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Items: 1 to 50 of 235

1.

Use of levosimendan in acute heart failure.

Harjola VP, Giannakoulas G, von Lewinski D, Matskeplishvili S, Mebazaa A, Papp Z, Schwinger RHG, Pollesello P, Parissis JT.

Eur Heart J Suppl. 2018 Dec;20(Suppl I):I2-I10. doi: 10.1093/eurheartj/suy039. Epub 2018 Dec 11.

2.

Antwort.

Schwinger RHG.

Dtsch Med Wochenschr. 2018 Jul;113(13):983-984. doi: 10.1055/a-0608-6767. Epub 2018 Jul 4. German. No abstract available.

PMID:
29972844
3.

[Cardiovascular Medication in Elderly Patients].

Schwinger RHG.

Dtsch Med Wochenschr. 2018 Feb;143(4):236-243. doi: 10.1055/s-0043-108475. Epub 2018 Feb 22. German.

PMID:
29471572
4.

The inodilator levosimendan as a treatment for acute heart failure in various settings.

Gustafsson F, Guarracino F, Schwinger RHG.

Eur Heart J Suppl. 2017 Mar;19(Suppl C):C2-C7. doi: 10.1093/eurheartj/sux001. Epub 2017 Mar 8.

5.

Guided de-escalation of antiplatelet treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention (TROPICAL-ACS): a randomised, open-label, multicentre trial.

Sibbing D, Aradi D, Jacobshagen C, Gross L, Trenk D, Geisler T, Orban M, Hadamitzky M, Merkely B, Kiss RG, Komócsi A, Dézsi CA, Holdt L, Felix SB, Parma R, Klopotowski M, Schwinger RHG, Rieber J, Huber K, Neumann FJ, Koltowski L, Mehilli J, Huczek Z, Massberg S; TROPICAL-ACS Investigators.

Lancet. 2017 Oct 14;390(10104):1747-1757. doi: 10.1016/S0140-6736(17)32155-4. Epub 2017 Aug 28.

PMID:
28855078
6.

Levosimendan beyond inotropy and acute heart failure: Evidence of pleiotropic effects on the heart and other organs: An expert panel position paper.

Farmakis D, Alvarez J, Gal TB, Brito D, Fedele F, Fonseca C, Gordon AC, Gotsman I, Grossini E, Guarracino F, Harjola VP, Hellman Y, Heunks L, Ivancan V, Karavidas A, Kivikko M, Lomivorotov V, Longrois D, Masip J, Metra M, Morelli A, Nikolaou M, Papp Z, Parkhomenko A, Poelzl G, Pollesello P, Ravn HB, Rex S, Riha H, Ricksten SE, Schwinger RHG, Vrtovec B, Yilmaz MB, Zielinska M, Parissis J.

Int J Cardiol. 2016 Nov 1;222:303-312. doi: 10.1016/j.ijcard.2016.07.202. Epub 2016 Jul 29. Review.

7.

The patient perspective: Quality of life in advanced heart failure with frequent hospitalisations.

Nieminen MS, Dickstein K, Fonseca C, Serrano JM, Parissis J, Fedele F, Wikström G, Agostoni P, Atar S, Baholli L, Brito D, Colet JC, Édes I, Gómez Mesa JE, Gorjup V, Garza EH, González Juanatey JR, Karanovic N, Karavidas A, Katsytadze I, Kivikko M, Matskeplishvili S, Merkely B, Morandi F, Novoa A, Oliva F, Ostadal P, Pereira-Barretto A, Pollesello P, Rudiger A, Schwinger RH, Wieser M, Yavelov I, Zymliński R.

Int J Cardiol. 2015 Jul 15;191:256-64. doi: 10.1016/j.ijcard.2015.04.235. Epub 2015 May 1. Review.

8.

Repetitive use of levosimendan for treatment of chronic advanced heart failure: clinical evidence, practical considerations, and perspectives: an expert panel consensus.

Nieminen MS, Altenberger J, Ben-Gal T, Böhmer A, Comin-Colet J, Dickstein K, Edes I, Fedele F, Fonseca C, García-González MJ, Giannakoulas G, Iakobishvili Z, Jääskeläinen P, Karavidas A, Kettner J, Kivikko M, Lund LH, Matskeplishvili ST, Metra M, Morandi F, Oliva F, Parkhomenko A, Parissis J, Pollesello P, Pölzl G, Schwinger RH, Segovia J, Seidel M, Vrtovec B, Wikström G.

