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Items: 1 to 50 of 183

1.

Kras/ADAM17-dependent Jag1-ICD reverse signalling sustains colorectal cancer progression and chemoresistance.

Pelullo M, Nardozza F, Zema S, Quaranta R, Nicoletti C, Besharat ZM, Felli MP, Cerbelli B, d'Amati G, Palermo R, Capalbo C, Talora C, Di Marcotullio L, Giannini G, Checquolo S, Screpanti I, Bellavia D.

Cancer Res. 2019 Sep 10. pii: canres.0145.2019. doi: 10.1158/0008-5472.CAN-19-0145. [Epub ahead of print]

PMID:
31506332
2.

Broadening phenotype of adenylosuccinate lyase deficiency: A novel clinical pattern resembling neuronal ceroid lipofuscinosis.

Mastrangelo M, Alfonsi C, Screpanti I, Masuelli L, Tavazzi B, Mei D, Giannotti F, Guerrini R, Leuzzi V.

Mol Genet Metab Rep. 2019 Aug 21;21:100502. doi: 10.1016/j.ymgmr.2019.100502. eCollection 2019 Dec.

3.

Interplay of protein corona and immune cells controls blood residency of liposomes.

Giulimondi F, Digiacomo L, Pozzi D, Palchetti S, Vulpis E, Capriotti AL, Chiozzi RZ, Laganà A, Amenitsch H, Masuelli L, Mahmoudi M, Screpanti I, Zingoni A, Caracciolo G.

Nat Commun. 2019 Aug 15;10(1):3686. doi: 10.1038/s41467-019-11642-7.

4.

Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype.

Giuli MV, Giuliani E, Screpanti I, Bellavia D, Checquolo S.

J Oncol. 2019 Jul 11;2019:8707053. doi: 10.1155/2019/8707053. eCollection 2019. Review.

5.

Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL.

Tottone L, Zhdanovskaya N, Carmona Pestaña Á, Zampieri M, Simeoni F, Lazzari S, Ruocco V, Pelullo M, Caiafa P, Felli MP, Checquolo S, Bellavia D, Talora C, Screpanti I, Palermo R.

Front Oncol. 2019 Apr 3;9:198. doi: 10.3389/fonc.2019.00198. eCollection 2019.

6.

Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia.

Quaglio D, Zhdanovskaya N, Tobajas G, Cuartas V, Balducci S, Christodoulou MS, Fabrizi G, Gargantilla M, Priego EM, Carmona Pestaña Á, Passarella D, Screpanti I, Botta B, Palermo R, Mori M, Ghirga F, Pérez-Pérez MJ.

ACS Med Chem Lett. 2019 Feb 26;10(4):639-643. doi: 10.1021/acsmedchemlett.8b00608. eCollection 2019 Apr 11.

PMID:
30996810
7.

Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells.

Ceccarelli S, Megiorni F, Bellavia D, Marchese C, Screpanti I, Checquolo S.

Stem Cells Int. 2019 Jan 6;2019:6264931. doi: 10.1155/2019/6264931. eCollection 2019. Review.

8.

IL-4-dependent Jagged1 expression/processing is associated with survival of chronic lymphocytic leukemia cells but not with Notch activation.

De Falco F, Del Papa B, Baldoni S, Sabatini R, Falzetti F, Di Ianni M, Martelli MP, Mezzasoma F, Pelullo M, Marconi P, Sportoletti P, Screpanti I, Rosati E.

Cell Death Dis. 2018 Nov 26;9(12):1160. doi: 10.1038/s41419-018-1185-6.

9.

Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer.

Ferrandino F, Grazioli P, Bellavia D, Campese AF, Screpanti I, Felli MP.

Front Immunol. 2018 Oct 11;9:2165. doi: 10.3389/fimmu.2018.02165. eCollection 2018. Review.

10.

Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation.

Ferrandino F, Bernardini G, Tsaouli G, Grazioli P, Campese AF, Noce C, Ciuffetta A, Vacca A, Besharat ZM, Bellavia D, Screpanti I, Felli MP.

Oncogene. 2018 Dec;37(49):6285-6298. doi: 10.1038/s41388-018-0401-2. Epub 2018 Jul 23.

11.

The Notch3 Receptor and Its Intracellular Signaling-Dependent Oncogenic Mechanisms.

Bellavia D, Checquolo S, Palermo R, Screpanti I.

Adv Exp Med Biol. 2018;1066:205-222. doi: 10.1007/978-3-319-89512-3_10. Review.

