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Items: 1 to 50 of 367

1.

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites.

Zhang S, Sakuma M, Deora GS, Levy CW, Klausing A, Breda C, Read KD, Edlin CD, Ross BP, Wright Muelas M, Day PJ, O'Hagan S, Kell DB, Schwarcz R, Leys D, Heyes DJ, Giorgini F, Scrutton NS.

Commun Biol. 2019 Jul 24;2(1):271. doi: 10.1038/s42003-019-0520-5.

PMID:
31925123
2.

Light-induced structural changes in a full-length cyanobacterial phytochrome probed by time-resolved X-ray scattering.

Heyes DJ, Hardman SJO, Pedersen MN, Woodhouse J, De La Mora E, Wulff M, Weik M, Cammarata M, Scrutton NS, Schirò G.

Commun Biol. 2019 Jan 3;2(1):1. doi: 10.1038/s42003-018-0242-0.

PMID:
31924873
3.

Techno-economic assessment of microbial limonene production.

Sun C, Theodoropoulos C, Scrutton NS.

Bioresour Technol. 2019 Dec 23;300:122666. doi: 10.1016/j.biortech.2019.122666. [Epub ahead of print]

4.

Observation of the Δg mechanism resulting from the ultrafast spin dynamics that follow the photolysis of coenzyme B12.

Hughes JA, Hardman SJO, Scrutton NS, Graham DM, Woodward JR, Jones AR.

J Chem Phys. 2019 Nov 28;151(20):201102. doi: 10.1063/1.5127258.

PMID:
31779325
5.

Taming the Reactivity of Monoterpene Synthases To Guide Regioselective Product Hydroxylation.

Leferink NGH, Ranaghan KE, Battye J, Johannissen LO, Hay S, van der Kamp MW, Mulholland AJ, Scrutton NS.

Chembiochem. 2019 Nov 4. doi: 10.1002/cbic.201900672. [Epub ahead of print]

PMID:
31682055
6.

Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis.

Zhang S, Heyes DJ, Feng L, Sun W, Johannissen LO, Liu H, Levy CW, Li X, Yang J, Yu X, Lin M, Hardman SJO, Hoeven R, Sakuma M, Hay S, Leys D, Rao Z, Zhou A, Cheng Q, Scrutton NS.

Nature. 2019 Oct;574(7780):722-725. doi: 10.1038/s41586-019-1685-2. Epub 2019 Oct 23.

PMID:
31645759
7.

Structure of the Cannabis sativa olivetol-producing enzyme reveals cyclization plasticity in type III polyketide synthases.

Kearsey LJ, Prandi N, Karuppiah V, Yan C, Leys D, Toogood H, Takano E, Scrutton NS.

FEBS J. 2019 Oct 12. doi: 10.1111/febs.15089. [Epub ahead of print]

PMID:
31605668
8.

What are the signatures of tunnelling in enzyme-catalysed reactions?

Johannissen LO, Iorgu AI, Scrutton NS, Hay S.

Faraday Discuss. 2019 Dec 16;221:367-378. doi: 10.1039/c9fd00044e.

PMID:
31544181
9.

Graphene-aramid nanocomposite fibres via superacid co-processing.

Roberts AD, Kelly P, Bain J, Morrison JJ, Wimpenny I, Barrow M, Woodward RT, Gresil M, Blanford C, Hay S, Blaker JJ, Yeates SG, Scrutton NS.

Chem Commun (Camb). 2019 Sep 26;55(78):11703-11706. doi: 10.1039/c9cc04548a.

PMID:
31509114
10.

An automated pipeline for the screening of diverse monoterpene synthase libraries.

Leferink NGH, Dunstan MS, Hollywood KA, Swainston N, Currin A, Jervis AJ, Takano E, Scrutton NS.

Sci Rep. 2019 Aug 15;9(1):11936. doi: 10.1038/s41598-019-48452-2.

11.

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites.

