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Graphene-aramid nanocomposite fibres via superacid co-processing.

Roberts AD, Kelly P, Bain J, Morrison JJ, Wimpenny I, Barrow M, Woodward RT, Gresil M, Blanford C, Hay S, Blaker JJ, Yeates SG, Scrutton NS.

Chem Commun (Camb). 2019 Sep 11. doi: 10.1039/c9cc04548a. [Epub ahead of print]


An automated pipeline for the screening of diverse monoterpene synthase libraries.

Leferink NGH, Dunstan MS, Hollywood KA, Swainston N, Currin A, Jervis AJ, Takano E, Scrutton NS.

Sci Rep. 2019 Aug 15;9(1):11936. doi: 10.1038/s41598-019-48452-2.


A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites.

Zhang S, Sakuma M, Deora GS, Levy CW, Klausing A, Breda C, Read KD, Edlin CD, Ross BP, Wright Muelas M, Day PJ, O'Hagan S, Kell DB, Schwarcz R, Leys D, Heyes DJ, Giorgini F, Scrutton NS.

Commun Biol. 2019 Jul 24;2:271. doi: 10.1038/s42003-019-0520-5. eCollection 2019.


Author Correction: Building a global alliance of biofoundries.

Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Feuvre RL, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR, Johnson RA, Keasling JD, Kitney RI, Kondo A, Liu C, Martin VJJ, Menolascina F, Ogino C, Patron NJ, Pavan M, Poh CL, Pretorius IS, Rosser SJ, Scrutton NS, Storch M, Tekotte H, Travnik E, Vickers CE, Yew WS, Yuan Y, Zhao H, Freemont PS.

Nat Commun. 2019 Jul 11;10(1):3132. doi: 10.1038/s41467-019-10862-1.


Synthetic biology for fibres, adhesives and active camouflage materials in protection and aerospace.

Roberts AD, Finnigan W, Wolde-Michael E, Kelly P, Blaker JJ, Hay S, Breitling R, Takano E, Scrutton NS.

MRS Commun. 2019 May 15;9(2):486-504. doi: 10.1557/mrc.2019.35. Epub 2019 Apr 24.


Bio-derived Production of Cinnamyl Alcohol via a Three Step Biocatalytic Cascade and Metabolic Engineering.

Klumbys E, Zebec Z, Weise NJ, Turner NJ, Scrutton NS.

Green Chem. 2019 May 15;20(3):658-663. doi: 10.1039/C7GC03325G. Epub 2018 Jan 5.


Experiment and Simulation Reveal How Mutations in Functional Plasticity Regions Guide Plant Monoterpene Synthase Product Outcome.

Leferink NGH, Ranaghan KE, Karuppiah V, Currin A, van der Kamp MW, Mulholland AJ, Scrutton NS.

ACS Catal. 2019 May 15;8(5):3780-3791. doi: 10.1021/acscatal.8b00692. Epub 2018 Mar 24.


Discovery, Characterisation, Engineering and Applications of Ene Reductases for Industrial Biocatalysis.

Toogood HS, Scrutton NS.

ACS Catal. 2019 May 15;8(4):3532-3549. doi: 10.1021/acscatal.8b00624. Epub 2018 Mar 20.


Convergence of theory and experiment on the role of preorganization, quantum tunneling and enzyme motions into flavoenzyme-catalyzed hydride transfer.

Delgado M, Görlich S, Longbotham JE, Scrutton NS, Hay S, Moliner V, Tuñón I.

ACS Catal. 2019 May 15;7(5):3190-3198. doi: 10.1021/acscatal.7b00201. Epub 2017 Apr 3.


Nonequivalence of Second Sphere "Noncatalytic" Residues in Pentaerythritol Tetranitrate Reductase in Relation to Local Dynamics Linked to H-Transfer in Reactions with NADH and NADPH Coenzymes.

Iorgu AI, Baxter NJ, Cliff MJ, Levy C, Waltho JP, Hay S, Scrutton NS.

ACS Catal. 2018 Dec 7;8(12):11589-11599. doi: 10.1021/acscatal.8b02810. Epub 2018 Oct 26.


Photochemical Spin Dynamics of the Vitamin B12 Derivative, Methylcobalamin.

Lukinović V, Woodward JR, Marrafa TC, Shanmugam M, Heyes DJ, Hardman SJO, Scrutton NS, Hay S, Fielding AJ, Jones AR.

J Phys Chem B. 2019 Jun 6;123(22):4663-4672. doi: 10.1021/acs.jpcb.9b01969. Epub 2019 May 23.


Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol-O-methyltransferase.

Czarnota S, Johannissen LO, Baxter NJ, Rummel F, Wilson AL, Cliff MJ, Levy CW, Scrutton NS, Waltho JP, Hay S.

