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NCX1 and NCX3 as potential factors contributing to neurodegeneration and neuroinflammation in the A53T transgenic mouse model of Parkinson's Disease.

Sirabella R, Sisalli MJ, Costa G, Omura K, Ianniello G, Pinna A, Morelli M, Di Renzo GM, Annunziato L, Scorziello A.

Cell Death Dis. 2018 Jun 25;9(7):725. doi: 10.1038/s41419-018-0775-7.


ApoSOD1 lacking dismutase activity neuroprotects motor neurons exposed to beta-methylamino-L-alanine through the Ca2+/Akt/ERK1/2 prosurvival pathway.

Petrozziello T, Secondo A, Tedeschi V, Esposito A, Sisalli M, Scorziello A, Di Renzo G, Annunziato L.

Cell Death Differ. 2017 Mar;24(3):511-522. doi: 10.1038/cdd.2016.154. Epub 2017 Jan 13.


Tracking the evolution of epialleles during neural differentiation and brain development: D-Aspartate oxidase as a model gene.

Florio E, Keller S, Coretti L, Affinito O, Scala G, Errico F, Fico A, Boscia F, Sisalli MJ, Reccia MG, Miele G, Monticelli A, Scorziello A, Lembo F, Colucci-D'Amato L, Minchiotti G, Avvedimento VE, Usiello A, Cocozza S, Chiariotti L.

Epigenetics. 2017 Jan 2;12(1):41-54. doi: 10.1080/15592294.2016.1260211. Epub 2016 Nov 18.


Sumoylation of LYS590 of NCX3 f-Loop by SUMO1 Participates in Brain Neuroprotection Induced by Ischemic Preconditioning.

Cuomo O, Pignataro G, Sirabella R, Molinaro P, Anzilotti S, Scorziello A, Sisalli MJ, Di Renzo G, Annunziato L.

Stroke. 2016 Apr;47(4):1085-93. doi: 10.1161/STROKEAHA.115.012514. Epub 2016 Mar 15.


Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection.

Testai L, Barrese V, Soldovieri MV, Ambrosino P, Martelli A, Vinciguerra I, Miceli F, Greenwood IA, Curtis MJ, Breschi MC, Sisalli MJ, Scorziello A, Canduela MJ, Grandes P, Calderone V, Taglialatela M.

Cardiovasc Res. 2016 May 1;110(1):40-50. doi: 10.1093/cvr/cvv281. Epub 2015 Dec 29.


Ionic homeostasis in brain conditioning.

Cuomo O, Vinciguerra A, Cerullo P, Anzilotti S, Brancaccio P, Bilo L, Scorziello A, Molinaro P, Di Renzo G, Pignataro G.

Front Neurosci. 2015 Aug 10;9:277. doi: 10.3389/fnins.2015.00277. eCollection 2015. Review.


Polychlorinated Biphenyls Induce Mitochondrial Dysfunction in SH-SY5Y Neuroblastoma Cells.

Cocco S, Secondo A, Del Viscovo A, Procaccini C, Formisano L, Franco C, Esposito A, Scorziello A, Matarese G, Di Renzo G, Canzoniero LM.

PLoS One. 2015 Jun 23;10(6):e0129481. doi: 10.1371/journal.pone.0129481. eCollection 2015.


Novel Cellular Mechanisms for Neuroprotection in Ischemic Preconditioning: A View from Inside Organelles.

Sisalli MJ, Annunziato L, Scorziello A.

Front Neurol. 2015 May 26;6:115. doi: 10.3389/fneur.2015.00115. eCollection 2015. Review.


Pharmacological characterization of the newly synthesized 5-amino-N-butyl-2-(4-ethoxyphenoxy)-benzamide hydrochloride (BED) as a potent NCX3 inhibitor that worsens anoxic injury in cortical neurons, organotypic hippocampal cultures, and ischemic brain.

Secondo A, Pignataro G, Ambrosino P, Pannaccione A, Molinaro P, Boscia F, Cantile M, Cuomo O, Esposito A, Sisalli MJ, Scorziello A, Guida N, Anzilotti S, Fiorino F, Severino B, Santagada V, Caliendo G, Di Renzo G, Annunziato L.

