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Items: 1 to 50 of 69

1.

Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design.

Brixius-Anderko S, Scott EE.

J Biol Chem. 2018 Nov 13. pii: jbc.RA118.006214. doi: 10.1074/jbc.RA118.006214. [Epub ahead of print]

2.

Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands.

Bart AG, Scott EE.

J Biol Chem. 2018 Dec 14;293(50):19201-19210. doi: 10.1074/jbc.RA118.005588. Epub 2018 Sep 25.

PMID:
30254074
3.

Endogenous insertion of non-native metalloporphyrins into human membrane cytochrome P450 enzymes.

Yadav R, Scott EE.

J Biol Chem. 2018 Oct 26;293(43):16623-16634. doi: 10.1074/jbc.RA118.005417. Epub 2018 Sep 14.

PMID:
30217815
4.

Developing an Analytical Framework to Characterize Student Reasoning about Complex Processes.

Scott EE, Anderson CW, Mashood KK, Matz RL, Underwood SM, Sawtelle V.

CBE Life Sci Educ. 2018 Sep;17(3):ar49. doi: 10.1187/cbe.17-10-0225.

5.

Comparison of Antifungal Azole Interactions with Adult Cytochrome P450 3A4 versus Neonatal Cytochrome P450 3A7.

Godamudunage MP, Grech AM, Scott EE.

Drug Metab Dispos. 2018 Sep;46(9):1329-1337. doi: 10.1124/dmd.118.082032. Epub 2018 Jul 10.

PMID:
29991575
6.

Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.

Fehl C, Vogt CD, Yadav R, Li K, Scott EE, Aubé J.

J Med Chem. 2018 Jun 14;61(11):4946-4960. doi: 10.1021/acs.jmedchem.8b00419. Epub 2018 May 24.

PMID:
29792703
7.

ESTIMATING THE COST OF AGRICULTURAL MORBIDITY IN MAINE AND NEW HAMPSHIRE.

Jones NM, Scott EE, Krupa N, Jenkins PL.

J Agric Saf Health. 2018 Jan 29;24(1):3-11. doi: 10.13031/jash.12146.

PMID:
29528602
8.

Spatiotemporal variation of bacterial water quality and the relationship with pasture land cover.

Scott EE, Leh MDK, Haggard BE.

J Water Health. 2017 Oct;15(6):839-848. doi: 10.2166/wh.2017.101.

PMID:
29215349
9.

Structural and functional effects of cytochrome b5 interactions with human cytochrome P450 enzymes.

Bart AG, Scott EE.

J Biol Chem. 2017 Dec 22;292(51):20818-20833. doi: 10.1074/jbc.RA117.000220. Epub 2017 Oct 27.

PMID:
29079577
10.

A Comparison of Interventional Approaches for Increasing Power Take-off Shielding on New York Farms.

Sorensen JA, Tinc PJ, Dalton D, Scott EE, Jenkins PL.

J Agromedicine. 2017;22(3):251-258. doi: 10.1080/1059924X.2017.1318726.

PMID:
28402231
11.

Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1.

Petrunak EM, Rogers SA, Aubé J, Scott EE.

Drug Metab Dispos. 2017 Jun;45(6):635-645. doi: 10.1124/dmd.117.075317. Epub 2017 Apr 3.

12.

ω- versus (ω-1)-hydroxylation: Cytochrome P450 4B1 sterics make the call.

Scott EE.

J Biol Chem. 2017 Mar 31;292(13):5622-5623. doi: 10.1074/jbc.H117.775494.

13.

Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1.

Li A, Yadav R, White JK, Herroon MK, Callahan BP, Podgorski I, Turro C, Scott EE, Kodanko JJ.

Chem Commun (Camb). 2017 Mar 28;53(26):3673-3676. doi: 10.1039/c7cc01459g.

14.

Structural insights into the function of steroidogenic cytochrome P450 17A1.

Yadav R, Petrunak EM, Estrada DF, Scott EE.

Mol Cell Endocrinol. 2017 Feb 5;441:68-75. doi: 10.1016/j.mce.2016.08.035. Epub 2016 Aug 24. Review.

15.

Development and Evaluation of a Basic First Aid Curriculum for Spanish-Speaking Dairy Workers.

Meyerhoff A, Tinc PJ, Scott EE.

J Agric Saf Health. 2016 Jul 27;22(3):163-172. doi: 10.13031/jash.22.11403.

PMID:
29140629
16.

Promising Tools in Prostate Cancer Research: Selective Non-Steroidal Cytochrome P450 17A1 Inhibitors.

Bonomo S, Hansen CH, Petrunak EM, Scott EE, Styrishave B, Jørgensen FS, Olsen L.

Sci Rep. 2016 Jul 12;6:29468. doi: 10.1038/srep29468.

17.

Increased risk of muscle tears below physiological temperature ranges.

Scott EE, Hamilton DF, Wallace RJ, Muir AY, Simpson AH.

Bone Joint Res. 2016 Feb;5(2):61-5. doi: 10.1302/2046-3758.52.2000484.

