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Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma.

Purzner T, Purzner J, Buckstaff T, Cozza G, Gholamin S, Rusert JM, Hartl TA, Sanders J, Conley N, Ge X, Langan M, Ramaswamy V, Ellis L, Litzenburger U, Bolin S, Theruvath J, Nitta R, Qi L, Li XN, Li G, Taylor MD, Wechsler-Reya RJ, Pinna LA, Cho YJ, Fuller MT, Elias JE, Scott MP.

Sci Signal. 2018 Sep 11;11(547). pii: eaau5147. doi: 10.1126/scisignal.aau5147.


Identification of a peptide inhibitor for the histone methyltransferase WHSC1.

Morrison MJ, Boriack-Sjodin PA, Swinger KK, Wigle TJ, Sadalge D, Kuntz KW, Scott MP, Janzen WP, Chesworth R, Duncan KW, Harvey DM, Lampe JW, Mitchell LH, Copeland RA.

PLoS One. 2018 May 9;13(5):e0197082. doi: 10.1371/journal.pone.0197082. eCollection 2018.


Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas.

Whitson RJ, Lee A, Urman NM, Mirza A, Yao CY, Brown AS, Li JR, Shankar G, Fry MA, Atwood SX, Lee EY, Hollmig ST, Aasi SZ, Sarin KY, Scott MP, Epstein EH Jr, Tang JY, Oro AE.

Nat Med. 2018 Mar;24(3):271-281. doi: 10.1038/nm.4476. Epub 2018 Feb 5.


Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.

Drew AE, Moradei O, Jacques SL, Rioux N, Boriack-Sjodin AP, Allain C, Scott MP, Jin L, Raimondi A, Handler JL, Ott HM, Kruger RG, McCabe MT, Sneeringer C, Riera T, Shapiro G, Waters NJ, Mitchell LH, Duncan KW, Moyer MP, Copeland RA, Smith J, Chesworth R, Ribich SA.

Sci Rep. 2017 Dec 21;7(1):17993. doi: 10.1038/s41598-017-18446-z.


Functions of maize genes encoding pyruvate phosphate dikinase in developing endosperm.

Lappe RR, Baier JW, Boehlein SK, Huffman R, Lin Q, Wattebled F, Settles AM, Hannah LC, Borisjuk L, Rolletschek H, Stewart JD, Scott MP, Hennen-Bierwagen TA, Myers AM.

Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):E24-E33. doi: 10.1073/pnas.1715668115. Epub 2017 Dec 18.


A Pectin Methylesterase ZmPme3 Is Expressed in Gametophyte factor1-s (Ga1-s) Silks and Maps to that Locus in Maize (Zea mays L.).

Moran Lauter AN, Muszynski MG, Huffman RD, Scott MP.

Front Plant Sci. 2017 Nov 7;8:1926. doi: 10.3389/fpls.2017.01926. eCollection 2017.


Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor.

Mitchell LH, Boriack-Sjodin PA, Smith S, Thomenius M, Rioux N, Munchhof M, Mills JE, Klaus C, Totman J, Riera TV, Raimondi A, Jacques SL, West K, Foley M, Waters NJ, Kuntz KW, Wigle TJ, Scott MP, Copeland RA, Smith JJ, Chesworth R.

ACS Med Chem Lett. 2015 Aug 27;7(2):134-8. doi: 10.1021/acsmedchemlett.5b00272. eCollection 2016 Feb 11.


Homeodomains, Hedgehogs, and Happiness.

Scott MP.

Curr Top Dev Biol. 2016;117:331-7. doi: 10.1016/bs.ctdb.2015.11.034. Epub 2016 Jan 21. Review.


Recurrent Selection for Transgene Activity Levels in Maize Results in Proxy Selection for a Native Gene with the Same Promoter.

Bodnar AL, Schroder MN, Scott MP.

PLoS One. 2016 Feb 19;11(2):e0148587. doi: 10.1371/journal.pone.0148587. eCollection 2016.


QQS orphan gene regulates carbon and nitrogen partitioning across species via NF-YC interactions.

Li L, Zheng W, Zhu Y, Ye H, Tang B, Arendsee ZW, Jones D, Li R, Ortiz D, Zhao X, Du C, Nettleton D, Scott MP, Salas-Fernandez MG, Yin Y, Wurtele ES.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14734-9. doi: 10.1073/pnas.1514670112. Epub 2015 Nov 9.


Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates.

Boriack-Sjodin PA, Jin L, Jacques SL, Drew A, Sneeringer C, Scott MP, Moyer MP, Ribich S, Moradei O, Copeland RA.

ACS Chem Biol. 2016 Mar 18;11(3):763-71. doi: 10.1021/acschembio.5b00773. Epub 2015 Nov 23.


Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma.

Ge X, Milenkovic L, Suyama K, Hartl T, Purzner T, Winans A, Meyer T, Scott MP.

Elife. 2015 Sep 15;4. doi: 10.7554/eLife.07068.


Multiple Surface Regions on the Niemann-Pick C2 Protein Facilitate Intracellular Cholesterol Transport.

McCauliff LA, Xu Z, Li R, Kodukula S, Ko DC, Scott MP, Kahn PC, Storch J.

J Biol Chem. 2015 Nov 6;290(45):27321-31. doi: 10.1074/jbc.M115.667469. Epub 2015 Aug 20.


AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma.

Li YH, Luo J, Mosley YY, Hedrick VE, Paul LN, Chang J, Zhang G, Wang YK, Banko MR, Brunet A, Kuang S, Wu JL, Chang CJ, Scott MP, Yang JY.

Cell Rep. 2015 Jul 28;12(4):599-609. doi: 10.1016/j.celrep.2015.06.054. Epub 2015 Jul 16.


Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1.

Milenkovic L, Weiss LE, Yoon J, Roth TL, Su YS, Sahl SJ, Scott MP, Moerner WE.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8320-5. doi: 10.1073/pnas.1510094112. Epub 2015 Jun 22.


A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.

Chan-Penebre E, Kuplast KG, Majer CR, Boriack-Sjodin PA, Wigle TJ, Johnston LD, Rioux N, Munchhof MJ, Jin L, Jacques SL, West KA, Lingaraj T, Stickland K, Ribich SA, Raimondi A, Scott MP, Waters NJ, Pollock RM, Smith JJ, Barbash O, Pappalardi M, Ho TF, Nurse K, Oza KP, Gallagher KT, Kruger R, Moyer MP, Copeland RA, Chesworth R, Duncan KW.

Nat Chem Biol. 2015 Jun;11(6):432-7. doi: 10.1038/nchembio.1810. Epub 2015 Apr 27.


The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis.

Eisner A, Pazyra-Murphy MF, Durresi E, Zhou P, Zhao X, Chadwick EC, Xu PX, Hillman RT, Scott MP, Greenberg ME, Segal RA.

Dev Cell. 2015 Apr 6;33(1):22-35. doi: 10.1016/j.devcel.2015.01.033. Epub 2015 Mar 26.


A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening.

Wigle TJ, Swinger KK, Campbell JE, Scholle MD, Sherrill J, Admirand EA, Boriack-Sjodin PA, Kuntz KW, Chesworth R, Moyer MP, Scott MP, Copeland RA.

J Biomol Screen. 2015 Jul;20(6):810-20. doi: 10.1177/1087057115575689. Epub 2015 Mar 9.


Solid-state synthesis and characterization of σ-alkane complexes, [Rh(L2)(η(2),η(2)-C7H12)][BAr(F)4] (L2 = bidentate chelating phosphine).

Pike SD, Chadwick FM, Rees NH, Scott MP, Weller AS, Krämer T, Macgregor SA.

J Am Chem Soc. 2015 Jan 21;137(2):820-33. doi: 10.1021/ja510437p. Epub 2015 Jan 12.


A rapid and simple method for DNA engineering using cycled ligation assembly.

Roth TL, Milenkovic L, Scott MP.

PLoS One. 2014 Sep 16;9(9):e107329. doi: 10.1371/journal.pone.0107329. eCollection 2014.


Reaction coupling between wild-type and disease-associated mutant EZH2.

Swalm BM, Knutson SK, Warholic NM, Jin L, Kuntz KW, Keilhack H, Smith JJ, Pollock RM, Moyer MP, Scott MP, Copeland RA, Wigle TJ.

ACS Chem Biol. 2014 Nov 21;9(11):2459-64. doi: 10.1021/cb500548b. Epub 2014 Aug 28.


Anthocyanin, phenolics and antioxidant activity changes in purple waxy corn as affected by traditional cooking.

Harakotr B, Suriharn B, Tangwongchai R, Scott MP, Lertrat K.

Food Chem. 2014 Dec 1;164:510-7. doi: 10.1016/j.foodchem.2014.05.069. Epub 2014 May 21.


DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells.

Klaus CR, Iwanowicz D, Johnston D, Campbell CA, Smith JJ, Moyer MP, Copeland RA, Olhava EJ, Scott MP, Pollock RM, Daigle SR, Raimondi A.

J Pharmacol Exp Ther. 2014 Sep;350(3):646-56. doi: 10.1124/jpet.114.214577. Epub 2014 Jul 3.


Comment on letter by Nicholls et al.--Ultrasound: a hands-on and kinaesthetic approach to anatomy education.