Int J Cardiol. 2014 Jun 15;174(2):360-7. doi: 10.1016/j.ijcard.2014.04.111. Epub 2014 Apr 18.

9.

Phosphorylation of myocardial eNOS is altered in patients suffering from type 2 diabetes.

Streit U, Reuter H, Bloch W, Wahlers T, Schwinger RH, Brixius K.

J Appl Physiol (1985). 2013 May 15;114(10):1366-74. doi: 10.1152/japplphysiol.00011.2011. Epub 2012 Dec 20.

10.

Calcium handling in human heart failure--abnormalities and target for therapy.

Reuter H, Schwinger RH.

Wien Med Wochenschr. 2012 Jul;162(13-14):297-301. Epub 2012 Jun 12. Review.

PMID:
22688623
11.

The Modified Glasgow Outcome Score for the prediction of outcome in patients after cardiac arrest: a prospective clinical proof of concept study.

Rana OR, Schröder JW, Kühnen JS, Saygili E, Gemein C, Zink MD, Schauerte P, Schiefer J, Schwinger RH, Weis J, Marx N, Kelm M, Meyer C, Saygili E.

Clin Res Cardiol. 2012 Jul;101(7):533-43. doi: 10.1007/s00392-012-0423-7. Epub 2012 Feb 10.

PMID:
22322567
12.

Cardio-selective beta-blocker: pharmacological evidence and their influence on exercise capacity.

Ladage D, Schwinger RH, Brixius K.

Cardiovasc Ther. 2013 Apr;31(2):76-83. doi: 10.1111/j.1755-5922.2011.00306.x. Epub 2012 Jan 26. Review.

PMID:
22279967
13.

Irregular electrical activation of intrinsic cardiac adrenergic cells increases catecholamine-synthesizing enzymes.

Saygili E, Günzel C, Saygili E, Noor-Ebad F, Schwinger RH, Mischke K, Marx N, Schauerte P, Rana OR.

Biochem Biophys Res Commun. 2011 Sep 30;413(3):432-5. doi: 10.1016/j.bbrc.2011.08.113. Epub 2011 Aug 30.

PMID:
21907185
14.

Hawthorn special extract WS® 1442 increases red blood cell NO-formation without altering red blood cell deformability.

Rieckeheer E, Schwinger RH, Bloch W, Brixius K.

Phytomedicine. 2011 Dec 15;19(1):20-4. doi: 10.1016/j.phymed.2011.08.059. Epub 2011 Sep 6.

PMID:
21899992
15.

Rate and irregularity of electrical activation during atrial fibrillation affect myocardial NGF expression via different signalling routes.

Saygili E, Rana OR, Günzel C, Rackauskas G, Saygili E, Noor-Ebad F, Gemein C, Zink MD, Schwinger RH, Mischke K, Weis J, Marx N, Schauerte P.

Cell Signal. 2012 Jan;24(1):99-105. doi: 10.1016/j.cellsig.2011.08.007. Epub 2011 Aug 26.

PMID:
21889978
16.

Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan.

Papp Z, Édes I, Fruhwald S, De Hert SG, Salmenperä M, Leppikangas H, Mebazaa A, Landoni G, Grossini E, Caimmi P, Morelli A, Guarracino F, Schwinger RH, Meyer S, Algotsson L, Wikström BG, Jörgensen K, Filippatos G, Parissis JT, González MJ, Parkhomenko A, Yilmaz MB, Kivikko M, Pollesello P, Follath F.

Int J Cardiol. 2012 Aug 23;159(2):82-7. doi: 10.1016/j.ijcard.2011.07.022. Epub 2011 Jul 23. Review.

PMID:
21784540
17.

Mechanical stretch of sympathetic neurons induces VEGF expression via a NGF and CNTF signaling pathway.

Saygili E, Pekassa M, Saygili E, Rackauskas G, Hommes D, Noor-Ebad F, Gemein C, Zink MD, Schwinger RH, Weis J, Marx N, Schauerte P, Rana OR.

Biochem Biophys Res Commun. 2011 Jun 24;410(1):62-7. doi: 10.1016/j.bbrc.2011.05.105. Epub 2011 May 24.

PMID:
21640078
18.

Age-related regional differences in cardiac nerve growth factor expression.

Saygili E, Kluttig R, Rana OR, Saygili E, Gemein C, Zink MD, Rackauskas G, Weis J, Schwinger RH, Marx N, Schauerte P.

