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Items: 1 to 50 of 167

1.

Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles.

Romanello V, Scalabrin M, Albiero M, Blaauw B, Scorrano L, Sandri M.

Cells. 2019 Jun 15;8(6). pii: E597. doi: 10.3390/cells8060597.

2.

DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass.

Favaro G, Romanello V, Varanita T, Andrea Desbats M, Morbidoni V, Tezze C, Albiero M, Canato M, Gherardi G, De Stefani D, Mammucari C, Blaauw B, Boncompagni S, Protasi F, Reggiani C, Scorrano L, Salviati L, Sandri M.

Nat Commun. 2019 Jun 12;10(1):2576. doi: 10.1038/s41467-019-10226-9.

3.

Too close not to encyst: Polycystic kidney disease and interorganellar contact sites.

Lorenzi I, Scorrano L.

Sci Signal. 2019 May 28;12(583). pii: eaaw6996. doi: 10.1126/scisignal.aaw6996. Review.

PMID:
31138767
4.

PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells.

Cseh AM, Fabian Z, Quintana-Cabrera R, Szabo A, Eros K, Soriano ME, Gallyas F, Scorrano L, Sumegi B.

Front Physiol. 2019 May 7;10:538. doi: 10.3389/fphys.2019.00538. eCollection 2019.

5.

Functional wiring of proteostatic and mitostatic modules ensures transient organismal survival during imbalanced mitochondrial dynamics.

Gumeni S, Evangelakou Z, Tsakiri EN, Scorrano L, Trougakos IP.

Redox Biol. 2019 Jun;24:101219. doi: 10.1016/j.redox.2019.101219. Epub 2019 May 17.

6.

Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy.

Tsakiri EN, Gumeni S, Vougas K, Pendin D, Papassideri I, Daga A, Gorgoulis V, Juhász G, Scorrano L, Trougakos IP.

Autophagy. 2019 Apr 19:1-17. doi: 10.1080/15548627.2019.1596477. [Epub ahead of print]

PMID:
31002009
7.

Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction.

von Stockum S, Sanchez-Martinez A, Corrà S, Chakraborty J, Marchesan E, Locatello L, Da Rè C, Cusumano P, Caicci F, Ferrari V, Costa R, Bubacco L, Rasotto MB, Szabo I, Whitworth AJ, Scorrano L, Ziviani E.

Life Sci Alliance. 2019 Apr 15;2(2). pii: e201900392. doi: 10.26508/lsa.201900392. Print 2019 Apr.

8.

Transcriptomic Analysis of Single Isolated Myofibers Identifies miR-27a-3p and miR-142-3p as Regulators of Metabolism in Skeletal Muscle.

Chemello F, Grespi F, Zulian A, Cancellara P, Hebert-Chatelain E, Martini P, Bean C, Alessio E, Buson L, Bazzega M, Armani A, Sandri M, Ferrazza R, Laveder P, Guella G, Reggiani C, Romualdi C, Bernardi P, Scorrano L, Cagnin S, Lanfranchi G.

Cell Rep. 2019 Mar 26;26(13):3784-3797.e8. doi: 10.1016/j.celrep.2019.02.105.

PMID:
30917329
Free Article
9.

Coming together to define membrane contact sites.

Scorrano L, De Matteis MA, Emr S, Giordano F, Hajnóczky G, Kornmann B, Lackner LL, Levine TP, Pellegrini L, Reinisch K, Rizzuto R, Simmen T, Stenmark H, Ungermann C, Schuldiner M.

Nat Commun. 2019 Mar 20;10(1):1287. doi: 10.1038/s41467-019-09253-3. Review.

10.

Finding a new balance to cure Charcot-Marie-Tooth 2A.

Iwata K, Scorrano L.

J Clin Invest. 2019 Mar 18;130:1533-1535. doi: 10.1172/JCI127820. eCollection 2019 Mar 18.

11.

Single cell analysis reveals the involvement of the long non-coding RNA Pvt1 in the modulation of muscle atrophy and mitochondrial network.

Alessio E, Buson L, Chemello F, Peggion C, Grespi F, Martini P, Massimino ML, Pacchioni B, Millino C, Romualdi C, Bertoli A, Scorrano L, Lanfranchi G, Cagnin S.

Nucleic Acids Res. 2019 Feb 28;47(4):1653-1670. doi: 10.1093/nar/gkz007.