PMID:
30030828
12.

Brain Targeting by Liposome-Biomolecular Corona Boosts Anticancer Efficacy of Temozolomide in Glioblastoma Cells.

Arcella A, Palchetti S, Digiacomo L, Pozzi D, Capriotti AL, Frati L, Oliva MA, Tsaouli G, Rota R, Screpanti I, Mahmoudi M, Caracciolo G.

ACS Chem Neurosci. 2018 Dec 19;9(12):3166-3174. doi: 10.1021/acschemneuro.8b00339. Epub 2018 Jul 31.

PMID:
30015470
13.

NOTCH1 Is Aberrantly Activated in Chronic Lymphocytic Leukemia Hematopoietic Stem Cells.

Di Ianni M, Baldoni S, Del Papa B, Aureli P, Dorillo E, De Falco F, Albi E, Varasano E, Di Tommaso A, Giancola R, Accorsi P, Rotta G, Rompietti C, Silva Barcelos EC, Campese AF, Di Bartolomeo P, Screpanti I, Rosati E, Falzetti F, Sportoletti P.

Front Oncol. 2018 Apr 20;8:105. doi: 10.3389/fonc.2018.00105. eCollection 2018.

14.

A non-conserved amino acid variant regulates differential signalling between human and mouse CD28.

Porciello N, Grazioli P, Campese AF, Kunkl M, Caristi S, Mastrogiovanni M, Muscolini M, Spadaro F, Favre C, Nunès JA, Borroto A, Alarcon B, Screpanti I, Tuosto L.

Nat Commun. 2018 Mar 14;9(1):1080. doi: 10.1038/s41467-018-03385-8.

15.

Notch signaling as a therapeutic target for acute lymphoblastic leukemia.

Bellavia D, Palermo R, Felli MP, Screpanti I, Checquolo S.

Expert Opin Ther Targets. 2018 Apr;22(4):331-342. doi: 10.1080/14728222.2018.1451840. Epub 2018 Mar 21. Review.

PMID:
29527929
16.

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.

Infante P, Faedda R, Bernardi F, Bufalieri F, Lospinoso Severini L, Alfonsi R, Mazzà D, Siler M, Coni S, Po A, Petroni M, Ferretti E, Mori M, De Smaele E, Canettieri G, Capalbo C, Maroder M, Screpanti I, Kool M, Pfister SM, Guardavaccaro D, Gulino A, Di Marcotullio L.

Nat Commun. 2018 Mar 7;9(1):976. doi: 10.1038/s41467-018-03339-0.

17.

Optimizing the identification of risk-relevant mutations by multigene panel testing in selected hereditary breast/ovarian cancer families.

Coppa A, Nicolussi A, D'Inzeo S, Capalbo C, Belardinilli F, Colicchia V, Petroni M, Zani M, Ferraro S, Rinaldi C, Buffone A, Bartolazzi A, Screpanti I, Ottini L, Giannini G.

Cancer Med. 2018 Jan;7(1):46-55. doi: 10.1002/cam4.1251. Epub 2017 Dec 22.

18.

Loss of miR-107, miR-181c and miR-29a-3p Promote Activation of Notch2 Signaling in Pediatric High-Grade Gliomas (pHGGs).

Catanzaro G, Sabato C, Russo M, Rosa A, Abballe L, Besharat ZM, Po A, Miele E, Bellavia D, Chiacchiarini M, Gessi M, Peruzzi G, Napolitano M, Antonelli M, Mastronuzzi A, Giangaspero F, Locatelli F, Screpanti I, Vacca A, Ferretti E.

Int J Mol Sci. 2017 Dec 17;18(12). pii: E2742. doi: 10.3390/ijms18122742.

19.

Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway.

Quaranta R, Pelullo M, Zema S, Nardozza F, Checquolo S, Lauer DM, Bufalieri F, Palermo R, Felli MP, Vacca A, Talora C, Di Marcotullio L, Screpanti I, Bellavia D.

Cell Death Dis. 2017 Jul 20;8(7):e2942. doi: 10.1038/cddis.2017.326.

20.

β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells.

Miele E, Po A, Begalli F, Antonucci L, Mastronuzzi A, Marras CE, Carai A, Cucchi D, Abballe L, Besharat ZM, Catanzaro G, Infante P, Di Marcotullio L, Canettieri G, De Smaele E, Screpanti I, Locatelli F, Ferretti E.

