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Items: 22


RIM-binding proteins recruit BK-channels to presynaptic release sites adjacent to voltage-gated Ca2+-channels.

Sclip A, Acuna C, Luo F, Südhof TC.

EMBO J. 2018 Aug 15;37(16). pii: e98637. doi: 10.15252/embj.201798637. Epub 2018 Jul 2.


The c-jun N-terminal kinase plays a key role in ocular degenerative changes in a mouse model of Alzheimer disease suggesting a correlation between ocular and brain pathologies.

Buccarello L, Sclip A, Sacchi M, Castaldo AM, Bertani I, ReCecconi A, Maestroni S, Zerbini G, Nucci P, Borsello T.

Oncotarget. 2017 Aug 3;8(47):83038-83051. doi: 10.18632/oncotarget.19886. eCollection 2017 Oct 10.


Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase.

Biggi S, Buccarello L, Sclip A, Lippiello P, Tonna N, Rumio C, Di Marino D, Miniaci MC, Borsello T.

Neural Plast. 2017;2017:6468356. doi: 10.1155/2017/6468356. Epub 2017 Mar 7.


Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction.

Sclip A, Bacaj T, Giam LR, Südhof TC.

PLoS One. 2016 Jun 27;11(6):e0158295. doi: 10.1371/journal.pone.0158295. eCollection 2016.


The cell-permeable Aβ1-6A2VTAT(D) peptide reverts synaptopathy induced by Aβ1-42wt.

Cimini S, Sclip A, Mancini S, Colombo L, Messa M, Cagnotto A, Di Fede G, Tagliavini F, Salmona M, Borsello T.

Neurobiol Dis. 2016 May;89:101-11. doi: 10.1016/j.nbd.2015.12.013. Epub 2015 Dec 22.


Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury.

Vercelli A, Biggi S, Sclip A, Repetto IE, Cimini S, Falleroni F, Tomasi S, Monti R, Tonna N, Morelli F, Grande V, Stravalaci M, Biasini E, Marin O, Bianco F, di Marino D, Borsello T.

Cell Death Dis. 2015 Aug 13;6:e1854. doi: 10.1038/cddis.2015.226.


Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease.

Tozzi A, Sclip A, Tantucci M, de Iure A, Ghiglieri V, Costa C, Di Filippo M, Borsello T, Calabresi P.

Neurobiol Aging. 2015 Jan;36(1):123-33. doi: 10.1016/j.neurobiolaging.2014.07.002. Epub 2014 Jul 10.


Determination of tissue levels of a neuroprotectant drug: the cell permeable JNK inhibitor peptide.

Davoli E, Sclip A, Cecchi M, Cimini S, Carrà A, Salmona M, Borsello T.

J Pharmacol Toxicol Methods. 2014 Jul-Aug;70(1):55-61. doi: 10.1016/j.vascn.2014.04.001. Epub 2014 May 9.


c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo.

Sclip A, Tozzi A, Abaza A, Cardinetti D, Colombo I, Calabresi P, Salmona M, Welker E, Borsello T.

Cell Death Dis. 2014 Jan 23;5:e1019. doi: 10.1038/cddis.2013.559.


Soluble Aβ oligomer-induced synaptopathy: c-Jun N-terminal kinase's role.

Sclip A, Arnaboldi A, Colombo I, Veglianese P, Colombo L, Messa M, Mancini S, Cimini S, Morelli F, Antoniou X, Welker E, Salmona M, Borsello T.

J Mol Cell Biol. 2013 Aug;5(4):277-9. doi: 10.1093/jmcb/mjt015. Epub 2013 Apr 18. No abstract available.


An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo.

Fluharty BR, Biasini E, Stravalaci M, Sclip A, Diomede L, Balducci C, La Vitola P, Messa M, Colombo L, Forloni G, Borsello T, Gobbi M, Harris DA.

J Biol Chem. 2013 Mar 15;288(11):7857-66. doi: 10.1074/jbc.M112.423954. Epub 2013 Jan 28.


The neurodegeneration in Alzheimer disease and the prion protein.

Forloni G, Sclip A, Borsello T, Balducci C.

