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Items: 1 to 50 of 70

1.

New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an in Vivo BRET-Based Discovery Platform.

Sartini S, Levati E, Maccesi M, Guerra M, Spadoni G, Bach S, Benincasa M, Scocchi M, Ottonello S, Rivara S, Montanini B.

ACS Chem Biol. 2019 Aug 16;14(8):1727-1736. doi: 10.1021/acschembio.9b00178. Epub 2019 Jul 30.

PMID:
31310497
2.

Sub-MIC effects of a proline-rich antibacterial peptide on clinical isolates of Acinetobacter baumannii.

Dolzani L, Milan A, Scocchi M, Lagatolla C, Bressan R, Benincasa M.

J Med Microbiol. 2019 Aug;68(8):1253-1265. doi: 10.1099/jmm.0.001028. Epub 2019 Jun 19.

PMID:
31215857
3.

Design, antimicrobial activity and mechanism of action of Arg-rich ultra-short cationic lipopeptides.

Armas F, Pacor S, Ferrari E, Guida F, Pertinhez TA, Romani AA, Scocchi M, Benincasa M.

PLoS One. 2019 Feb 21;14(2):e0212447. doi: 10.1371/journal.pone.0212447. eCollection 2019.

4.

Search for Shorter Portions of the Proline-Rich Antimicrobial Peptide Fragment Bac5(1-25) That Retain Antimicrobial Activity by Blocking Protein Synthesis.

Mardirossian M, Sola R, Degasperi M, Scocchi M.

ChemMedChem. 2019 Feb 5;14(3):343-348. doi: 10.1002/cmdc.201800734. Epub 2019 Jan 17.

PMID:
30615305
5.

Fragments of the Nonlytic Proline-Rich Antimicrobial Peptide Bac5 Kill Escherichia coli Cells by Inhibiting Protein Synthesis.

Mardirossian M, Barrière Q, Timchenko T, Müller C, Pacor S, Mergaert P, Scocchi M, Wilson DN.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00534-18. doi: 10.1128/AAC.00534-18. Print 2018 Aug.

6.

Induced expression of cathelicidins in trout (Oncorhynchus mykiss) challenged with four different bacterial pathogens.

Furlan M, Rosani U, Gambato S, Irato P, Manfrin A, Mardirossian M, Venier P, Pallavicini A, Scocchi M.

J Pept Sci. 2018 Jul;24(7):e3089. doi: 10.1002/psc.3089. Epub 2018 May 28.

PMID:
29808604
7.

D-BMAP18 Antimicrobial Peptide Is Active In vitro, Resists to Pulmonary Proteases but Loses Its Activity in a Murine Model of Pseudomonas aeruginosa Lung Infection.

Mardirossian M, Pompilio A, Degasperi M, Runti G, Pacor S, Di Bonaventura G, Scocchi M.

Front Chem. 2017 Jun 19;5:40. doi: 10.3389/fchem.2017.00040. eCollection 2017.

8.

Proline-rich antimicrobial peptides targeting protein synthesis.

Graf M, Mardirossian M, Nguyen F, Seefeldt AC, Guichard G, Scocchi M, Innis CA, Wilson DN.

Nat Prod Rep. 2017 Jul 1;34(7):702-711. doi: 10.1039/c7np00020k. Epub 2017 May 24. Review.

PMID:
28537612
9.

The Mechanism of Killing by the Proline-Rich Peptide Bac7(1-35) against Clinical Strains of Pseudomonas aeruginosa Differs from That against Other Gram-Negative Bacteria.

Runti G, Benincasa M, Giuffrida G, Devescovi G, Venturi V, Gennaro R, Scocchi M.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e01660-16. doi: 10.1128/AAC.01660-16. Print 2017 Apr.

10.

Methods for Elucidating the Mechanism of Action of Proline-Rich and Other Non-lytic Antimicrobial Peptides.

Benincasa M, Runti G, Mardirossian M, Gennaro R, Scocchi M.

Methods Mol Biol. 2017;1548:283-295. doi: 10.1007/978-1-4939-6737-7_20.

PMID:
28013512
11.

Antimicrobial and host cell-directed activities of Gly/Ser-rich peptides from salmonid cathelicidins.

D'Este F, Benincasa M, Cannone G, Furlan M, Scarsini M, Volpatti D, Gennaro R, Tossi A, Skerlavaj B, Scocchi M.

Fish Shellfish Immunol. 2016 Dec;59:456-468. doi: 10.1016/j.fsi.2016.11.004. Epub 2016 Nov 3.

PMID:
27818338
12.

In vitro and in vivo evaluation of BMAP-derived peptides for the treatment of cystic fibrosis-related pulmonary infections.