ACS Chem Neurosci. 2015 Aug 19;6(8):1361-70. doi: 10.1021/acschemneuro.5b00043. Epub 2015 May 19.


A new cell-penetrating peptide that blocks the autoinhibitory XIP domain of NCX1 and enhances antiporter activity.

Molinaro P, Pannaccione A, Sisalli MJ, Secondo A, Cuomo O, Sirabella R, Cantile M, Ciccone R, Scorziello A, di Renzo G, Annunziato L.

Mol Ther. 2015 Mar;23(3):465-76. doi: 10.1038/mt.2014.231. Epub 2014 Dec 11.


Involvement of the Na+/Ca2+ exchanger isoform 1 (NCX1) in neuronal growth factor (NGF)-induced neuronal differentiation through Ca2+-dependent Akt phosphorylation.

Secondo A, Esposito A, Sirabella R, Boscia F, Pannaccione A, Molinaro P, Cantile M, Ciccone R, Sisalli MJ, Scorziello A, Di Renzo G, Annunziato L.

J Biol Chem. 2015 Jan 16;290(3):1319-31. doi: 10.1074/jbc.M114.555516. Epub 2014 Nov 21.


Proteolytic control of neurite outgrowth inhibitor NOGO-A by the cAMP/PKA pathway.

Sepe M, Lignitto L, Porpora M, Delle Donne R, Rinaldi L, Belgianni G, Colucci G, Cuomo O, Viggiano D, Scorziello A, Garbi C, Annunziato L, Feliciello A.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15729-34. doi: 10.1073/pnas.1410274111. Epub 2014 Oct 20.


Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models.

Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani B, Parsons SJ, De Placido S, Bianco R.

Breast Cancer Res. 2014 May 5;16(3):R45. doi: 10.1186/bcr3650.


Prepuberal intranasal dopamine treatment in an animal model of ADHD ameliorates deficient spatial attention, working memory, amino acid transmitters and synaptic markers in prefrontal cortex, ventral and dorsal striatum.

Ruocco LA, Treno C, Gironi Carnevale UA, Arra C, Mattern C, Huston JP, de Souza Silva MA, Nikolaus S, Scorziello A, Nieddu M, Boatto G, Illiano P, Pagano C, Tino A, Sadile AG.

Amino Acids. 2014 Sep;46(9):2105-22. doi: 10.1007/s00726-014-1753-8. Epub 2014 May 27.


Endoplasmic reticulum refilling and mitochondrial calcium extrusion promoted in neurons by NCX1 and NCX3 in ischemic preconditioning are determinant for neuroprotection.

Sisalli MJ, Secondo A, Esposito A, Valsecchi V, Savoia C, Di Renzo GF, Annunziato L, Scorziello A.

Cell Death Differ. 2014 Jul;21(7):1142-9. doi: 10.1038/cdd.2014.32. Epub 2014 Mar 14.


NCX3 regulates mitochondrial Ca(2+) handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death.

Scorziello A, Savoia C, Sisalli MJ, Adornetto A, Secondo A, Boscia F, Esposito A, Polishchuk EV, Polishchuk RS, Molinaro P, Carlucci A, Lignitto L, Di Renzo G, Feliciello A, Annunziato L.

J Cell Sci. 2013 Dec 15;126(Pt 24):5566-77. doi: 10.1242/jcs.129668. Epub 2013 Oct 7.


Conjunctival instillation of plasminogen eliminates ocular lesion in B6.129P2-Plg(tm1Jld) transgenic mice, a model of ligneous conjunctivitis.

Pignataro G, Vinciguerra A, Cuomo O, Sirabella R, Di Renzo GF, Scorziello A.

Pharmacol Res. 2013 Aug;74:45-8. doi: 10.1016/j.phrs.2013.04.012. Epub 2013 May 16.


New roles of NCX in glial cells: activation of microglia in ischemia and differentiation of oligodendrocytes.

Boscia F, D'Avanzo C, Pannaccione A, Secondo A, Casamassa A, Formisano L, Guida N, Scorziello A, Di Renzo G, Annunziato L.

