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Items: 1 to 50 of 56

1.

Human Adipose-Derived Mesenchymal Stem Cells Modify Lung Immunity and Improve Antibacterial Defense in Pneumosepsis Caused by Klebsiella pneumoniae.

Perlee D, de Vos AF, Scicluna BP, Mancheño P, de la Rosa O, Dalemans W, Nürnberg P, Lombardo E, van der Poll T.

Stem Cells Transl Med. 2019 Apr 29. doi: 10.1002/sctm.18-0260. [Epub ahead of print]

2.

Understanding Heterogeneity in Biological Phenotypes of ARDS by Leukocyte Expression Profiles.

Bos LD, Scicluna BP, Ong DSY, Cremer OL, van der Poll T, Schultz MJ; MARS consortium .

Am J Respir Crit Care Med. 2019 Jan 15. doi: 10.1164/rccm.201809-1808OC. [Epub ahead of print]

PMID:
30645145
3.

The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions.

Hsiao CC, Chu TY, Wu CJ, van den Biggelaar M, Pabst C, Hébert J, Kuijpers TW, Scicluna BP, I KY, Chen TC, Liebscher I, Hamann J, Lin HH.

Front Immunol. 2018 Dec 3;9:2830. doi: 10.3389/fimmu.2018.02830. eCollection 2018.

4.

The Search for Efficacious New Therapies in Sepsis Needs to Embrace Heterogeneity.

Scicluna BP, Baillie JK.

Am J Respir Crit Care Med. 2019 Apr 15;199(8):936-938. doi: 10.1164/rccm.201811-2148ED. No abstract available.

5.

Kinase activity is impaired in neutrophils of sepsis patients.

Hoogendijk AJ, van Vught LA, Wiewel MA, Fuhler GM, Belkasim-Bohoudi H, Horn J, Schultz MJ, Scicluna BP, Peppelenbosch MP, van 't Veer C, de Vos AF, van der Poll T.

Haematologica. 2019 Jun;104(6):e233-e235. doi: 10.3324/haematol.2018.201913. Epub 2018 Dec 4. No abstract available.

6.

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.

Domínguez-Andrés J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, Arts RJW, Oosting M, Moorlag SJCFM, Groh LA, Zwaag J, Koch RM, Ter Horst R, Joosten LAB, Wijmenga C, Michelucci A, van der Poll T, Kox M, Pickkers P, Kumar V, Stunnenberg H, Netea MG.

Cell Metab. 2019 Jan 8;29(1):211-220.e5. doi: 10.1016/j.cmet.2018.09.003. Epub 2018 Oct 4.

PMID:
30293776
7.

Classification of patients with septic shock: Are we there yet?

Wittebole X, Scicluna BP.

J Crit Care. 2018 Oct;47:320-321. doi: 10.1016/j.jcrc.2018.07.026. Epub 2018 Jul 27. No abstract available.

PMID:
30107978
8.

Intravenous Infusion of Human Adipose Mesenchymal Stem Cells Modifies the Host Response to Lipopolysaccharide in Humans: A Randomized, Single-Blind, Parallel Group, Placebo Controlled Trial.

Perlee D, van Vught LA, Scicluna BP, Maag A, Lutter R, Kemper EM, van 't Veer C, Punchard MA, González J, Richard MP, Dalemans W, Lombardo E, de Vos AF, van der Poll T.

Stem Cells. 2018 Nov;36(11):1778-1788. doi: 10.1002/stem.2891. Epub 2018 Aug 20.

PMID:
30063804
9.

Validation of a Host Response Assay, SeptiCyte LAB, for Discriminating Sepsis from Systemic Inflammatory Response Syndrome in the ICU.

Miller RR 3rd, Lopansri BK, Burke JP, Levy M, Opal S, Rothman RE, D'Alessio FR, Sidhaye VK, Aggarwal NR, Balk R, Greenberg JA, Yoder M, Patel G, Gilbert E, Afshar M, Parada JP, Martin GS, Esper AM, Kempker JA, Narasimhan M, Tsegaye A, Hahn S, Mayo P, van der Poll T, Schultz MJ, Scicluna BP, Klein Klouwenberg P, Rapisarda A, Seldon TA, McHugh LC, Yager TD, Cermelli S, Sampson D, Rothwell V, Newman R, Bhide S, Fox BA, Kirk JT, Navalkar K, Davis RF, Brandon RA, Brandon RB.

Am J Respir Crit Care Med. 2018 Oct 1;198(7):903-913. doi: 10.1164/rccm.201712-2472OC.

