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Items: 1 to 50 of 97

1.

Myc Is Required for Adaptive ß-Cell Replication in Young Mice but Is not Sufficient in One-Year-Old Mice Fed with a High-Fat Diet.

Rosselot C, Kumar A, Lakshmipathi J, Zhang P, Lu G, Katz LS, Prochownik EV, Stewart AF, Lambertini L, Scott DK, Garcia-Ocaña A.

Diabetes. 2019 Jul 10. pii: db181368. doi: 10.2337/db18-1368. [Epub ahead of print]

PMID:
31292135
2.

Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells.

Wang P, Karakose E, Liu H, Swartz E, Ackeifi C, Zlatanic V, Wilson J, González BJ, Bender A, Takane KK, Ye L, Harb G, Pagliuca F, Homann D, Egli D, Argmann C, Scott DK, Garcia-Ocaña A, Stewart AF.

Cell Metab. 2019 Mar 5;29(3):638-652.e5. doi: 10.1016/j.cmet.2018.12.005. Epub 2018 Dec 20.

PMID:
30581122
3.

Aging of Antiviral CD8+ Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue Homing.

Davenport B, Eberlein J, van der Heide V, Jhun K, Nguyen TT, Victorino F, Trotta A, Chipuk J, Yi Z, Zhang W, Clambey ET, Scott DK, Homann D.

J Immunol. 2019 Jan 15;202(2):460-475. doi: 10.4049/jimmunol.1801277. Epub 2018 Dec 14.

PMID:
30552164
4.

Two-Layered and Stretchable e-Textile Patches for Wearable Healthcare Electronics.

La TG, Qiu S, Scott DK, Bakhtiari R, Kuziek JWP, Mathewson KE, Rieger J, Chung HJ.

Adv Healthc Mater. 2018 Nov;7(22):e1801033. doi: 10.1002/adhm.201801033. Epub 2018 Oct 19.

PMID:
30338670
5.

Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation.

Kumar A, Katz LS, Schulz AM, Kim M, Honig LB, Li L, Davenport B, Homann D, Garcia-Ocaña A, Herman MA, Haynes CM, Chipuk JE, Scott DK.

Diabetes. 2018 Aug;67(8):1561-1575. doi: 10.2337/db17-0943. Epub 2018 May 15.

6.

Replication confers β cell immaturity.

Puri S, Roy N, Russ HA, Leonhardt L, French EK, Roy R, Bengtsson H, Scott DK, Stewart AF, Hebrok M.

Nat Commun. 2018 Feb 2;9(1):485. doi: 10.1038/s41467-018-02939-0.

7.

T3 and Glucose Coordinately Stimulate ChREBP-Mediated Ucp1 Expression in Brown Adipocytes From Male Mice.

Katz LS, Xu S, Ge K, Scott DK, Gershengorn MC.

Endocrinology. 2018 Jan 1;159(1):557-569. doi: 10.1210/en.2017-00579.

8.

Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.

Wang H, Bender A, Wang P, Karakose E, Inabnet WB, Libutti SK, Arnold A, Lambertini L, Stang M, Chen H, Kasai Y, Mahajan M, Kinoshita Y, Fernandez-Ranvier G, Becker TC, Takane KK, Walker LA, Saul S, Chen R, Scott DK, Ferrer J, Antipin Y, Donovan M, Uzilov AV, Reva B, Schadt EE, Losic B, Argmann C, Stewart AF.

Nat Commun. 2017 Oct 3;8(1):767. doi: 10.1038/s41467-017-00992-9.

9.

MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect.

Shtraizent N, DeRossi C, Nayar S, Sachidanandam R, Katz LS, Prince A, Koh AP, Vincek A, Hadas Y, Hoshida Y, Scott DK, Eliyahu E, Freeze HH, Sadler KC, Chu J.

Elife. 2017 Jun 23;6. pii: e22477. doi: 10.7554/eLife.22477.

10.

DNA methylation alters transcriptional rates of differentially expressed genes and contributes to pathophysiology in mice fed a high fat diet.

Zhang P, Chu T, Dedousis N, Mantell BS, Sipula I, Li L, Bunce KD, Shaw PA, Katz LS, Zhu J, Argmann C, O'Doherty RM, Peters DG, Scott DK.

Mol Metab. 2017 Feb 3;6(4):327-339. doi: 10.1016/j.molmet.2017.02.001. eCollection 2017 Apr.

11.