Adv Exp Med Biol. 2013;961:307-16. doi: 10.1007/978-1-4614-4756-6_26. Review.


Genetically modified mice as a strategy to unravel the role played by the Na(+)/Ca (2+) exchanger in brain ischemia and in spatial learning and memory deficits.

Molinaro P, Cataldi M, Cuomo O, Viggiano D, Pignataro G, Sirabella R, Secondo A, Boscia F, Pannaccione A, Scorziello A, Sokolow S, Herchuelz A, Di Renzo G, Annunziato L.

Adv Exp Med Biol. 2013;961:213-22. doi: 10.1007/978-1-4614-4756-6_18. Review.


New insights in mitochondrial calcium handling by sodium/calcium exchanger.

Scorziello A, Savoia C, Secondo A, Boscia F, Sisalli MJ, Esposito A, Carlucci A, Molinaro P, Lignitto L, Di Renzo G, Feliciello A, Annunziato L.

Adv Exp Med Biol. 2013;961:203-9. doi: 10.1007/978-1-4614-4756-6_17. Review.


Transcriptional regulation of ncx1 gene in the brain.

Valsecchi V, Pignataro G, Sirabella R, Matrone C, Boscia F, Scorziello A, Sisalli MJ, Esposito E, Zambrano N, Cataldi M, Di Renzo G, Annunziato L.

Adv Exp Med Biol. 2013;961:137-45. doi: 10.1007/978-1-4614-4756-6_12. Review.


Neurounina-1, a novel compound that increases Na+/Ca2+ exchanger activity, effectively protects against stroke damage.

Molinaro P, Cantile M, Cuomo O, Secondo A, Pannaccione A, Ambrosino P, Pignataro G, Fiorino F, Severino B, Gatta E, Sisalli MJ, Milanese M, Scorziello A, Bonanno G, Robello M, Santagada V, Caliendo G, Di Renzo G, Annunziato L.

Mol Pharmacol. 2013 Jan;83(1):142-56. doi: 10.1124/mol.112.080986. Epub 2012 Oct 11.


A new concept: Aβ1-42 generates a hyperfunctional proteolytic NCX3 fragment that delays caspase-12 activation and neuronal death.

Pannaccione A, Secondo A, Molinaro P, D'Avanzo C, Cantile M, Esposito A, Boscia F, Scorziello A, Sirabella R, Sokolow S, Herchuelz A, Di Renzo G, Annunziato L.

J Neurosci. 2012 Aug 1;32(31):10609-17. doi: 10.1523/JNEUROSCI.6429-11.2012. Erratum in: J Neurosci. 2012 Dec 12;32(50):18269. Sokolow, Sophie [added]; Herchuelz, André [added].


Sorcin induces a drug-resistant phenotype in human colorectal cancer by modulating Ca(2+) homeostasis.

Maddalena F, Laudiero G, Piscazzi A, Secondo A, Scorziello A, Lombardi V, Matassa DS, Fersini A, Neri V, Esposito F, Landriscina M.

Cancer Res. 2011 Dec 15;71(24):7659-69. doi: 10.1158/0008-5472.CAN-11-2172. Epub 2011 Nov 3.


Na+ -Ca2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memory.

Molinaro P, Viggiano D, Nisticò R, Sirabella R, Secondo A, Boscia F, Pannaccione A, Scorziello A, Mehdawy B, Sokolow S, Herchuelz A, Di Renzo GF, Annunziato L.

J Neurosci. 2011 May 18;31(20):7312-21. doi: 10.1523/JNEUROSCI.6296-10.2011.


Rosuvastatin-induced neuroprotection in cortical neurons exposed to OGD/reoxygenation is due to nitric oxide inhibition and ERK1/2 pathway activation.

Savoia C, Sisalli MJ, Di Renzo G, Annunziato L, Scorziello A.

Int J Physiol Pathophysiol Pharmacol. 2011;3(1):57-64. Epub 2011 Jan 6.


Control of PKA stability and signalling by the RING ligase praja2.

Lignitto L, Carlucci A, Sepe M, Stefan E, Cuomo O, Nisticò R, Scorziello A, Savoia C, Garbi C, Annunziato L, Feliciello A.

