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Items: 1 to 50 of 62

1.

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

Moutaoufik MT, Malty R, Amin S, Zhang Q, Phanse S, Gagarinova A, Zilocchi M, Hoell L, Minic Z, Gagarinova M, Aoki H, Stockwell J, Jessulat M, Goebels F, Broderick K, Scott NE, Vlasblom J, Musso G, Prasad B, Lamantea E, Garavaglia B, Rajput A, Murayama K, Okazaki Y, Foster LJ, Bader GD, Cayabyab FS, Babu M.

iScience. 2019 Sep 27;19:1114-1132. doi: 10.1016/j.isci.2019.08.057. Epub 2019 Sep 4.

2.

A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae.

Feldman MF, Mayer Bridwell AE, Scott NE, Vinogradov E, McKee SR, Chavez SM, Twentyman J, Stallings CL, Rosen DA, Harding CM.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18655-18663. doi: 10.1073/pnas.1907833116. Epub 2019 Aug 27.

3.

A general protein O-glycosylation machinery conserved in Burkholderia species improves bacterial fitness and elicits glycan immunogenicity in humans.

Fathy Mohamed Y, Scott NE, Molinaro A, Creuzenet C, Ortega X, Lertmemongkolchai G, Tunney MM, Green H, Jones AM, DeShazer D, Currie BJ, Foster LJ, Ingram R, De Castro C, Valvano MA.

J Biol Chem. 2019 Sep 6;294(36):13248-13268. doi: 10.1074/jbc.RA119.009671. Epub 2019 Jul 26.

PMID:
31350337
4.

Peptidyl-Prolyl Isomerase ppiB Is Essential for Proteome Homeostasis and Virulence in Burkholderia pseudomallei.

Bzdyl NM, Scott NE, Norville IH, Scott AE, Atkins T, Pang S, Sarovich DS, Coombs G, Inglis TJJ, Kahler CM, Sarkar-Tyson M.

Infect Immun. 2019 Sep 19;87(10). pii: e00528-19. doi: 10.1128/IAI.00528-19. Print 2019 Oct.

PMID:
31331957
5.

Expanding our understanding of the role of microbial glycoproteomes through high-throughput mass spectrometry approaches.

Scott NE.

Glycoconj J. 2019 Aug;36(4):259-266. doi: 10.1007/s10719-019-09875-1. Epub 2019 Jul 4.

PMID:
31270739
6.

Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes.

Di Venanzio G, Flores-Mireles AL, Calix JJ, Haurat MF, Scott NE, Palmer LD, Potter RF, Hibbing ME, Friedman L, Wang B, Dantas G, Skaar EP, Hultgren SJ, Feldman MF.

Nat Commun. 2019 Jun 24;10(1):2763. doi: 10.1038/s41467-019-10706-y.

7.

Salmonella Effectors SseK1 and SseK3 Target Death Domain Proteins in the TNF and TRAIL Signaling Pathways.

Newson JPM, Scott NE, Yeuk Wah Chung I, Wong Fok Lung T, Giogha C, Gan J, Wang N, Strugnell RA, Brown NF, Cygler M, Pearson JS, Hartland EL.

Mol Cell Proteomics. 2019 Jun;18(6):1138-1156. doi: 10.1074/mcp.RA118.001093. Epub 2019 Mar 22.

PMID:
30902834
8.

A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host.

Harding CM, Nasr MA, Scott NE, Goyette-Desjardins G, Nothaft H, Mayer AE, Chavez SM, Huynh JP, Kinsella RL, Szymanski CM, Stallings CL, Segura M, Feldman MF.

Nat Commun. 2019 Feb 21;10(1):891. doi: 10.1038/s41467-019-08869-9.

9.

Proteomics Reveals Multiple Phenotypes Associated with N-linked Glycosylation in Campylobacter jejuni.

Cain JA, Dale AL, Niewold P, Klare WP, Man L, White MY, Scott NE, Cordwell SJ.

Mol Cell Proteomics. 2019 Apr;18(4):715-734. doi: 10.1074/mcp.RA118.001199. Epub 2019 Jan 7.

