turner PV, Haschek WM, Bolon B, Diegel K, Hayes MA, McEwen B, Sargeant AM, Scudamore CL, Stalker M, von Beust B, Wancket LM.

Vet Pathol. 2015 Jan;52(1):7-17. doi: 10.1177/0300985813519652. Epub 2014 Feb 19.


Future of disease surveillance.

Prentice AG, Kelly DF, Scudamore CL.

Vet Rec. 2013 Dec 14;173(23):585-6. doi: 10.1136/vr.f7407. No abstract available.


An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess.

Bentley L, Esapa CT, Nesbit MA, Head RA, Evans H, Lath D, Scudamore CL, Hough TA, Podrini C, Hannan FM, Fraser WD, Croucher PI, Brown MA, Brown SD, Cox RD, Thakker RV.

Endocrinology. 2014 Mar;155(3):908-22. doi: 10.1210/en.2013-1247. Epub 2013 Dec 3.


High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice.

Podrini C, Cambridge EL, Lelliott CJ, Carragher DM, Estabel J, Gerdin AK, Karp NA, Scudamore CL; Sanger Mouse Genetics Project, Ramirez-Solis R, White JK.

Mamm Genome. 2013 Jun;24(5-6):240-51. doi: 10.1007/s00335-013-9456-0. Epub 2013 May 28.


Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G, Forment JV, Fu B, Del Castillo Velasco-Herrera M, Edwards A, van der Weyden L, Yang F; Sanger Mouse Genetics Project, Ramirez-Solis R, Estabel J, Gallagher FA, Logan DW, Arends MJ, Tsang SH, Mahajan VB, Scudamore CL, White JK, Jackson SP, Gergely F, Adams DJ.

PLoS Genet. 2012;8(11):e1003022. doi: 10.1371/journal.pgen.1003022. Epub 2012 Nov 15.


Correlation of histopathology, urinary biomarkers, and gene expression responses following hexachloro-1:3-butadiene-induced acute nephrotoxicity in male Hanover Wistar rats: a 28-day time course study.

Maguire DP, Turton JA, Scudamore CL, Swain AJ, McClure FJ, Smyth R, Pereira IB, Munday MR, York MJ.

Toxicol Pathol. 2013 Jul;41(5):779-94. doi: 10.1177/0192623312464306. Epub 2012 Nov 6.


Gadd45γ and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression.

Warr N, Carre GA, Siggers P, Faleato JV, Brixey R, Pope M, Bogani D, Childers M, Wells S, Scudamore CL, Tedesco M, del Barco Barrantes I, Nebreda AR, Trainor PA, Greenfield A.

Dev Cell. 2012 Nov 13;23(5):1020-31. doi: 10.1016/j.devcel.2012.09.016. Epub 2012 Oct 25.


Metabolic profiling of the rat liver after chronic ingestion of alpha-naphthylisothiocyanate using in vivo and ex vivo magnetic resonance spectroscopy.

Solanky BS, Sanchez-Canon GJ, Cobbold JF, Taylor-Robinson SD, Bell JD, Scudamore CL, Ross E, Holder JC, So PW, Cox IJ.

Toxicol Sci. 2012 Apr;126(2):306-16. doi: 10.1093/toxsci/kfs019. Epub 2012 Jan 18.


Urinary biomarkers in hexachloro-1:3-butadiene-induced acute kidney injury in the female Hanover Wistar rat; correlation of α-glutathione S-transferase, albumin and kidney injury molecule-1 with histopathology and gene expression.

Swain A, Turton J, Scudamore CL, Pereira I, Viswanathan N, Smyth R, Munday M, McClure F, Gandhi M, Sondh S, York M.

J Appl Toxicol. 2011 May;31(4):366-77. doi: 10.1002/jat.1624.


International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies.

Bolon B, Barale-Thomas E, Bradley A, Ettlin RA, Franchi CA, George C, Giusti AM, Hall R, Jacobsen M, Konishi Y, Ledieu D, Morton D, Park JH, Scudamore CL, Tsuda H, Vijayasarathi SK, Wijnands MV.

J Toxicol Pathol. 2010 Sep;23(3):171-81. doi: 10.1293/tox.23.171. Epub 2010 Oct 5.


International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies.

Bolon B, Barale-Thomas E, Bradley A, Ettlin RA, Franchi CA, George C, Giusti AM, Hall R, Jacobsen M, Konishi Y, Ledieu D, Morton D, Park JH, Scudamore CL, Tsuda H, Vijayasarathi SK, Wijnands MV.

Exp Toxicol Pathol. 2011 Jan;63(1-2):187-95. doi: 10.1016/j.etp.2010.07.006. Epub 2010 Aug 17. Review.


International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies.

Bolon Chair B, Barale-Thomas E, Bradley A, Ettlin RA, Franchi CA, George C, Giusti AM, Hall R, Jacobsen M, Konishi Y, Ledieu D, Morton D, Park JH, Scudamore CL, Tsuda H, Vijayasarathi SK, Wijnands MV.

Toxicol Pathol. 2010 Oct;38(6):984-92. doi: 10.1177/0192623310378137. Epub 2010 Aug 17.


Abdominal fibrosarcoma associated with a retained surgical swab in a dog.

Rayner EL, Scudamore CL, Francis I, Schöniger S.

J Comp Pathol. 2010 Jul;143(1):81-5. doi: 10.1016/j.jcpa.2009.12.009. Epub 2010 Jan 21.


Future directions in training veterinarians for careers in toxicological pathology in the United Kingdom.

Scudamore CL, Smith SH.

J Vet Med Educ. 2007 Fall;34(4):450-7. doi: 10.3138/jvme.34.4.450.


TGF-beta 1 regulates adhesion of mucosal mast cell homologues to laminin-1 through expression of integrin alpha 7.

Rosbottom A, Scudamore CL, von der Mark H, Thornton EM, Wright SH, Miller HR.

J Immunol. 2002 Nov 15;169(10):5689-95.


Chemokine and cytokine expression in murine intestinal epithelium following Nippostrongylus brasiliensis infection.

Rosbottom A, Knight PA, McLachlan G, Thornton EM, Wright SW, Miller HR, Scudamore CL.

Parasite Immunol. 2002 Feb;24(2):67-75.


Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts.

Pemberton AD, Zamolodchikova TS, Scudamore CL, Chilvers ER, Miller HR, Walker TR.

Eur J Biochem. 2002 Feb;269(4):1171-80.


Canine dysautonomia: two clinical cases.

Jamieson PM, Scudamore CL, Ruppert CE, Mauchline S, Simpson JW.

J Small Anim Pract. 2002 Jan;43(1):22-6.


Characterisation of tryptase and a granzyme H-like chymase isolated from equine mastocytoma tissue.

Pemberton AD, McEuen AR, Scudamore CL.

Vet Immunol Immunopathol. 2001 Dec;83(3-4):253-67.


Sertoli cell tumour in an Amur tiger.

Scudamore CL, Meredith AL.

J Comp Pathol. 2001 Jan;124(1):79-82.


Canine hypertrophic osteoarthropathy associated with a malignant Sertoli cell tumour.

Barrand KR, Scudamore CL.

J Small Anim Pract. 2001 Mar;42(3):143-5.


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