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Items: 1 to 50 of 231

1.

Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.

Bigdeli TB, Genovese G, Georgakopoulos P, Meyers JL, Peterson RE, Iyegbe CO, Medeiros H, Valderrama J, Achtyes ED, Kotov R, Stahl EA, Abbott C, Azevedo MH, Belliveau RA, Bevilacqua E, Bromet EJ, Byerley W, Carvalho CB, Chapman SB, DeLisi LE, Dumont AL, O'Dushlaine C, Evgrafov OV, Fochtmann LJ, Gage D, Kennedy JL, Kinkead B, Macedo A, Moran JL, Morley CP, Dewan MJ, Nemesh J, Perkins DO, Purcell SM, Rakofsky JJ, Scolnick EM, Sklar BM, Sklar P, Smoller JW, Sullivan PF, Macciardi F, Marder SR, Gur RC, Gur RE, Braff DL; Consortium on the Genetics of Schizophrenia (COGS) Investigators, Nicolini H, Escamilla MA, Vawter MP, Sobell JL, Malaspina D, Lehrer DS, Buckley PF, Rapaport MH, Knowles JA; Genomic Psychiatry Cohort (GPC) Consortium, Fanous AH, Pato MT, McCarroll SA, Pato CN.

Mol Psychiatry. 2019 Oct 7. doi: 10.1038/s41380-019-0517-y. [Epub ahead of print]

PMID:
31591465
2.

Molecular mechanisms of the preventable causes of cancer in the United States.

Golemis EA, Scheet P, Beck TN, Scolnick EM, Hunter DJ, Hawk E, Hopkins N.

Genes Dev. 2018 Jul 1;32(13-14):868-902. doi: 10.1101/gad.314849.118. Epub 2018 Jun 26. Review.

3.

A vaccine to prevent cervical cancer: academic and industrial collaboration and a Lasker award.

Scolnick EM.

Clin Transl Immunology. 2017 Dec 28;7(1):e1002. doi: 10.1002/cti2.1002. eCollection 2018. No abstract available.

4.

The Path to New Therapies for Schizophrenia and Bipolar Illness.

Scolnick EM.

FASEB J. 2017 Apr;31(4):1254-1259. doi: 10.1096/fj.201700028. Review.

PMID:
28360375
5.

Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder.

Song J, Bergen SE, Di Florio A, Karlsson R, Charney A, Ruderfer DM, Stahl EA; Members of the International Cohort Collection for Bipolar Disorder (ICCBD), Chambert KD, Moran JL, Gordon-Smith K, Forty L, Green EK, Jones I, Jones L, Scolnick EM, Sklar P, Smoller JW, Lichtenstein P, Hultman C, Craddock N, Landén M.

Mol Psychiatry. 2017 Aug;22(8):1223. doi: 10.1038/mp.2016.246. Epub 2017 Feb 14.

PMID:
28194006
6.

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects.

