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Items: 39

1.

Non-isotopic dual parameter competition assay suitable for high-throughput screening of histone deacetylases.

Riester D, Hildmann C, Haus P, Galetovic A, Schober A, Schwienhorst A, Meyer-Almes FJ.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3651-6. doi: 10.1016/j.bmcl.2009.04.102. Epub 2009 May 3.

PMID:
19457659
2.

Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation.

Kuhn AN, van Santen MA, Schwienhorst A, Urlaub H, Lührmann R.

RNA. 2009 Jan;15(1):153-75. doi: 10.1261/rna.1332609. Epub 2008 Nov 24.

3.

HKI 46F08, a novel potent histone deacetylase inhibitor, exhibits antitumoral activity against embryonic childhood cancer cells.

Wegener D, Deubzer HE, Oehme I, Milde T, Hildmann C, Schwienhorst A, Witt O.

Anticancer Drugs. 2008 Oct;19(9):849-57. doi: 10.1097/CAD.0b013e32830efbeb.

PMID:
18765999
4.

Identification of novel small-molecule histone deacetylase inhibitors by medium-throughput screening using a fluorigenic assay.

Wegener D, Hildmann C, Riester D, Schober A, Meyer-Almes FJ, Deubzer HE, Oehme I, Witt O, Lang S, Jaensch M, Makarov V, Lange C, Busse B, Schwienhorst A.

Biochem J. 2008 Jul 1;413(1):143-50. doi: 10.1042/BJ20080536.

PMID:
18384290
5.

Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).

Schäfer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M.

Bioorg Med Chem. 2008 Feb 15;16(4):2011-33. Epub 2007 Nov 4.

PMID:
18054239
6.

Structure of a novel thrombin inhibitor with an uncharged D-amino acid as P1 residue.

Friedrich R, Riester D, Göttig P, Thürk M, Schwienhorst A, Bode W.

Eur J Med Chem. 2008 Jun;43(6):1330-5. Epub 2007 Sep 9.

PMID:
17950494
7.

Inhibitor-mediated stabilization of the conformational structure of a histone deacetylase-like amidohydrolase.

Kern S, Riester D, Hildmann C, Schwienhorst A, Meyer-Almes FJ.

FEBS J. 2007 Jul;274(14):3578-3588. doi: 10.1111/j.1742-4658.2007.05887.x.

8.

Factors affecting the substrate specificity of histone deacetylases.

Riester D, Hildmann C, Grünewald S, Beckers T, Schwienhorst A.

Biochem Biophys Res Commun. 2007 Jun 1;357(2):439-45. Epub 2007 Apr 3.

PMID:
17428445
9.

Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor.

Nielsen TK, Hildmann C, Riester D, Wegener D, Schwienhorst A, Ficner R.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 1;63(Pt 4):270-3. Epub 2007 Mar 23.

10.

Histone deacetylases--an important class of cellular regulators with a variety of functions.

Hildmann C, Riester D, Schwienhorst A.

Appl Microbiol Biotechnol. 2007 Jun;75(3):487-97. Epub 2007 Mar 22. Review.

PMID:
17377789
11.

Histone deacetylase inhibitors--turning epigenic mechanisms of gene regulation into tools of therapeutic intervention in malignant and other diseases.

Riester D, Hildmann C, Schwienhorst A.

Appl Microbiol Biotechnol. 2007 Jun;75(3):499-514. Epub 2007 Mar 22. Review.

PMID:
17377788
12.

Histone deacetylase inhibitor assay based on fluorescence resonance energy transfer.

Riester D, Hildmann C, Schwienhorst A, Meyer-Almes FJ.

Anal Biochem. 2007 Mar 1;362(1):136-41. Epub 2007 Jan 4.

PMID:
17250798
13.

Direct thrombin inhibitors - a survey of recent developments.

Schwienhorst A.

Cell Mol Life Sci. 2006 Dec;63(23):2773-91. Review.

PMID:
17103113
14.

An active site tyrosine residue is essential for amidohydrolase but not for esterase activity of a class 2 histone deacetylase-like bacterial enzyme.

Moreth K, Riester D, Hildmann C, Hempel R, Wegener D, Schober A, Schwienhorst A.

Biochem J. 2007 Feb 1;401(3):659-65.

15.

Substrate and inhibitor specificity of class 1 and class 2 histone deacetylases.

Hildmann C, Wegener D, Riester D, Hempel R, Schober A, Merana J, Giurato L, Guccione S, Nielsen TK, Ficner R, Schwienhorst A.

J Biotechnol. 2006 Jun 25;124(1):258-70. Epub 2006 Mar 29.

PMID:
16567013
16.

Crystal structure of a bacterial class 2 histone deacetylase homologue.

Nielsen TK, Hildmann C, Dickmanns A, Schwienhorst A, Ficner R.

J Mol Biol. 2005 Nov 18;354(1):107-20. Epub 2005 Oct 7.

PMID:
16242151
17.

Thrombin inhibitors identified by computer-assisted multiparameter design.

Riester D, Wirsching F, Salinas G, Keller M, Gebinoga M, Kamphausen S, Merkwirth C, Goetz R, Wiesenfeldt M, Stürzebecher J, Bode W, Friedrich R, Thürk M, Schwienhorst A.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8597-602. Epub 2005 Jun 3.