PMID:
29624409
10.

Validation of a Novel Molecular Host Response Assay to Diagnose Infection in Hospitalized Patients Admitted to the ICU With Acute Respiratory Failure.

Koster-Brouwer ME, Verboom DM, Scicluna BP, van de Groep K, Frencken JF, Janssen D, Schuurman R, Schultz MJ, van der Poll T, Bonten MJM, Cremer OL; MARS Consortium.

Crit Care Med. 2018 Mar;46(3):368-374. doi: 10.1097/CCM.0000000000002735.

PMID:
29474322
11.

The host response in critically ill sepsis patients on statin therapy: a prospective observational study.

Wiewel MA, Scicluna BP, van Vught LA, Hoogendijk AJ, Zwinderman AH, Lutter R, Horn J, Cremer OL, Bonten MJ, Schultz MJ, van der Poll T.

Ann Intensive Care. 2018 Jan 18;8(1):9. doi: 10.1186/s13613-017-0349-3.

12.

Are histones real pathogenic agents in sepsis?

van der Poll T, van de Veerdonk FL, Scicluna BP, Netea MG.

Nat Rev Immunol. 2018 Feb;18(2):148. doi: 10.1038/nri.2017.157. Epub 2017 Dec 27. No abstract available.

PMID:
29279614
13.

Biomarkers in Sepsis.

van Engelen TSR, Wiersinga WJ, Scicluna BP, van der Poll T.

Crit Care Clin. 2018 Jan;34(1):139-152. doi: 10.1016/j.ccc.2017.08.010. Epub 2017 Oct 12. Review.

PMID:
29149935
14.

Molecular Biomarker to Assist in Diagnosing Abdominal Sepsis upon ICU Admission.

Scicluna BP, Wiewel MA, van Vught LA, Hoogendijk AJ, Klarenbeek AM, Franitza M, Toliat MR, Nürnberg P, Horn J, Bonten MJ, Schultz MJ, Cremer OL, van der Poll T.

Am J Respir Crit Care Med. 2018 Apr 15;197(8):1070-1073. doi: 10.1164/rccm.201707-1339LE. No abstract available.

PMID:
28972859
15.

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.

Scicluna BP, van Vught LA, Zwinderman AH, Wiewel MA, Davenport EE, Burnham KL, Nürnberg P, Schultz MJ, Horn J, Cremer OL, Bonten MJ, Hinds CJ, Wong HR, Knight JC, van der Poll T; MARS consortium.

Lancet Respir Med. 2017 Oct;5(10):816-826. doi: 10.1016/S2213-2600(17)30294-1. Epub 2017 Aug 29.

PMID:
28864056
16.

Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment.

Mills JD, Iyer AM, van Scheppingen J, Bongaarts A, Anink JJ, Janssen B, Zimmer TS, Spliet WG, van Rijen PC, Jansen FE, Feucht M, Hainfellner JA, Krsek P, Zamecnik J, Kotulska K, Jozwiak S, Jansen A, Lagae L, Curatolo P, Kwiatkowski DJ, Pasterkamp RJ, Senthilkumar K, von Oerthel L, Hoekman MF, Gorter JA, Crino PB, Mühlebner A, Scicluna BP, Aronica E.

Sci Rep. 2017 Aug 14;7(1):8089. doi: 10.1038/s41598-017-06145-8.

17.

Association of Gender With Outcome and Host Response in Critically Ill Sepsis Patients.

van Vught LA, Scicluna BP, Wiewel MA, Hoogendijk AJ, Klein Klouwenberg PMC, Ong DSY, Cremer OL, Horn J, Franitza M, Toliat MR, Nürnberg P, Bonten MMJ, Schultz MJ, van der Poll T; MARS Consortium.

Crit Care Med. 2017 Nov;45(11):1854-1862. doi: 10.1097/CCM.0000000000002649.

PMID:
28806220
18.

The immunopathology of sepsis and potential therapeutic targets.

van der Poll T, van de Veerdonk FL, Scicluna BP, Netea MG.

Nat Rev Immunol. 2017 Jul;17(7):407-420. doi: 10.1038/nri.2017.36. Epub 2017 Apr 24. Review.

PMID:
28436424
19.

The gut microbiota as a modulator of innate immunity during melioidosis.

Lankelma JM, Birnie E, Weehuizen TAF, Scicluna BP, Belzer C, Houtkooper RH, Roelofs JJTH, de Vos AF, van der Poll T, Budding AE, Wiersinga WJ.

