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The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function.

Ramirez GA, Coletto LA, Bozzolo EP, Citterio L, Delli Carpini S, Zagato L, Rovere-Querini P, Lanzani C, Manunta P, Manfredi AA, Sciorati C.

J Neuroimmunol. 2018 Dec 15;325:43-53. doi: 10.1016/j.jneuroim.2018.10.010. Epub 2018 Oct 23.


Ion Channels and Transporters in Inflammation: Special Focus on TRP Channels and TRPC6.

Ramirez GA, Coletto LA, Sciorati C, Bozzolo EP, Manunta P, Rovere-Querini P, Manfredi AA.

Cells. 2018 Jul 4;7(7). pii: E70. doi: 10.3390/cells7070070. Review.


Exacerbation of Murine Experimental Autoimmune Myositis by Toll-Like Receptor 7/8.

Sciorati C, Monno A, Doglio MG, Rigamonti E, Ascherman DP, Manfredi AA, Rovere-Querini P.

Arthritis Rheumatol. 2018 Aug;70(8):1276-1287. doi: 10.1002/art.40503. Epub 2018 Jun 27.


A CD8α- Subset of CD4+SLAMF7+ Cytotoxic T Cells Is Expanded in Patients With IgG4-Related Disease and Decreases Following Glucocorticoid Treatment.

Della-Torre E, Bozzalla-Cassione E, Sciorati C, Ruggiero E, Lanzillotta M, Bonfiglio S, Mattoo H, Perugino CA, Bozzolo E, Rovati L, Arcidiacono PG, Balzano G, Lazarevic D, Bonini C, Falconi M, Stone JH, Dagna L, Pillai S, Manfredi AA.

Arthritis Rheumatol. 2018 Jul;70(7):1133-1143. doi: 10.1002/art.40469. Epub 2018 May 20.


The clearance of cell remnants and the regeneration of the injured muscle depend on soluble pattern recognition receptor PTX3.

Vezzoli M, Sciorati C, Campana L, Monno A, Doglio MG, Rigamonti E, Corna G, Touvier T, Castiglioni A, Capobianco A, Mantovani A, Manfredi AA, Garlanda C, Rovere-Querini P.

Mol Med. 2017 Jan;22:809-820. doi: 10.2119/molmed.2016.00002. Epub 2016 Nov 23.


Cell death, clearance and immunity in the skeletal muscle.

Sciorati C, Rigamonti E, Manfredi AA, Rovere-Querini P.

Cell Death Differ. 2016 Jun;23(6):927-37. doi: 10.1038/cdd.2015.171. Epub 2016 Feb 12. Review.


Plasma levels of M-CSF are increased in ANCA-associated vasculitides with active nephritis.

Ramirez GA, Blasi M, Sciorati C, Rovere-Querini P, Manfredi AA.

Results Immunol. 2015 Oct 21;5:33-6. doi: 10.1016/j.rinim.2015.10.002. eCollection 2015.


Naproxcinod shows significant advantages over naproxen in the mdx model of Duchenne Muscular Dystrophy.

Miglietta D, De Palma C, Sciorati C, Vergani B, Pisa V, Villa A, Ongini E, Clementi E.

Orphanet J Rare Dis. 2015 Aug 22;10:101. doi: 10.1186/s13023-015-0311-0.


Fat deposition and accumulation in the damaged and inflamed skeletal muscle: cellular and molecular players.

Sciorati C, Clementi E, Manfredi AA, Rovere-Querini P.

Cell Mol Life Sci. 2015 Jun;72(11):2135-56. doi: 10.1007/s00018-015-1857-7. Epub 2015 Feb 18. Review.


Required role of apoptotic myogenic precursors and toll-like receptor stimulation for the establishment of autoimmune myositis in experimental murine models.

Sciorati C, Monno A, Ascherman DP, Seletti E, Manfredi AA, Rovere-Querini P.

Arthritis Rheumatol. 2015 Mar;67(3):809-22. doi: 10.1002/art.38985.


