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Mechano-biological model of glioblastoma cells in response to osmotic stress.

Pozzi G, Marchesi S, Scita G, Ambrosi D, Ciarletta P.

Math Biosci Eng. 2019 Apr 1;16(4):2795-2810. doi: 10.3934/mbe.2019139.


Collagen prolyl hydroxylation-dependent metabolic perturbation governs epigenetic remodeling and mesenchymal transition in pluripotent and cancer cells.

D'Aniello C, Cermola F, Palamidessi A, Wanderlingh LG, Gagliardi M, Migliaccio A, Varrone F, Casalino L, Matarazzo MR, De Cesare D, Scita G, Patriarca EJ, Minchiotti G.

Cancer Res. 2019 May 6. pii: canres.2070.2018. doi: 10.1158/0008-5472.CAN-18-2070. [Epub ahead of print]


Local actin nucleation tunes centrosomal microtubule nucleation during passage through mitosis.

Farina F, Ramkumar N, Brown L, Samandar Eweis D, Anstatt J, Waring T, Bithell J, Scita G, Thery M, Blanchoin L, Zech T, Baum B.

EMBO J. 2019 Jun 3;38(11). pii: e99843. doi: 10.15252/embj.201899843. Epub 2019 Apr 23.


Frustration-induced phases in migrating cell clusters.

Copenhagen K, Malet-Engra G, Yu W, Scita G, Gov N, Gopinathan A.

Sci Adv. 2018 Sep 12;4(9):eaar8483. doi: 10.1126/sciadv.aar8483. eCollection 2018 Sep.


A NUMB-EFA6B-ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility.

Zobel M, Disanza A, Senic-Matuglia F, Franco M, Colaluca IN, Confalonieri S, Bisi S, Barbieri E, Caldieri G, Sigismund S, Pece S, Chavrier P, Di Fiore PP, Scita G.

J Cell Biol. 2018 Sep 3;217(9):3161-3182. doi: 10.1083/jcb.201802023. Epub 2018 Jul 30.


Inhibition of Cyclin-Dependent Kinase 5: A Strategy to Improve Sorafenib Response in Hepatocellular Carcinoma Therapy.

Ardelt MA, Fröhlich T, Martini E, Müller M, Kanitz V, Atzberger C, Cantonati P, Meßner M, Posselt L, Lehr T, Wojtyniak JG, Ulrich M, Arnold GJ, König L, Parazzoli D, Zahler S, Rothenfußer S, Mayr D, Gerbes A, Scita G, Vollmar AM, Pachmayr J.

Hepatology. 2019 Jan;69(1):376-393. doi: 10.1002/hep.30190. Epub 2018 Dec 22.


Author Correction: A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.

Corallino S, Malinverno C, Neumann B, Tischer C, Palamidessi A, Frittoli E, Panagiotakopoulou M, Disanza A, Malet-Engra G, Nastaly P, Galli C, Luise C, Bertalot G, Pece S, Di Fiore PP, Gauthier N, Ferrari A, Maiuri P, Scita G.

Nat Commun. 2018 May 22;9(1):2085. doi: 10.1038/s41467-018-04515-y.


Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis.

Sathe M, Muthukrishnan G, Rae J, Disanza A, Thattai M, Scita G, Parton RG, Mayor S.

Nat Commun. 2018 May 9;9(1):1835. doi: 10.1038/s41467-018-03955-w.


From jamming to collective cell migration through a boundary induced transition.

Chepizhko O, Lionetti MC, Malinverno C, Giampietro C, Scita G, Zapperi S, La Porta CAM.

Soft Matter. 2018 May 16;14(19):3774-3782. doi: 10.1039/c8sm00128f.


Co-optation of Tandem DNA Repeats for the Maintenance of Mesenchymal Identity.

Balestrieri C, Alfarano G, Milan M, Tosi V, Prosperini E, Nicoli P, Palamidessi A, Scita G, Diaferia GR, Natoli G.

Cell. 2018 May 17;173(5):1150-1164.e14. doi: 10.1016/j.cell.2018.03.081. Epub 2018 Apr 26.


Flocking transitions in confluent tissues.

Giavazzi F, Paoluzzi M, Macchi M, Bi D, Scita G, Manning ML, Cerbino R, Marchetti MC.

Soft Matter. 2018 May 9;14(18):3471-3477. doi: 10.1039/c8sm00126j.


A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.

Corallino S, Malinverno C, Neumann B, Tischer C, Palamidessi A, Frittoli E, Panagiotakopoulou M, Disanza A, Malet-Engra G, Nastaly P, Galli C, Luise C, Bertalot G, Pece S, Di Fiore PP, Gauthier N, Ferrari A, Maiuri P, Scita G.