PLoS Negl Trop Dis. 2017 Apr 19;11(4):e0005548. doi: 10.1371/journal.pntd.0005548. eCollection 2017 Apr.

20.

Turning a New Page in Sepsis Molecular Diagnostics Necessitates Context-Specific Biomarkers.

Scicluna BP, van der Poll T.

Crit Care Med. 2017 Apr;45(4):e457. doi: 10.1097/CCM.0000000000002214. No abstract available.

PMID:
28291106
21.

Sepsis Patients Display a Reduced Capacity to Activate Nuclear Factor-κB in Multiple Cell Types.

Hoogendijk AJ, Garcia-Laorden MI, van Vught LA, Wiewel MA, Belkasim-Bohoudi H, Duitman J, Horn J, Schultz MJ, Scicluna BP, van 't Veer C, de Vos AF, van der Poll T.

Crit Care Med. 2017 May;45(5):e524-e531. doi: 10.1097/CCM.0000000000002294.

PMID:
28240686
22.

The Host Response in Patients with Sepsis Developing Intensive Care Unit-acquired Secondary Infections.

van Vught LA, Wiewel MA, Hoogendijk AJ, Frencken JF, Scicluna BP, Klein Klouwenberg PMC, Zwinderman AH, Lutter R, Horn J, Schultz MJ, Bonten MMJ, Cremer OL, van der Poll T.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):458-470. doi: 10.1164/rccm.201606-1225OC.

PMID:
28107024
23.

Prior Use of Calcium Channel Blockers Is Associated With Decreased Mortality in Critically Ill Patients With Sepsis: A Prospective Observational Study.

Wiewel MA, van Vught LA, Scicluna BP, Hoogendijk AJ, Frencken JF, Zwinderman AH, Horn J, Cremer OL, Bonten MJ, Schultz MJ, van der Poll T; Molecular Diagnosis and Risk Stratification of Sepsis (MARS) Consortium.

Crit Care Med. 2017 Mar;45(3):454-463. doi: 10.1097/CCM.0000000000002236.

PMID:
28079604
24.

Risk factors, host response and outcome of hypothermic sepsis.

Wiewel MA, Harmon MB, van Vught LA, Scicluna BP, Hoogendijk AJ, Horn J, Zwinderman AH, Cremer OL, Bonten MJ, Schultz MJ, van der Poll T, Juffermans NP, Wiersinga WJ.

Crit Care. 2016 Oct 14;20(1):328.

25.

Association of diabetes and diabetes treatment with the host response in critically ill sepsis patients.

van Vught LA, Scicluna BP, Hoogendijk AJ, Wiewel MA, Klein Klouwenberg PM, Cremer OL, Horn J, Nürnberg P, Bonten MM, Schultz MJ, van der Poll T.

Crit Care. 2016 Aug 6;20(1):252. doi: 10.1186/s13054-016-1429-8.

26.

Comparative Analysis of the Host Response to Community-acquired and Hospital-acquired Pneumonia in Critically Ill Patients.

van Vught LA, Scicluna BP, Wiewel MA, Hoogendijk AJ, Klein Klouwenberg PM, Franitza M, Toliat MR, Nürnberg P, Cremer OL, Horn J, Schultz MJ, Bonten MM, van der Poll T.

Am J Respir Crit Care Med. 2016 Dec 1;194(11):1366-1374.

PMID:
27267747
27.

Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis.

van Vught LA, Klein Klouwenberg PM, Spitoni C, Scicluna BP, Wiewel MA, Horn J, Schultz MJ, Nürnberg P, Bonten MJ, Cremer OL, van der Poll T; MARS Consortium.

JAMA. 2016 Apr 12;315(14):1469-79. doi: 10.1001/jama.2016.2691.

PMID:
26975785
28.

Admission Hyperglycemia in Critically Ill Sepsis Patients: Association With Outcome and Host Response.

van Vught LA, Wiewel MA, Klein Klouwenberg PM, Hoogendijk AJ, Scicluna BP, Ong DS, Cremer OL, Horn J, Bonten MM, Schultz MJ, van der Poll T; Molecular Diagnosis and Risk Stratification of Sepsis Consortium.

Crit Care Med. 2016 Jul;44(7):1338-46. doi: 10.1097/CCM.0000000000001650.

PMID:
26958752
29.

Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients.

Claushuis TA, van Vught LA, Scicluna BP, Wiewel MA, Klein Klouwenberg PM, Hoogendijk AJ, Ong DS, Cremer OL, Horn J, Franitza M, Toliat MR, Nürnberg P, Zwinderman AH, Bonten MJ, Schultz MJ, van der Poll T; Molecular Diagnosis and Risk Stratification of Sepsis Consortium.