18.

The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function.

Scott EE, Wolf CR, Otyepka M, Humphreys SC, Reed JR, Henderson CJ, McLaughlin LA, Paloncýová M, Navrátilová V, Berka K, Anzenbacher P, Dahal UP, Barnaba C, Brozik JA, Jones JP, Estrada DF, Laurence JS, Park JW, Backes WL.

Drug Metab Dispos. 2016 Apr;44(4):576-90. doi: 10.1124/dmd.115.068569. Epub 2016 Feb 5. Review.

19.

Cytochrome P450 17A1 Interactions with the FMN Domain of Its Reductase as Characterized by NMR.

Estrada DF, Laurence JS, Scott EE.

J Biol Chem. 2016 Feb 19;291(8):3990-4003. doi: 10.1074/jbc.M115.677294. Epub 2015 Dec 30.

20.

Developing Surveillance Methodology for Agricultural and Logging Injury in New Hampshire Using Electronic Administrative Data Sets.

Scott EE, Hirabayashi L, Krupa NL, Sorensen JA, Jenkins PL.

J Occup Environ Med. 2015 Aug;57(8):866-72. doi: 10.1097/JOM.0000000000000482.

PMID:
26247640
21.

Estimation of agricultural and logging injury incidence in Maine using electronic administrative data sets.

Scott EE, Krupa NL, Horsman M, Jenkins PL.

J Agromedicine. 2015;20(2):195-204. doi: 10.1080/1059924X.2015.1009668.

PMID:
25906278
22.

Structures of human steroidogenic cytochrome P450 17A1 with substrates.

Petrunak EM, DeVore NM, Porubsky PR, Scott EE.

J Biol Chem. 2014 Nov 21;289(47):32952-64. doi: 10.1074/jbc.M114.610998. Epub 2014 Oct 9.

23.

Human cytochrome P450 17A1 conformational selection: modulation by ligand and cytochrome b5.

Estrada DF, Skinner AL, Laurence JS, Scott EE.

J Biol Chem. 2014 May 16;289(20):14310-20. doi: 10.1074/jbc.M114.560144. Epub 2014 Mar 26.

24.

Correlating structure and function of drug-metabolizing enzymes: progress and ongoing challenges.

Johnson EF, Connick JP, Reed JR, Backes WL, Desai MC, Xu L, Estrada DF, Laurence JS, Scott EE.

Drug Metab Dispos. 2014 Jan;42(1):9-22. doi: 10.1124/dmd.113.054627. Epub 2013 Oct 15. Review.

25.

Electronic merger of large health care data sets: cautionary notes from a study of agricultural morbidity in New York State.

Scott EE, Krupa NL, Sorensen J, Jenkins PL.

J Agromedicine. 2013;18(4):334-9. doi: 10.1080/1059924X.2013.826608.

PMID:
24125048
26.

Benzylmorpholine analogs as selective inhibitors of lung cytochrome P450 2A13 for the chemoprevention of lung cancer in tobacco users.

Blake LC, Roy A, Neul D, Schoenen FJ, Aubé J, Scott EE.

Pharm Res. 2013 Sep;30(9):2290-302. doi: 10.1007/s11095-013-1054-z. Epub 2013 Jun 12.

27.

Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR.

Estrada DF, Laurence JS, Scott EE.

J Biol Chem. 2013 Jun 7;288(23):17008-18. doi: 10.1074/jbc.M113.468926. Epub 2013 Apr 25.

28.

Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism.

Walsh AA, Szklarz GD, Scott EE.

J Biol Chem. 2013 May 3;288(18):12932-43. doi: 10.1074/jbc.M113.452953. Epub 2013 Mar 18.

29.

Assessment of production performance in 2 breeds of broilers fed prebiotics as feed additives.

Hanning I, Clement A, Owens C, Park SH, Pendleton S, Scott EE, Almeida G, Gonzalez Gil F, Ricke SC.

Poult Sci. 2012 Dec;91(12):3295-9. doi: 10.3382/ps.2012-02557.

PMID:
23155043
30.

Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes.

DeVore NM, Scott EE.

J Biol Chem. 2012 Aug 3;287(32):26576-85. doi: 10.1074/jbc.M112.372813. Epub 2012 Jun 14.

31.

Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.

Stephens ES, Walsh AA, Scott EE.

Drug Metab Dispos. 2012 Sep;40(9):1797-802. doi: 10.1124/dmd.112.045161. Epub 2012 Jun 13.

32.

Impact of housekeeping on lead exposure in indoor law enforcement shooting ranges.

Scott EE, Pavelchak N, DePersis R.

J Occup Environ Hyg. 2012;9(3):D45-51. doi: 10.1080/15459624.2011.648571. No abstract available.

PMID:
22353015
33.

Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001.

DeVore NM, Scott EE.

Nature. 2012 Jan 22;482(7383):116-9. doi: 10.1038/nature10743.

34.

Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine.

DeVore NM, Meneely KM, Bart AG, Stephens ES, Battaile KP, Scott EE.