Marshall CR, Howrigan DP, Merico D, Thiruvahindrapuram B, Wu W, Greer DS, Antaki D, Shetty A, Holmans PA, Pinto D, Gujral M, Brandler WM, Malhotra D, Wang Z, Fajarado KVF, Maile MS, Ripke S, Agartz I, Albus M, Alexander M, Amin F, Atkins J, Bacanu SA, Belliveau RA Jr, Bergen SE, Bertalan M, Bevilacqua E, Bigdeli TB, Black DW, Bruggeman R, Buccola NG, Buckner RL, Bulik-Sullivan B, Byerley W, Cahn W, Cai G, Cairns MJ, Campion D, Cantor RM, Carr VJ, Carrera N, Catts SV, Chambert KD, Cheng W, Cloninger CR, Cohen D, Cormican P, Craddock N, Crespo-Facorro B, Crowley JJ, Curtis D, Davidson M, Davis KL, Degenhardt F, Del Favero J, DeLisi LE, Dikeos D, Dinan T, Djurovic S, Donohoe G, Drapeau E, Duan J, Dudbridge F, Eichhammer P, Eriksson J, Escott-Price V, Essioux L, Fanous AH, Farh KH, Farrell MS, Frank J, Franke L, Freedman R, Freimer NB, Friedman JI, Forstner AJ, Fromer M, Genovese G, Georgieva L, Gershon ES, Giegling I, Giusti-Rodríguez P, Godard S, Goldstein JI, Gratten J, de Haan L, Hamshere ML, Hansen M, Hansen T, Haroutunian V, Hartmann AM, Henskens FA, Herms S, Hirschhorn JN, Hoffmann P, Hofman A, Huang H, Ikeda M, Joa I, Kähler AK, Kahn RS, Kalaydjieva L, Karjalainen J, Kavanagh D, Keller MC, Kelly BJ, Kennedy JL, Kim Y, Knowles JA, Konte B, Laurent C, Lee P, Lee SH, Legge SE, Lerer B, Levy DL, Liang KY, Lieberman J, Lönnqvist J, Loughland CM, Magnusson PKE, Maher BS, Maier W, Mallet J, Mattheisen M, Mattingsdal M, McCarley RW, McDonald C, McIntosh AM, Meier S, Meijer CJ, Melle I, Mesholam-Gately RI, Metspalu A, Michie PT, Milani L, Milanova V, Mokrab Y, Morris DW, Müller-Myhsok B, Murphy KC, Murray RM, Myin-Germeys I, Nenadic I, Nertney DA, Nestadt G, Nicodemus KK, Nisenbaum L, Nordin A, O'Callaghan E, O'Dushlaine C, Oh SY, Olincy A, Olsen L, O'Neill FA, Van Os J, Pantelis C, Papadimitriou GN, Parkhomenko E, Pato MT, Paunio T; Psychosis Endophenotypes International Consortium, Perkins DO, Pers TH, Pietiläinen O, Pimm J, Pocklington AJ, Powell J, Price A, Pulver AE, Purcell SM, Quested D, Rasmussen HB, Reichenberg A, Reimers MA, Richards AL, Roffman JL, Roussos P, Ruderfer DM, Salomaa V, Sanders AR, Savitz A, Schall U, Schulze TG, Schwab SG, Scolnick EM, Scott RJ, Seidman LJ, Shi J, Silverman JM, Smoller JW, Söderman E, Spencer CCA, Stahl EA, Strengman E, Strohmaier J, Stroup TS, Suvisaari J, Svrakic DM, Szatkiewicz JP, Thirumalai S, Tooney PA, Veijola J, Visscher PM, Waddington J, Walsh D, Webb BT, Weiser M, Wildenauer DB, Williams NM, Williams S, Witt SH, Wolen AR, Wormley BK, Wray NR, Wu JQ, Zai CC, Adolfsson R, Andreassen OA, Blackwood DHR, Bramon E, Buxbaum JD, Cichon S, Collier DA, Corvin A, Daly MJ, Darvasi A, Domenici E, Esko T, Gejman PV, Gill M, Gurling H, Hultman CM, Iwata N, Jablensky AV, Jönsson EG, Kendler KS, Kirov G, Knight J, Levinson DF, Li QS, McCarroll SA, McQuillin A, Moran JL, Mowry BJ, Nöthen MM, Ophoff RA, Owen MJ, Palotie A, Pato CN, Petryshen TL, Posthuma D, Rietschel M, Riley BP, Rujescu D, Sklar P, St Clair D, Walters JTR, Werge T, Sullivan PF, O'Donovan MC, Scherer SW, Neale BM, Sebat J; CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium.

Nat Genet. 2017 Jan;49(1):27-35. doi: 10.1038/ng.3725. Epub 2016 Nov 21. Erratum in: Nat Genet. 2017 Mar 30;49(4):651. Nat Genet. 2017 Sep 27;49(10 ):1558.

7.

Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.

Kim MJ, Biag J, Fass DM, Lewis MC, Zhang Q, Fleishman M, Gangwar SP, Machius M, Fromer M, Purcell SM, McCarroll SA, Rudenko G, Premont RT, Scolnick EM, Haggarty SJ.

Mol Psychiatry. 2017 Mar;22(3):417-429. doi: 10.1038/mp.2016.98. Epub 2016 Jul 26.

8.

Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder.