12.

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation.

Tsakiri EN, Gumeni S, Iliaki KK, Benaki D, Vougas K, Sykiotis GP, Gorgoulis VG, Mikros E, Scorrano L, Trougakos IP.

Aging Cell. 2019 Feb;18(1):e12845. doi: 10.1111/acel.12845. Epub 2018 Dec 10.

13.

Proenkephalin Derived Peptides Are Involved in the Modulation of Mitochondrial Respiratory Control During Epileptogenesis.

Burtscher J, Bean C, Zangrandi L, Kmiec I, Agostinho A, Scorrano L, Gnaiger E, Schwarzer C.

Front Mol Neurosci. 2018 Sep 25;11:351. doi: 10.3389/fnmol.2018.00351. eCollection 2018.

14.

Shipping Calpastatin to the Rescue: Prevention of Neuromuscular Degeneration through Mitofusin 2.

Rebelo P, Giacomello M, Scorrano L.

Cell Metab. 2018 Oct 2;28(4):536-538. doi: 10.1016/j.cmet.2018.09.017.

PMID:
30282045
15.

The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function.

Quintana-Cabrera R, Quirin C, Glytsou C, Corrado M, Urbani A, Pellattiero A, Calvo E, Vázquez J, Enríquez JA, Gerle C, Soriano ME, Bernardi P, Scorrano L.

Nat Commun. 2018 Aug 24;9(1):3399. doi: 10.1038/s41467-018-05655-x.

16.

Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21.

Restelli LM, Oettinghaus B, Halliday M, Agca C, Licci M, Sironi L, Savoia C, Hench J, Tolnay M, Neutzner A, Schmidt A, Eckert A, Mallucci G, Scorrano L, Frank S.

Cell Rep. 2018 Aug 7;24(6):1407-1414. doi: 10.1016/j.celrep.2018.07.023.

17.

Rapidly purified ganglion cells from neonatal mouse retinas allow studies of mitochondrial morphology and autophagy.

Zaninello M, Scorrano L.

Pharmacol Res. 2018 Dec;138:16-24. doi: 10.1016/j.phrs.2018.07.024. Epub 2018 Aug 2.

PMID:
30077733
18.

Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production.

Amini P, Stojkov D, Felser A, Jackson CB, Courage C, Schaller A, Gelman L, Soriano ME, Nuoffer JM, Scorrano L, Benarafa C, Yousefi S, Simon HU.

Nat Commun. 2018 Jul 27;9(1):2958. doi: 10.1038/s41467-018-05387-y.

19.

Leducq Network: Modulating Autophagy to Treat Cardiovascular Disease.

Madrigal-Matute J, Scorrano L, Sadoshima J.

Circ Res. 2018 Jul 20;123(3):323-325. doi: 10.1161/CIRCRESAHA.118.313091. No abstract available.

PMID:
30026377
20.

Mitochondria Restrict Growth of the Intracellular Parasite Toxoplasma gondii by Limiting Its Uptake of Fatty Acids.

Pernas L, Bean C, Boothroyd JC, Scorrano L.

Cell Metab. 2018 Apr 3;27(4):886-897.e4. doi: 10.1016/j.cmet.2018.02.018.

21.

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.

Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG.

Genome Biol. 2018 Mar 16;19(1):37. doi: 10.1186/s13059-018-1401-9.

22.

Flaming Mitochondria: The Anti-inflammatory Drug Leflunomide Boosts Mitofusins.

Pellattiero A, Scorrano L.

Cell Chem Biol. 2018 Mar 15;25(3):231-233. doi: 10.1016/j.chembiol.2018.02.014.

23.

An ode to mitochondria biologists, new and old.

Pellegrini L, Scorrano L.

Biochem Biophys Res Commun. 2018 May 27;500(1):1. doi: 10.1016/j.bbrc.2018.02.207. Epub 2018 Mar 1. No abstract available.

PMID:
29501743
24.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

25.

The INs and OUTs of mitofusins.

Giacomello M, Scorrano L.

J Cell Biol. 2018 Feb 5;217(2):439-440. doi: 10.1083/jcb.201801042. Epub 2018 Jan 18.

26.

Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease.