PMID:
30617158
10.

Characterization of the Citrobacter rodentium Cpx regulon and its role in host infection.

Vogt SL, Scholz R, Peng Y, Guest RL, Scott NE, Woodward SE, Foster LJ, Raivio TL, Finlay BB.

Mol Microbiol. 2019 Mar;111(3):700-716. doi: 10.1111/mmi.14182. Epub 2019 Feb 11.

PMID:
30536519
11.

Protein O-fucosyltransferase 2-mediated O-glycosylation of the adhesin MIC2 is dispensable for Toxoplasma gondii tachyzoite infection.

Khurana S, Coffey MJ, John A, Uboldi AD, Huynh MH, Stewart RJ, Carruthers VB, Tonkin CJ, Goddard-Borger ED, Scott NE.

J Biol Chem. 2019 Feb 1;294(5):1541-1553. doi: 10.1074/jbc.RA118.005357. Epub 2018 Dec 4.

PMID:
30514763
12.

Transmission of Cricket paralysis virus via exosome-like vesicles during infection of Drosophila cells.

Kerr CH, Dalwadi U, Scott NE, Yip CK, Foster LJ, Jan E.

Sci Rep. 2018 Nov 26;8(1):17353. doi: 10.1038/s41598-018-35717-5.

13.

Surface Exposure and Packing of Lipoproteins into Outer Membrane Vesicles Are Coupled Processes in Bacteroides.

Valguarnera E, Scott NE, Azimzadeh P, Feldman MF.

mSphere. 2018 Nov 7;3(6). pii: e00559-18. doi: 10.1128/mSphere.00559-18.

14.

Synthesis and use of 6,6,6-trifluoro-L-fucose to block core-fucosylation in hybridoma cell lines.

McKenzie NC, Scott NE, John A, White JM, Goddard-Borger ED.

Carbohydr Res. 2018 Jul 30;465:4-9. doi: 10.1016/j.carres.2018.05.008. Epub 2018 May 23.

PMID:
29874559
15.

Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers.

Weisel K, Scott NE, Tompson DJ, Votta BJ, Madhavan S, Povey K, Wolstenholme A, Simeoni M, Rudo T, Richards-Peterson L, Sahota T, Wang JG, Lich J, Finger J, Verticelli A, Reilly M, Gough PJ, Harris PA, Bertin J, Wang ML.

Pharmacol Res Perspect. 2017 Dec;5(6). doi: 10.1002/prp2.365.

16.

Post-translational Mechanisms of Host Subversion by Bacterial Effectors.

Scott NE, Hartland EL.

Trends Mol Med. 2017 Dec;23(12):1088-1102. doi: 10.1016/j.molmed.2017.10.003. Epub 2017 Nov 14. Review.

PMID:
29150361
17.

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.

Malty RH, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, Minic Z, Goebels F, Musso G, Wu Z, Abou-Tok H, Meyer M, Deineko V, Kassir S, Sidhu V, Jessulat M, Scott NE, Xiong X, Vlasblom J, Prasad B, Foster LJ, Alberio T, Garavaglia B, Yu H, Bader GD, Nakamura K, Parkinson J, Babu M.

Cell Syst. 2017 Dec 27;5(6):564-577.e12. doi: 10.1016/j.cels.2017.10.010. Epub 2017 Nov 8.

18.

A rapid and accurate approach for prediction of interactomes from co-elution data (PrInCE).

Stacey RG, Skinnider MA, Scott NE, Foster LJ.

BMC Bioinformatics. 2017 Oct 23;18(1):457. doi: 10.1186/s12859-017-1865-8.

19.

Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts.

Lopaticki S, Yang ASP, John A, Scott NE, Lingford JP, O'Neill MT, Erickson SM, McKenzie NC, Jennison C, Whitehead LW, Douglas DN, Kneteman NM, Goddard-Borger ED, Boddey JA.

Nat Commun. 2017 Sep 15;8(1):561. doi: 10.1038/s41467-017-00571-y.