Mardirossian M, Pompilio A, Crocetta V, De Nicola S, Guida F, Degasperi M, Gennaro R, Di Bonaventura G, Scocchi M.

Amino Acids. 2016 Sep;48(9):2253-60. doi: 10.1007/s00726-016-2266-4. Epub 2016 Jun 6.

PMID:
27270571
13.

Inner membrane proteins YgdD and SbmA are required for the complete susceptibility of E. coli to the proline-rich antimicrobial peptide arasin 1(1-25).

Paulsen VS, Mardirossian M, Blencke HM, Benincasa M, Runti G, Nepa M, Haug T, Stensvåg K, Scocchi M.

Microbiology. 2016 Feb 8. doi: 10.1099/mic.0.000249. [Epub ahead of print]

PMID:
26860543
14.

Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome.

Seefeldt AC, Graf M, Pérébaskine N, Nguyen F, Arenz S, Mardirossian M, Scocchi M, Wilson DN, Innis CA.

Nucleic Acids Res. 2016 Mar 18;44(5):2429-38. doi: 10.1093/nar/gkv1545. Epub 2016 Jan 20.

15.

The human cathelicidin LL-37--A pore-forming antibacterial peptide and host-cell modulator.

Xhindoli D, Pacor S, Benincasa M, Scocchi M, Gennaro R, Tossi A.

Biochim Biophys Acta. 2016 Mar;1858(3):546-66. doi: 10.1016/j.bbamem.2015.11.003. Epub 2015 Nov 10. Review.

16.

Non-Membrane Permeabilizing Modes of Action of Antimicrobial Peptides on Bacteria.

Scocchi M, Mardirossian M, Runti G, Benincasa M.

Curr Top Med Chem. 2016;16(1):76-88. Review.

PMID:
26139115
17.

Lipopolysaccharide Phosphorylation by the WaaY Kinase Affects the Susceptibility of Escherichia coli to the Human Antimicrobial Peptide LL-37.

Bociek K, Ferluga S, Mardirossian M, Benincasa M, Tossi A, Gennaro R, Scocchi M.

J Biol Chem. 2015 Aug 7;290(32):19933-41. doi: 10.1074/jbc.M114.634758. Epub 2015 Jun 22.

18.

PEGylation of the peptide Bac7(1-35) reduces renal clearance while retaining antibacterial activity and bacterial cell penetration capacity.

Benincasa M, Zahariev S, Pelillo C, Milan A, Gennaro R, Scocchi M.

Eur J Med Chem. 2015 May 5;95:210-9. doi: 10.1016/j.ejmech.2015.03.028. Epub 2015 Mar 19.

PMID:
25817771
19.

Effect of size and N-terminal residue characteristics on bacterial cell penetration and antibacterial activity of the proline-rich peptide Bac7.

Guida F, Benincasa M, Zahariev S, Scocchi M, Berti F, Gennaro R, Tossi A.

J Med Chem. 2015 Feb 12;58(3):1195-204. doi: 10.1021/jm501367p. Epub 2015 Jan 14.

PMID:
25525837
20.

The host antimicrobial peptide Bac71-35 binds to bacterial ribosomal proteins and inhibits protein synthesis.

Mardirossian M, Grzela R, Giglione C, Meinnel T, Gennaro R, Mergaert P, Scocchi M.

Chem Biol. 2014 Dec 18;21(12):1639-47. doi: 10.1016/j.chembiol.2014.10.009. Epub 2014 Nov 13.

21.

Proteolytic activity of Escherichia coli oligopeptidase B against proline-rich antimicrobial peptides.

Mattiuzzo M, De Gobba C, Runti G, Mardirossian M, Bandiera A, Gennaro R, Scocchi M.

J Microbiol Biotechnol. 2014 Feb 28;24(2):160-7.

22.

Enteric YaiW is a surface-exposed outer membrane lipoprotein that affects sensitivity to an antimicrobial peptide.

Arnold MF, Caro-Hernandez P, Tan K, Runti G, Wehmeier S, Scocchi M, Doerrler WT, Walker GC, Ferguson GP.

J Bacteriol. 2014 Jan;196(2):436-44. doi: 10.1128/JB.01179-13. Epub 2013 Nov 8.

23.
24.

Functional and structural study of the dimeric inner membrane protein SbmA.

Corbalan N, Runti G, Adler C, Covaceuszach S, Ford RC, Lamba D, Beis K, Scocchi M, Vincent PA.

J Bacteriol. 2013 Dec;195(23):5352-61. doi: 10.1128/JB.00824-13. Epub 2013 Sep 27.

25.

Functional characterization of SbmA, a bacterial inner membrane transporter required for importing the antimicrobial peptide Bac7(1-35).

Runti G, Lopez Ruiz Mdel C, Stoilova T, Hussain R, Jennions M, Choudhury HG, Benincasa M, Gennaro R, Beis K, Scocchi M.