Prion. 2013 Jan-Feb;7(1):60-5. doi: 10.4161/pri.23286. Epub 2013 Jan 1. Review.


Specific inhibition of the JNK pathway promotes locomotor recovery and neuroprotection after mouse spinal cord injury.

Repici M, Chen X, Morel MP, Doulazmi M, Sclip A, Cannaya V, Veglianese P, Kraftsik R, Mariani J, Borsello T, Dusart I.

Neurobiol Dis. 2012 Jun;46(3):710-21. doi: 10.1016/j.nbd.2012.03.014. Epub 2012 Mar 9.


Crosstalk between JNK and SUMO signaling pathways: deSUMOylation is protective against H2O2-induced cell injury.

Feligioni M, Brambilla E, Camassa A, Sclip A, Arnaboldi A, Morelli F, Antoniou X, Borsello T.

PLoS One. 2011;6(12):e28185. doi: 10.1371/journal.pone.0028185. Epub 2011 Dec 2.


c-Jun N-terminal kinase regulates soluble Aβ oligomers and cognitive impairment in AD mouse model.

Sclip A, Antoniou X, Colombo A, Camici GG, Pozzi L, Cardinetti D, Feligioni M, Veglianese P, Bahlmann FH, Cervo L, Balducci C, Costa C, Tozzi A, Calabresi P, Forloni G, Borsello T.

J Biol Chem. 2011 Dec 23;286(51):43871-80. doi: 10.1074/jbc.M111.297515. Epub 2011 Oct 27.


JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models.

Ploia C, Antoniou X, Sclip A, Grande V, Cardinetti D, Colombo A, Canu N, Benussi L, Ghidoni R, Forloni G, Borsello T.

J Alzheimers Dis. 2011;26(2):315-29. doi: 10.3233/JAD-2011-110320.


Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein.

Balducci C, Beeg M, Stravalaci M, Bastone A, Sclip A, Biasini E, Tapella L, Colombo L, Manzoni C, Borsello T, Chiesa R, Gobbi M, Salmona M, Forloni G.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2295-300. doi: 10.1073/pnas.0911829107. Epub 2010 Jan 19.


JNK contributes to Hif-1alpha regulation in hypoxic neurons.

Antoniou X, Sclip A, Ploia C, Colombo A, Moroy G, Borsello T.

Molecules. 2009 Dec 30;15(1):114-27. doi: 10.3390/molecules15010114.


Role of Glycogen Synthase Kinase-3β in APP Hyperphosphorylation Induced by NMDA Stimulation in Cortical Neurons.

Ploia C, Sclip A, Colombo A, Repici M, Gardoni F, Di Luca M, Forloni G, Antoniou X, Borsello T.

Pharmaceuticals (Basel). 2010 Jan 7;3(1):42-58.


c-Jun N-terminal kinase pathway activation in human and experimental cerebral contusion.

Ortolano F, Colombo A, Zanier ER, Sclip A, Longhi L, Perego C, Stocchetti N, Borsello T, De Simoni MG.

J Neuropathol Exp Neurol. 2009 Sep;68(9):964-71. doi: 10.1097/NEN.0b013e3181b20670.


JNK regulates APP cleavage and degradation in a model of Alzheimer's disease.

Colombo A, Bastone A, Ploia C, Sclip A, Salmona M, Forloni G, Borsello T.

Neurobiol Dis. 2009 Mar;33(3):518-25. doi: 10.1016/j.nbd.2008.12.014. Epub 2009 Jan 8.


c-Jun N-terminal kinase binding domain-dependent phosphorylation of mitogen-activated protein kinase kinase 4 and mitogen-activated protein kinase kinase 7 and balancing cross-talk between c-Jun N-terminal kinase and extracellular signal-regulated kinase pathways in cortical neurons.

Repici M, Mare L, Colombo A, Ploia C, Sclip A, Bonny C, Nicod P, Salmona M, Borsello T.

Neuroscience. 2009 Mar 3;159(1):94-103. doi: 10.1016/j.neuroscience.2008.11.049. Epub 2008 Dec 14.


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