Fakruddin M, Wei FY, Suzuki T, Asano K, Kaieda T, Omori A, Izumi R, Fujimura A, Kaitsuka T, Miyata K, Araki K, Oike Y, Scorrano L, Suzuki T, Tomizawa K.

Cell Rep. 2018 Jan 9;22(2):482-496. doi: 10.1016/j.celrep.2017.12.051.

27.

Milder degenerative effects of Carfilzomib vs. Bortezomib in the Drosophila model: a link to clinical adverse events.

Tsakiri EN, Terpos E, Papanagnou ED, Kastritis E, Brieudes V, Halabalaki M, Bagratuni T, Florea BI, Overkleeft HS, Scorrano L, Skaltsounis AL, Dimopoulos MA, Trougakos IP.

Sci Rep. 2017 Dec 19;7(1):17802. doi: 10.1038/s41598-017-17596-4.

28.

SPLICS: a split green fluorescent protein-based contact site sensor for narrow and wide heterotypic organelle juxtaposition.

Cieri D, Vicario M, Giacomello M, Vallese F, Filadi R, Wagner T, Pozzan T, Pizzo P, Scorrano L, Brini M, Calì T.

Cell Death Differ. 2018 Jun;25(6):1131-1145. doi: 10.1038/s41418-017-0033-z. Epub 2017 Dec 11.

29.

RevAMPing Mitochondrial Shape to Live Longer.

Pernas L, Scorrano L.

Cell Metab. 2017 Dec 5;26(6):805-806. doi: 10.1016/j.cmet.2017.11.010.

30.

Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission.

Rehklau K, Hoffmann L, Gurniak CB, Ott M, Witke W, Scorrano L, Culmsee C, Rust MB.

Cell Death Dis. 2017 Oct 5;8(10):e3063. doi: 10.1038/cddis.2017.448.

31.

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells.

Loubiere C, Clavel S, Gilleron J, Harisseh R, Fauconnier J, Ben-Sahra I, Kaminski L, Laurent K, Herkenne S, Lacas-Gervais S, Ambrosetti D, Alcor D, Rocchi S, Cormont M, Michiels JF, Mari B, Mazure NM, Scorrano L, Lacampagne A, Gharib A, Tanti JF, Bost F.

Sci Rep. 2017 Jul 11;7(1):5040. doi: 10.1038/s41598-017-05052-2.

32.

Molecular definitions of autophagy and related processes.

Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G.

EMBO J. 2017 Jul 3;36(13):1811-1836. doi: 10.15252/embj.201796697. Epub 2017 Jun 8. Review.

33.

Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence.

Tezze C, Romanello V, Desbats MA, Fadini GP, Albiero M, Favaro G, Ciciliot S, Soriano ME, Morbidoni V, Cerqua C, Loefler S, Kern H, Franceschi C, Salvioli S, Conte M, Blaauw B, Zampieri S, Salviati L, Scorrano L, Sandri M.

Cell Metab. 2017 Jun 6;25(6):1374-1389.e6. doi: 10.1016/j.cmet.2017.04.021. Epub 2017 May 25.

34.

Poly(adenosine diphosphate-ribose) polymerase as therapeutic target: lessons learned from its inhibitors.

Cseh AM, Fábián Z, Sümegi B, Scorrano L.

Oncotarget. 2017 Jul 25;8(30):50221-50239. doi: 10.18632/oncotarget.16859. Review.

35.

Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation.

Guedouari H, Daigle T, Scorrano L, Hebert-Chatelain E.

Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):169-176. doi: 10.1016/j.bbamcr.2016.10.015. Epub 2016 Nov 15.

36.

Judging a tumor cell by its cover: a matter of mitochondrial contact sites.

Lakshminarayanan S, Scorrano L.

EMBO J. 2017 Jun 1;36(11):1465-1467. doi: 10.15252/embj.201796637. Epub 2017 Mar 16. No abstract available.

37.

Reply to Filadi et al.: Does Mitofusin 2 tether or separate endoplasmic reticulum and mitochondria?

Naon D, Zaninello M, Giacomello M, Varanita T, Grespi F, Lakshminaranayan S, Serafini A, Semenzato M, Herkenne S, Hernández-Alvarez MI, Zorzano A, De Stefani D, Dorn GW 2nd, Scorrano L.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2268-E2269. doi: 10.1073/pnas.1618610114. Epub 2017 Mar 13. No abstract available.

38.

Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control.