7-Tesla magnetic resonance imaging precisely and noninvasively reflects inflammation and remodeling of the skeletal muscle in a mouse model of antisynthetase syndrome.

Sciorati C, Esposito A, Campana L, Canu T, Monno A, Palmisano A, De Cobelli F, Del Maschio A, Ascheman DP, Manfredi AA, Rovere-Querini P.

Biomed Res Int. 2014;2014:879703. doi: 10.1155/2014/879703. Epub 2014 May 5.


Macrophage plasticity in skeletal muscle repair.

Rigamonti E, Zordan P, Sciorati C, Rovere-Querini P, Brunelli S.

Biomed Res Int. 2014;2014:560629. doi: 10.1155/2014/560629. Epub 2014 Apr 17. Review.


Nitric oxide controls fat deposition in dystrophic skeletal muscle by regulating fibro-adipogenic precursor differentiation.

Cordani N, Pisa V, Pozzi L, Sciorati C, Clementi E.

Stem Cells. 2014 Apr;32(4):874-85. doi: 10.1002/stem.1587. Erratum in: Stem Cells. 2018 May;36(5):810.


The nitric oxide-donor molsidomine modulates the innate inflammatory response in a mouse model of muscular dystrophy.

Zordan P, Sciorati C, Campana L, Cottone L, Clementi E, Querini PR, Brunelli S.

Eur J Pharmacol. 2013 Sep 5;715(1-3):296-303. doi: 10.1016/j.ejphar.2013.05.007. Epub 2013 May 23.


Ibuprofen plus isosorbide dinitrate treatment in the mdx mice ameliorates dystrophic heart structure.

Sciorati C, Staszewsky L, Zambelli V, Russo I, Salio M, Novelli D, Di Grigoli G, Moresco RM, Clementi E, Latini R.

Pharmacol Res. 2013 Jul;73:35-43. doi: 10.1016/j.phrs.2013.04.009. Epub 2013 May 1.


Nitric oxide donor and non steroidal anti inflammatory drugs as a therapy for muscular dystrophies: evidence from a safety study with pilot efficacy measures in adult dystrophic patients.

D'Angelo MG, Gandossini S, Martinelli Boneschi F, Sciorati C, Bonato S, Brighina E, Comi GP, Turconi AC, Magri F, Stefanoni G, Brunelli S, Bresolin N, Cattaneo D, Clementi E.

Pharmacol Res. 2012 Apr;65(4):472-9. doi: 10.1016/j.phrs.2012.01.006. Epub 2012 Jan 25.


Nitric oxide sustains long-term skeletal muscle regeneration by regulating fate of satellite cells via signaling pathways requiring Vangl2 and cyclic GMP.

Buono R, Vantaggiato C, Pisa V, Azzoni E, Bassi MT, Brunelli S, Sciorati C, Clementi E.

Stem Cells. 2012 Feb;30(2):197-209. doi: 10.1002/stem.783.


Ozonated autohemotherapy: protection of kidneys from ischemia in rats subjected to unilateral nephrectomy.

Foglieni C, Fulgenzi A, Belloni D, Sciorati C, Ferrero E, Ferrero ME.

BMC Nephrol. 2011 Nov 14;12:61. doi: 10.1186/1471-2369-12-61.


A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy.

Sciorati C, Miglietta D, Buono R, Pisa V, Cattaneo D, Azzoni E, Brunelli S, Clementi E.

Pharmacol Res. 2011 Sep;64(3):210-7. doi: 10.1016/j.phrs.2011.05.003. Epub 2011 May 12.


Peroxynitrite-An ugly biofactor?

Ascenzi P, di Masi A, Sciorati C, Clementi E.

Biofactors. 2010 Jul-Aug;36(4):264-73. doi: 10.1002/biof.103. Review.


Co-administration of ibuprofen and nitric oxide is an effective experimental therapy for muscular dystrophy, with immediate applicability to humans.

Sciorati C, Buono R, Azzoni E, Casati S, Ciuffreda P, D'Angelo G, Cattaneo D, Brunelli S, Clementi E.

Br J Pharmacol. 2010 Jul;160(6):1550-60. doi: 10.1111/j.1476-5381.2010.00809.x.