Nat Commun. 2018 Apr 16;9(1):1475. doi: 10.1038/s41467-018-03571-8. Erratum in: Nat Commun. 2018 May 22;9(1):2085.


The 'endocytic matrix reloaded' and its impact on the plasticity of migratory strategies.

Sigismund S, Scita G.

Curr Opin Cell Biol. 2018 Oct;54:9-17. doi: 10.1016/ Epub 2018 Mar 12. Review.


Modulation of RAB5A early endosome trafficking in response to KRas mediated macropinocytic fluxes in pancreatic cancer cells.

Teske C, Schweitzer C, Palamidessi A, Aust DE, Scita G, Weitz J, Welsch T.

Biochem Biophys Res Commun. 2017 Nov 4;493(1):528-533. doi: 10.1016/j.bbrc.2017.08.157. Epub 2017 Sep 1.


Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.

Gerboth S, Frittoli E, Palamidessi A, Baltanas FC, Salek M, Rappsilber J, Giuliani C, Troglio F, Rolland Y, Pruneri G, Kreutmair S, Pallavicini I, Zobel M, Cinquanta M, Minucci S, Gomez C, Santos E, Illert AL, Scita G.

Leukemia. 2018 Mar;32(3):820-827. doi: 10.1038/leu.2017.267. Epub 2017 Aug 18.


Understanding the human knee and its relationship to total knee replacement.

Vaienti E, Scita G, Ceccarelli F, Pogliacomi F.

Acta Biomed. 2017 Jun 7;88(2S):6-16. doi: 10.23750/abm.v88i2 -S.6507. Review.


Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch.

Tod J, Hanley CJ, Morgan MR, Rucka M, Mellows T, Lopez MA, Kiely P, Moutasim KA, Frampton SJ, Sabnis D, Fine DR, Johnson C, Marshall JF, Scita G, Jenei V, Thomas GJ.

J Pathol. 2017 Sep;243(1):37-50. doi: 10.1002/path.4923. Epub 2017 Aug 7.


Rab2 promotes autophagic and endocytic lysosomal degradation.

Lőrincz P, Tóth S, Benkő P, Lakatos Z, Boda A, Glatz G, Zobel M, Bisi S, Hegedűs K, Takáts S, Scita G, Juhász G.

J Cell Biol. 2017 Jul 3;216(7):1937-1947. doi: 10.1083/jcb.201611027. Epub 2017 May 8.


Endocytic reawakening of motility in jammed epithelia.

Malinverno C, Corallino S, Giavazzi F, Bergert M, Li Q, Leoni M, Disanza A, Frittoli E, Oldani A, Martini E, Lendenmann T, Deflorian G, Beznoussenko GV, Poulikakos D, Haur OK, Uroz M, Trepat X, Parazzoli D, Maiuri P, Yu W, Ferrari A, Cerbino R, Scita G.

Nat Mater. 2017 May;16(5):587-596. doi: 10.1038/nmat4848. Epub 2017 Jan 30.


Harnessing membrane trafficking to promote cancer spreading and invasion: The case of RAB2A.

Kajiho H, Kajiho Y, Scita G.

Small GTPases. 2018 Jul 4;9(4):304-309. doi: 10.1080/21541248.2016.1223990. Epub 2017 Jan 27. Review.


Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes.

Delage E, Cervantes DC, Pénard E, Schmitt C, Syan S, Disanza A, Scita G, Zurzolo C.

Sci Rep. 2016 Dec 23;6:39632. doi: 10.1038/srep39632.


SOS1, ARHGEF1, and DOCK2 rho-GEFs Mediate JAK-Dependent LFA-1 Activation by Chemokines.

Toffali L, Montresor A, Mirenda M, Scita G, Laudanna C.

J Immunol. 2017 Jan 15;198(2):708-717. doi: 10.4049/jimmunol.1600933. Epub 2016 Dec 16.


Bursts of activity in collective cell migration.

Chepizhko O, Giampietro C, Mastrapasqua E, Nourazar M, Ascagni M, Sugni M, Fascio U, Leggio L, Malinverno C, Scita G, Santucci S, Alava MJ, Zapperi S, La Porta CA.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11408-11413. Epub 2016 Sep 28.


Direct interaction between exocyst and Wave complexes promotes cell protrusions and motility.

Biondini M, Sadou-Dubourgnoux A, Paul-Gilloteaux P, Zago G, Arslanhan MD, Waharte F, Formstecher E, Hertzog M, Yu J, Guerois R, Gautreau A, Scita G, Camonis J, Parrini MC.