BMC Cancer. 2017 Jul 17;17(1):488. doi: 10.1186/s12885-017-3477-0.

21.

Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia.

Mori M, Tottone L, Quaglio D, Zhdanovskaya N, Ingallina C, Fusto M, Ghirga F, Peruzzi G, Crestoni ME, Simeoni F, Giulimondi F, Talora C, Botta B, Screpanti I, Palermo R.

Sci Rep. 2017 May 19;7(1):2213. doi: 10.1038/s41598-017-02316-9.

22.

Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.

Coni S, Mancuso AB, Di Magno L, Sdruscia G, Manni S, Serrao SM, Rotili D, Spiombi E, Bufalieri F, Petroni M, Kusio-Kobialka M, De Smaele E, Ferretti E, Capalbo C, Mai A, Niewiadomski P, Screpanti I, Di Marcotullio L, Canettieri G.

Sci Rep. 2017 Apr 21;7:46645. doi: 10.1038/srep46645. No abstract available.

23.

PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma.

Colicchia V, Petroni M, Guarguaglini G, Sardina F, Sahún-Roncero M, Carbonari M, Ricci B, Heil C, Capalbo C, Belardinilli F, Coppa A, Peruzzi G, Screpanti I, Lavia P, Gulino A, Giannini G.

Oncogene. 2017 Aug 17;36(33):4682-4691. doi: 10.1038/onc.2017.40. Epub 2017 Apr 10.

PMID:
28394338
24.

Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma.

Po A, Silvano M, Miele E, Capalbo C, Eramo A, Salvati V, Todaro M, Besharat ZM, Catanzaro G, Cucchi D, Coni S, Di Marcotullio L, Canettieri G, Vacca A, Stassi G, De Smaele E, Tartaglia M, Screpanti I, De Maria R, Ferretti E.

Oncogene. 2017 Aug 10;36(32):4641-4652. doi: 10.1038/onc.2017.91. Epub 2017 Apr 3.

25.

Corrigendum: The loss of ATP2C1 impairs the DNA damage response and induces altered skin homeostasis: Consequences for epidermal biology in Hailey-Hailey disease.

Cialfi S, Le Pera L, De Blasio C, Mariano G, Palermo R, Zonfrilli A, Uccelletti D, Palleschi C, Biolcati G, Barbieri L, Screpanti I, Talora C.

Sci Rep. 2017 Mar 16;7:44514. doi: 10.1038/srep44514. No abstract available.

26.

The mazy case of Notch and immunoregulatory cells.

Grazioli P, Felli MP, Screpanti I, Campese AF.

J Leukoc Biol. 2017 Aug;102(2):361-368. doi: 10.1189/jlb.1VMR1216-505R. Epub 2017 Mar 14. Review.

PMID:
28292944
27.

Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.

Coni S, Mancuso AB, Di Magno L, Sdruscia G, Manni S, Serrao SM, Rotili D, Spiombi E, Bufalieri F, Petroni M, Kusio-Kobialka M, De Smaele E, Ferretti E, Capalbo C, Mai A, Niewiadomski P, Screpanti I, Di Marcotullio L, Canettieri G.

Sci Rep. 2017 Mar 9;7:44079. doi: 10.1038/srep44079. Erratum in: Sci Rep. 2017 Apr 21;7:46645.

28.

Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype.

Infante P, Alfonsi R, Ingallina C, Quaglio D, Ghirga F, D'Acquarica I, Bernardi F, Di Magno L, Canettieri G, Screpanti I, Gulino A, Botta B, Mori M, Di Marcotullio L.

Cell Death Dis. 2016 Sep 22;7(9):e2376. doi: 10.1038/cddis.2016.195.

29.

Manipulation of lipoplex concentration at the cell surface boosts transfection efficiency in hard-to-transfect cells.

Palchetti S, Pozzi D, Marchini C, Amici A, Andreani C, Bartolacci C, Digiacomo L, Gambini V, Cardarelli F, Di Rienzo C, Peruzzi G, Amenitsch H, Palermo R, Screpanti I, Caracciolo G.

Nanomedicine. 2017 Feb;13(2):681-691. doi: 10.1016/j.nano.2016.08.019. Epub 2016 Aug 23.

PMID:
27565691
30.

The loss of ATP2C1 impairs the DNA damage response and induces altered skin homeostasis: Consequences for epidermal biology in Hailey-Hailey disease.