Epidermal electronics for electromyography: An application to swallowing therapy.

Constantinescu G, Jeong JW, Li X, Scott DK, Jang KI, Chung HJ, Rogers JA, Rieger J.

Med Eng Phys. 2016 Aug;38(8):807-12. doi: 10.1016/j.medengphy.2016.04.023. Epub 2016 May 30.

PMID:
27255865
12.

PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2.

Lakshmipathi J, Alvarez-Perez JC, Rosselot C, Casinelli GP, Stamateris RE, Rausell-Palamos F, O'Donnell CP, Vasavada RC, Scott DK, Alonso LC, Garcia-Ocaña A.

Diabetes. 2016 May;65(5):1283-96. doi: 10.2337/db15-1398. Epub 2016 Feb 11.

13.

Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia.

Martins FO, Delgado TC, Viegas J, Gaspar JM, Scott DK, O'Doherty RM, Macedo MP, Jones JG.

Br J Pharmacol. 2016 Jan;173(2):267-78. doi: 10.1111/bph.13362.

14.

Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation.

Zhang P, Kumar A, Katz LS, Li L, Paulynice M, Herman MA, Scott DK.

Diabetes. 2015 Dec;64(12):4158-70. doi: 10.2337/db15-0239. Epub 2015 Sep 17.

15.

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.

Wang P, Alvarez-Perez JC, Felsenfeld DP, Liu H, Sivendran S, Bender A, Kumar A, Sanchez R, Scott DK, Garcia-Ocaña A, Stewart AF.

Nat Med. 2015 Apr;21(4):383-8. doi: 10.1038/nm.3820. Epub 2015 Mar 9.

16.

Diabetes mellitus--advances and challenges in human β-cell proliferation.

Wang P, Fiaschi-Taesch NM, Vasavada RC, Scott DK, García-Ocaña A, Stewart AF.

Nat Rev Endocrinol. 2015 Apr;11(4):201-12. doi: 10.1038/nrendo.2015.9. Epub 2015 Feb 17. Review.

PMID:
25687999
17.

Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map.

Bernal-Mizrachi E, Kulkarni RN, Scott DK, Mauvais-Jarvis F, Stewart AF, Garcia-Ocaña A.

Diabetes. 2014 Mar;63(3):819-31. doi: 10.2337/db13-1146. Review.

18.

Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human β-cell replication: a revised model of human β-cell G1/S control.

Fiaschi-Taesch NM, Kleinberger JW, Salim FG, Troxell R, Wills R, Tanwir M, Casinelli G, Cox AE, Takane KK, Srinivas H, Scott DK, Stewart AF.

Diabetes. 2013 Jul;62(7):2460-70. doi: 10.2337/db12-0778. Epub 2013 Mar 14.

19.

Human pancreatic β-cell G1/S molecule cell cycle atlas.

Fiaschi-Taesch NM, Kleinberger JW, Salim FG, Troxell R, Wills R, Tanwir M, Casinelli G, Cox AE, Takane KK, Scott DK, Stewart AF.

Diabetes. 2013 Jul;62(7):2450-9. doi: 10.2337/db12-0777. Epub 2013 Mar 14.

20.

²H enrichment distribution of hepatic glycogen from ²H₂O reveals the contribution of dietary fructose to glycogen synthesis.

Delgado TC, Martins FO, Carvalho F, Gonçalves A, Scott DK, O'Doherty R, Macedo MP, Jones JG.

Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E384-91. doi: 10.1152/ajpendo.00185.2012. Epub 2012 Dec 4.

21.

Effect of cyclosporine A on hepatic carbohydrate metabolism and hepatic gene expression in rat.

Delgado TC, Barosa C, Nunes PM, Scott DK, O'Doherty RM, Cerdán S, Geraldes CF, Jones JG.

Expert Opin Drug Metab Toxicol. 2012 Oct;8(10):1223-30. doi: 10.1517/17425255.2012.709500. Epub 2012 Aug 8.

PMID:
22870958
22.

Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver.

Stefanovic-Racic M, Yang X, Turner MS, Mantell BS, Stolz DB, Sumpter TL, Sipula IJ, Dedousis N, Scott DK, Morel PA, Thomson AW, O'Doherty RM.

Diabetes. 2012 Sep;61(9):2330-9. doi: 10.2337/db11-1523. Epub 2012 Jul 30.

23.

ChREBP mediates glucose-stimulated pancreatic β-cell proliferation.

Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK.