Age (Dordr). 2012 Jun;34(3):659-67. doi: 10.1007/s11357-011-9262-0. Epub 2011 May 11.

19.

[Physical activity and endothelial dysfunction in type 2 diabetic patients: the role of nitric oxide and oxidative stress].

Brinkmann C, Schwinger RH, Brixius K.

Wien Med Wochenschr. 2011 Jun;161(11-12):305-14. doi: 10.1007/s10354-011-0868-8. Epub 2011 Mar 7. German. Erratum in: Wien Med Wochenschr. 2011 Sep;161(17-18):455.

PMID:
21360292
20.

Transmurality of scar influences the effect of a hybrid-intervention with autologous bone marrow cell injection and aortocoronary bypass surgery (MNC/CABG) in patients after myocardial infarction.

Müller-Ehmsen J, Tossios P, Schmidt M, Scheid C, Unal N, Bovenschulte H, Hackenbroch M, Krug B, Goßmann A, Mehlhorn U, Schwinger RH, Erdmann E.

Int J Cardiol. 2012 May 3;156(3):303-8. doi: 10.1016/j.ijcard.2010.11.010. Epub 2010 Dec 24.

PMID:
21185612
21.

Increased Ca2+ sensitivity of myofibrillar tension in ischaemic vs dilated cardiomyopathy.

Lee S, Lu R, Müller-Ehmsen J, Schwinger RH, Brixius K.

Clin Exp Pharmacol Physiol. 2010 Dec;37(12):1134-8. doi: 10.1111/j.1440-1681.2010.05443.x.

PMID:
20804510
22.

Sympathetic neurons express and secrete MMP-2 and MT1-MMP to control nerve sprouting via pro-NGF conversion.

Saygili E, Schauerte P, Pekassa M, Saygili E, Rackauskas G, Schwinger RH, Weis J, Weber C, Marx N, Rana OR.

Cell Mol Neurobiol. 2011 Jan;31(1):17-25. doi: 10.1007/s10571-010-9548-2. Epub 2010 Aug 4.

PMID:
20683769
23.

[Symptomatic pericardial cyst].

Rasp O, Paetzel C, Eichinger W, Schwinger RH.

Med Klin (Munich). 2010 Jun;105(6):437-8. doi: 10.1007/s00063-010-1075-x. German. No abstract available.

PMID:
20582504
24.

Nebivolol lowers blood pressure and increases weight loss in patients with hypertension and diabetes in regard to age.

Ladage D, Reidenbach C, Rieckeheer E, Graf C, Schwinger RH, Brixius K.

J Cardiovasc Pharmacol. 2010 Sep;56(3):275-81. doi: 10.1097/FJC.0b013e3181eb4ff2.

PMID:
20571428
25.

Total beta-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy.

Lee S, Grafweg S, Schneider T, Jimenez M, Giacobino JP, Ghanem A, Tiemann K, Bloch W, Müller-Ehmsen J, Schwinger RH, Brixius K.

Physiol Res. 2010;59(5):679-89. Epub 2010 Apr 20.

26.

eNOS phosphorylation and translocation are altered in male but not female mice by increased activation of the Gαq protein.

Ruiz-Holst C, Bölck B, Ghanem A, Tiemann K, Brokat S, Regitz-Zagrosek V, Bloch W, Schwinger RH, Brixius K.

Can J Physiol Pharmacol. 2010 Feb;88(2):121-9. doi: 10.1139/Y09-115.

PMID:
20237586
27.

Electrical stimulation of sympathetic neurons induces autocrine/paracrine effects of NGF mediated by TrkA.

Saygili E, Schauerte P, Küppers F, Heck L, Weis J, Weber C, Schwinger RH, Hoffmann R, Schröder JW, Marx N, Rana OR.

J Mol Cell Cardiol. 2010 Jul;49(1):79-87. doi: 10.1016/j.yjmcc.2010.01.019. Epub 2010 Feb 2.

PMID:
20138055
28.

Mechanical stretch induces nerve sprouting in rat sympathetic neurocytes.

Rana OR, Schauerte P, Hommes D, Schwinger RH, Schröder JW, Hoffmann R, Saygili E.

Auton Neurosci. 2010 Jun 24;155(1-2):25-32. doi: 10.1016/j.autneu.2010.01.003. Epub 2010 Feb 1.

PMID:
20122881
29.

Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1.

Hauck C, Potter T, Bartz M, Wittwer T, Wahlers T, Mehlhorn U, Scheiner-Bobis G, McDonough AA, Bloch W, Schwinger RH, Müller-Ehmsen J.

