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Items: 33


Platelet-derived transforming growth factor-β1 promotes keratinocyte proliferation in cutaneous wound healing.

Chong DLW, Trinder S, Labelle M, Rodriguez-Justo M, Hughes S, Holmes AM, Scotton CJ, Porter JC.

J Tissue Eng Regen Med. 2020 Feb 18. doi: 10.1002/term.3022. [Epub ahead of print]


Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects.

Kotkowiak W, Wengel J, Scotton CJ, Pasternak A.

J Med Chem. 2019 Mar 14;62(5):2499-2507. doi: 10.1021/acs.jmedchem.8b01806. Epub 2019 Feb 22.


Biocompatibility and toxicity of graphene quantum dots for potential application in photodynamic therapy.

Tabish TA, Scotton CJ, Ferguson DCJ, Lin L, der Veen AV, Lowry S, Ali M, Jabeen F, Ali M, Winyard PG, Zhang S.

Nanomedicine (Lond). 2018 Aug 1;13(15):1923-1937. doi: 10.2217/nnm-2018-0018. Epub 2018 Aug 20.


Molecular epidemiology of Pseudomonas aeruginosa in an unsegregated bronchiectasis cohort sharing hospital facilities with a cystic fibrosis cohort.

Mitchelmore PJ, Randall J, Bull MJ, Moore KA, O'Neill PA, Paszkiewicz K, Mahenthiralingam E, Scotton CJ, Sheldon CD, Withers NJ, Brown AR.

Thorax. 2017 Aug 26. pii: thoraxjnl-2016-209889. doi: 10.1136/thoraxjnl-2016-209889. [Epub ahead of print]


Delving Deep into the Proteome of Lung Fibrosis Brings Plasma Cells to the Surface.

Gibbons MA, Scotton CJ.

Am J Respir Crit Care Med. 2017 Nov 15;196(10):1238-1240. doi: 10.1164/rccm.201706-1186ED. No abstract available.


Differential Expression of VEGF-Axxx Isoforms Is Critical for Development of Pulmonary Fibrosis.

Barratt SL, Blythe T, Jarrett C, Ourradi K, Shelley-Fraser G, Day MJ, Qiu Y, Harper S, Maher TM, Oltean S, Hames TJ, Scotton CJ, Welsh GI, Bates DO, Millar AB.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):479-493. doi: 10.1164/rccm.201603-0568OC.


TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells.

Smoktunowicz N, Platé M, Stern AO, D'Antongiovanni V, Robinson E, Chudasama V, Caddick S, Scotton CJ, Jarai G, Chambers RC.

Oncotarget. 2016 Oct 4;7(40):65471-65484. doi: 10.18632/oncotarget.11472.


Developing a Collaborative Agenda for Humanities and Social Scientific Research on Laboratory Animal Science and Welfare.

Davies GF, Greenhough BJ, Hobson-West P, Kirk RG, Applebee K, Bellingan LC, Berdoy M, Buller H, Cassaday HJ, Davies K, Diefenbacher D, Druglitrø T, Escobar MP, Friese C, Herrmann K, Hinterberger A, Jarrett WJ, Jayne K, Johnson AM, Johnson ER, Konold T, Leach MC, Leonelli S, Lewis DI, Lilley EJ, Longridge ER, McLeod CM, Miele M, Nelson NC, Ormandy EH, Pallett H, Poort L, Pound P, Ramsden E, Roe E, Scalway H, Schrader A, Scotton CJ, Scudamore CL, Smith JA, Whitfield L, Wolfensohn S.

PLoS One. 2016 Jul 18;11(7):e0158791. doi: 10.1371/journal.pone.0158791. eCollection 2016.


Platform Technologies for Directly Reconstructing 3D Living Biomaterials.

Jayasinghe SN, Auguste J, Scotton CJ.

Adv Mater. 2015 Dec 16;27(47):7794-9. doi: 10.1002/adma.201503001. Epub 2015 Oct 28.


The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection.

Smoktunowicz N, Alexander RE, Franklin L, Williams AE, Holman B, Mercer PF, Jarai G, Scotton CJ, Chambers RC.

Dis Model Mech. 2015 Sep;8(9):1129-39. doi: 10.1242/dmm.019984. Epub 2015 Jul 2.


Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis.

Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ, Hobbs AJ.

Br J Pharmacol. 2014 Jul;171(14):3463-75. doi: 10.1111/bph.12694.


Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages.

Kallis YN, Scotton CJ, Mackinnon AC, Goldin RD, Wright NA, Iredale JP, Chambers RC, Forbes SJ.

PLoS One. 2014 Jan 27;9(1):e86241. doi: 10.1371/journal.pone.0086241. eCollection 2014.


Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease.

Datta A, Alexander R, Sulikowski MG, Nicholson AG, Maher TM, Scotton CJ, Chambers RC.

J Immunol. 2013 Nov 1;191(9):4867-79. doi: 10.4049/jimmunol.1300588. Epub 2013 Sep 30.


Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation.

Mercer PF, Williams AE, Scotton CJ, José RJ, Sulikowski M, Moffatt JD, Murray LA, Chambers RC.