Diabetes. 2012 Aug;61(8):2004-15. doi: 10.2337/db11-0802. Epub 2012 May 14.

24.

β-catenin is essential for ethanol metabolism and protection against alcohol-mediated liver steatosis in mice.

Liu S, Yeh TH, Singh VP, Shiva S, Krauland L, Li H, Zhang P, Kharbanda K, Ritov V, Monga SP, Scott DK, Eagon PK, Behari J.

Hepatology. 2012 Mar;55(3):931-40. doi: 10.1002/hep.24766.

25.

Activation of protein kinase C-ζ in pancreatic β-cells in vivo improves glucose tolerance and induces β-cell expansion via mTOR activation.

Velazquez-Garcia S, Valle S, Rosa TC, Takane KK, Demirci C, Alvarez-Perez JC, Mellado-Gil JM, Ernst S, Scott DK, Vasavada RC, Alonso LC, Garcia-Ocaña A.

Diabetes. 2011 Oct;60(10):2546-59. doi: 10.2337/db10-1783. Epub 2011 Sep 12.

26.

cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication.

Karslioglu E, Kleinberger JW, Salim FG, Cox AE, Takane KK, Scott DK, Stewart AF.

Mol Endocrinol. 2011 Oct;25(10):1760-72. doi: 10.1210/me.2011-1074. Epub 2011 Sep 1.

27.

miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma.

Weeraratne SD, Amani V, Neiss A, Teider N, Scott DK, Pomeroy SL, Cho YJ.

Neuro Oncol. 2011 Feb;13(2):165-75. doi: 10.1093/neuonc/noq179. Epub 2010 Dec 22.

28.

Transcriptional regulation of human dual specificity protein phosphatase 1 (DUSP1) gene by glucocorticoids.

Shipp LE, Lee JV, Yu CY, Pufall M, Zhang P, Scott DK, Wang JC.

PLoS One. 2010 Oct 29;5(10):e13754. doi: 10.1371/journal.pone.0013754.

29.

Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression.

Guthalu Kondegowda N, Joshi-Gokhale S, Harb G, Williams K, Zhang XY, Takane KK, Zhang P, Scott DK, Stewart AF, Garcia-Ocaña A, Vasavada RC.

Diabetes. 2010 Dec;59(12):3131-8. doi: 10.2337/db09-1796. Epub 2010 Sep 28.

30.

Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.

Teider N, Scott DK, Neiss A, Weeraratne SD, Amani VM, Wang Y, Marquez VE, Cho YJ, Pomeroy SL.

Neuro Oncol. 2010 Dec;12(12):1244-56. doi: 10.1093/neuonc/noq091. Epub 2010 Sep 16.

31.

Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6.

Fiaschi-Taesch NM, Salim F, Kleinberger J, Troxell R, Cozar-Castellano I, Selk K, Cherok E, Takane KK, Scott DK, Stewart AF.

Diabetes. 2010 Aug;59(8):1926-36. doi: 10.2337/db09-1776.

32.

c-Myc is required for the CHREBP-dependent activation of glucose-responsive genes.

Zhang P, Metukuri MR, Bindom SM, Prochownik EV, O'Doherty RM, Scott DK.

Mol Endocrinol. 2010 Jun;24(6):1274-86. doi: 10.1210/me.2009-0437. Epub 2010 Apr 9.

33.

Risk factors, management and outcomes of adverse drug reactions in adult patients on antiretrovirals at Kenyatta National Hospital, Nairobi.

Mwangangi LE, Juma R, Scott DK, Nyamu DG, Kuria KA.

East Afr Med J. 2010 Feb;87(2):58-65.

PMID:
23057257
34.

Determination of hydroxyurea in serum or plasma using gas chromatography-mass spectrometry (GC-MS).

Scott DK, Neville K, Garg U.

Methods Mol Biol. 2010;603:279-87. doi: 10.1007/978-1-60761-459-3_26.

PMID:
20077079
35.

Determination of benzoic acid in serum or plasma by gas chromatography-mass spectrometry (GC/MS).

Knoblauch JM, Scott DK, Smith LD, Garg U.

Methods Mol Biol. 2010;603:121-8. doi: 10.1007/978-1-60761-459-3_11.

PMID:
20077064
36.

Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3.

Chen J, Li J, Lim FC, Wu Q, Douek DC, Scott DK, Ravussin E, Hsu HC, Jazwinski SM, Mountz JD; Louisiana Healthy Aging Study.