Song J, Bergen SE, Di Florio A, Karlsson R, Charney A, Ruderfer DM, Stahl EA; Members of the International Cohort Collection for Bipolar Disorder (ICCBD), Chambert KD, Moran JL, Gordon-Smith K, Forty L, Green EK, Jones I, Jones L, Scolnick EM, Sklar P, Smoller JW, Lichtenstein P, Hultman C, Craddock N, Landén M, Smoller JW, Perlis RH, Lee PH, Castro VM, Hoffnagle AG, Sklar P, Stahl EA, Purcell SM, Ruderfer DM, Charney AW, Roussos P, Michele Pato CP, Medeiros H, Sobel J, Craddock N, Jones I, Forty L, Florio AD, Green E, Jones L, Gordon-Smith K, Landen M, Hultman C, Jureus A, Bergen S, McCarroll S, Moran J, Smoller JW, Chambert K, Belliveau RA.

Mol Psychiatry. 2016 Sep;21(9):1290-7. doi: 10.1038/mp.2015.165. Epub 2015 Oct 27. Erratum in: Mol Psychiatry. 2017 Aug;22(8):1223.

9.

Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia.

Rees E, Kirov G, Walters JT, Richards AL, Howrigan D, Kavanagh DH, Pocklington AJ, Fromer M, Ruderfer DM, Georgieva L, Carrera N, Gormley P, Palta P, Williams H, Dwyer S, Johnson JS, Roussos P, Barker DD, Banks E, Milanova V, Rose SA, Chambert K, Mahajan M, Scolnick EM, Moran JL, Tsuang MT, Glatt SJ, Chen WJ, Hwu HG; Taiwanese Trios Exome Sequencing Consortium, Neale BM, Palotie A, Sklar P, Purcell SM, McCarroll SA, Holmans P, Owen MJ, O'Donovan MC.

Transl Psychiatry. 2015 Jul 21;5:e607. doi: 10.1038/tp.2015.99.

10.

A polygenic burden of rare disruptive mutations in schizophrenia.

Purcell SM, Moran JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, O'Dushlaine C, Chambert K, Bergen SE, Kähler A, Duncan L, Stahl E, Genovese G, Fernández E, Collins MO, Komiyama NH, Choudhary JS, Magnusson PK, Banks E, Shakir K, Garimella K, Fennell T, DePristo M, Grant SG, Haggarty SJ, Gabriel S, Scolnick EM, Lander ES, Hultman CM, Sullivan PF, McCarroll SA, Sklar P.

Nature. 2014 Feb 13;506(7487):185-90. doi: 10.1038/nature12975. Epub 2014 Jan 22.

11.

De novo mutations in schizophrenia implicate synaptic networks.

Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, Carrera N, Humphreys I, Johnson JS, Roussos P, Barker DD, Banks E, Milanova V, Grant SG, Hannon E, Rose SA, Chambert K, Mahajan M, Scolnick EM, Moran JL, Kirov G, Palotie A, McCarroll SA, Holmans P, Sklar P, Owen MJ, Purcell SM, O'Donovan MC.

Nature. 2014 Feb 13;506(7487):179-84. doi: 10.1038/nature12929. Epub 2014 Jan 22.

12.

Validating therapeutic targets through human genetics.

Plenge RM, Scolnick EM, Altshuler D.

Nat Rev Drug Discov. 2013 Aug;12(8):581-94. doi: 10.1038/nrd4051. Epub 2013 Jul 19. Review.

PMID:
23868113
13.

Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.

Bergen SE, O'Dushlaine CT, Ripke S, Lee PH, Ruderfer DM, Akterin S, Moran JL, Chambert KD, Handsaker RE, Backlund L, Ösby U, McCarroll S, Landen M, Scolnick EM, Magnusson PK, Lichtenstein P, Hultman CM, Purcell SM, Sklar P, Sullivan PF.

Mol Psychiatry. 2012 Sep;17(9):880-6. doi: 10.1038/mp.2012.73. Epub 2012 Jun 12.

14.

Advancing drug discovery for schizophrenia.

Marder SR, Roth B, Sullivan PF, Scolnick EM, Nestler EJ, Geyer MA, Welnberger DR, Karayiorgou M, Guidotti A, Gingrich J, Akbarian S, Buchanan RW, Lieberman JA, Conn PJ, Haggarty SJ, Law AJ, Campbell B, Krystal JH, Moghaddam B, Sawa A, Caron MG, George SR, Allen JA, Solis M.