Am J Respir Cell Mol Biol. 2014 Jan;50(1):144-57. doi: 10.1165/rcmb.2013-0142OC.


Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation.

Scotton CJ, Hayes B, Alexander R, Datta A, Forty EJ, Mercer PF, Blanchard A, Chambers RC.

Eur Respir J. 2013 Dec;42(6):1633-45. doi: 10.1183/09031936.00182412. Epub 2013 Mar 21.


Coagulation cascade proteinases in lung injury and fibrosis.

Chambers RC, Scotton CJ.

Proc Am Thorac Soc. 2012 Jul;9(3):96-101. doi: 10.1513/pats.201201-006AW. Review.


Innate immunity in lung fibrosis: a therapeutic role for surfactant protein D?

Scotton CJ, Chambers RC.

Am J Respir Crit Care Med. 2012 Mar 1;185(5):471-3. doi: 10.1164/rccm.201112-2193ED. No abstract available.


Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes.

Cho WS, Duffin R, Howie SE, Scotton CJ, Wallace WA, Macnee W, Bradley M, Megson IL, Donaldson K.

Part Fibre Toxicol. 2011 Sep 6;8:27. doi: 10.1186/1743-8977-8-27.


Bio-electrosprayed living composite matrix implanted into mouse models.

Jayasinghe SN, Warnes G, Scotton CJ.

Macromol Biosci. 2011 Oct 10;11(10):1364-9. doi: 10.1002/mabi.201100131. Epub 2011 Jul 13.


Novel therapeutic approaches for pulmonary fibrosis.

Datta A, Scotton CJ, Chambers RC.

Br J Pharmacol. 2011 May;163(1):141-72. doi: 10.1111/j.1476-5381.2011.01247.x. Review.


Bleomycin revisited: towards a more representative model of IPF?

Scotton CJ, Chambers RC.

Am J Physiol Lung Cell Mol Physiol. 2010 Oct;299(4):L439-41. doi: 10.1152/ajplung.00258.2010. Epub 2010 Jul 30. No abstract available.


Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis.

Aguilar S, Scotton CJ, McNulty K, Nye E, Stamp G, Laurent G, Bonnet D, Janes SM.

PLoS One. 2009 Nov 24;4(11):e8013. doi: 10.1371/journal.pone.0008013.


Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury.

Scotton CJ, Krupiczojc MA, Königshoff M, Mercer PF, Lee YC, Kaminski N, Morser J, Post JM, Maher TM, Nicholson AG, Moffatt JD, Laurent GJ, Derian CK, Eickelberg O, Chambers RC.

J Clin Invest. 2009 Sep;119(9):2550-63. doi: 10.1172/JCI33288. Epub 2009 Aug 3.


Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia.

Atzori L, Lucattelli M, Scotton CJ, Laurent GJ, Bartalesi B, De Cunto G, Lunghi B, Chambers RC, Lungarella G.

Am J Respir Cell Mol Biol. 2009 Dec;41(6):680-7. doi: 10.1165/rcmb.2007-0386OC. Epub 2009 Mar 23.


Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis.

Mercer PF, Johns RH, Scotton CJ, Krupiczojc MA, Königshoff M, Howell DC, McAnulty RJ, Das A, Thorley AJ, Tetley TD, Eickelberg O, Chambers RC.

Am J Respir Crit Care Med. 2009 Mar 1;179(5):414-25. doi: 10.1164/rccm.200712-1827OC. Epub 2008 Dec 5.


Coagulation signalling following tissue injury: focus on the role of factor Xa.

Krupiczojc MA, Scotton CJ, Chambers RC.

Int J Biochem Cell Biol. 2008;40(6-7):1228-37. doi: 10.1016/j.biocel.2008.02.026. Epub 2008 Mar 7. Review.


Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways.

Deng X, Mercer PF, Scotton CJ, Gilchrist A, Chambers RC.

Mol Biol Cell. 2008 Jun;19(6):2520-33. doi: 10.1091/mbc.E07-07-0720. Epub 2008 Mar 19.


Molecular targets in pulmonary fibrosis: the myofibroblast in focus.

Scotton CJ, Chambers RC.

Chest. 2007 Oct;132(4):1311-21. Review.


Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D.

J Clin Invest. 2006 Jun;116(6):1606-14. Epub 2006 May 18.


Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis.

Howell DC, Johns RH, Lasky JA, Shan B, Scotton CJ, Laurent GJ, Chambers RC.

Am J Pathol. 2005 May;166(5):1353-65.


Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13.

Scotton CJ, Martinez FO, Smelt MJ, Sironi M, Locati M, Mantovani A, Sozzani S.

J Immunol. 2005 Jan 15;174(2):834-45.


Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer.

Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S, Bridger G, Balkwill FR.

Cancer Res. 2002 Oct 15;62(20):5930-8.


Epithelial cancer cell migration: a role for chemokine receptors?

Scotton CJ, Wilson JL, Milliken D, Stamp G, Balkwill FR.

Cancer Res. 2001 Jul 1;61(13):4961-5.

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