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Items: 13


A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology.

Phillips BW, Schlage WK, Titz B, Kogel U, Sciuscio D, Martin F, Leroy P, Vuillaume G, Krishnan S, Lee T, Veljkovic E, Elamin A, Merg C, Ivanov NV, Peitsch MC, Hoeng J, Vanscheeuwijck P.

Food Chem Toxicol. 2018 Jun;116(Pt B):388-413. doi: 10.1016/j.fct.2018.04.015. Epub 2018 Apr 11.


Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints.

Phillips B, Titz B, Kogel U, Sharma D, Leroy P, Xiang Y, Vuillaume G, Lebrun S, Sciuscio D, Ho J, Nury C, Guedj E, Elamin A, Esposito M, Krishnan S, Schlage WK, Veljkovic E, Ivanov NV, Martin F, Peitsch MC, Hoeng J, Vanscheeuwijck P.

Food Chem Toxicol. 2017 Nov;109(Pt 1):315-332. doi: 10.1016/j.fct.2017.09.001. Epub 2017 Sep 5.


Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma.

Kurscheid S, Bady P, Sciuscio D, Samarzija I, Shay T, Vassallo I, Criekinge WV, Daniel RT, van den Bent MJ, Marosi C, Weller M, Mason WP, Domany E, Stupp R, Delorenzi M, Hegi ME.

Genome Biol. 2015 Jan 27;16:16. doi: 10.1186/s13059-015-0583-7.


MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status.

Bady P, Sciuscio D, Diserens AC, Bloch J, van den Bent MJ, Marosi C, Dietrich PY, Weller M, Mariani L, Heppner FL, Mcdonald DR, Lacombe D, Stupp R, Delorenzi M, Hegi ME.

Acta Neuropathol. 2012 Oct;124(4):547-60. doi: 10.1007/s00401-012-1016-2. Epub 2012 Jul 19. Erratum in: Acta Neuropathol. 2013 Jul;126(1):159.


The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence.

Lambiv WL, Vassallo I, Delorenzi M, Shay T, Diserens AC, Misra A, Feuerstein B, Murat A, Migliavacca E, Hamou MF, Sciuscio D, Burger R, Domany E, Stupp R, Hegi ME.

Neuro Oncol. 2011 Jul;13(7):736-47. doi: 10.1093/neuonc/nor036. Epub 2011 Jun 3.


Extent and patterns of MGMT promoter methylation in glioblastoma- and respective glioblastoma-derived spheres.

Sciuscio D, Diserens AC, van Dommelen K, Martinet D, Jones G, Janzer RC, Pollo C, Hamou MF, Kaina B, Stupp R, Levivier M, Hegi ME.

Clin Cancer Res. 2011 Jan 15;17(2):255-66. doi: 10.1158/1078-0432.CCR-10-1931. Epub 2010 Nov 19.


Expression of O⁶-methylguanine-DNA methyltransferase in childhood medulloblastoma.

Faoro D, von Bueren AO, Shalaby T, Sciuscio D, Hürlimann ML, Arnold L, Gerber NU, Haybaeck J, Mittelbronn M, Rutkowski S, Hegi M, Grotzer MA.

J Neurooncol. 2011 May;103(1):59-69. doi: 10.1007/s11060-010-0366-7. Epub 2010 Sep 5.


Epigenetic deregulation of DNA repair and its potential for therapy.

Hegi ME, Sciuscio D, Murat A, Levivier M, Stupp R.

Clin Cancer Res. 2009 Aug 15;15(16):5026-31. doi: 10.1158/1078-0432.CCR-08-1169. Epub 2009 Aug 11. Review.


Cell-cycle specificity of sulforaphane-mediated apoptosis in Jurkat T-leukemia cells.

Fimognari C, Lenzi M, Sciuscio D, Cantelli-Forti G, Hrelia P.

In Vivo. 2007 Mar-Apr;21(2):377-80.


Combination of doxorubicin and sulforaphane for reversing doxorubicin-resistant phenotype in mouse fibroblasts with p53Ser220 mutation.

Fimognari C, Lenzi M, Sciuscio D, Cantelli-Forti G, Hrelia P.

Ann N Y Acad Sci. 2007 Jan;1095:62-9.


Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts characterized by p53 mutations.

Fimognari C, Nüsse M, Lenzi M, Sciuscio D, Cantelli-Forti G, Hrelia P.

Mutat Res. 2006 Oct 10;601(1-2):92-101. Epub 2006 Jul 14.


Toward refinement of the colony-forming unit-granulocyte/macrophage clonogenic assay: inclusion of a metabolic system.

Dal Negro G, Vandin L, Bonato M, Sciuscio D.

Toxicol In Vitro. 2006 Aug;20(5):743-9. Epub 2005 Dec 1.


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