Ann N Y Acad Sci. 2011 Oct;1236:30-43. doi: 10.1111/j.1749-6632.2011.06216.x. Erratum in: Ann N Y Acad Sci. 2012 Jul;1259:145. Saw, Akira [corrected to Sawa, Akira].

15.

AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.

Kuai L, Ong SE, Madison JM, Wang X, Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, Haggarty SJ.

Chem Biol. 2011 Jul 29;18(7):891-906. doi: 10.1016/j.chembiol.2011.03.017.

16.

AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.

Pan JQ, Lewis MC, Ketterman JK, Clore EL, Riley M, Richards KR, Berry-Scott E, Liu X, Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, Haggarty SJ.

Neuropsychopharmacology. 2011 Jun;36(7):1397-411. doi: 10.1038/npp.2011.24. Epub 2011 Mar 9.

17.

Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling.

Kuai L, Wang X, Madison JM, Schreiber SL, Scolnick EM, Haggarty SJ.

ACS Chem Neurosci. 2010 Jan 28;1(4):325-342.

18.

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.

Liu Y, Blackwood DH, Caesar S, de Geus EJ, Farmer A, Ferreira MA, Ferrier IN, Fraser C, Gordon-Smith K, Green EK, Grozeva D, Gurling HM, Hamshere ML, Heutink P, Holmans PA, Hoogendijk WJ, Hottenga JJ, Jones L, Jones IR, Kirov G, Lin D, McGuffin P, Moskvina V, Nolen WA, Perlis RH, Posthuma D, Scolnick EM, Smit AB, Smit JH, Smoller JW, St Clair D, van Dyck R, Verhage M, Willemsen G, Young AH, Zandbelt T, Boomsma DI, Craddock N, O'Donovan MC, Owen MJ, Penninx BW, Purcell S, Sklar P, Sullivan PF; Wellcome Trust Case-Control Consortium.

Mol Psychiatry. 2011 Jan;16(1):2-4. doi: 10.1038/mp.2009.107. Epub 2010 Mar 30. No abstract available.

19.

Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

Raychaudhuri S, Plenge RM, Rossin EJ, Ng AC; International Schizophrenia Consortium, Purcell SM, Sklar P, Scolnick EM, Xavier RJ, Altshuler D, Daly MJ.

PLoS Genet. 2009 Jun;5(6):e1000534. doi: 10.1371/journal.pgen.1000534. Epub 2009 Jun 26.

20.

A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder.

Perlis RH, Smoller JW, Ferreira MA, McQuillin A, Bass N, Lawrence J, Sachs GS, Nimgaonkar V, Scolnick EM, Gurling H, Sklar P, Purcell S.

Am J Psychiatry. 2009 Jun;166(6):718-25. doi: 10.1176/appi.ajp.2009.08111633. Epub 2009 May 15.

21.

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, Smoller JW, Grozeva D, Stone J, Nikolov I, Chambert K, Hamshere ML, Nimgaonkar VL, Moskvina V, Thase ME, Caesar S, Sachs GS, Franklin J, Gordon-Smith K, Ardlie KG, Gabriel SB, Fraser C, Blumenstiel B, Defelice M, Breen G, Gill M, Morris DW, Elkin A, Muir WJ, McGhee KA, Williamson R, MacIntyre DJ, MacLean AW, St CD, Robinson M, Van Beck M, Pereira AC, Kandaswamy R, McQuillin A, Collier DA, Bass NJ, Young AH, Lawrence J, Ferrier IN, Anjorin A, Farmer A, Curtis D, Scolnick EM, McGuffin P, Daly MJ, Corvin AP, Holmans PA, Blackwood DH, Gurling HM, Owen MJ, Purcell SM, Sklar P, Craddock N; Wellcome Trust Case Control Consortium.

Nat Genet. 2008 Sep;40(9):1056-8. doi: 10.1038/ng.209.

22.

Whole-genome association study of bipolar disorder.

Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PI, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumenstiel B, Defelice M, Ardlie KG, Franklin J, Muir WJ, McGhee KA, MacIntyre DJ, McLean A, VanBeck M, McQuillin A, Bass NJ, Robinson M, Lawrence J, Anjorin A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH, Gurling HM, Purcell SM.

Mol Psychiatry. 2008 Jun;13(6):558-69. doi: 10.1038/sj.mp.4002151. Epub 2008 Mar 4.