J Bacteriol. 2013 Dec;195(23):5343-51. doi: 10.1128/JB.00818-13. Epub 2013 Sep 27.

26.

Structure-activity relationships of the antimicrobial peptide arasin 1 - and mode of action studies of the N-terminal, proline-rich region.

Paulsen VS, Blencke HM, Benincasa M, Haug T, Eksteen JJ, Styrvold OB, Scocchi M, Stensvåg K.

PLoS One. 2013;8(1):e53326. doi: 10.1371/journal.pone.0053326. Epub 2013 Jan 11.

27.

Partial complementation of Sinorhizobium meliloti bacA mutant phenotypes by the Mycobacterium tuberculosis BacA protein.

Arnold MF, Haag AF, Capewell S, Boshoff HI, James EK, McDonald R, Mair I, Mitchell AM, Kerscher B, Mitchell TJ, Mergaert P, Barry CE 3rd, Scocchi M, Zanda M, Campopiano DJ, Ferguson GP.

J Bacteriol. 2013 Jan;195(2):389-98. doi: 10.1128/JB.01445-12. Epub 2012 Nov 16.

28.

Potential novel therapeutic strategies in cystic fibrosis: antimicrobial and anti-biofilm activity of natural and designed α-helical peptides against Staphylococcus aureus, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia.

Pompilio A, Crocetta V, Scocchi M, Pomponio S, Di Vincenzo V, Mardirossian M, Gherardi G, Fiscarelli E, Dicuonzo G, Gennaro R, Di Bonaventura G.

BMC Microbiol. 2012 Jul 23;12:145. doi: 10.1186/1471-2180-12-145.

29.

Use of unnatural amino acids to probe structure-activity relationships and mode-of-action of antimicrobial peptides.

Tossi A, Scocchi M, Zahariev S, Gennaro R.

Methods Mol Biol. 2012;794:169-83. doi: 10.1007/978-1-61779-331-8_10.

PMID:
21956562
30.

Antibacterial and anti-biofilm effects of cathelicidin peptides against pathogens isolated from cystic fibrosis patients.

Pompilio A, Scocchi M, Pomponio S, Guida F, Di Primio A, Fiscarelli E, Gennaro R, Di Bonaventura G.

Peptides. 2011 Sep;32(9):1807-14. doi: 10.1016/j.peptides.2011.08.002. Epub 2011 Aug 7.

PMID:
21849157
31.

Proline-rich antimicrobial peptides: converging to a non-lytic mechanism of action.

Scocchi M, Tossi A, Gennaro R.

Cell Mol Life Sci. 2011 Jul;68(13):2317-30. doi: 10.1007/s00018-011-0721-7. Epub 2011 May 19. Review.

PMID:
21594684
32.

The proline-rich peptide Bac7(1-35) reduces mortality from Salmonella typhimurium in a mouse model of infection.

Benincasa M, Pelillo C, Zorzet S, Garrovo C, Biffi S, Gennaro R, Scocchi M.

BMC Microbiol. 2010 Jun 23;10:178. doi: 10.1186/1471-2180-10-178.

33.

Internalization of a thiazole-modified peptide in Sinorhizobium meliloti occurs by BacA-dependent and -independent mechanisms.

Wehmeier S, Arnold MF, Marlow VL, Aouida M, Myka KK, Fletcher V, Benincasa M, Scocchi M, Ramotar D, Ferguson GP.

Microbiology. 2010 Sep;156(Pt 9):2702-13. doi: 10.1099/mic.0.039909-0. Epub 2010 May 27.

PMID:
20507886
34.

Spontaneous neurocognitive retrieval of patients with sub-acute ischemic stroke is associated with dietary protein intake.

Aquilani R, Scocchi M, Iadarola P, Viglio S, Pasini E, Condello S, Boschi F, Pastoris O, Bongiorno AI, Verri M.

Nutr Neurosci. 2010 Jun;13(3):129-34. doi: 10.1179/147683010X12611460764002.

PMID:
20423562
35.

BacA is essential for bacteroid development in nodules of galegoid, but not phaseoloid, legumes.

Karunakaran R, Haag AF, East AK, Ramachandran VK, Prell J, James EK, Scocchi M, Ferguson GP, Poole PS.

J Bacteriol. 2010 Jun;192(11):2920-8. doi: 10.1128/JB.00020-10. Epub 2010 Apr 2.

36.

Role of Cathelicidin Peptides in Bovine Host Defense and Healing.

Tomasinsig L, Benincasa M, Scocchi M, Skerlavaj B, Tossi A, Zanetti M, Gennaro R.

Probiotics Antimicrob Proteins. 2010 Mar;2(1):12-20. doi: 10.1007/s12602-010-9035-6.