Eur J Pharmacol. 2009 Nov 10;622(1-3):7-14. doi: 10.1016/j.ejphar.2009.08.039. Epub 2009 Sep 12.

30.

Effects of the beta3-adrenergic agonist BRL 37344 on endothelial nitric oxide synthase phosphorylation and force of contraction in human failing myocardium.

Napp A, Brixius K, Pott C, Ziskoven C, Boelck B, Mehlhorn U, Schwinger RH, Bloch W.

J Card Fail. 2009 Feb;15(1):57-67. doi: 10.1016/j.cardfail.2008.08.006. Epub 2008 Oct 14.

PMID:
19181295
31.

Regulation of nerve growth factor in the heart: the role of the calcineurin-NFAT pathway.

Rana OR, Saygili E, Meyer C, Gemein C, Krüttgen A, Andrzejewski MG, Ludwig A, Schotten U, Schwinger RH, Weber C, Weis J, Mischke K, Rassaf T, Kelm M, Schauerte P.

J Mol Cell Cardiol. 2009 Apr;46(4):568-78. doi: 10.1016/j.yjmcc.2008.12.006. Epub 2008 Dec 25.

PMID:
19150448
32.

The angiotensin-calcineurin-NFAT pathway mediates stretch-induced up-regulation of matrix metalloproteinases-2/-9 in atrial myocytes.

Saygili E, Rana OR, Meyer C, Gemein C, Andrzejewski MG, Ludwig A, Weber C, Schotten U, Krüttgen A, Weis J, Schwinger RH, Mischke K, Rassaf T, Kelm M, Schauerte P.

Basic Res Cardiol. 2009 Jul;104(4):435-48. doi: 10.1007/s00395-008-0772-6. Epub 2009 Jan 15.

PMID:
19148693
33.

Role of balloon occlusion for mononuclear bone marrow cell deposition after intracoronary injection in pigs with reperfused myocardial infarction.

Tossios P, Krausgrill B, Schmidt M, Fischer T, Halbach M, Fries JW, Fahnenstich S, Frommolt P, Heppelmann I, Schmidt A, Schomäcker K, Fischer JH, Bloch W, Mehlhorn U, Schwinger RH, Müller-Ehmsen J.

Eur Heart J. 2008 Aug;29(15):1911-21. doi: 10.1093/eurheartj/ehn218. Epub 2008 Jun 10.

PMID:
18544545
34.

Reduced troponin I phosphorylation and increased Ca(2+)-dependent ATP-consumption in triton X-skinned fiber preparations from Galphaq overexpressor mice.

Pott C, Willkomm L, Grafweg S, Bölck B, Dorn GW 2nd, Schwinger RH, Brixius K.

Mol Cell Biochem. 2008 Jul;314(1-2):133-41. doi: 10.1007/s11010-008-9774-9. Epub 2008 May 13.

PMID:
18473122
35.

Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone.

Randriamboavonjy V, Pistrosch F, Bölck B, Schwinger RH, Dixit M, Badenhoop K, Cohen RA, Busse R, Fleming I.

Circulation. 2008 Jan 1;117(1):52-60. Epub 2007 Dec 10.

PMID:
18071073
36.

A simple device to apply equibiaxial strain to cells cultured on flexible membranes.

Rana OR, Zobel C, Saygili E, Brixius K, Gramley F, Schimpf T, Mischke K, Frechen D, Knackstedt C, Schwinger RH, Schauerte P, Saygili E.

Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H532-40. Epub 2007 Oct 26.

37.

Sarcoplasmic Ca2+ release is prolonged in nonfailing myocardium of diabetic patients.

Reuter H, Grönke S, Adam C, Ribati M, Brabender J, Zobel C, Frank KF, Wippermann J, Schwinger RH, Brixius K, Müller-Ehmsen J.

Mol Cell Biochem. 2008 Jan;308(1-2):141-9. Epub 2007 Oct 20.

PMID:
17952561
38.

Genetically changed mice with chronic deficiency or overexpression of the beta-adrenoceptors--what can we learn for the therapy of heart failure?

Lee S, Schwinger RH, Brixius K.

Pflugers Arch. 2008 Feb;455(5):767-74. Epub 2007 Sep 14. Review.

PMID:
17874127
39.

Isoform-specific downregulation of peroxiredoxin in human failing myocardium.

Brixius K, Schwinger RH, Hoyer F, Napp A, Renner R, Bölck B, Kümin A, Fischer U, Mehlhorn U, Werner S, Bloch W.