Glytsou C, Calvo E, Cogliati S, Mehrotra A, Anastasia I, Rigoni G, Raimondi A, Shintani N, Loureiro M, Vazquez J, Pellegrini L, Enriquez JA, Scorrano L, Soriano ME.

Cell Rep. 2016 Dec 13;17(11):3024-3034. doi: 10.1016/j.celrep.2016.11.049.

39.

Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure.

Cahill TJ, Leo V, Kelly M, Stockenhuber A, Kennedy NW, Bao L, Cereghetti GM, Harper AR, Czibik G, Liao C, Bellahcene M, Steeples V, Ghaffari S, Yavari A, Mayer A, Poulton J, Ferguson DJ, Scorrano L, Hettiarachchi NT, Peers C, Boyle J, Hill RB, Simmons A, Watkins H, Dear TN, Ashrafian H.

J Biol Chem. 2016 Dec 2;291(49):25762. No abstract available.

40.

Cardioprotection and lifespan extension by the natural polyamine spermidine.

Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F.

Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14.

41.

Cell biology: The organelle replication connection.

Ziviani E, Scorrano L.

Nature. 2016 Oct 20;538(7625):326-327. doi: 10.1038/538326b. No abstract available.

PMID:
27762361
42.

Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether.

Naon D, Zaninello M, Giacomello M, Varanita T, Grespi F, Lakshminaranayan S, Serafini A, Semenzato M, Herkenne S, Hernández-Alvarez MI, Zorzano A, De Stefani D, Dorn GW 2nd, Scorrano L.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11249-11254. Epub 2016 Sep 19.

43.

Macroautophagy inhibition maintains fragmented mitochondria to foster T cell receptor-dependent apoptosis.

Corrado M, Mariotti FR, Trapani L, Taraborrelli L, Nazio F, Cianfanelli V, Soriano ME, Schrepfer E, Cecconi F, Scorrano L, Campello S.

EMBO J. 2016 Aug 15;35(16):1793-809. doi: 10.15252/embj.201593727. Epub 2016 Jul 7.

44.

Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice.

Sala-Vila A, Navarro-Lérida I, Sánchez-Alvarez M, Bosch M, Calvo C, López JA, Calvo E, Ferguson C, Giacomello M, Serafini A, Scorrano L, Enriquez JA, Balsinde J, Parton RG, Vázquez J, Pol A, Del Pozo MA.

Sci Rep. 2016 Jun 6;6:27351. doi: 10.1038/srep27351.

45.

Changing perspective on oncometabolites: from metabolic signature of cancer to tumorigenic and immunosuppressive agents.

Corrado M, Scorrano L, Campello S.

Oncotarget. 2016 Jul 19;7(29):46692-46706. doi: 10.18632/oncotarget.8727. Review.

46.

DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress.

Oettinghaus B, D'Alonzo D, Barbieri E, Restelli LM, Savoia C, Licci M, Tolnay M, Frank S, Scorrano L.

Biochim Biophys Acta. 2016 Aug;1857(8):1267-1276. doi: 10.1016/j.bbabio.2016.03.016. Epub 2016 Mar 17.

47.

Mitofusins, from Mitochondria to Metabolism.

Schrepfer E, Scorrano L.

Mol Cell. 2016 Mar 3;61(5):683-694. doi: 10.1016/j.molcel.2016.02.022. Review.

48.

Mitochondrial Cristae: Where Beauty Meets Functionality.

Cogliati S, Enriquez JA, Scorrano L.

Trends Biochem Sci. 2016 Mar;41(3):261-273. doi: 10.1016/j.tibs.2016.01.001. Epub 2016 Feb 6. Review.

PMID:
26857402
49.

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function.

Pernas L, Scorrano L.

Annu Rev Physiol. 2016;78:505-31. doi: 10.1146/annurev-physiol-021115-105011. Epub 2015 Nov 19. Review.

PMID:
26667075
50.

Early effects of the antineoplastic agent salinomycin on mitochondrial function.

Managò A, Leanza L, Carraretto L, Sassi N, Grancara S, Quintana-Cabrera R, Trimarco V, Toninello A, Scorrano L, Trentin L, Semenzato G, Gulbins E, Zoratti M, Szabò I.

Cell Death Dis. 2015 Oct 22;6:e1930. doi: 10.1038/cddis.2015.263.

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