Zhang S, Sakuma M, Deora GS, Levy CW, Klausing A, Breda C, Read KD, Edlin CD, Ross BP, Wright Muelas M, Day PJ, O'Hagan S, Kell DB, Schwarcz R, Leys D, Heyes DJ, Giorgini F, Scrutton NS.

Commun Biol. 2019 Jul 24;2:271. doi: 10.1038/s42003-019-0520-5. eCollection 2019.

12.

Author Correction: Building a global alliance of biofoundries.

Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Feuvre RL, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR, Johnson RA, Keasling JD, Kitney RI, Kondo A, Liu C, Martin VJJ, Menolascina F, Ogino C, Patron NJ, Pavan M, Poh CL, Pretorius IS, Rosser SJ, Scrutton NS, Storch M, Tekotte H, Travnik E, Vickers CE, Yew WS, Yuan Y, Zhao H, Freemont PS.

Nat Commun. 2019 Jul 11;10(1):3132. doi: 10.1038/s41467-019-10862-1.

13.

Synthetic biology for fibres, adhesives and active camouflage materials in protection and aerospace.

Roberts AD, Finnigan W, Wolde-Michael E, Kelly P, Blaker JJ, Hay S, Breitling R, Takano E, Scrutton NS.

MRS Commun. 2019 May 15;9(2):486-504. doi: 10.1557/mrc.2019.35. Epub 2019 Apr 24.

14.

Bio-derived Production of Cinnamyl Alcohol via a Three Step Biocatalytic Cascade and Metabolic Engineering.

Klumbys E, Zebec Z, Weise NJ, Turner NJ, Scrutton NS.

Green Chem. 2019 May 15;20(3):658-663. doi: 10.1039/C7GC03325G. Epub 2018 Jan 5.

15.

Experiment and Simulation Reveal How Mutations in Functional Plasticity Regions Guide Plant Monoterpene Synthase Product Outcome.

Leferink NGH, Ranaghan KE, Karuppiah V, Currin A, van der Kamp MW, Mulholland AJ, Scrutton NS.

ACS Catal. 2019 May 15;8(5):3780-3791. doi: 10.1021/acscatal.8b00692. Epub 2018 Mar 24.

16.

Discovery, Characterisation, Engineering and Applications of Ene Reductases for Industrial Biocatalysis.

Toogood HS, Scrutton NS.

ACS Catal. 2019 May 15;8(4):3532-3549. doi: 10.1021/acscatal.8b00624. Epub 2018 Mar 20.

17.

Convergence of theory and experiment on the role of preorganization, quantum tunneling and enzyme motions into flavoenzyme-catalyzed hydride transfer.

Delgado M, Görlich S, Longbotham JE, Scrutton NS, Hay S, Moliner V, Tuñón I.

ACS Catal. 2019 May 15;7(5):3190-3198. doi: 10.1021/acscatal.7b00201. Epub 2017 Apr 3.

18.

Nonequivalence of Second Sphere "Noncatalytic" Residues in Pentaerythritol Tetranitrate Reductase in Relation to Local Dynamics Linked to H-Transfer in Reactions with NADH and NADPH Coenzymes.

Iorgu AI, Baxter NJ, Cliff MJ, Levy C, Waltho JP, Hay S, Scrutton NS.

ACS Catal. 2018 Dec 7;8(12):11589-11599. doi: 10.1021/acscatal.8b02810. Epub 2018 Oct 26.

19.

Photochemical Spin Dynamics of the Vitamin B12 Derivative, Methylcobalamin.

Lukinović V, Woodward JR, Marrafa TC, Shanmugam M, Heyes DJ, Hardman SJO, Scrutton NS, Hay S, Fielding AJ, Jones AR.

J Phys Chem B. 2019 Jun 6;123(22):4663-4672. doi: 10.1021/acs.jpcb.9b01969. Epub 2019 May 23.

PMID:
31081330
20.

Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol-O-methyltransferase.

Czarnota S, Johannissen LO, Baxter NJ, Rummel F, Wilson AL, Cliff MJ, Levy CW, Scrutton NS, Waltho JP, Hay S.