PMID:
26780897
37.

Structural aspects of plant antimicrobial peptides.

Padovan L, Scocchi M, Tossi A.

Curr Protein Pept Sci. 2010 May;11(3):210-9. Review.

PMID:
20088769
38.

Normalization of zinc intake enhances neurological retrieval of patients suffering from ischemic strokes.

Aquilani R, Baiardi P, Scocchi M, Iadarola P, Verri M, Sessarego P, Boschi F, Pasini E, Pastoris O, Viglio S.

Nutr Neurosci. 2009 Oct;12(5):219-25. doi: 10.1179/147683009X423445.

PMID:
19761652
39.

Rapid and reliable detection of antimicrobial peptide penetration into gram-negative bacteria based on fluorescence quenching.

Benincasa M, Pacor S, Gennaro R, Scocchi M.

Antimicrob Agents Chemother. 2009 Aug;53(8):3501-4. doi: 10.1128/AAC.01620-08. Epub 2009 May 26.

40.

The salmonid cathelicidins: a gene family with highly varied C-terminal antimicrobial domains.

Scocchi M, Pallavicini A, Salgaro R, Bociek K, Gennaro R.

Comp Biochem Physiol B Biochem Mol Biol. 2009 Apr;152(4):376-81. doi: 10.1016/j.cbpb.2009.01.003. Epub 2009 Jan 10.

PMID:
19168146
41.

Essential role for the BacA protein in the uptake of a truncated eukaryotic peptide in Sinorhizobium meliloti.

Marlow VL, Haag AF, Kobayashi H, Fletcher V, Scocchi M, Walker GC, Ferguson GP.

J Bacteriol. 2009 Mar;191(5):1519-27. doi: 10.1128/JB.01661-08. Epub 2008 Dec 12.

42.

Protein supplementation may enhance the spontaneous recovery of neurological alterations in patients with ischaemic stroke.

Aquilani R, Scocchi M, Iadarola P, Franciscone P, Verri M, Boschi F, Pasini E, Viglio S.

Clin Rehabil. 2008 Dec;22(12):1042-50. doi: 10.1177/0269215508094244.

PMID:
19052243
43.

Effect of calorie-protein supplementation on the cognitive recovery of patients with subacute stroke.

Aquilani R, Scocchi M, Boschi F, Viglio S, Iadarola P, Pastoris O, Verri M.

Nutr Neurosci. 2008 Oct;11(5):235-40. doi: 10.1179/147683008X301586.

PMID:
18782484
44.

Investigating the mode of action of proline-rich antimicrobial peptides using a genetic approach: a tool to identify new bacterial targets amenable to the design of novel antibiotics.

Scocchi M, Mattiuzzo M, Benincasa M, Antcheva N, Tossi A, Gennaro R.

Methods Mol Biol. 2008;494:161-76. doi: 10.1007/978-1-59745-419-3_9.

PMID:
18726573
45.

Role of the Escherichia coli SbmA in the antimicrobial activity of proline-rich peptides.

Mattiuzzo M, Bandiera A, Gennaro R, Benincasa M, Pacor S, Antcheva N, Scocchi M.

Mol Microbiol. 2007 Oct;66(1):151-63. Epub 2007 Aug 28.

46.

Dual mode of action of Bac7, a proline-rich antibacterial peptide.

Podda E, Benincasa M, Pacor S, Micali F, Mattiuzzo M, Gennaro R, Scocchi M.

Biochim Biophys Acta. 2006 Nov;1760(11):1732-40. Epub 2006 Sep 19.

PMID:
17059867
47.

Fungicidal activity of five cathelicidin peptides against clinically isolated yeasts.

Benincasa M, Scocchi M, Pacor S, Tossi A, Nobili D, Basaglia G, Busetti M, Gennaro R.

J Antimicrob Chemother. 2006 Nov;58(5):950-9. Epub 2006 Oct 5.

PMID:
17023499
48.

The influence of comorbidities and complications on discharge function in stroke rehabilitation inpatients.

Ferriero G, Franchignoni F, Benevolo E, Ottonello M, Scocchi M, Xanthi M.

Eura Medicophys. 2006 Jun;42(2):91-6.

49.

Structural aspects and biological properties of the cathelicidin PMAP-36.

Scocchi M, Zelezetsky I, Benincasa M, Gennaro R, Mazzoli A, Tossi A.

FEBS J. 2005 Sep;272(17):4398-406.

50.

Antimicrobial activity of Bac7 fragments against drug-resistant clinical isolates.

Benincasa M, Scocchi M, Podda E, Skerlavaj B, Dolzani L, Gennaro R.

Peptides. 2004 Dec;25(12):2055-61.

PMID:
15572192

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