Griksaitis MJ, Scott MP, Finn GM.

Med Teach. 2014 Jul;36(7):644. doi: 10.3109/0142159X.2014.917289. No abstract available.


Meeting research needs with postmortem biospecimen donation: summary of recommendations for postmortem recovery of normal human biospecimens for research.

Mucci NR, Moore HM, Brigham LE, Goldthwaite CA, Little AR, Lockhart NC, Scott MP, Struewing JP, Vincent SL, Compton CC; cancer Human Biobank (caHUB) Acquisition of Normal Tissue Subgroup, National Cancer Institute.

Biopreserv Biobank. 2013 Apr;11(2):77-82. doi: 10.1089/bio.2012.0063. Erratum in: Biopreserv Biobank. 2013 Jun;11(3):191.


Insight into insulin secretion from transcriptome and genetic analysis of insulin-producing cells of Drosophila.

Cao J, Ni J, Ma W, Shiu V, Milla LA, Park S, Spletter ML, Tang S, Zhang J, Wei X, Kim SK, Scott MP.

Genetics. 2014 May;197(1):175-92. doi: 10.1534/genetics.113.160663. Epub 2014 Feb 20.


Wing tips: The wing disc as a platform for studying Hedgehog signaling.

Hartl TA, Scott MP.

Methods. 2014 Jun 15;68(1):199-206. doi: 10.1016/j.ymeth.2014.02.002. Epub 2014 Feb 17. Review.


Genetic and biochemical differences in populations bred for extremes in maize grain methionine concentration.

Newell MA, Vogel KE, Adams M, Aydin N, Bodnar AL, Ali M, Lauter AN, Scott MP.

BMC Plant Biol. 2014 Feb 19;14:49. doi: 10.1186/1471-2229-14-49.


Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor.

Basavapathruni A, Olhava EJ, Daigle SR, Therkelsen CA, Jin L, Boriack-Sjodin PA, Allain CJ, Klaus CR, Raimondi A, Scott MP, Dovletoglou A, Richon VM, Pollock RM, Copeland RA, Moyer MP, Chesworth R, Pearson PG, Waters NJ.

Biopharm Drug Dispos. 2014 May;35(4):237-52. doi: 10.1002/bdd.1889. Epub 2014 Feb 14.


Resistant starch: promise for improving human health.

Birt DF, Boylston T, Hendrich S, Jane JL, Hollis J, Li L, McClelland J, Moore S, Phillips GJ, Rowling M, Schalinske K, Scott MP, Whitley EM.

Adv Nutr. 2013 Nov 6;4(6):587-601. doi: 10.3945/an.113.004325. eCollection 2013 Nov. Review.


Twelve tips for teaching with ultrasound in the undergraduate curriculum.

Griksaitis MJ, Scott MP, Finn GM.

Med Teach. 2014 Jan;36(1):19-24. doi: 10.3109/0142159X.2013.847909. Epub 2013 Oct 24.


Neuropilin-2 contributes to tumorigenicity in a mouse model of Hedgehog pathway medulloblastoma.

Hayden Gephart MG, Su YS, Bandara S, Tsai FC, Hong J, Conley N, Rayburn H, Milenkovic L, Meyer T, Scott MP.

J Neurooncol. 2013 Nov;115(2):161-8. doi: 10.1007/s11060-013-1216-1. Epub 2013 Sep 12.


Engineered knottin peptide enables noninvasive optical imaging of intracranial medulloblastoma.

Moore SJ, Hayden Gephart MG, Bergen JM, Su YS, Rayburn H, Scott MP, Cochran JR.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14598-603. doi: 10.1073/pnas.1311333110. Epub 2013 Aug 15.


Genetic dissection of a cell-autonomous neurodegenerative disorder: lessons learned from mouse models of Niemann-Pick disease type C.

Lopez ME, Scott MP.

Dis Model Mech. 2013 Sep;6(5):1089-100. doi: 10.1242/dmm.012385. Epub 2013 Aug 1. Review.


Iron bioavailability of maize hemoglobin in a Caco-2 cell culture model.

Bodnar AL, Proulx AK, Scott MP, Beavers A, Reddy MB.

J Agric Food Chem. 2013 Jul 31;61(30):7349-56. doi: 10.1021/jf3020188. Epub 2013 Jul 19.


Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.

Daigle SR, Olhava EJ, Therkelsen CA, Basavapathruni A, Jin L, Boriack-Sjodin PA, Allain CJ, Klaus CR, Raimondi A, Scott MP, Waters NJ, Chesworth R, Moyer MP, Copeland RA, Richon VM, Pollock RM.