Life Sci. 2007 Aug 16;81(10):823-31. Epub 2007 Jul 26.

PMID:
17727896
40.

Differential increase of CD34, KDR/CD34, CD133/CD34 and CD117/CD34 positive cells in peripheral blood of patients with acute myocardial infarction.

Grundmann F, Scheid C, Braun D, Zobel C, Reuter H, Schwinger RH, Müller-Ehmsen J.

Clin Res Cardiol. 2007 Sep;96(9):621-7. Epub 2007 Aug 13.

PMID:
17676354
41.

Incidence and outcome of gastrointestinal complications after cardiopulmonary bypass.

Geissler HJ, Fischer UM, Grunert S, Kuhn-Régnier F, Hoelscher A, Schwinger RH, Mehlhorn U, Hekmat K.

Interact Cardiovasc Thorac Surg. 2006 Jun;5(3):239-42. Epub 2006 Feb 8.

PMID:
17670556
42.

Enhanced heterogeneity of myocardial conduction and severe cardiac electrical instability in annexin A7-deficient mice.

Schrickel JW, Brixius K, Herr C, Clemen CS, Sasse P, Reetz K, Grohé C, Meyer R, Tiemann K, Schröder R, Bloch W, Nickenig G, Fleischmann BK, Noegel AA, Schwinger RH, Lewalter T.

Cardiovasc Res. 2007 Nov 1;76(2):257-68. Epub 2007 Jul 6.

PMID:
17662970
43.

Nebivolol induces eNOS activation and NO-liberation in murine corpus cavernosum.

Reidenbach C, Schwinger RH, Steinritz D, Kehe K, Thiermann H, Klotz T, Sommer F, Bloch W, Brixius K.

Life Sci. 2007 Jun 6;80(26):2421-7. Epub 2007 Apr 25.

PMID:
17512554
44.

Mesenchymal stem cells induce endothelial activation via paracine mechanisms.

Ladage D, Brixius K, Steingen C, Mehlhorn U, Schwinger RH, Bloch W, Schmidt A.

Endothelium. 2007 Mar-Apr;14(2):53-63.

PMID:
17497361
45.

Chronic treatment with carvedilol improves Ca(2+)-dependent ATP consumption in triton X-skinned fiber preparations of human myocardium.

Brixius K, Lu R, Boelck B, Grafweg S, Hoyer F, Pott C, Mehlhorn U, Bloch W, Schwinger RH.

J Pharmacol Exp Ther. 2007 Jul;322(1):222-7. Epub 2007 Apr 4.

PMID:
17409273
46.

Beta3-adrenergic eNOS stimulation in left ventricular murine myocardium.

Brixius K, Bloch W, Ziskoven C, Bölck B, Napp A, Pott C, Steinritz D, Jiminez M, Addicks K, Giacobino JP, Schwinger RH.

Can J Physiol Pharmacol. 2006 Oct;84(10):1051-60.

PMID:
17328145
47.

Nitric oxide, erectile dysfunction and beta-blocker treatment (MR NOED study): benefit of nebivolol versus metoprolol in hypertensive men.

Brixius K, Middeke M, Lichtenthal A, Jahn E, Schwinger RH.

Clin Exp Pharmacol Physiol. 2007 Apr;34(4):327-31.

PMID:
17324145
48.

Losartan prevents stretch-induced electrical remodeling in cultured atrial neonatal myocytes.

Saygili E, Rana OR, Saygili E, Reuter H, Frank K, Schwinger RH, Müller-Ehmsen J, Zobel C.

Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2898-905. Epub 2007 Feb 9.

49.

Mechanisms of Ca2+-dependent calcineurin activation in mechanical stretch-induced hypertrophy.

Zobel C, Rana OR, Saygili E, Bölck B, Saygili E, Diedrichs H, Reuter H, Frank K, Müller-Ehmsen J, Pfitzer G, Schwinger RH.

Cardiology. 2007;107(4):281-90. Epub 2007 Jan 29.

PMID:
17264507
50.

Altered tension cost in (TG(mREN-2)27) rats overexpressing the mouse renin gene.

Zobel C, Zavidou-Saroti P, Bölck B, Brixius K, Reuter H, Frank K, Diedrichs H, Müller-Ehmsen J, Bloch W, Schwinger RH.

Eur J Appl Physiol. 2007 Jan;99(2):121-32. Epub 2006 Oct 25.

PMID:
17063360

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