ACS Catal. 2019 May 3;9(5):4394-4401. doi: 10.1021/acscatal.9b00174. Epub 2019 Apr 9.

21.

Isotopically labeled flavoenzymes and their uses in probing reaction mechanisms.

Iorgu AI, Cliff MJ, Waltho JP, Scrutton NS, Hay S.

Methods Enzymol. 2019;620:145-166. doi: 10.1016/bs.mie.2019.03.009. Epub 2019 Mar 29.

PMID:
31072485
22.

Building a global alliance of biofoundries.

Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Le Feuvre R, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR, Johnson RA, Keasling JD, Kitney RI, Kondo A, Liu C, Martin VJJ, Menolascina F, Ogino C, Patron NJ, Pavan M, Poh CL, Pretorius IS, Rosser SJ, Scrutton NS, Storch M, Tekotte H, Travnik E, Vickers CE, Yew WS, Yuan Y, Zhao H, Freemont PS.

Nat Commun. 2019 May 9;10(1):2040. doi: 10.1038/s41467-019-10079-2. No abstract available. Erratum in: Nat Commun. 2019 Jul 11;10(1):3132.

23.

Solvent-slaved protein motions accompany proton coupled electron transfer reactions catalysed by copper nitrite reductase.

Hedison TM, Heyes DJ, Shanmugam M, Iorgu AI, Scrutton NS.

Chem Commun (Camb). 2019 May 25;55(42):5863-5866. doi: 10.1039/c9cc01026b. Epub 2019 May 3.

PMID:
31049498
24.

Selectivity through discriminatory induced fit enables switching of NAD(P)H coenzyme specificity in Old Yellow Enzyme ene-reductases.

Iorgu AI, Hedison TM, Hay S, Scrutton NS.

FEBS J. 2019 Aug;286(16):3117-3128. doi: 10.1111/febs.14862. Epub 2019 May 13.

25.

SelProm: A Queryable and Predictive Expression Vector Selection Tool for Escherichia coli.

Jervis AJ, Carbonell P, Taylor S, Sung R, Dunstan MS, Robinson CJ, Breitling R, Takano E, Scrutton NS.

ACS Synth Biol. 2019 Jul 19;8(7):1478-1483. doi: 10.1021/acssynbio.8b00399. Epub 2019 Mar 18.

26.

Light-induced structural changes in a full-length cyanobacterial phytochrome probed by time-resolved X-ray scattering.

Heyes DJ, Hardman SJO, Pedersen MN, Woodhouse J, De La Mora E, Wulff M, Weik M, Cammarata M, Scrutton NS, Schirò G.

Commun Biol. 2019 Jan 3;2:1. doi: 10.1038/s42003-018-0242-0. eCollection 2019.

27.

Tripping the light fantastic in membrane redox biology: linking dynamic structures to function in ER electron transfer chains.

Hedison TM, Scrutton NS.

FEBS J. 2019 Jun;286(11):2004-2017. doi: 10.1111/febs.14757. Epub 2019 Jan 30. Review.

28.

Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli.

Jervis AJ, Carbonell P, Vinaixa M, Dunstan MS, Hollywood KA, Robinson CJ, Rattray NJW, Yan C, Swainston N, Currin A, Sung R, Toogood H, Taylor S, Faulon JL, Breitling R, Takano E, Scrutton NS.

ACS Synth Biol. 2019 Jan 18;8(1):127-136. doi: 10.1021/acssynbio.8b00398. Epub 2019 Jan 7.

PMID:
30563328
29.

C3 and C6 Modification-Specific OYE Biotransformations of Synthetic Carvones and Sequential BVMO Chemoenzymatic Synthesis of Chiral Caprolactones.

Issa IS, Toogood HS, Johannissen LO, Raftery J, Scrutton NS, Gardiner JM.

Chemistry. 2019 Feb 26;25(12):2983-2988. doi: 10.1002/chem.201805219. Epub 2019 Jan 15.

30.

From Bugs to Bioplastics: Total (+)-Dihydrocarvide Biosynthesis by Engineered Escherichia coli.