ACS Catal. 2019 May 3;9(5):4394-4401. doi: 10.1021/acscatal.9b00174. Epub 2019 Apr 9.


Isotopically labeled flavoenzymes and their uses in probing reaction mechanisms.

Iorgu AI, Cliff MJ, Waltho JP, Scrutton NS, Hay S.

Methods Enzymol. 2019;620:145-166. doi: 10.1016/bs.mie.2019.03.009. Epub 2019 Mar 29.


Building a global alliance of biofoundries.

Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Le Feuvre R, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR, Johnson RA, Keasling JD, Kitney RI, Kondo A, Liu C, Martin VJJ, Menolascina F, Ogino C, Patron NJ, Pavan M, Poh CL, Pretorius IS, Rosser SJ, Scrutton NS, Storch M, Tekotte H, Travnik E, Vickers CE, Yew WS, Yuan Y, Zhao H, Freemont PS.

Nat Commun. 2019 May 9;10(1):2040. doi: 10.1038/s41467-019-10079-2. No abstract available. Erratum in: Nat Commun. 2019 Jul 11;10(1):3132.


Solvent-slaved protein motions accompany proton coupled electron transfer reactions catalysed by copper nitrite reductase.

Hedison TM, Heyes DJ, Shanmugam M, Iorgu AI, Scrutton NS.

Chem Commun (Camb). 2019 May 25;55(42):5863-5866. doi: 10.1039/c9cc01026b. Epub 2019 May 3.


Selectivity through discriminatory induced fit enables switching of NAD(P)H coenzyme specificity in Old Yellow Enzyme ene-reductases.

Iorgu AI, Hedison TM, Hay S, Scrutton NS.

FEBS J. 2019 Aug;286(16):3117-3128. doi: 10.1111/febs.14862. Epub 2019 May 13.


SelProm: A Queryable and Predictive Expression Vector Selection Tool for Escherichia coli.

Jervis AJ, Carbonell P, Taylor S, Sung R, Dunstan MS, Robinson CJ, Breitling R, Takano E, Scrutton NS.

ACS Synth Biol. 2019 Jul 19;8(7):1478-1483. doi: 10.1021/acssynbio.8b00399. Epub 2019 Mar 18.


Light-induced structural changes in a full-length cyanobacterial phytochrome probed by time-resolved X-ray scattering.

Heyes DJ, Hardman SJO, Pedersen MN, Woodhouse J, De La Mora E, Wulff M, Weik M, Cammarata M, Scrutton NS, Schirò G.

Commun Biol. 2019 Jan 3;2:1. doi: 10.1038/s42003-018-0242-0. eCollection 2019.


Tripping the light fantastic in membrane redox biology: linking dynamic structures to function in ER electron transfer chains.

Hedison TM, Scrutton NS.

FEBS J. 2019 Jun;286(11):2004-2017. doi: 10.1111/febs.14757. Epub 2019 Jan 30. Review.


Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli.

Jervis AJ, Carbonell P, Vinaixa M, Dunstan MS, Hollywood KA, Robinson CJ, Rattray NJW, Yan C, Swainston N, Currin A, Sung R, Toogood H, Taylor S, Faulon JL, Breitling R, Takano E, Scrutton NS.

ACS Synth Biol. 2019 Jan 18;8(1):127-136. doi: 10.1021/acssynbio.8b00398. Epub 2019 Jan 7.


C3 and C6 Modification-Specific OYE Biotransformations of Synthetic Carvones and Sequential BVMO Chemoenzymatic Synthesis of Chiral Caprolactones.

Issa IS, Toogood HS, Johannissen LO, Raftery J, Scrutton NS, Gardiner JM.

Chemistry. 2019 Feb 26;25(12):2983-2988. doi: 10.1002/chem.201805219. Epub 2019 Jan 15.


From Bugs to Bioplastics: Total (+)-Dihydrocarvide Biosynthesis by Engineered Escherichia coli.

Ascue Avalos GA, Toogood HS, Tait S, Messiha HL, Scrutton NS.

Chembiochem. 2019 Mar 15;20(6):785-792. doi: 10.1002/cbic.201800606. Epub 2019 Jan 21.


The sacrificial inactivation of the blue-light photosensor cryptochrome from Drosophila melanogaster.

Kutta RJ, Archipowa N, Scrutton NS.

Phys Chem Chem Phys. 2018 Nov 21;20(45):28767-28776. doi: 10.1039/c8cp04671a.


Selective cellular imaging with lanthanide-based upconversion nanoparticles.

Nampi PP, Vakurov A, Mackenzie LE, Scrutton NS, Millner PA, Jose G, Saha S.

J Biophotonics. 2019 Apr;12(4):e201800256. doi: 10.1002/jbio.201800256. Epub 2019 Jan 2.


An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals.