Nat Cell Biol. 2011 Apr;13(4):412-22. doi: 10.1038/ncb2209. Epub 2011 Mar 20.


NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning.

Valsecchi V, Pignataro G, Del Prete A, Sirabella R, Matrone C, Boscia F, Scorziello A, Sisalli MJ, Esposito E, Zambrano N, Di Renzo G, Annunziato L.

Stroke. 2011 Mar;42(3):754-63. doi: 10.1161/STROKEAHA.110.597583. Epub 2011 Feb 3.


NCX1 expression and functional activity increase in microglia invading the infarct core.

Boscia F, Gala R, Pannaccione A, Secondo A, Scorziello A, Di Renzo G, Annunziato L.

Stroke. 2009 Nov;40(11):3608-17. doi: 10.1161/STROKEAHA.109.557439. Epub 2009 Sep 10.


Anoxia-induced NF-kappaB-dependent upregulation of NCX1 contributes to Ca2+ refilling into endoplasmic reticulum in cortical neurons.

Sirabella R, Secondo A, Pannaccione A, Scorziello A, Valsecchi V, Adornetto A, Bilo L, Di Renzo G, Annunziato L.

Stroke. 2009 Mar;40(3):922-9. doi: 10.1161/STROKEAHA.108.531962. Epub 2009 Jan 22.


Post-ischemic brain damage: effect of ischemic preconditioning and postconditioning and identification of potential candidates for stroke therapy.

Pignataro G, Scorziello A, Di Renzo G, Annunziato L.

FEBS J. 2009 Jan;276(1):46-57. doi: 10.1111/j.1742-4658.2008.06769.x. Review.


Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia.

Carlucci A, Adornetto A, Scorziello A, Viggiano D, Foca M, Cuomo O, Annunziato L, Gottesman M, Feliciello A.

EMBO J. 2008 Apr 9;27(7):1073-84. doi: 10.1038/emboj.2008.33. Epub 2008 Mar 6.


A critical role for the potassium-dependent sodium-calcium exchanger NCKX2 in protection against focal ischemic brain damage.

Cuomo O, Gala R, Pignataro G, Boscia F, Secondo A, Scorziello A, Pannaccione A, Viggiano D, Adornetto A, Molinaro P, Li XF, Lytton J, Di Renzo G, Annunziato L.

J Neurosci. 2008 Feb 27;28(9):2053-63. doi: 10.1523/JNEUROSCI.4912-07.2008.


Targeted disruption of Na+/Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage.

Molinaro P, Cuomo O, Pignataro G, Boscia F, Sirabella R, Pannaccione A, Secondo A, Scorziello A, Adornetto A, Gala R, Viggiano D, Sokolow S, Herchuelz A, Schurmans S, Di Renzo G, Annunziato L.

J Neurosci. 2008 Jan 30;28(5):1179-84. doi: 10.1523/JNEUROSCI.4671-07.2008.


Antithrombin reduces ischemic volume, ameliorates neurologic deficits, and prolongs animal survival in both transient and permanent focal ischemia.

Cuomo O, Pignataro G, Gala R, Scorziello A, Gravino E, Piazza O, Tufano R, Di Renzo G, Annunziato L.

Stroke. 2007 Dec;38(12):3272-9. Epub 2007 Nov 1.


NO-induced neuroprotection in ischemic preconditioning stimulates mitochondrial Mn-SOD activity and expression via Ras/ERK1/2 pathway.

Scorziello A, Santillo M, Adornetto A, Dell'aversano C, Sirabella R, Damiano S, Canzoniero LM, Renzo GF, Annunziato L.

J Neurochem. 2007 Nov;103(4):1472-80. Epub 2007 Aug 6.


Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death.

Pannaccione A, Boscia F, Scorziello A, Adornetto A, Castaldo P, Sirabella R, Taglialatela M, Di Renzo GF, Annunziato L.

Mol Pharmacol. 2007 Sep;72(3):665-73. Epub 2007 May 10.


The Na+/Ca2+ exchanger isoform 3 (NCX3) but not isoform 2 (NCX2) and 1 (NCX1) singly transfected in BHK cells plays a protective role in a model of in vitro hypoxia.

