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Items: 29

1.

GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer.

Bevill SM, Olivares-Quintero JF, Sciaky N, Golitz BT, Singh D, Beltran AS, Rashid NU, Stuhlmiller TJ, Hale A, Moorman NJ, Santos CM, Angus SP, Zawistowski JS, Johnson GL.

Mol Cancer Res. 2019 Jul;17(7):1503-1518. doi: 10.1158/1541-7786.MCR-18-1121. Epub 2019 Apr 18.

PMID:
31000582
2.

Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2.

Synodos for NF2 Consortium, Allaway R, Angus SP, Beauchamp RL, Blakeley JO, Bott M, Burns SS, Carlstedt A, Chang LS, Chen X, Clapp DW, Desouza PA, Erdin S, Fernandez-Valle C, Guinney J, Gusella JF, Haggarty SJ, Johnson GL, La Rosa S, Morrison H, Petrilli AM, Plotkin SR, Pratap A, Ramesh V, Sciaky N, Stemmer-Rachamimov A, Stuhlmiller TJ, Talkowski ME, Welling DB, Yates CW, Zawistowski JS, Zhao WN.

PLoS One. 2018 Jun 13;13(6):e0197350. doi: 10.1371/journal.pone.0197350. eCollection 2018.

3.

Proteomic analysis defines kinase taxonomies specific for subtypes of breast cancer.

Collins KAL, Stuhlmiller TJ, Zawistowski JS, East MP, Pham TT, Hall CR, Goulet DR, Bevill SM, Angus SP, Velarde SH, Sciaky N, Oprea TI, Graves LM, Johnson GL, Gomez SM.

Oncotarget. 2018 Jan 29;9(21):15480-15497. doi: 10.18632/oncotarget.24337. eCollection 2018 Mar 20.

4.

New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging.

Brighton HE, Angus SP, Bo T, Roques J, Tagliatela AC, Darr DB, Karagoz K, Sciaky N, Gatza ML, Sharpless NE, Johnson GL, Bear JE.

Cancer Res. 2018 Jan 15;78(2):542-557. doi: 10.1158/0008-5472.CAN-17-1653. Epub 2017 Nov 27.

5.

Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition.

Stuhlmiller TJ, Zawistowski JS, Chen X, Sciaky N, Angus SP, Hicks ST, Parry TL, Huang W, Beak JY, Willis MS, Johnson GL, Jensen BC.

J Am Heart Assoc. 2017 Oct 19;6(10). pii: e006635. doi: 10.1161/JAHA.117.006635.

6.

Enhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex.

Zawistowski JS, Bevill SM, Goulet DR, Stuhlmiller TJ, Beltran AS, Olivares-Quintero JF, Singh D, Sciaky N, Parker JS, Rashid NU, Chen X, Duncan JS, Whittle MC, Angus SP, Velarde SH, Golitz BT, He X, Santos C, Darr DB, Gallagher K, Graves LM, Perou CM, Carey LA, Earp HS, Johnson GL.

Cancer Discov. 2017 Mar;7(3):302-321. doi: 10.1158/2159-8290.CD-16-0653. Epub 2017 Jan 20.

7.

Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome.

Kim Y, Lee HM, Xiong Y, Sciaky N, Hulbert SW, Cao X, Everitt JI, Jin J, Roth BL, Jiang YH.

Nat Med. 2017 Feb;23(2):213-222. doi: 10.1038/nm.4257. Epub 2016 Dec 26.

8.

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.

Kroeze WK, Sassano MF, Huang XP, Lansu K, McCorvy JD, Giguère PM, Sciaky N, Roth BL.

Nat Struct Mol Biol. 2015 May;22(5):362-9. doi: 10.1038/nsmb.3014. Epub 2015 Apr 20.

9.

Pillars article: Three-dimensional segregation of supramolecular activation clusters in T cells. Nature. 1998. 395: 82-86.

Monks CR, Freiberg BA, Kupfer H, Sciaky N, Kupfer A.

J Immunol. 2015 May 1;194(9):4061-5. No abstract available.

10.

Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains.

Stuhlmiller TJ, Miller SM, Zawistowski JS, Nakamura K, Beltran AS, Duncan JS, Angus SP, Collins KA, Granger DA, Reuther RA, Graves LM, Gomez SM, Kuan PF, Parker JS, Chen X, Sciaky N, Carey LA, Earp HS, Jin J, Johnson GL.

Cell Rep. 2015 Apr 21;11(3):390-404. doi: 10.1016/j.celrep.2015.03.037. Epub 2015 Apr 9.

11.

The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells.

Gama V, Swahari V, Schafer J, Kole AJ, Evans A, Huang Y, Cliffe A, Golitz B, Sciaky N, Pei XH, Xiong Y, Deshmukh M.

Sci Signal. 2014 Jul 15;7(334):ra67. doi: 10.1126/scisignal.2005309.

12.

SWI/SNF chromatin-remodeling factor Smarcd3/Baf60c controls epithelial-mesenchymal transition by inducing Wnt5a signaling.