Ascue Avalos GA, Toogood HS, Tait S, Messiha HL, Scrutton NS.

Chembiochem. 2019 Mar 15;20(6):785-792. doi: 10.1002/cbic.201800606. Epub 2019 Jan 21.

31.

The sacrificial inactivation of the blue-light photosensor cryptochrome from Drosophila melanogaster.

Kutta RJ, Archipowa N, Scrutton NS.

Phys Chem Chem Phys. 2018 Nov 21;20(45):28767-28776. doi: 10.1039/c8cp04671a.

32.

Selective cellular imaging with lanthanide-based upconversion nanoparticles.

Nampi PP, Vakurov A, Mackenzie LE, Scrutton NS, Millner PA, Jose G, Saha S.

J Biophotonics. 2019 Apr;12(4):e201800256. doi: 10.1002/jbio.201800256. Epub 2019 Jan 2.

33.

An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals.

Carbonell P, Jervis AJ, Robinson CJ, Yan C, Dunstan M, Swainston N, Vinaixa M, Hollywood KA, Currin A, Rattray NJW, Taylor S, Spiess R, Sung R, Williams AR, Fellows D, Stanford NJ, Mulherin P, Le Feuvre R, Barran P, Goodacre R, Turner NJ, Goble C, Chen GG, Kell DB, Micklefield J, Breitling R, Takano E, Faulon JL, Scrutton NS.

Commun Biol. 2018 Jun 8;1:66. doi: 10.1038/s42003-018-0076-9. eCollection 2018.

34.

A Toolbox for Diverse Oxyfunctionalisation of Monoterpenes.

Hernandez-Ortega A, Vinaixa M, Zebec Z, Takano E, Scrutton NS.

Sci Rep. 2018 Sep 26;8(1):14396. doi: 10.1038/s41598-018-32816-1.

35.

Multifragment DNA Assembly of Biochemical Pathways via Automated Ligase Cycling Reaction.

Robinson CJ, Dunstan MS, Swainston N, Titchmarsh J, Takano E, Scrutton NS, Jervis AJ.

Methods Enzymol. 2018;608:369-392. doi: 10.1016/bs.mie.2018.04.011.

PMID:
30173770
36.

Chemoenzymatic Synthesis of the Intermediates in the Peppermint Monoterpenoid Biosynthetic Pathway.

Cheallaigh AN, Mansell DJ, Toogood HS, Tait S, Lygidakis A, Scrutton NS, Gardiner JM.

J Nat Prod. 2018 Jul 27;81(7):1546-1552. doi: 10.1021/acs.jnatprod.7b01026. Epub 2018 Jul 6.

PMID:
29979593
37.

PartsGenie: an integrated tool for optimizing and sharing synthetic biology parts.

Swainston N, Dunstan M, Jervis AJ, Robinson CJ, Carbonell P, Williams AR, Faulon JL, Scrutton NS, Kell DB.

Bioinformatics. 2018 Jul 1;34(13):2327-2329. doi: 10.1093/bioinformatics/bty105.

PMID:
29949952
38.

A living foundry for Synthetic Biological Materials: A synthetic biology roadmap to new advanced materials.

Le Feuvre RA, Scrutton NS.

Synth Syst Biotechnol. 2018 Apr 17;3(2):105-112. doi: 10.1016/j.synbio.2018.04.002. eCollection 2018 Jun. Review.

39.

Trapping methods for probing functional intermediates in nitric oxide synthases and related enzymes.

Hedison TM, Hay S, Scrutton NS.

Front Biosci (Landmark Ed). 2018 Jun 1;23:1874-1888. Review.

PMID:
29772534
40.

Engineering the "Missing Link" in Biosynthetic (-)-Menthol Production: Bacterial Isopulegone Isomerase.

Currin A, Dunstan MS, Johannissen LO, Hollywood KA, Vinaixa M, Jervis AJ, Swainston N, Rattray NJW, Gardiner JM, Kell DB, Takano E, Toogood HS, Scrutton NS.