20.

The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD).

Scott NE, Giogha C, Pollock GL, Kennedy CL, Webb AI, Williamson NA, Pearson JS, Hartland EL.

J Biol Chem. 2017 Oct 20;292(42):17337-17350. doi: 10.1074/jbc.M117.805036. Epub 2017 Aug 31.

21.

The role of mass spectrometry analysis in bacterial effector characterization.

Scott NE, Hartland EL.

Biochem J. 2017 Aug 7;474(16):2779-2784. doi: 10.1042/BCJ20160797.

PMID:
28784697
22.

Pathogenic Acinetobacter species have a functional type I secretion system and contact-dependent inhibition systems.

Harding CM, Pulido MR, Di Venanzio G, Kinsella RL, Webb AI, Scott NE, Pachón J, Feldman MF.

J Biol Chem. 2017 Jun 2;292(22):9075-9087. doi: 10.1074/jbc.M117.781575. Epub 2017 Apr 3.

23.

A forward genetic screen identifies a negative regulator of rapid Ca2+-dependent cell egress (MS1) in the intracellular parasite Toxoplasma gondii.

McCoy JM, Stewart RJ, Uboldi AD, Li D, Schröder J, Scott NE, Papenfuss AT, Lehane AM, Foster LJ, Tonkin CJ.

J Biol Chem. 2017 May 5;292(18):7662-7674. doi: 10.1074/jbc.M117.775114. Epub 2017 Mar 3.

24.

Interactome disassembly during apoptosis occurs independent of caspase cleavage.

Scott NE, Rogers LD, Prudova A, Brown NF, Fortelny N, Overall CM, Foster LJ.

Mol Syst Biol. 2017 Jan 12;13(1):906. doi: 10.15252/msb.20167067.

25.

Characterizing Glycoproteins by Mass Spectrometry in Campylobacter jejuni.

Scott NE.

Methods Mol Biol. 2017;1512:211-232.

PMID:
27885610
26.

The Type III Effector NleD from Enteropathogenic Escherichia coli Differentiates between Host Substrates p38 and JNK.

Creuzburg K, Giogha C, Wong Fok Lung T, Scott NE, Mühlen S, Hartland EL, Pearson JS.

Infect Immun. 2017 Jan 26;85(2). pii: e00620-16. doi: 10.1128/IAI.00620-16. Print 2017 Feb.

27.

Genetic Dissection of the Type VI Secretion System in Acinetobacter and Identification of a Novel Peptidoglycan Hydrolase, TagX, Required for Its Biogenesis.

Weber BS, Hennon SW, Wright MS, Scott NE, de Berardinis V, Foster LJ, Ayala JA, Adams MD, Feldman MF.

MBio. 2016 Oct 11;7(5). pii: e01253-16. doi: 10.1128/mBio.01253-16.

28.

Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase.

Bround MJ, Wambolt R, Cen H, Asghari P, Albu RF, Han J, McAfee D, Pourrier M, Scott NE, Bohunek L, Kulpa JE, Chen SR, Fedida D, Brownsey RW, Borchers CH, Foster LJ, Mayor T, Moore ED, Allard MF, Johnson JD.

J Biol Chem. 2016 Nov 4;291(45):23490-23505. Epub 2016 Sep 12.

29.

Protein O-linked glycosylation in the plant pathogen Ralstonia solanacearum.

Elhenawy W, Scott NE, Tondo ML, Orellano EG, Foster LJ, Feldman MF.

Glycobiology. 2016 Mar;26(3):301-11. doi: 10.1093/glycob/cwv098. Epub 2015 Nov 3.

30.

High-Frequency Variation of Purine Biosynthesis Genes Is a Mechanism of Success in Campylobacter jejuni.

Cameron A, Huynh S, Scott NE, Frirdich E, Apel D, Foster LJ, Parker CT, Gaynor EC.

MBio. 2015 Sep 29;6(5):e00612-15. doi: 10.1128/mBio.00612-15.

31.

Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation.