Blood. 2016 Jun 16;127(24):3062-72. doi: 10.1182/blood-2015-11-680744. Epub 2016 Mar 8.

30.

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis.

Cheng SC, Scicluna BP, Arts RJ, Gresnigt MS, Lachmandas E, Giamarellos-Bourboulis EJ, Kox M, Manjeri GR, Wagenaars JA, Cremer OL, Leentjens J, van der Meer AJ, van de Veerdonk FL, Bonten MJ, Schultz MJ, Willems PH, Pickkers P, Joosten LA, van der Poll T, Netea MG.

Nat Immunol. 2016 Apr;17(4):406-13. doi: 10.1038/ni.3398. Epub 2016 Mar 7.

PMID:
26950237
31.

The Impact of HIV Co-Infection on the Genomic Response to Sepsis.

Huson MA, Scicluna BP, van Vught LA, Wiewel MA, Hoogendijk AJ, Cremer OL, Bonten MJ, Schultz MJ, Franitza M, Toliat MR, Nürnberg P, Grobusch MP, van der Poll T.

PLoS One. 2016 Feb 12;11(2):e0148955. doi: 10.1371/journal.pone.0148955. eCollection 2016.

32.

Reply: FAIM3:PLAC8 Ratio Compared with Existing Biomarkers for Diagnosis of Severe Community-acquired Pneumonia: Comparing Apples to Oranges?

Scicluna BP, van Vught LA, van der Poll T, Klein Klouwenberg PM, Cremer OL.

Am J Respir Crit Care Med. 2016 Jan 1;193(1):102-3. doi: 10.1164/rccm.201509-1752LE. No abstract available.

PMID:
26720792
33.

Plasma fractalkine is a sustained marker of disease severity and outcome in sepsis patients.

Hoogendijk AJ, Wiewel MA, van Vught LA, Scicluna BP, Belkasim-Bohoudi H, Horn J, Zwinderman AH, Klein Klouwenberg PM, Cremer OL, Bonten MJ, Schultz MJ, van der Poll T; MARS consortium.

Crit Care. 2015 Nov 25;19:412. doi: 10.1186/s13054-015-1125-0.

34.

Reply: Comprehensive Validation of the FAIM3:PLAC8 Ratio in Time-matched Public Gene Expression Data.

Scicluna BP, Klein Klouwenberg PM, van der Poll T; all the authors.

Am J Respir Crit Care Med. 2015 Nov 15;192(10):1261-2. doi: 10.1164/rccm.201508-1552LE. No abstract available.

PMID:
26568248
35.

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia.

Schuijt TJ, Lankelma JM, Scicluna BP, de Sousa e Melo F, Roelofs JJ, de Boer JD, Hoogendijk AJ, de Beer R, de Vos A, Belzer C, de Vos WM, van der Poll T, Wiersinga WJ.

Gut. 2016 Apr;65(4):575-83. doi: 10.1136/gutjnl-2015-309728. Epub 2015 Oct 28.

36.

Chemokine ligand 9 modulates cardiac repolarization via Cxcr3 receptor binding.

Scicluna BP, Remme CA, Rivaud M, Wilde AA, Bezzina CR, Verkerk AO.

Int J Cardiol. 2015 Dec 15;201:49-52. doi: 10.1016/j.ijcard.2015.07.096. Epub 2015 Jul 31. No abstract available.

PMID:
26288327
37.

A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission.

Scicluna BP, Klein Klouwenberg PM, van Vught LA, Wiewel MA, Ong DS, Zwinderman AH, Franitza M, Toliat MR, Nürnberg P, Hoogendijk AJ, Horn J, Cremer OL, Schultz MJ, Bonten MJ, van der Poll T.

Am J Respir Crit Care Med. 2015 Oct 1;192(7):826-35. doi: 10.1164/rccm.201502-0355OC.

PMID:
26121490
38.

Modular Transcriptional Networks of the Host Pulmonary Response during Early and Late Pneumococcal Pneumonia.

Scicluna BP, van Lieshout MH, Blok DC, Florquin S, van der Poll T.

Mol Med. 2015 May 12;21:430-41. doi: 10.2119/molmed.2014.00263.

39.

The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans.

van der Meer AJ, Scicluna BP, Moerland PD, Lin J, Jacobson EW, Vlasuk GP, van der Poll T.