FEBS J. 2012 May;279(9):1621-31. doi: 10.1111/j.1742-4658.2011.08412.x. Epub 2011 Nov 25.

35.

A correction factor for estimating statewide agricultural injuries from ambulance reports.

Scott EE, Earle-Richardson G, Krupa N, Jenkins P.

Ann Epidemiol. 2011 Oct;21(10):767-72. doi: 10.1016/j.annepidem.2011.07.005.

PMID:
21884968
36.

Amino acid uptake by temperate tree species characteristic of low- and high-fertility habitats.

Scott EE, Rothstein DE.

Oecologia. 2011 Oct;167(2):547-57. doi: 10.1007/s00442-011-2009-x. Epub 2011 May 8.

PMID:
21553264
37.

Improving agricultural injury surveillance: a comparison of incidence and type of injury event among three data sources.

Earle-Richardson GB, Jenkins PL, Scott EE, May JJ.

Am J Ind Med. 2011 Aug;54(8):586-96. doi: 10.1002/ajim.20960. Epub 2011 May 2.

PMID:
21538445
38.

Crystal structure of histamine dehydrogenase from Nocardioides simplex.

Reed T, Lushington GH, Xia Y, Hirakawa H, Travis DM, Mure M, Scott EE, Limburg J.

J Biol Chem. 2010 Aug 13;285(33):25782-91. doi: 10.1074/jbc.M109.084301. Epub 2010 Jun 10.

39.

Human cytochrome P450 2E1 structures with fatty acid analogs reveal a previously unobserved binding mode.

Porubsky PR, Battaile KP, Scott EE.

J Biol Chem. 2010 Jul 16;285(29):22282-90. doi: 10.1074/jbc.M110.109017. Epub 2010 May 12.

40.

Targeting drug-metabolizing enzymes for effective chemoprevention and chemotherapy.

Swanson HI, Njar VC, Yu Z, Castro DJ, Gonzalez FJ, Williams DE, Huang Y, Kong AN, Doloff JC, Ma J, Waxman DJ, Scott EE.

Drug Metab Dispos. 2010 Apr;38(4):539-44. doi: 10.1124/dmd.109.031351.

41.

Crystal structure of prolyl 4-hydroxylase from Bacillus anthracis.

Culpepper MA, Scott EE, Limburg J.

Biochemistry. 2010 Jan 12;49(1):124-33. doi: 10.1021/bi901771z.

42.

Key residues controlling binding of diverse ligands to human cytochrome P450 2A enzymes.

DeVore NM, Smith BD, Wang JL, Lushington GH, Scott EE.

Drug Metab Dispos. 2009 Jun;37(6):1319-27. doi: 10.1124/dmd.109.026765. Epub 2009 Feb 27.

43.

Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates.

Porubsky PR, Meneely KM, Scott EE.

J Biol Chem. 2008 Nov 28;283(48):33698-707. doi: 10.1074/jbc.M805999200. Epub 2008 Sep 24.

44.

Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes.

DeVore NM, Smith BD, Urban MJ, Scott EE.

Drug Metab Dispos. 2008 Dec;36(12):2582-90. doi: 10.1124/dmd.108.023770. Epub 2008 Sep 8.

45.

Expression, purification, crystallization and preliminary X-ray studies of a prolyl-4-hydroxylase protein from Bacillus anthracis.

Miller MA, Scott EE, Limburg J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Sep 1;64(Pt 9):788-91. doi: 10.1107/S1744309108023439. Epub 2008 Aug 9.

46.

Expression, purification, crystallization and preliminary X-ray studies of histamine dehydrogenase from Nocardioides simplex.

Reed TM, Hirakawa H, Mure M, Scott EE, Limburg J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Sep 1;64(Pt 9):785-7. doi: 10.1107/S1744309108023336. Epub 2008 Aug 9.

47.

p-dimethylaminocinnamaldehyde derivatization for colorimetric detection and HPLC-UV/vis-MS/MS identification of indoles.

Porubsky PR, Scott EE, Williams TD.

Arch Biochem Biophys. 2008 Jul 1;475(1):14-7. doi: 10.1016/j.abb.2008.03.035. Epub 2008 Apr 7.

48.

Functional characterization of CYP2A13 polymorphisms.

Schlicht KE, Michno N, Smith BD, Scott EE, Murphy SE.

Xenobiotica. 2007 Dec;37(12):1439-49.

PMID:
17922361
49.

Structure of the human lung cytochrome P450 2A13.

Smith BD, Sanders JL, Porubsky PR, Lushington GH, Stout CD, Scott EE.

J Biol Chem. 2007 Jun 8;282(23):17306-13. Epub 2007 Apr 11.

50.

Possible pathway(s) of testosterone egress from the active site of cytochrome P450 2B1: a steered molecular dynamics simulation.

Li W, Liu H, Scott EE, Gräter F, Halpert JR, Luo X, Shen J, Jiang H.

Drug Metab Dispos. 2005 Jul;33(7):910-9. Epub 2005 Apr 8.

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