Carbonell P, Jervis AJ, Robinson CJ, Yan C, Dunstan M, Swainston N, Vinaixa M, Hollywood KA, Currin A, Rattray NJW, Taylor S, Spiess R, Sung R, Williams AR, Fellows D, Stanford NJ, Mulherin P, Le Feuvre R, Barran P, Goodacre R, Turner NJ, Goble C, Chen GG, Kell DB, Micklefield J, Breitling R, Takano E, Faulon JL, Scrutton NS.

Commun Biol. 2018 Jun 8;1:66. doi: 10.1038/s42003-018-0076-9. eCollection 2018.


A Toolbox for Diverse Oxyfunctionalisation of Monoterpenes.

Hernandez-Ortega A, Vinaixa M, Zebec Z, Takano E, Scrutton NS.

Sci Rep. 2018 Sep 26;8(1):14396. doi: 10.1038/s41598-018-32816-1.



Scrutton N.

Methods Enzymol. 2018;608:xvii-xviii. doi: 10.1016/S0076-6879(18)30341-0. No abstract available.


Multifragment DNA Assembly of Biochemical Pathways via Automated Ligase Cycling Reaction.

Robinson CJ, Dunstan MS, Swainston N, Titchmarsh J, Takano E, Scrutton NS, Jervis AJ.

Methods Enzymol. 2018;608:369-392. doi: 10.1016/bs.mie.2018.04.011.


Chemoenzymatic Synthesis of the Intermediates in the Peppermint Monoterpenoid Biosynthetic Pathway.

Cheallaigh AN, Mansell DJ, Toogood HS, Tait S, Lygidakis A, Scrutton NS, Gardiner JM.

J Nat Prod. 2018 Jul 27;81(7):1546-1552. doi: 10.1021/acs.jnatprod.7b01026. Epub 2018 Jul 6.


PartsGenie: an integrated tool for optimizing and sharing synthetic biology parts.

Swainston N, Dunstan M, Jervis AJ, Robinson CJ, Carbonell P, Williams AR, Faulon JL, Scrutton NS, Kell DB.

Bioinformatics. 2018 Jul 1;34(13):2327-2329. doi: 10.1093/bioinformatics/bty105.


A living foundry for Synthetic Biological Materials: A synthetic biology roadmap to new advanced materials.

Le Feuvre RA, Scrutton NS.

Synth Syst Biotechnol. 2018 Apr 17;3(2):105-112. doi: 10.1016/j.synbio.2018.04.002. eCollection 2018 Jun. Review.


Trapping methods for probing functional intermediates in nitric oxide synthases and related enzymes.

Hedison TM, Hay S, Scrutton NS.

Front Biosci (Landmark Ed). 2018 Jun 1;23:1874-1888. Review.


Engineering the "Missing Link" in Biosynthetic (-)-Menthol Production: Bacterial Isopulegone Isomerase.

Currin A, Dunstan MS, Johannissen LO, Hollywood KA, Vinaixa M, Jervis AJ, Swainston N, Rattray NJW, Gardiner JM, Kell DB, Takano E, Toogood HS, Scrutton NS.

ACS Catal. 2018 Mar 2;8(3):2012-2020. doi: 10.1021/acscatal.7b04115. Epub 2018 Jan 24.


Photochemical Mechanism of an Atypical Algal Phytochrome.

Choudry U, Heyes DJ, Hardman SJO, Sakuma M, Sazanovich IV, Woodhouse J, De La Mora E, Pedersen MN, Wulff M, Weik M, Schirò G, Scrutton NS.

Chembiochem. 2018 May 18;19(10):1036-1043. doi: 10.1002/cbic.201800016. Epub 2018 Apr 20.


Biocatalytic Routes to Lactone Monomers for Polymer Production.

Messiha HL, Ahmed ST, Karuppiah V, Suardíaz R, Ascue Avalos GA, Fey N, Yeates S, Toogood HS, Mulholland AJ, Scrutton NS.

Biochemistry. 2018 Apr 3;57(13):1997-2008. doi: 10.1021/acs.biochem.8b00169. Epub 2018 Mar 22.


Selenzyme: enzyme selection tool for pathway design.

Carbonell P, Wong J, Swainston N, Takano E, Turner NJ, Scrutton NS, Kell DB, Breitling R, Faulon JL.

Bioinformatics. 2018 Jun 15;34(12):2153-2154. doi: 10.1093/bioinformatics/bty065.


Stepwise Hydride Transfer in a Biological System: Insights into the Reaction Mechanism of the Light-Dependent Protochlorophyllide Oxidoreductase.

Archipowa N, Kutta RJ, Heyes DJ, Scrutton NS.

Angew Chem Int Ed Engl. 2018 Mar 1;57(10):2682-2686. doi: 10.1002/anie.201712729. Epub 2018 Feb 5.