Necdin is expressed in cachectic skeletal muscle to protect fibers from tumor-induced wasting.

Sciorati C, Touvier T, Buono R, Pessina P, François S, Perrotta C, Meneveri R, Clementi E, Brunelli S.

J Cell Sci. 2009 Apr 15;122(Pt 8):1119-25. doi: 10.1242/jcs.041665.


Binding of sFRP-3 to EGF in the extra-cellular space affects proliferation, differentiation and morphogenetic events regulated by the two molecules.

Scardigli R, Gargioli C, Tosoni D, Borello U, Sampaolesi M, Sciorati C, Cannata S, Clementi E, Brunelli S, Cossu G.

PLoS One. 2008 Jun 18;3(6):e2471. doi: 10.1371/journal.pone.0002471.


Necdin mediates skeletal muscle regeneration by promoting myoblast survival and differentiation.

Deponti D, François S, Baesso S, Sciorati C, Innocenzi A, Broccoli V, Muscatelli F, Meneveri R, Clementi E, Cossu G, Brunelli S.

J Cell Biol. 2007 Oct 22;179(2):305-19.


Nitric oxide release combined with nonsteroidal antiinflammatory activity prevents muscular dystrophy pathology and enhances stem cell therapy.

Brunelli S, Sciorati C, D'Antona G, Innocenzi A, Covarello D, Galvez BG, Perrotta C, Monopoli A, Sanvito F, Bottinelli R, Ongini E, Cossu G, Clementi E.

Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):264-9. Epub 2006 Dec 20.


Ex vivo treatment with nitric oxide increases mesoangioblast therapeutic efficacy in muscular dystrophy.

Sciorati C, Galvez BG, Brunelli S, Tagliafico E, Ferrari S, Cossu G, Clementi E.

J Cell Sci. 2006 Dec 15;119(Pt 24):5114-23.


Nitric oxide: emerging concepts about its use in cell-based therapies.

Brunelli S, Rovere-Querini P, Sciorati C, Manfredi AA, Clementi E.

Expert Opin Investig Drugs. 2007 Jan;16(1):33-43. Review.


Protective effect of EDTA preadministration on renal ischemia.

Foglieni C, Fulgenzi A, Ticozzi P, Pellegatta F, Sciorati C, Belloni D, Ferrero E, Ferrero ME.

BMC Nephrol. 2006 Mar 15;7:5.


MICA expressed by multiple myeloma and monoclonal gammopathy of undetermined significance plasma cells Costimulates pamidronate-activated gammadelta lymphocytes.

Girlanda S, Fortis C, Belloni D, Ferrero E, Ticozzi P, Sciorati C, Tresoldi M, Vicari A, Spies T, Groh V, Caligaris-Cappio F, Ferrarini M.

Cancer Res. 2005 Aug 15;65(16):7502-8.


Nitric oxide, ceramide and sphingomyelinase-coupled receptors: a tale of enzymes and messengers coordinating cell death, survival and differentiation.

Perrotta C, De Palma C, Falcone S, Sciorati C, Clementi E.

Life Sci. 2005 Aug 19;77(14):1732-9. Review.


Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway: key events in Escherichia coli-elicited apoptosis of dendritic cells.

Falcone S, Perrotta C, De Palma C, Pisconti A, Sciorati C, Capobianco A, Rovere-Querini P, Manfredi AA, Clementi E.

J Immunol. 2004 Oct 1;173(7):4452-63.


Nitric oxide confers therapeutic activity to dendritic cells in a mouse model of melanoma.

Perrotta C, Falcone S, Capobianco A, Camporeale A, Sciorati C, De Palma C, Pisconti A, Rovere-Querini P, Bellone M, Manfredi AA, Clementi E.

Cancer Res. 2004 Jun 1;64(11):3767-71.


Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide.

Nisoli E, Clementi E, Paolucci C, Cozzi V, Tonello C, Sciorati C, Bracale R, Valerio A, Francolini M, Moncada S, Carruba MO.