18.

Members of the histone deacetylase superfamily differ in substrate specificity towards small synthetic substrates.

Riester D, Wegener D, Hildmann C, Schwienhorst A.

Biochem Biophys Res Commun. 2004 Nov 19;324(3):1116-23.

PMID:
15485670
19.

A new amidohydrolase from Bordetella or Alcaligenes strain FB188 with similarities to histone deacetylases.

Hildmann C, Ninkovic M, Dietrich R, Wegener D, Riester D, Zimmermann T, Birch OM, Bernegger C, Loidl P, Schwienhorst A.

J Bacteriol. 2004 Apr;186(8):2328-39.

20.

Directed evolution towards protease-resistant hirudin variants.

Wirsching F, Keller M, Hildmann C, Riester D, Schwienhorst A.

Mol Genet Metab. 2003 Dec;80(4):451-62.

PMID:
14654359
21.

Recent progress in the development of assays suited for histone deacetylase inhibitor screening.

Wegener D, Hildmann C, Schwienhorst A.

Mol Genet Metab. 2003 Sep-Oct;80(1-2):138-47. Review.

PMID:
14567963
22.

Improved fluorogenic histone deacetylase assay for high-throughput-screening applications.

Wegener D, Hildmann C, Riester D, Schwienhorst A.

Anal Biochem. 2003 Oct 15;321(2):202-8.

PMID:
14511685
23.

Genetic algorithm for the design of molecules with desired properties.

Kamphausen S, Höltge N, Wirsching F, Morys-Wortmann C, Riester D, Goetz R, Thürk M, Schwienhorst A.

J Comput Aided Mol Des. 2002 Aug-Sep;16(8-9):551-67.

PMID:
12602950
24.

A fluorogenic histone deacetylase assay well suited for high-throughput activity screening.

Wegener D, Wirsching F, Riester D, Schwienhorst A.

Chem Biol. 2003 Jan;10(1):61-8.

PMID:
12573699
26.
27.

A new reporter gene system suited for cell-free protein synthesis and high-throughput screening in small reaction volumes.

Hempel R, Wirsching F, Schober A, Schwienhorst A.

Anal Biochem. 2001 Oct 15;297(2):177-82.

PMID:
11673885
28.

Fluorogenic assay for penicillin G acylase activity.

Ninkovic M, Riester D, Wirsching F, Dietrich R, Schwienhorst A.

Anal Biochem. 2001 May 15;292(2):228-33.

PMID:
11355855
29.

Cation radius effects on cell-free translation in rabbit reticulocyte lysate.

Hempel R, Schmidt-Brauns J, Gebinoga M, Wirsching F, Schwienhorst A.

Biochem Biophys Res Commun. 2001 May 4;283(2):267-72.

PMID:
11327692
30.

High-fidelity in vitro recombination using a proofreading polymerase.

Ninkovic M, Dietrich R, Aral G, Schwienhorst A.

Biotechniques. 2001 Mar;30(3):530-4, 536.

31.

Selection of viral RNA-derived tRNA-like structures with improved valylation activities.

Wientges J, Pütz J, Giegé R, Florentz C, Schwienhorst A.

Biochemistry. 2000 May 23;39(20):6207-18.

PMID:
10821696
32.

Novel vector for generating RNAs with defined 3' ends and its use in antiviral strategies.

Schwienhorst A, Lindemann BF.

Biotechniques. 1998 Jan;24(1):116, 118, 120, 122 passim.

33.

Display of functional thrombin inhibitor hirudin on the surface of phage M13.

Wirsching F, Opitz T, Dietrich R, Schwienhorst A.

Gene. 1997 Dec 19;204(1-2):177-84.

PMID:
9434182
34.

Rapid selection of aminoacyl-tRNAs based on biotinylation of alpha-NH2 group of charged amino acids.

Pütz J, Wientges J, Sissler M, Giegé R, Florentz C, Schwienhorst A.

Nucleic Acids Res. 1997 May 1;25(9):1862-3.

35.

Optimizing doped libraries by using genetic algorithms.

Tomandl D, Schober A, Schwienhorst A.

J Comput Aided Mol Des. 1997 Jan;11(1):29-38.

PMID:
9139109
36.

Hamming chromatography.

Schwienhorst A, Schober A, Günther R, Stadler PF.

Mol Divers. 1996 May;1(3):187-92.

PMID:
9237210
37.

Growth kinetics of a bacteriophage in continuous culture.

Schwienhorst A, Lindemann BF, Eigen M.

Biotechnol Bioeng. 1996 Apr 20;50(2):217-21.

PMID:
18626939
38.

Combinatorial libraries by cassette mutagenesis.

Borrego B, Wienecke A, Schwienhorst A.

Nucleic Acids Res. 1995 May 25;23(10):1834-5. No abstract available.

39.

Accurate high-speed liquid handling of very small biological samples.

Schober A, Günther R, Schwienhorst A, Döring M, Lindemann BF.

Biotechniques. 1993 Aug;15(2):324-9.

PMID:
8373601

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