J Cell Sci. 2016 Oct 15;129(20):3756-3769. Epub 2016 Sep 2.


RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs.

Kajiho H, Kajiho Y, Frittoli E, Confalonieri S, Bertalot G, Viale G, Di Fiore PP, Oldani A, Garre M, Beznoussenko GV, Palamidessi A, Vecchi M, Chavrier P, Perez F, Scita G.

EMBO Rep. 2016 Jul;17(7):1061-80. doi: 10.15252/embr.201642032. Epub 2016 Jun 2.


Increasing both the public health potential of basic research and the scientist satisfaction. An international survey of bio-scientists.

Sorrentino C, Boggio A, Confalonieri S, Hemenway D, Scita G, Ballabeni A.

Version 2. F1000Res. 2016 Jan 12 [revised 2016 Jan 1];5:56. doi: 10.12688/f1000research.7683.2. eCollection 2016.


The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling.

Giampietro C, Disanza A, Bravi L, Barrios-Rodiles M, Corada M, Frittoli E, Savorani C, Lampugnani MG, Boggetti B, Niessen C, Wrana JL, Scita G, Dejana E.

J Cell Biol. 2015 Dec 21;211(6):1177-92. doi: 10.1083/jcb.201501089. Epub 2015 Dec 14.


Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells.

Cremaschi P, Oliverio M, Leva V, Bione S, Carriero R, Mazzucco G, Palamidessi A, Scita G, Biamonti G, Montecucco A.

PLoS One. 2015 Jul 7;10(7):e0130561. doi: 10.1371/journal.pone.0130561. eCollection 2015.


RABGTPases in MT1-MMP trafficking and cell invasion: Physiology versus pathology.

Linder S, Scita G.

Small GTPases. 2015;6(3):145-52. doi: 10.4161/21541248.2014.985484. Epub 2015 Jun 24.


Correction: eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF).

Menna E, Disanza A, Cagnoli C, Schenk U, Gelsomino G, Frittoli E, Hertzog M, Offenhauser N, Sawallisch C, Kreienkamp HJ, Gertler FB, Di Fiore PP, Scita G, Matteoli M.

PLoS Biol. 2015 Jun 3;13(6):e1002184. doi: 10.1371/journal.pbio.1002184. eCollection 2015 Jun. No abstract available.


Epithelial-to-Mesenchymal Plasticity Harnesses Endocytic Circuitries.

Corallino S, Malabarba MG, Zobel M, Di Fiore PP, Scita G.

Front Oncol. 2015 Feb 26;5:45. doi: 10.3389/fonc.2015.00045. eCollection 2015. Review.


Nuclear and cellular plasticity: nuclear RAC1 takes center stage.

Disanza A, Scita G.

Dev Cell. 2015 Feb 9;32(3):261-3. doi: 10.1016/j.devcel.2015.01.015.


Collective cell motility promotes chemotactic prowess and resistance to chemorepulsion.

Malet-Engra G, Yu W, Oldani A, Rey-Barroso J, Gov NS, Scita G, Dupré L.

Curr Biol. 2015 Jan 19;25(2):242-250. doi: 10.1016/j.cub.2014.11.030. Epub 2015 Jan 8.


The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination.

Rolland Y, Marighetti P, Malinverno C, Confalonieri S, Luise C, Ducano N, Palamidessi A, Bisi S, Kajiho H, Troglio F, Shcherbakova OG, Dunn AR, Oldani A, Lanzetti L, Di Fiore PP, Disanza A, Scita G.

Dev Cell. 2014 Sep 8;30(5):553-68. doi: 10.1016/j.devcel.2014.08.006.


ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress.

Kumar A, Mazzanti M, Mistrik M, Kosar M, Beznoussenko GV, Mironov AA, Garrè M, Parazzoli D, Shivashankar GV, Scita G, Bartek J, Foiani M.

Cell. 2014 Jul 31;158(3):633-46. doi: 10.1016/j.cell.2014.05.046.


A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination.

Frittoli E, Palamidessi A, Marighetti P, Confalonieri S, Bianchi F, Malinverno C, Mazzarol G, Viale G, Martin-Padura I, Garré M, Parazzoli D, Mattei V, Cortellino S, Bertalot G, Di Fiore PP, Scita G.

J Cell Biol. 2014 Jul 21;206(2):307-28. doi: 10.1083/jcb.201403127.


Strength recovery after proximal humeral fractures treated with locking plate.

Verdano MA, Baudi P, Pellegrini A, Lunini E, Aliani D, Scita G, Schiavi P, Costantino C, Ceccarelli F.

Musculoskelet Surg. 2014 Apr;98 Suppl 1:61-9. doi: 10.1007/s12306-014-0323-2. Epub 2014 Mar 23.


Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors.

Kast DJ, Yang C, Disanza A, Boczkowska M, Madasu Y, Scita G, Svitkina T, Dominguez R.

Nat Struct Mol Biol. 2014 Apr;21(4):413-22. doi: 10.1038/nsmb.2781. Epub 2014 Mar 2.


Osteolytic bone metastasis is hampered by impinging on the interplay among autophagy, anoikis and ossification.

Maroni P, Bendinelli P, Matteucci E, Locatelli A, Nakamura T, Scita G, Desiderio MA.

Cell Death Dis. 2014 Jan 16;5:e1005. doi: 10.1038/cddis.2013.465.


L-Proline induces a mesenchymal-like invasive program in embryonic stem cells by remodeling H3K9 and H3K36 methylation.

Comes S, Gagliardi M, Laprano N, Fico A, Cimmino A, Palamidessi A, De Cesare D, De Falco S, Angelini C, Scita G, Patriarca EJ, Matarazzo MR, Minchiotti G.

Stem Cell Reports. 2013 Oct 10;1(4):307-21. doi: 10.1016/j.stemcr.2013.09.001. eCollection 2013.


The GTPase-activating protein RN-tre controls focal adhesion turnover and cell migration.

Palamidessi A, Frittoli E, Ducano N, Offenhauser N, Sigismund S, Kajiho H, Parazzoli D, Oldani A, Gobbi M, Serini G, Di Fiore PP, Scita G, Lanzetti L.

Curr Biol. 2013 Dec 2;23(23):2355-64. doi: 10.1016/j.cub.2013.09.060. Epub 2013 Nov 14.


CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP.

Disanza A, Bisi S, Winterhoff M, Milanesi F, Ushakov DS, Kast D, Marighetti P, Romet-Lemonne G, Müller HM, Nickel W, Linkner J, Waterschoot D, Ampè C, Cortellino S, Palamidessi A, Dominguez R, Carlier MF, Faix J, Scita G.

EMBO J. 2013 Oct 16;32(20):2735-50. doi: 10.1038/emboj.2013.208. Epub 2013 Sep 27.


LIN7-IRSp53: A novel pathway for filopodia and neurite formation?

Ferrari I, Crespi A, Scita G, Pietrini G.

Commun Integr Biol. 2012 Nov 1;5(6):631-3. doi: 10.4161/cib.21686.


Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity.

Menna E, Zambetti S, Morini R, Donzelli A, Disanza A, Calvigioni D, Braida D, Nicolini C, Orlando M, Fossati G, Cristina Regondi M, Pattini L, Frassoni C, Francolini M, Scita G, Sala M, Fahnestock M, Matteoli M.

EMBO J. 2013 Jun 12;32(12):1730-44. doi: 10.1038/emboj.2013.107. Epub 2013 May 17.


CIP4 controls CCL19-driven cell steering and chemotaxis in chronic lymphocytic leukemia.

Malet-Engra G, Viaud J, Ysebaert L, Farcé M, Lafouresse F, Laurent G, Gaits-Iacovoni F, Scita G, Dupré L.

Cancer Res. 2013 Jun 1;73(11):3412-24. doi: 10.1158/0008-5472.CAN-12-3564. Epub 2013 May 3.


Membrane and actin dynamics interplay at lamellipodia leading edge.

Bisi S, Disanza A, Malinverno C, Frittoli E, Palamidessi A, Scita G.

Curr Opin Cell Biol. 2013 Oct;25(5):565-73. doi: 10.1016/ Epub 2013 Apr 29. Review.


Arthroscopic treatment for cuff tear: strength recovery at 12 months of follow-up.

Verdano MA, Pellegrini A, Scita G, Costantino C, Ceccarelli F.

Musculoskelet Surg. 2013 Apr;97(1):51-6. doi: 10.1007/s12306-013-0241-8. Epub 2013 Jan 29.


SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression.

Werner A, Disanza A, Reifenberger N, Habeck G, Becker J, Calabrese M, Urlaub H, Lorenz H, Schulman B, Scita G, Melchior F.

Nat Cell Biol. 2013 Feb;15(2):179-88. doi: 10.1038/ncb2661. Epub 2013 Jan 13.


The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.

Wiedmann RM, von Schwarzenberg K, Palamidessi A, Schreiner L, Kubisch R, Liebl J, Schempp C, Trauner D, Vereb G, Zahler S, Wagner E, Müller R, Scita G, Vollmar AM.

Cancer Res. 2012 Nov 15;72(22):5976-87. doi: 10.1158/0008-5472.CAN-12-1772. Epub 2012 Sep 17.

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