Volkers G, Worrall LJ, Kwan DH, Yu CC, Baumann L, Lameignere E, Wasney GA, Scott NE, Wakarchuk W, Foster LJ, Withers SG, Strynadka NC.

Nat Struct Mol Biol. 2015 Aug;22(8):627-35. doi: 10.1038/nsmb.3060. Epub 2015 Jul 20.

PMID:
26192331
32.

Novel Host Proteins and Signaling Pathways in Enteropathogenic E. coli Pathogenesis Identified by Global Phosphoproteome Analysis.

Scholz R, Imami K, Scott NE, Trimble WS, Foster LJ, Finlay BB.

Mol Cell Proteomics. 2015 Jul;14(7):1927-45. doi: 10.1074/mcp.M114.046847. Epub 2015 May 5.

33.

Enrichment and identification of bacterial glycopeptides by mass spectrometry.

Scott NE, Cordwell SJ.

Methods Mol Biol. 2015;1295:355-68. doi: 10.1007/978-1-4939-2550-6_25.

PMID:
25820733
34.

Acinetobacter strains carry two functional oligosaccharyltransferases, one devoted exclusively to type IV pilin, and the other one dedicated to O-glycosylation of multiple proteins.

Harding CM, Nasr MA, Kinsella RL, Scott NE, Foster LJ, Weber BS, Fiester SE, Actis LA, Tracy EN, Munson RS Jr, Feldman MF.

Mol Microbiol. 2015 Jun;96(5):1023-41. doi: 10.1111/mmi.12986. Epub 2015 Apr 6.

35.

Clinical implications of glycoproteomics for Acinetobacter baumannii.

Kinsella RL, Scott NE, Feldman MF.

Expert Rev Proteomics. 2015 Feb;12(1):1-3. doi: 10.1586/14789450.2015.987756. Epub 2014 Dec 11.

PMID:
25496064
36.

Development of a computational framework for the analysis of protein correlation profiling and spatial proteomics experiments.

Scott NE, Brown LM, Kristensen AR, Foster LJ.

J Proteomics. 2015 Apr 6;118:112-29. doi: 10.1016/j.jprot.2014.10.024. Epub 2014 Nov 20.

PMID:
25464368
37.

Comparative proteomics and glycoproteomics reveal increased N-linked glycosylation and relaxed sequon specificity in Campylobacter jejuni NCTC11168 O.

Scott NE, Marzook NB, Cain JA, Solis N, Thaysen-Andersen M, Djordjevic SP, Packer NH, Larsen MR, Cordwell SJ.

J Proteome Res. 2014 Nov 7;13(11):5136-50. doi: 10.1021/pr5005554. Epub 2014 Aug 25.

PMID:
25093254
38.

Diversity within the O-linked protein glycosylation systems of acinetobacter species.

Scott NE, Kinsella RL, Edwards AV, Larsen MR, Dutta S, Saba J, Foster LJ, Feldman MF.

Mol Cell Proteomics. 2014 Sep;13(9):2354-70. doi: 10.1074/mcp.M114.038315. Epub 2014 Jun 10.

39.

A general protein O-glycosylation system within the Burkholderia cepacia complex is involved in motility and virulence.

Lithgow KV, Scott NE, Iwashkiw JA, Thomson EL, Foster LJ, Feldman MF, Dennis JJ.

Mol Microbiol. 2014 Apr;92(1):116-37. doi: 10.1111/mmi.12540. Epub 2014 Mar 5.

40.

Motion generated in the unstable upper cervical spine during head tilt-chin lift and jaw thrust maneuvers.

Prasarn ML, Horodyski M, Scott NE, Konopka G, Conrad B, Rechtine GR.

Spine J. 2014 Apr;14(4):609-14. doi: 10.1016/j.spinee.2013.06.080. Epub 2013 Oct 23.

PMID:
24269083
41.

Site-specific glycan-peptide analysis for determination of N-glycoproteome heterogeneity.

Parker BL, Thaysen-Andersen M, Solis N, Scott NE, Larsen MR, Graham ME, Packer NH, Cordwell SJ.

