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Items: 16


Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease.

van der Made TK, Fedecostante M, Scotcher D, Rostami-Hodjegan A, Sastre Toraño J, Middel I, Koster AS, Gerritsen KG, Jankowski V, Jankowski J, Hoenderop JGJ, Masereeuw R, Galetin A.

Mol Pharm. 2019 Nov 4;16(11):4551-4562. doi: 10.1021/acs.molpharmaceut.9b00681. Epub 2019 Sep 27.


Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance.

Matsuzaki T, Scotcher D, Darwich AS, Galetin A, Rostami-Hodjegan A.

J Pharmacol Exp Ther. 2019 Feb;368(2):157-168. doi: 10.1124/jpet.118.251413. Epub 2018 Nov 9. Erratum in: J Pharmacol Exp Ther. 2019 Mar;368(3):474.


The Global State of the Genetic Counseling Profession.

Abacan M, Alsubaie L, Barlow-Stewart K, Caanen B, Cordier C, Courtney E, Davoine E, Edwards J, Elackatt NJ, Gardiner K, Guan Y, Huang LH, Malmgren CI, Kejriwal S, Kim HJ, Lambert D, Lantigua-Cruz PA, Lee JMH, Lodahl M, Lunde Å, Macaulay S, Macciocca I, Margarit S, Middleton A, Moldovan R, Ngeow J, Obregon-Tito AJ, Ormond KE, Paneque M, Powell K, Sanghavi K, Scotcher D, Scott J, Juhé CS, Shkedi-Rafid S, Wessels TM, Yoon SY, Wicklund C.

Eur J Hum Genet. 2019 Feb;27(2):183-197. doi: 10.1038/s41431-018-0252-x. Epub 2018 Oct 5. Review.


Experiences of Women Who Have Had Carrier Testing for Duchenne Muscular Dystrophy and Becker Muscular Dystrophy During Adolescence.

Fraser HG, Redmond RZ, Scotcher DF.

J Genet Couns. 2018 Dec;27(6):1349-1359. doi: 10.1007/s10897-018-0266-0. Epub 2018 Jul 4.


Phenotypic Heterogeneity in a Congenital Disorder of Glycosylation Caused by Mutations in STT3A.

Ghosh A, Urquhart J, Daly S, Ferguson A, Scotcher D, Morris AAM, Clayton-Smith J.

J Child Neurol. 2017 May;32(6):560-565. doi: 10.1177/0883073817696816. Epub 2017 Mar 16.


The role of genetic counsellors in genomic healthcare in the United Kingdom: a statement by the Association of Genetic Nurses and Counsellors.

Middleton A, Marks P, Bruce A, Protheroe-Davies LK, King C, Claber O, Houghton C, Giffney C, Macleod R, Dolling C, Kenwrick S, Scotcher D, Hall G, Patch C, Boyes L.

Eur J Hum Genet. 2017 Mar 22;25(6):659-661. doi: 10.1038/ejhg.2017.28. Epub 2017 Mar 22.


Microsomal and Cytosolic Scaling Factors in Dog and Human Kidney Cortex and Application for In Vitro-In Vivo Extrapolation of Renal Metabolic Clearance.

Scotcher D, Billington S, Brown J, Jones CR, Brown CDA, Rostami-Hodjegan A, Galetin A.

Drug Metab Dispos. 2017 May;45(5):556-568. doi: 10.1124/dmd.117.075242. Epub 2017 Mar 7.


Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations.

Scotcher D, Jones CR, Galetin A, Rostami-Hodjegan A.

J Pharmacol Exp Ther. 2017 Mar;360(3):484-495. doi: 10.1124/jpet.116.237438. Epub 2017 Jan 5.


Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation.

Scotcher D, Jones C, Posada M, Galetin A, Rostami-Hodjegan A.

AAPS J. 2016 Sep;18(5):1082-1094. doi: 10.1208/s12248-016-9959-1. Epub 2016 Aug 9. Review.


Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part I: In Vitro Systems and Physiological Data.

Scotcher D, Jones C, Posada M, Rostami-Hodjegan A, Galetin A.

AAPS J. 2016 Sep;18(5):1067-1081. doi: 10.1208/s12248-016-9942-x. Epub 2016 Jun 30. Review.


Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance.

Scotcher D, Jones C, Rostami-Hodjegan A, Galetin A.

Eur J Pharm Sci. 2016 Oct 30;94:59-71. doi: 10.1016/j.ejps.2016.03.018. Epub 2016 Mar 28.


Shock, adjust, decide: reproductive decision making in cystic fibrosis (CF) carrier couples--a qualitative study.

Myring J, Beckett W, Jassi R, Roberts T, Sayers R, Scotcher D, McAllister M.

J Genet Couns. 2011 Aug;20(4):404-17. doi: 10.1007/s10897-011-9363-z. Epub 2011 Apr 5.


The uptake and acceptability to patients of cystic fibrosis carrier testing offered in pregnancy by the GP.

Hartley NE, Scotcher D, Harris H, Williamson P, Wallace A, Craufurd D, Harris R.

J Med Genet. 1997 Jun;34(6):459-64.


Pilot study of the acceptability of cystic fibrosis carrier testing during routine antenatal consultations in general practice.

Harris H, Scotcher D, Hartley N, Wallace A, Craufurd D, Harris R.

Br J Gen Pract. 1996 Apr;46(405):225-7.


Cystic fibrosis carrier testing in early pregnancy by general practitioners.

Harris H, Scotcher D, Hartley N, Wallace A, Craufurd D, Harris R.

BMJ. 1993 Jun 12;306(6892):1580-3.


Cystic fibrosis carrier screening at first diagnosis of pregnancy in general practice.

Harris HJ, Scotcher D, Craufurd D, Wallace A, Harris R.

Lancet. 1992 Jun 20;339(8808):1539. No abstract available.


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