Secondo A, Staiano IR, Scorziello A, Sirabella R, Boscia F, Adornetto A, Canzoniero LM, Di Renzo G, Annunziato L.

Ann N Y Acad Sci. 2007 Mar;1099:481-5. Review.


ncx1, ncx2, and ncx3 gene product expression and function in neuronal anoxia and brain ischemia.

Annunziato L, Pignataro G, Boscia F, Sirabella R, Formisano L, Saggese M, Cuomo O, Gala R, Secondo A, Viggiano D, Molinaro P, Valsecchi V, Tortiglione A, Adornetto A, Scorziello A, Cataldi M, Di Renzo GF.

Ann N Y Acad Sci. 2007 Mar;1099:413-26. Review.


BHK cells transfected with NCX3 are more resistant to hypoxia followed by reoxygenation than those transfected with NCX1 and NCX2: Possible relationship with mitochondrial membrane potential.

Secondo A, Staiano RI, Scorziello A, Sirabella R, Boscia F, Adornetto A, Valsecchi V, Molinaro P, Canzoniero LM, Di Renzo G, Annunziato L.

Cell Calcium. 2007 Dec;42(6):521-35. Epub 2007 Mar 6.


Involvement of the nitric oxide/protein kinase G pathway in polychlorinated biphenyl-induced cell death in SH-SY 5Y neuroblastoma cells.

Canzoniero LM, Adornetto A, Secondo A, Magi S, Dell'aversano C, Scorziello A, Amoroso S, Di Renzo G.

J Neurosci Res. 2006 Aug 15;84(3):692-7.


Mitochondrial AKAP121 links cAMP and src signaling to oxidative metabolism.

Livigni A, Scorziello A, Agnese S, Adornetto A, Carlucci A, Garbi C, Castaldo I, Annunziato L, Avvedimento EV, Feliciello A.

Mol Biol Cell. 2006 Jan;17(1):263-71. Epub 2005 Oct 26.


Divergent modulation of iron regulatory proteins and ferritin biosynthesis by hypoxia/reoxygenation in neurones and glial cells.

Irace C, Scorziello A, Maffettone C, Pignataro G, Matrone C, Adornetto A, Santamaria R, Annunziato L, Colonna A.

J Neurochem. 2005 Dec;95(5):1321-31. Epub 2005 Aug 31.


Involvement of Na+-Ca2+ exchanger in intracellular Ca2+ increase and neuronal injury induced by polychlorinated biphenyls in human neuroblastoma SH-SY5Y cells.

Magi S, Castaldo P, Carrieri G, Scorziello A, Di Renzo G, Amoroso S.

J Pharmacol Exp Ther. 2005 Oct;315(1):291-6. Epub 2005 Jul 11.


HIF-1alpha reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion.

Matrone C, Pignataro G, Molinaro P, Irace C, Scorziello A, Di Renzo GF, Annunziato L.

J Neurochem. 2004 Jul;90(2):368-78.


Neuronal NOS activation during oxygen and glucose deprivation triggers cerebellar granule cell death in the later reoxygenation phase.

Scorziello A, Pellegrini C, Secondo A, Sirabella R, Formisano L, Sibaud L, Amoroso S, Canzoniero LM, Annunziato L, Di Renzo GF.

J Neurosci Res. 2004 Jun 15;76(6):812-21.


Evidence for a protective role played by the Na+/Ca2+ exchanger in cerebral ischemia induced by middle cerebral artery occlusion in male rats.

Pignataro G, Tortiglione A, Scorziello A, Giaccio L, Secondo A, Severino B, Santagada V, Caliendo G, Amoroso S, Di Renzo G, Annunziato L.

Neuropharmacology. 2004 Mar;46(3):439-48.


Na+/Ca2+ exchanger in Na+ efflux-Ca2+ influx mode of operation exerts a neuroprotective role in cellular models of in vitro anoxia and in vivo cerebral ischemia.

Tortiglione A, Pignataro G, Minale M, Secondo A, Scorziello A, Di Renzo GF, Amoroso S, Caliendo G, Santagada V, Annunziato L.

Ann N Y Acad Sci. 2002 Nov;976:408-12. No abstract available.


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