Crit Care Med. 2015 Jun;43(6):e199-202. doi: 10.1097/CCM.0000000000000949.

PMID:
25978169
40.

Reduced Responsiveness of Blood Leukocytes to Lipopolysaccharide Does not Predict Nosocomial Infections in Critically Ill Patients.

van Vught LA, Wiewel MA, Hoogendijk AJ, Scicluna BP, Belkasim-Bohoudi H, Horn J, Schultz MJ, van der Poll T.

Shock. 2015 Aug;44(2):110-4. doi: 10.1097/SHK.0000000000000391.

PMID:
25895151
41.

IFN-γ priming of macrophages represses a part of the inflammatory program and attenuates neutrophil recruitment.

Hoeksema MA, Scicluna BP, Boshuizen MC, van der Velden S, Neele AE, Van den Bossche J, Matlung HL, van den Berg TK, Goossens P, de Winther MP.

J Immunol. 2015 Apr 15;194(8):3909-16. doi: 10.4049/jimmunol.1402077. Epub 2015 Mar 6.

42.

Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition.

Lodder EM, Scicluna BP, Beekman L, Arends D, Moerland PD, Tanck MW, Adriaens ME, Bezzina CR.

Circ Cardiovasc Genet. 2014 Dec;7(6):790-8. doi: 10.1161/CIRCGENETICS.114.000537. Epub 2014 Sep 12.

PMID:
25217174
43.

The effect of age on the systemic inflammatory response in patients with community-acquired pneumonia.

van Vught LA, Endeman H, Meijvis SC, Zwinderman AH, Scicluna BP, Biesma DH, van der Poll T.

Clin Microbiol Infect. 2014 Nov;20(11):1183-8. doi: 10.1111/1469-0691.12717. Epub 2014 Jul 18.

44.

Role of tumor necrosis factor-α in the human systemic endotoxin-induced transcriptome.

Scicluna BP, van 't Veer C, Nieuwdorp M, Felsmann K, Wlotzka B, Stroes ES, van der Poll T.

PLoS One. 2013 Nov 13;8(11):e79051. doi: 10.1371/journal.pone.0079051. eCollection 2013.

45.

NLRP3 and ASC differentially affect the lung transcriptome during pneumococcal pneumonia.

van Lieshout MH, Scicluna BP, Florquin S, van der Poll T.

Am J Respir Cell Mol Biol. 2014 Apr;50(4):699-712. doi: 10.1165/rcmb.2013-0015OC.

PMID:
24164497
46.

Interleukin-27: a potential new sepsis biomarker exposed through genome-wide transcriptional profiling.

Scicluna BP, van der Poll T.

Crit Care. 2012 Dec 27;16(6):188. doi: 10.1186/cc11893.

47.

Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction.

Lodder EM, Scicluna BP, Milano A, Sun AY, Tang H, Remme CA, Moerland PD, Tanck MW, Pitt GS, Marchuk DA, Bezzina CR.

PLoS Genet. 2012;8(12):e1003113. doi: 10.1371/journal.pgen.1003113. Epub 2012 Dec 6.

48.

Functional Nav1.8 channels in intracardiac neurons: the link between SCN10A and cardiac electrophysiology.

Verkerk AO, Remme CA, Schumacher CA, Scicluna BP, Wolswinkel R, de Jonge B, Bezzina CR, Veldkamp MW.

Circ Res. 2012 Jul 20;111(3):333-43. doi: 10.1161/CIRCRESAHA.112.274035. Epub 2012 Jun 20.

PMID:
22723301
49.

Load-reducing therapy prevents development of arrhythmogenic right ventricular cardiomyopathy in plakoglobin-deficient mice.

Fabritz L, Hoogendijk MG, Scicluna BP, van Amersfoorth SC, Fortmueller L, Wolf S, Laakmann S, Kreienkamp N, Piccini I, Breithardt G, Noppinger PR, Witt H, Ebnet K, Wichter T, Levkau B, Franke WW, Pieperhoff S, de Bakker JM, Coronel R, Kirchhof P.

J Am Coll Cardiol. 2011 Feb 8;57(6):740-50. doi: 10.1016/j.jacc.2010.09.046.

50.

Quantitative trait loci for electrocardiographic parameters and arrhythmia in the mouse.

Scicluna BP, Tanck MW, Remme CA, Beekman L, Coronel R, Wilde AA, Bezzina CR.

J Mol Cell Cardiol. 2011 Mar;50(3):380-9. doi: 10.1016/j.yjmcc.2010.09.009. Epub 2010 Sep 18.

PMID:
20854825

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