Mech Ageing Dev. 2010 Jan;131(1):29-37. doi: 10.1016/j.mad.2009.11.003. Epub 2009 Nov 24.

37.

Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance.

Huang W, Metlakunta A, Dedousis N, Zhang P, Sipula I, Dube JJ, Scott DK, O'Doherty RM.

Diabetes. 2010 Feb;59(2):347-57. doi: 10.2337/db09-0016. Epub 2009 Nov 23.

38.

cAMP prevents glucose-mediated modifications of histone H3 and recruitment of the RNA polymerase II holoenzyme to the L-PK gene promoter.

Burke SJ, Collier JJ, Scott DK.

J Mol Biol. 2009 Sep 25;392(3):578-88. doi: 10.1016/j.jmb.2009.07.053. Epub 2009 Jul 23.

39.

cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4alpha, and CBP.

Burke SJ, Collier JJ, Scott DK.

FASEB J. 2009 Sep;23(9):2855-65. doi: 10.1096/fj.08-126631. Epub 2009 Apr 30.

PMID:
19406844
40.

Lessons from the first comprehensive molecular characterization of cell cycle control in rodent insulinoma cell lines.

Cozar-Castellano I, Harb G, Selk K, Takane K, Vasavada R, Sicari B, Law B, Zhang P, Scott DK, Fiaschi-Taesch N, Stewart AF.

Diabetes. 2008 Nov;57(11):3056-68. doi: 10.2337/db08-0393. Epub 2008 Jul 23.

41.

The MODY1 gene for hepatocyte nuclear factor 4alpha and a feedback loop control COUP-TFII expression in pancreatic beta cells.

Perilhou A, Tourrel-Cuzin C, Zhang P, Kharroubi I, Wang H, Fauveau V, Scott DK, Wollheim CB, Vasseur-Cognet M.

Mol Cell Biol. 2008 Jul;28(14):4588-97. doi: 10.1128/MCB.01191-07. Epub 2008 May 12.

42.

Detailed molecular analysis of the induction of the L-PK gene by glucose.

Eckert DT, Zhang P, Collier JJ, O'Doherty RM, Scott DK.

Biochem Biophys Res Commun. 2008 Jul 18;372(1):131-6. doi: 10.1016/j.bbrc.2008.05.002. Epub 2008 May 9.

43.

Effect of UV radiation on the neonatal skin immune system- implications for melanoma.

Muller HK, Malley RC, McGee HM, Scott DK, Wozniak T, Woods GM.

Photochem Photobiol. 2008 Jan-Feb;84(1):47-54. doi: 10.1111/j.1751-1097.2007.00246.x. Review.

PMID:
18173700
44.

Proteomics identifies enhanced expression of stefin A in neonatal murine skin compared with adults: functional implications.

Scott DK, Lord R, Muller HK, Malley RC, Woods GM.

Br J Dermatol. 2007 Jun;156(6):1156-62. Epub 2007 Apr 17.

PMID:
17441952
45.

Glucose infusion in mice: a new model to induce beta-cell replication.

Alonso LC, Yokoe T, Zhang P, Scott DK, Kim SK, O'Donnell CP, Garcia-Ocaña A.

Diabetes. 2007 Jul;56(7):1792-801. Epub 2007 Mar 30.

46.

c-Myc and ChREBP regulate glucose-mediated expression of the L-type pyruvate kinase gene in INS-1-derived 832/13 cells.

Collier JJ, Zhang P, Pedersen KB, Burke SJ, Haycock JW, Scott DK.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E48-56. Epub 2007 Mar 6.

47.

The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions.

Pedersen KB, Zhang P, Doumen C, Charbonnet M, Lu D, Newgard CB, Haycock JW, Lange AJ, Scott DK.

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E788-801. Epub 2006 Nov 14.

48.

Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma.

Scott DK, Straughton D, Cole M, Bailey S, Ellison DW, Clifford SC.

Cell Cycle. 2006 Oct;5(20):2381-9. Epub 2006 Oct 16.

PMID:
17102621
50.

CD8 T-cell immune phenotype of successful aging.

Hsu HC, Scott DK, Zhang P, Zhou J, Yang P, Wu Q, Schroeder HW Jr, Gerald LB, Ravussin E, Jazwinski SM, Mountz JD; Louisiana Healthy Aging Study.

Mech Ageing Dev. 2006 Mar;127(3):231-9. Epub 2005 Nov 28.

PMID:
16313945

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