J Proteome Res. 2013 Dec 6;12(12):5791-800. doi: 10.1021/pr400783j. Epub 2013 Nov 1.

PMID:
24090084
42.

Secretome of transmissible Pseudomonas aeruginosa AES-1R grown in a cystic fibrosis lung-like environment.

Scott NE, Hare NJ, White MY, Manos J, Cordwell SJ.

J Proteome Res. 2013 Dec 6;12(12):5357-69. doi: 10.1021/pr4007365. Epub 2013 Oct 9.

PMID:
23991618
43.

A common pathway for O-linked protein-glycosylation and synthesis of capsule in Acinetobacter baumannii.

Lees-Miller RG, Iwashkiw JA, Scott NE, Seper A, Vinogradov E, Schild S, Feldman MF.

Mol Microbiol. 2013 Sep;89(5):816-30. doi: 10.1111/mmi.12300. Epub 2013 Jul 12.

44.

Safety, pharmacokinetics, and pharmacodynamics of escalating repeat doses of GSK249320 in patients with stroke.

Cramer SC, Abila B, Scott NE, Simeoni M, Enney LA; MAG111539 Study Investigators.

Stroke. 2013 May;44(5):1337-42. doi: 10.1161/STROKEAHA.111.674366. Epub 2013 Mar 7.

45.

In vitro activity of Neisseria meningitidis PglL O-oligosaccharyltransferase with diverse synthetic lipid donors and a UDP-activated sugar.

Musumeci MA, Hug I, Scott NE, Ielmini MV, Foster LJ, Wang PG, Feldman MF.

J Biol Chem. 2013 Apr 12;288(15):10578-87. doi: 10.1074/jbc.M112.432815. Epub 2013 Mar 4.

46.

Diversity in the protein N-glycosylation pathways within the Campylobacter genus.

Nothaft H, Scott NE, Vinogradov E, Liu X, Hu R, Beadle B, Fodor C, Miller WG, Li J, Cordwell SJ, Szymanski CM.

Mol Cell Proteomics. 2012 Nov;11(11):1203-19. doi: 10.1074/mcp.M112.021519. Epub 2012 Aug 2.

47.

Modification of the Campylobacter jejuni N-linked glycan by EptC protein-mediated addition of phosphoethanolamine.

Scott NE, Nothaft H, Edwards AV, Labbate M, Djordjevic SP, Larsen MR, Szymanski CM, Cordwell SJ.

J Biol Chem. 2012 Aug 24;287(35):29384-96. doi: 10.1074/jbc.M112.380212. Epub 2012 Jul 2.

48.

Identification of a general O-linked protein glycosylation system in Acinetobacter baumannii and its role in virulence and biofilm formation.

Iwashkiw JA, Seper A, Weber BS, Scott NE, Vinogradov E, Stratilo C, Reiz B, Cordwell SJ, Whittal R, Schild S, Feldman MF.

PLoS Pathog. 2012;8(6):e1002758. doi: 10.1371/journal.ppat.1002758. Epub 2012 Jun 7.

49.

Sequence TTKF ↓ QE defines the site of proteolytic cleavage in Mhp683 protein, a novel glycosaminoglycan and cilium adhesin of Mycoplasma hyopneumoniae.

Bogema DR, Scott NE, Padula MP, Tacchi JL, Raymond BB, Jenkins C, Cordwell SJ, Minion FC, Walker MJ, Djordjevic SP.

J Biol Chem. 2011 Dec 2;286(48):41217-29. doi: 10.1074/jbc.M111.226084. Epub 2011 Oct 3.

50.

Proteomics of the oxidative stress response induced by hydrogen peroxide and paraquat reveals a novel AhpC-like protein in Pseudomonas aeruginosa.

Hare NJ, Scott NE, Shin EH, Connolly AM, Larsen MR, Palmisano G, Cordwell SJ.

Proteomics. 2011 Aug;11(15):3056-69. doi: 10.1002/pmic.201000807. Epub 2011 Jun 14.

PMID:
21674802

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