23.

Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.

Mutsuddi M, Morris DW, Waggoner SG, Daly MJ, Scolnick EM, Sklar P.

Am J Hum Genet. 2006 Nov;79(5):903-9. Epub 2006 Oct 3.

24.

A cell-based ultra-high-throughput screening assay for identifying inhibitors of D-amino acid oxidase.

Brandish PE, Chiu CS, Schneeweis J, Brandon NJ, Leech CL, Kornienko O, Scolnick EM, Strulovici B, Zheng W.

J Biomol Screen. 2006 Aug;11(5):481-7. Epub 2006 Jun 7.

PMID:
16760370
25.

Mechanisms of action of medicines for schizophrenia and bipolar illness: status and limitations.

Scolnick EM.

Biol Psychiatry. 2006 Jun 1;59(11):1039-45. Epub 2006 Apr 17. Review.

PMID:
16616720
26.

Schizophrenia: do the genetics and neurobiology of neuregulin provide a pathogenesis model?

Scolnick EM, Petryshen T, Sklar P.

Harv Rev Psychiatry. 2006 Mar-Apr;14(2):64-77. Review.

PMID:
16603473
27.

Cure therapeutics and strategic prevention: raising the bar for mental health research.

Insel TR, Scolnick EM.

Mol Psychiatry. 2006 Jan;11(1):11-7. Review.

28.

The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection.

Xiong Y, Wiltsie J, Woods A, Guo J, Pivnichny JV, Tang W, Bansal A, Cummings RT, Cunningham BR, Friedlander AM, Douglas CM, Salowe SP, Zaller DM, Scolnick EM, Schmatz DM, Bartizal K, Hermes JD, MacCoss M, Chapman KT.

Bioorg Med Chem Lett. 2006 Feb 15;16(4):964-8. Epub 2005 Dec 9.

PMID:
16338135
29.

Anthrax lethal factor inhibition.

Shoop WL, Xiong Y, Wiltsie J, Woods A, Guo J, Pivnichny JV, Felcetto T, Michael BF, Bansal A, Cummings RT, Cunningham BR, Friedlander AM, Douglas CM, Patel SB, Wisniewski D, Scapin G, Salowe SP, Zaller DM, Chapman KT, Scolnick EM, Schmatz DM, Bartizal K, MacCoss M, Hermes JD.

Proc Natl Acad Sci U S A. 2005 May 31;102(22):7958-63. Epub 2005 May 23.

30.

Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortex.

Brandish PE, Su M, Holder DJ, Hodor P, Szumiloski J, Kleinhanz RR, Forbes JE, McWhorter ME, Duenwald SJ, Parrish ML, Na S, Liu Y, Phillips RL, Renger JJ, Sankaranarayanan S, Simon AJ, Scolnick EM.

Neuron. 2005 Mar 24;45(6):861-72.

31.

High-throughput cell-based screening using scintillation proximity assay for the discovery of inositol phosphatase inhibitors.

Zheng W, Brandish PE, Kolodin DG, Scolnick EM, Strulovici B.

J Biomol Screen. 2004 Mar;9(2):132-40.

PMID:
15006136
32.

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity.

Sur C, Mallorga PJ, Wittmann M, Jacobson MA, Pascarella D, Williams JB, Brandish PE, Pettibone DJ, Scolnick EM, Conn PJ.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13674-9. Epub 2003 Oct 31.

33.
34.

Developing novel treatments for mood disorders: accelerating discovery.

Tamminga CA, Nemeroff CB, Blakely RD, Brady L, Carter CS, Davis KL, Dingledine R, Gorman JM, Grigoriadis DE, Henderson DC, B Innis RB, Killen J, Laughren TP, McDonald WM, M Murphy GM Jr, Paul SM, Rudorfer MV, Sausville E, Schatzberg AF, Scolnick EM, Suppes T.

Biol Psychiatry. 2002 Sep 15;52(6):589-609. Review.

PMID:
12361670
35.

Discovery and development of antidepressants: a perspective from a pharmaceutical discovery company.

Scolnick EM.

Biol Psychiatry. 2002 Aug 1;52(3):154-6. No abstract available.

PMID:
12182921
36.