Science. 2003 Feb 7;299(5608):896-9.


Nitric oxide regulates oestrogen-activated signalling pathways at multiple levels through cyclic GMP-dependent recruitment of insulin receptor substrate 1.

Falcone S, Mauro L, de Rose G, Paolucci C, Sciorati C, Ando S, Clementi E.

Biochem J. 2002 Aug 15;366(Pt 1):165-73.


Flow cytometric analysis of inflammatory cells in ischemic rat brain.

Campanella M, Sciorati C, Tarozzo G, Beltramo M.

Stroke. 2002 Feb;33(2):586-92.


Inhibition of caspases maintains the antineoplastic function of gammadelta T cells repeatedly challenged with lymphoma cells.

Ferrarini M, Consogno G, Rovere P, Sciorati C, Dagna L, Resta D, Rugarli C, Manfredi AA.

Cancer Res. 2001 Apr 1;61(7):3092-5.


Human IgM anti-GM1 autoantibodies modulate intracellular calcium homeostasis in neuroblastoma cells.

Quattrini A, Lorenzetti I, Sciorati C, Corbo M, Previtali SC, Feltri ML, Canal N, Wrabetz L, Nemni R, Clementi E.

J Neuroimmunol. 2001 Mar 1;114(1-2):213-9.


Products of the phospholipase A(2) pathway mediate the dihydrorhodamine fluorescence response evoked by endogenous and exogenous peroxynitrite in PC12 cells.

Palomba L, Sestili P, Guidarelli A, Sciorati C, Clementi E, Fiorani M, Cantoni O.

Free Radic Biol Med. 2000 Oct 15;29(8):783-9.


The p75 receptor: first insights into the transduction mechanisms leading to either cell death or survival.

Meldolesi J, Sciorati C, Clementi E.

Trends Pharmacol Sci. 2000 Jul;21(7):242-3. Review. No abstract available.


Wild-type huntingtin protects from apoptosis upstream of caspase-3.

Rigamonti D, Bauer JH, De-Fraja C, Conti L, Sipione S, Sciorati C, Clementi E, Hackam A, Hayden MR, Li Y, Cooper JK, Ross CA, Govoni S, Vincenz C, Cattaneo E.

J Neurosci. 2000 May 15;20(10):3705-13.


Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide.

De Nadai C, Sestili P, Cantoni O, Lièvremont JP, Sciorati C, Barsacchi R, Moncada S, Meldolesi J, Clementi E.

Proc Natl Acad Sci U S A. 2000 May 9;97(10):5480-5.


Generation of nitric oxide by the inducible nitric oxide synthase protects gamma delta T cells from Mycobacterium tuberculosis-induced apoptosis.

Sciorati C, Rovere P, Ferrarini M, Paolucci C, Heltai S, Vaiani R, Clementi E, Manfredi AA.

J Immunol. 1999 Aug 1;163(3):1570-6.


The p75(NTR)-induced apoptotic program develops through a ceramide-caspase pathway negatively regulated by nitric oxide.

Lièvremont JP, Sciorati C, Morandi E, Paolucci C, Bunone G, Della Valle G, Meldolesi J, Clementi E.

J Biol Chem. 1999 May 28;274(22):15466-72.


Blockade of the Fas-triggered intracellular signaling pathway in human melanomas is circumvented by cytotoxic lymphocytes.

Ferrarini M, Imro MA, Sciorati C, Heltai S, Protti MP, Pellicciari C, Rovere P, Manfredi AA, Rugarli C.

Int J Cancer. 1999 May 17;81(4):573-9.


The mechanism of the nitric oxide-mediated enhancement of tert-butylhydroperoxide-induced DNA single strand breakage.

Guidarelli A, Clementi E, Sciorati C, Cantoni O.

Br J Pharmacol. 1998 Nov;125(5):1074-80.


Effects of nitric oxide on proliferation and differentiation of rat brown adipocytes in primary cultures.

Nisoli E, Clementi E, Tonello C, Sciorati C, Briscini L, Carruba MO.

Br J Pharmacol. 1998 Oct;125(4):888-94.

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