1H, 15N and 13C backbone resonance assignments of pentaerythritol tetranitrate reductase from Enterobacter cloacae PB2.

Iorgu AI, Baxter NJ, Cliff MJ, Waltho JP, Hay S, Scrutton NS.

Biomol NMR Assign. 2018 Apr;12(1):79-83. doi: 10.1007/s12104-017-9791-2. Epub 2017 Nov 22.


Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase.

Karuppiah V, Ranaghan KE, Leferink NGH, Johannissen LO, Shanmugam M, Ní Cheallaigh A, Bennett NJ, Kearsey LJ, Takano E, Gardiner JM, van der Kamp MW, Hay S, Mulholland AJ, Leys D, Scrutton NS.

ACS Catal. 2017 Sep 1;7(9):6268-6282. doi: 10.1021/acscatal.7b01924. Epub 2017 Aug 9.


Ab Initio QM/MM Modeling of the Rate-Limiting Proton Transfer Step in the Deamination of Tryptamine by Aromatic Amine Dehydrogenase.

Ranaghan KE, Morris WG, Masgrau L, Senthilkumar K, Johannissen LO, Scrutton NS, Harvey JN, Manby FR, Mulholland AJ.

J Phys Chem B. 2017 Oct 26;121(42):9785-9798. doi: 10.1021/acs.jpcb.7b06892. Epub 2017 Oct 17.


Retooling microorganisms for the fermentative production of alcohols.

Toogood HS, Scrutton NS.

Curr Opin Biotechnol. 2018 Apr;50:1-10. doi: 10.1016/j.copbio.2017.08.010. Epub 2017 Sep 6. Review.


Enzymes make light work of hydrocarbon production.

Scrutton NS.

Science. 2017 Sep 1;357(6354):872-873. doi: 10.1126/science.aao4399. No abstract available.


Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis.

Gahloth D, Dunstan MS, Quaglia D, Klumbys E, Lockhart-Cairns MP, Hill AM, Derrington SR, Scrutton NS, Turner NJ, Leys D.

Nat Chem Biol. 2017 Sep;13(9):975-981. doi: 10.1038/nchembio.2434. Epub 2017 Jul 17.


biochem4j: Integrated and extensible biochemical knowledge through graph databases.

Swainston N, Batista-Navarro R, Carbonell P, Dobson PD, Dunstan M, Jervis AJ, Vinaixa M, Williams AR, Ananiadou S, Faulon JL, Mendes P, Kell DB, Scrutton NS, Breitling R.

PLoS One. 2017 Jul 14;12(7):e0179130. doi: 10.1371/journal.pone.0179130. eCollection 2017.


Liver microsomal lipid enhances the activity and redox coupling of colocalized cytochrome P450 reductase-cytochrome P450 3A4 in nanodiscs.

Liu KC, Hughes JMX, Hay S, Scrutton NS.

FEBS J. 2017 Jul;284(14):2302-2319. doi: 10.1111/febs.14129. Epub 2017 Jun 30.


Structural insights into the ene-reductase synthesis of profens.

Waller J, Toogood HS, Karuppiah V, Rattray NJW, Mansell DJ, Leys D, Gardiner JM, Fryszkowska A, Ahmed ST, Bandichhor R, Reddy GP, Scrutton NS.

Org Biomol Chem. 2017 May 23;15(20):4440-4448. doi: 10.1039/c7ob00163k.


Engineering proximal vs. distal heme-NO coordination via dinitrosyl dynamics: implications for NO sensor design.

Kekilli D, Petersen CA, Pixton DA, Ghafoor DD, Abdullah GH, Dworkowski FSN, Wilson MT, Heyes DJ, Hardman SJO, Murphy LM, Strange RW, Scrutton NS, Andrew CR, Hough MA.

Chem Sci. 2017 Mar 1;8(3):1986-1994. doi: 10.1039/c6sc04190f. Epub 2016 Nov 16.


Vertebrate Cryptochromes are Vestigial Flavoproteins.

Kutta RJ, Archipowa N, Johannissen LO, Jones AR, Scrutton NS.

Sci Rep. 2017 Mar 20;7:44906. doi: 10.1038/srep44906.


Speeding up enzyme engineering computationally.

Scrutton NS.

IUCrJ. 2016 Dec 24;4(Pt 1):5-6. doi: 10.1107/S2052252516019692. eCollection 2017 Jan 1.


Direct Evidence of an Excited-State Triplet Species upon Photoactivation of the Chlorophyll Precursor Protochlorophyllide.

Brandariz-de-Pedro G, Heyes DJ, Hardman SJ, Shanmugam M, Jones AR, Weber S, Nohr D, Scrutton NS, Fielding AJ.

J Phys Chem Lett. 2017 Mar 16;8(6):1219-1223. doi: 10.1021/acs.jpclett.7b00200. Epub 2017 Mar 2.


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