A peptide-based fluorescence resonance energy transfer assay for Bacillus anthracis lethal factor protease.

Cummings RT, Salowe SP, Cunningham BR, Wiltsie J, Park YW, Sonatore LM, Wisniewski D, Douglas CM, Hermes JD, Scolnick EM.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6603-6. Epub 2002 May 7.

37.

"Natural history" clinical trials: an enduring contribution to modern medical practice.

Scolnick EM, Slater EE, Williams GW.

Adv Protein Chem. 2001;56:1-12. Review. No abstract available.

PMID:
11329850
38.

Distinct mechanism for antidepressant activity by blockade of central substance P receptors.

Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, Reines SA, Liu G, Snavely D, Wyatt-Knowles E, Hale JJ, Mills SG, MacCoss M, Swain CJ, Harrison T, Hill RG, Hefti F, Scolnick EM, Cascieri MA, Chicchi GG, Sadowski S, Williams AR, Hewson L, Smith D, Carlson EJ, Hargreaves RJ, Rupniak NM.

Science. 1998 Sep 11;281(5383):1640-5.

39.

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor.

Kohl NE, Mosser SD, deSolms SJ, Giuliani EA, Pompliano DL, Graham SL, Smith RL, Scolnick EM, Oliff A, Gibbs JB.

Science. 1993 Jun 25;260(5116):1934-7.

PMID:
8316833
40.

Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.

Gibbs JB, Pompliano DL, Mosser SD, Rands E, Lingham RB, Singh SB, Scolnick EM, Kohl NE, Oliff A.

J Biol Chem. 1993 Apr 15;268(11):7617-20.

41.

Identification of amino acid residues required for Ras p21 target activation.

Marshall MS, Davis LJ, Keys RD, Mosser SD, Hill WS, Scolnick EM, Gibbs JB.

Mol Cell Biol. 1991 Aug;11(8):3997-4004.

42.

The partnership of academia and industry in pharmacologic research.

Scolnick EM.

J Lab Clin Med. 1991 Jan;117(1):8-14. No abstract available.

PMID:
1846168
43.

Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP).

Gibbs JB, Marshall MS, Scolnick EM, Dixon RA, Vogel US.

J Biol Chem. 1990 Nov 25;265(33):20437-42.

44.

Structure/function relationships of ras and guanosine triphosphatase-activating protein.

Gibbs JB, Schaber MD, Garsky VM, Vogel US, Scolnick EM, Dixon RA, Marshall MS.

Soc Gen Physiol Ser. 1990;45:77-85. Review. No abstract available.

PMID:
2198666
45.

Xenopus oocyte germinal-vesicle breakdown induced by [Val12]Ras is inhibited by a cytosol-localized Ras mutant.

Gibbs JB, Schaber MD, Schofield TL, Scolnick EM, Sigal IS.

Proc Natl Acad Sci U S A. 1989 Sep;86(17):6630-4.

46.

A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity.

Marshall MS, Hill WS, Ng AS, Vogel US, Schaber MD, Scolnick EM, Dixon RA, Sigal IS, Gibbs JB.

EMBO J. 1989 Apr;8(4):1105-10.

47.

Ras interaction with the GTPase-activating protein (GAP).

Schaber MD, Garsky VM, Boylan D, Hill WS, Scolnick EM, Marshall MS, Sigal IS, Gibbs JB.

Proteins. 1989;6(3):306-15.

PMID:
2516318
48.

Cloning of bovine GAP and its interaction with oncogenic ras p21.

Vogel US, Dixon RA, Schaber MD, Diehl RE, Marshall MS, Scolnick EM, Sigal IS, Gibbs JB.

Nature. 1988 Sep 1;335(6185):90-3.

PMID:
2842690
49.

Purification of ras GTPase activating protein from bovine brain.

Gibbs JB, Schaber MD, Allard WJ, Sigal IS, Scolnick EM.

Proc Natl Acad Sci U S A. 1988 Jul;85(14):5026-30.

50.

Active human immunodeficiency virus protease is required for viral infectivity.

Kohl NE, Emini EA, Schleif WA, Davis LJ, Heimbach JC, Dixon RA, Scolnick EM, Sigal IS.

Proc Natl Acad Sci U S A. 1988 Jul;85(13):4686-90.

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