Blood. 2013 Aug 8;122(6):1017-25. doi: 10.1182/blood-2013-04-497644. Epub 2013 Jun 25.


Changes in endogenous gene transcript and protein levels in maize plants expressing the soybean ferritin transgene.

Kanobe MN, Rodermel SR, Bailey T, Scott MP.

Front Plant Sci. 2013 Jun 14;4:196. doi: 10.3389/fpls.2013.00196. eCollection 2013.


Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys²⁷ methylation by human polycomb repressive complex 2 and vSET.

Swalm BM, Hallenbeck KK, Majer CR, Jin L, Scott MP, Moyer MP, Copeland RA, Wigle TJ.

Biochem J. 2013 Jul 15;453(2):241-7. doi: 10.1042/BJ20130439.


Regulation of ribosome biogenesis by nucleostemin 3 promotes local and systemic growth in Drosophila.

Hartl TA, Ni J, Cao J, Suyama KL, Patchett S, Bussiere C, Gui DY, Tang S, Kaplan DD, Fish M, Johnson AW, Scott MP.

Genetics. 2013 May;194(1):101-15. doi: 10.1534/genetics.112.149104. Epub 2013 Feb 22.


Divergent properties of prolamins in wheat and maize.

Zhang W, Sangtong V, Peterson J, Scott MP, Messing J.

Planta. 2013 Jun;237(6):1465-73. doi: 10.1007/s00425-013-1857-5. Epub 2013 Feb 23.


The chromatin remodeling factor Chd1l is required in the preimplantation embryo.

Snider AC, Leong D, Wang QT, Wysocka J, Yao MW, Scott MP.

Biol Open. 2013 Feb 15;2(2):121-31. doi: 10.1242/bio.20122949. Epub 2012 Nov 19.


Kif3a is necessary for initiation and maintenance of medulloblastoma.

Barakat MT, Humke EW, Scott MP.

Carcinogenesis. 2013 Jun;34(6):1382-92. doi: 10.1093/carcin/bgt041. Epub 2013 Feb 6.


Microtubules enable the planar cell polarity of airway cilia.

Vladar EK, Bayly RD, Sangoram AM, Scott MP, Axelrod JD.

Curr Biol. 2012 Dec 4;22(23):2203-12. doi: 10.1016/j.cub.2012.09.046. Epub 2012 Nov 1.


A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.

Knutson SK, Wigle TJ, Warholic NM, Sneeringer CJ, Allain CJ, Klaus CR, Sacks JD, Raimondi A, Majer CR, Song J, Scott MP, Jin L, Smith JJ, Olhava EJ, Chesworth R, Moyer MP, Richon VM, Copeland RA, Keilhack H, Pollock RM, Kuntz KW.

Nat Chem Biol. 2012 Nov;8(11):890-6. doi: 10.1038/nchembio.1084. Epub 2012 Sep 30.


Complement is dispensable for neurodegeneration in Niemann-Pick disease type C.

Lopez ME, Klein AD, Scott MP.

J Neuroinflammation. 2012 Sep 17;9:216. doi: 10.1186/1742-2094-9-216.


Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L.

Basavapathruni A, Jin L, Daigle SR, Majer CR, Therkelsen CA, Wigle TJ, Kuntz KW, Chesworth R, Pollock RM, Scott MP, Moyer MP, Richon VM, Copeland RA, Olhava EJ.

Chem Biol Drug Des. 2012 Dec;80(6):971-80. doi: 10.1111/cbdd.12050. Epub 2012 Oct 9.


Genome-wide association study for oat (Avena sativa L.) beta-glucan concentration using germplasm of worldwide origin.

Newell MA, Asoro FG, Scott MP, White PJ, Beavis WD, Jannink JL.

Theor Appl Genet. 2012 Dec;125(8):1687-96. doi: 10.1007/s00122-012-1945-0. Epub 2012 Aug 3.


A687V EZH2 is a gain-of-function mutation found in lymphoma patients.

Majer CR, Jin L, Scott MP, Knutson SK, Kuntz KW, Keilhack H, Smith JJ, Moyer MP, Richon VM, Copeland RA, Wigle TJ.

FEBS Lett. 2012 Sep 21;586(19):3448-51. doi: 10.1016/j.febslet.2012.07.066. Epub 2012 Jul 28.


Genetic and physical fine mapping of the novel brown midrib gene bm6 in maize (Zea mays L.) to a 180 kb region on chromosome 2.

Chen Y, Liu H, Ali F, Scott MP, Ji Q, Frei UK, Lübberstedt T.

Theor Appl Genet. 2012 Oct;125(6):1223-35. doi: 10.1007/s00122-012-1908-5. Epub 2012 Jun 20.


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