Jordan NV, Prat A, Abell AN, Zawistowski JS, Sciaky N, Karginova OA, Zhou B, Golitz BT, Perou CM, Johnson GL.

Mol Cell Biol. 2013 Aug;33(15):3011-25. doi: 10.1128/MCB.01443-12. Epub 2013 May 28.

13.

A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.

Farrell MS, Pei Y, Wan Y, Yadav PN, Daigle TL, Urban DJ, Lee HM, Sciaky N, Simmons A, Nonneman RJ, Huang XP, Hufeisen SJ, Guettier JM, Moy SS, Wess J, Caron MG, Calakos N, Roth BL.

Neuropsychopharmacology. 2013 Apr;38(5):854-62. doi: 10.1038/npp.2012.251. Epub 2012 Dec 5.

14.

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons.

Huang HS, Allen JA, Mabb AM, King IF, Miriyala J, Taylor-Blake B, Sciaky N, Dutton JW Jr, Lee HM, Chen X, Jin J, Bridges AS, Zylka MJ, Roth BL, Philpot BD.

Nature. 2011 Dec 21;481(7380):185-9. doi: 10.1038/nature10726.

15.

The presynaptic component of the serotonergic system is required for clozapine's efficacy.

Yadav PN, Abbas AI, Farrell MS, Setola V, Sciaky N, Huang XP, Kroeze WK, Crawford LK, Piel DA, Keiser MJ, Irwin JJ, Shoichet BK, Deneris ES, Gingrich J, Beck SG, Roth BL.

Neuropsychopharmacology. 2011 Feb;36(3):638-51. doi: 10.1038/npp.2010.195. Epub 2010 Nov 3.

16.

Symplekin specifies mitotic fidelity by supporting microtubule dynamics.

Cappell KM, Larson B, Sciaky N, Whitehurst AW.

Mol Cell Biol. 2010 Nov;30(21):5135-44. doi: 10.1128/MCB.00758-10. Epub 2010 Sep 7.

17.

Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype.

Borikova AL, Dibble CF, Sciaky N, Welch CM, Abell AN, Bencharit S, Johnson GL.

J Biol Chem. 2010 Apr 16;285(16):11760-4. doi: 10.1074/jbc.C109.097220. Epub 2010 Feb 24.

18.

Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity.

Strachan RT, Sciaky N, Cronan MR, Kroeze WK, Roth BL.

Mol Pharmacol. 2010 Mar;77(3):327-38. doi: 10.1124/mol.109.061440. Epub 2009 Nov 20.

19.

Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells.

Crose LE, Hilder TL, Sciaky N, Johnson GL.

J Biol Chem. 2009 May 15;284(20):13301-5. doi: 10.1074/jbc.C900009200. Epub 2009 Mar 24.

20.

Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration.

Kim TY, Healy KD, Der CJ, Sciaky N, Bang YJ, Juliano RL.

J Biol Chem. 2008 Nov 21;283(47):32762-70. doi: 10.1074/jbc.M800617200. Epub 2008 Sep 11.

21.
22.

Three-dimensional segregation of supramolecular activation clusters in T cells.

Monks CR, Freiberg BA, Kupfer H, Sciaky N, Kupfer A.

Nature. 1998 Sep 3;395(6697):82-6.

PMID:
9738502
23.

Golgi tubule traffic and the effects of brefeldin A visualized in living cells.

Sciaky N, Presley J, Smith C, Zaal KJ, Cole N, Moreira JE, Terasaki M, Siggia E, Lippincott-Schwartz J.

J Cell Biol. 1997 Dec 1;139(5):1137-55.

24.

Heterogeneity of epidermal growth factor binding kinetics on individual cells.

Chung JC, Sciaky N, Gross DJ.

Biophys J. 1997 Aug;73(2):1089-102.

25.

Localization of endogenous furin in cultured cell lines.

Shapiro J, Sciaky N, Lee J, Bosshart H, Angeletti RH, Bonifacino JS.

J Histochem Cytochem. 1997 Jan;45(1):3-12.

PMID:
9010463
26.

Diffusional mobility of Golgi proteins in membranes of living cells.

Cole NB, Smith CL, Sciaky N, Terasaki M, Edidin M, Lippincott-Schwartz J.

Science. 1996 Aug 9;273(5276):797-801.

PMID:
8670420
27.

Golgi dispersal during microtubule disruption: regeneration of Golgi stacks at peripheral endoplasmic reticulum exit sites.

Cole NB, Sciaky N, Marotta A, Song J, Lippincott-Schwartz J.

Mol Biol Cell. 1996 Apr;7(4):631-50.

28.

Developmental induction of Golgi structure and function in the primitive eukaryote Giardia lamblia.

Luján HD, Marotta A, Mowatt MR, Sciaky N, Lippincott-Schwartz J, Nash TE.

J Biol Chem. 1995 Mar 3;270(9):4612-8.

29.

Regulatory aspects of the synthesis of 5-phosphoribosyl-1-pyrophosphate in human red blood cells.

Sciaky N, Razin A, Gazit B, Mager J.

Adv Exp Med Biol. 1973;41:87-92. No abstract available.

PMID:
4364693

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