Cialfi S, Le Pera L, De Blasio C, Mariano G, Palermo R, Zonfrilli A, Uccelletti D, Palleschi C, Biolcati G, Barbieri L, Screpanti I, Talora C.

Sci Rep. 2016 Aug 16;6:31567. doi: 10.1038/srep31567. Erratum in: Sci Rep. 2017 Mar 16;7:44514.

31.

A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development.

Klein-Hessling S, Rudolf R, Muhammad K, Knobeloch KP, Maqbool MA, Cauchy P, Andrau JC, Avots A, Talora C, Ellenrieder V, Screpanti I, Serfling E, Patra AK.

Nat Commun. 2016 Jun 17;7:11841. doi: 10.1038/ncomms11841.

32.

MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs.

Catanzaro G, Besharat ZM, Garg N, Ronci M, Pieroni L, Miele E, Mastronuzzi A, Carai A, Alfano V, Po A, Screpanti I, Locatelli F, Urbani A, Ferretti E.

Stem Cells Int. 2016;2016:2683042. doi: 10.1155/2016/2683042. Epub 2016 Jan 6.

33.

Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression.

Franciosa G, Diluvio G, Gaudio FD, Giuli MV, Palermo R, Grazioli P, Campese AF, Talora C, Bellavia D, D'Amati G, Besharat ZM, Nicoletti C, Siebel CW, Choy L, Rustighi A, Sal GD, Screpanti I, Checquolo S.

Oncogene. 2016 Sep 8;35(36):4741-51. doi: 10.1038/onc.2016.5. Epub 2016 Feb 15.

34.

The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint.

Di Magno L, Basile A, Coni S, Manni S, Sdruscia G, D'Amico D, Antonucci L, Infante P, De Smaele E, Cucchi D, Ferretti E, Di Marcotullio L, Screpanti I, Canettieri G.

Oncotarget. 2016 Feb 23;7(8):9538-49. doi: 10.18632/oncotarget.7070.

35.

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.

Benvenuto M, Masuelli L, De Smaele E, Fantini M, Mattera R, Cucchi D, Bonanno E, Di Stefano E, Frajese GV, Orlandi A, Screpanti I, Gulino A, Modesti A, Bei R.

Oncotarget. 2016 Feb 23;7(8):9250-70. doi: 10.18632/oncotarget.7062.

36.

Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β.

Verginelli F, Adesso L, Limon I, Alisi A, Gueguen M, Panera N, Giorda E, Raimondi L, Ciarapica R, Campese AF, Screpanti I, Stifani S, Kitajewski J, Miele L, Rota R, Locatelli F.

Oncotarget. 2015 Dec 22;6(41):43216-29. doi: 10.18632/oncotarget.6456.

37.

CD3ε recruits Numb to promote TCR degradation.

Martin-Blanco N, Jiménez Teja D, Bretones G, Borroto A, Caraballo M, Screpanti I, León J, Alarcón B, Canelles M.

Int Immunol. 2016 Mar;28(3):127-37. doi: 10.1093/intimm/dxv060. Epub 2015 Oct 27.

PMID:
26507128
38.

Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth.

D'Amico D, Antonucci L, Di Magno L, Coni S, Sdruscia G, Macone A, Miele E, Infante P, Di Marcotullio L, De Smaele E, Ferretti E, Ciapponi L, Giangaspero F, Yates JR 3rd, Agostinelli E, Cardinali B, Screpanti I, Gulino A, Canettieri G.

Dev Cell. 2015 Oct 12;35(1):21-35. doi: 10.1016/j.devcel.2015.09.008.

39.

The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress.

Petroni M, Sardina F, Heil C, Sahún-Roncero M, Colicchia V, Veschi V, Albini S, Fruci D, Ricci B, Soriani A, Di Marcotullio L, Screpanti I, Gulino A, Giannini G.

Cell Death Differ. 2016 Feb;23(2):197-206. doi: 10.1038/cdd.2015.81. Epub 2015 Jun 12.

40.

Characterization of medulloblastoma in Fanconi Anemia: a novel mutation in the BRCA2 gene and SHH molecular subgroup.

Miele E, Mastronuzzi A, Po A, Carai A, Alfano V, Serra A, Colafati GS, Strocchio L, Antonelli M, Buttarelli FR, Zani M, Ferraro S, Buffone A, Vacca A, Screpanti I, Giangaspero F, Giannini G, Locatelli F, Ferretti E.

Biomark Res. 2015 Jun 6;3:13. doi: 10.1186/s40364-015-0038-z. eCollection 2015.

41.

Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL.

De Falco F, Sabatini R, Del Papa B, Falzetti F, Di Ianni M, Sportoletti P, Baldoni S, Screpanti I, Marconi P, Rosati E.

Oncotarget. 2015 Jun 30;6(18):16559-72.

42.

The deregulated expression of miR-125b in acute myeloid leukemia is dependent on the transcription factor C/EBPα.

Vargas Romero P, Cialfi S, Palermo R, De Blasio C, Checquolo S, Bellavia D, Chiaretti S, Foà R, Amadori A, Gulino A, Zardo G, Talora C, Screpanti I.

Leukemia. 2015 Dec;29(12):2442-5. doi: 10.1038/leu.2015.117. Epub 2015 May 18. No abstract available.

43.

Validation of the Ion Torrent PGM sequencing for the prospective routine molecular diagnostic of colorectal cancer.

Belardinilli F, Capalbo C, Buffone A, Petroni M, Colicchia V, Ferraro S, Zani M, Nicolussi A, D'Inzeo S, Coppa A, Screpanti I, Gulino A, Giannini G.

Clin Biochem. 2015 Sep;48(13-14):908-10. doi: 10.1016/j.clinbiochem.2015.04.003. Epub 2015 Apr 11.

PMID:
25872148
44.

Proteomic analysis of human Sonic Hedgehog (SHH) medulloblastoma stem-like cells.

Ronci M, Catanzaro G, Pieroni L, Po A, Besharat ZM, Greco V, Levi Mortera S, Screpanti I, Ferretti E, Urbani A.

Mol Biosyst. 2015 Jun;11(6):1603-11. doi: 10.1039/c5mb00034c.

PMID:
25756958
45.

Notch3/Jagged1 circuitry reinforces notch signaling and sustains T-ALL.

Pelullo M, Quaranta R, Talora C, Checquolo S, Cialfi S, Felli MP, te Kronnie G, Borga C, Besharat ZM, Palermo R, Di Marcotullio L, Capobianco AJ, Gulino A, Screpanti I, Bellavia D.

Neoplasia. 2014 Dec;16(12):1007-17. doi: 10.1016/j.neo.2014.10.004.

46.

Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth.

Di Magno L, Manzi D, D'Amico D, Coni S, Macone A, Infante P, Di Marcotullio L, De Smaele E, Ferretti E, Screpanti I, Agostinelli E, Gulino A, Canettieri G.

Cell Cycle. 2014;13(21):3404-13. doi: 10.4161/15384101.2014.952973.

47.

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.

Infante P, Mori M, Alfonsi R, Ghirga F, Aiello F, Toscano S, Ingallina C, Siler M, Cucchi D, Po A, Miele E, D'Amico D, Canettieri G, De Smaele E, Ferretti E, Screpanti I, Uccello Barretta G, Botta M, Botta B, Gulino A, Di Marcotullio L.

EMBO J. 2015 Jan 13;34(2):200-17. doi: 10.15252/embj.201489213. Epub 2014 Dec 4.

48.

Constitutive phosphorylation of the active Notch1 intracellular domain in chronic lymphocytic leukemia cells with NOTCH1 mutation.

De Falco F, Sabatini R, Falzetti F, Di Ianni M, Sportoletti P, Baldoni S, Del Papa B, Screpanti I, Marconi P, Rosati E.

Leukemia. 2015 Apr;29(4):994-8. doi: 10.1038/leu.2014.329. Epub 2014 Nov 26. No abstract available.

PMID:
25425197
49.

Novel and recurrent BRCA2 mutations in Italian breast/ovarian cancer families widen the ovarian cancer cluster region boundaries to exons 13 and 14.

Coppa A, Buffone A, Capalbo C, Nicolussi A, D'Inzeo S, Belardinilli F, Colicchia V, Petroni M, Granato T, Midulla C, Zani M, Ferraro S, Screpanti I, Gulino A, Giannini G.

Breast Cancer Res Treat. 2014 Dec;148(3):629-35. doi: 10.1007/s10549-014-3196-z. Epub 2014 Nov 14.

PMID:
25395318
50.

Numb-dependent integration of pre-TCR and p53 function in T-cell precursor development.

Martin-Blanco NM, Checquolo S, Del Gaudio F, Palermo R, Franciosa G, Di Marcotullio L, Gulino A, Canelles M, Screpanti I.

Cell Death Dis. 2014 Oct 16;5:e1472. doi: 10.1038/cddis.2014.438.

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