ACS Catal. 2018 Mar 2;8(3):2012-2020. doi: 10.1021/acscatal.7b04115. Epub 2018 Jan 24.

41.

Photochemical Mechanism of an Atypical Algal Phytochrome.

Choudry U, Heyes DJ, Hardman SJO, Sakuma M, Sazanovich IV, Woodhouse J, De La Mora E, Pedersen MN, Wulff M, Weik M, Schirò G, Scrutton NS.

Chembiochem. 2018 May 18;19(10):1036-1043. doi: 10.1002/cbic.201800016. Epub 2018 Apr 20.

PMID:
29544024
42.

Biocatalytic Routes to Lactone Monomers for Polymer Production.

Messiha HL, Ahmed ST, Karuppiah V, Suardíaz R, Ascue Avalos GA, Fey N, Yeates S, Toogood HS, Mulholland AJ, Scrutton NS.

Biochemistry. 2018 Apr 3;57(13):1997-2008. doi: 10.1021/acs.biochem.8b00169. Epub 2018 Mar 22.

PMID:
29533655
43.

Selenzyme: enzyme selection tool for pathway design.

Carbonell P, Wong J, Swainston N, Takano E, Turner NJ, Scrutton NS, Kell DB, Breitling R, Faulon JL.

Bioinformatics. 2018 Jun 15;34(12):2153-2154. doi: 10.1093/bioinformatics/bty065.

PMID:
29425325
44.

Stepwise Hydride Transfer in a Biological System: Insights into the Reaction Mechanism of the Light-Dependent Protochlorophyllide Oxidoreductase.

Archipowa N, Kutta RJ, Heyes DJ, Scrutton NS.

Angew Chem Int Ed Engl. 2018 Mar 1;57(10):2682-2686. doi: 10.1002/anie.201712729. Epub 2018 Feb 5.

45.

1H, 15N and 13C backbone resonance assignments of pentaerythritol tetranitrate reductase from Enterobacter cloacae PB2.

Iorgu AI, Baxter NJ, Cliff MJ, Waltho JP, Hay S, Scrutton NS.

Biomol NMR Assign. 2018 Apr;12(1):79-83. doi: 10.1007/s12104-017-9791-2. Epub 2017 Nov 22.

46.

Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase.

Karuppiah V, Ranaghan KE, Leferink NGH, Johannissen LO, Shanmugam M, Ní Cheallaigh A, Bennett NJ, Kearsey LJ, Takano E, Gardiner JM, van der Kamp MW, Hay S, Mulholland AJ, Leys D, Scrutton NS.

ACS Catal. 2017 Sep 1;7(9):6268-6282. doi: 10.1021/acscatal.7b01924. Epub 2017 Aug 9.

47.

Ab Initio QM/MM Modeling of the Rate-Limiting Proton Transfer Step in the Deamination of Tryptamine by Aromatic Amine Dehydrogenase.

Ranaghan KE, Morris WG, Masgrau L, Senthilkumar K, Johannissen LO, Scrutton NS, Harvey JN, Manby FR, Mulholland AJ.

J Phys Chem B. 2017 Oct 26;121(42):9785-9798. doi: 10.1021/acs.jpcb.7b06892. Epub 2017 Oct 17.

PMID:
28930453
48.

Retooling microorganisms for the fermentative production of alcohols.

Toogood HS, Scrutton NS.

Curr Opin Biotechnol. 2018 Apr;50:1-10. doi: 10.1016/j.copbio.2017.08.010. Epub 2017 Sep 6. Review.

49.

Enzymes make light work of hydrocarbon production.

Scrutton NS.

Science. 2017 Sep 1;357(6354):872-873. doi: 10.1126/science.aao4399. No abstract available.

PMID:
28860372
50.

Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis.

Gahloth D, Dunstan MS, Quaglia D, Klumbys E, Lockhart-Cairns MP, Hill AM, Derrington SR, Scrutton NS, Turner NJ, Leys D.

Nat Chem Biol. 2017 Sep;13(9):975-981. doi: 10.1038/nchembio.2434. Epub 2017 Jul 17.

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